Table 4 Tacrolimus-aspirin combination therapy and its effect on adverse pregnancy outcomes
|  | Tacrolimus + aspirin combination therapy | logistic regression analysis | ||||
|---|---|---|---|---|---|---|
Factor | Tacrolimus only | Tacrolimus + aspirin | p value | OR | 95% CI | p value |
n | 13 | 16 | Â | Â | Â | Â |
Overall APO (%) | 7 (53.8) | 9 (56.2) | 1.00 | 1.10 | 0.25–4.8 | 0.90 |
Maternal APO (%) | 5 (38.5) | 8 (50.0) | 0.80 | 1.60 | 0.36–7.07 | 0.54 |
Neonatal APO (%) | 8 (61.5) | 7 (43.8) | 0.56 | 0.49 | 0.11–2.16 | 0.34 |
PROMISSE APO (%) | 2 (15.4) | 3 (18.8) | 1.00 | 1.27 | 0.18–9.02 | 0.81 |
Flare during pregnancy (%) | 3 (23.1) | 5 (31.2) | 0.70 | 1.52 | 0.29–8.03 | 0.63 |
flare after delivery (%) | 1 (10.0) | 1 (7.7) | 1.0 | 0.75 | 0.04–13.7 | 0.85 |
Hypertensive Disorders of Pregnancy (%) | 4 (30.8) | 3 (18.8) | 0.67 | 0.52 | 0.93–2.90 | 0.46 |
Preeclampsia (%) | 2 (15.4) | 1 (6.2) | 0.57 | 0.37 | 0.03–4.57 | 0.44 |
Eclampsia (%) | 0 (0.0) | 0 (0.0) | NA | NA | NA | NA |
HELLP syndrome (%) | 0 (0.0) | 0 (0.0) | 1.00 | NA | NA | NA |
Gestational DM (%) | 2 (15.4) | 4 (25.0) | 0.66 | 1.83 | 0.28–12.1 | 0.53 |
Oligohydramnios (%) | 1 (7.7) | 0 (0.0) | 0.45 | NA | NA | NA |
Maternal death (%) | 0 (0.0) | 0 (0.0) | NA | NA | NA | NA |
Total duration of gestation (days) | 263 [166, 273] | 266 [245.8, 272] | 0.71 | NA | NA | NA |
Preterm birth (%) | 3 (27.3) | 2 (14.3) | 0.62 | 0.44 | 0.06–3.29 | 0.43 |
Spontaneous abortion (%) | 1 (8.3) | 1 (6.7) | 1.00 | 0.79 | 0.04–14 | 0.87 |
Missed abortion (%) | 1 (7.7) | 0 (0.0) | 0.48 | NA | NA | NA |
Iatrogenic abortion (%) | 1 (7.7) | 2 (12.5) | 1.00 | 1.70 | 0.14–21.3 | 0.68 |
Still birth (%) | 0 (0.0) | 0 (0.0) | NA | NA | NA | NA |
Planned C section (%) | 1 (10.0) | 2 (15.4) | 1.00 | 1.64 | 0.13–21.1 | 0.71 |
Emergency C section (%) | 6 (60.0) | 7 (53.8) | 1.00 | 0.78 | 0.15–4.13 | 0.77 |
Height at birth (cm) | 46.3 [43.8, 49.9] | 48.0 [44.0, 50.0] | 0.64 | NA | NA | NA |
Weight at birth (g) | 2577 [2123, 2889] | 2882 [2532, 3025] | 0.17 | NA | NA | NA |
Low birth weight (%) | 5 (50.0) | 3 (23.1) | 0.22 | 0.30 | 0.05–1.80 | 0.19 |
SGA (%) | 2 (20.0) | 2 (15.4) | 1.00 | 0.73 | 0.08–6.31 | 0.77 |
Apgar score > 7 (1 min) | 8 (80.0) | 13 (100.0) | 0.35 | NA | NA | NA |
Apgar score > 7 (5 min) | 9 (90.0) | 13 (100.0) | 0.89 | NA | NA | NA |
Major malformation (%) | 0 (0.0) | 1 (7.7) | 1.00 | NA | NA | NA |
Death of the neonate (%) | 1 (10.0) | 0 (0.0) | 0.44 | NA | NA | NA |