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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Impaired immune tolerance mediated by reduced Tfr cells in rheumatoid arthritis linked to gut microbiota dysbiosis and altered metabolites

Fig. 1

The comparisons in the expressions of CD4 + T, Th17, Treg, c-Tfr, and c-Tfh cells between patients with RA and HCs. The number of Th17 and c-Tfh cells as well as the ratio of Th17/Treg cells was not changed between RA and HCs, while the number of Treg and c-Tfr cells was reduced in new-onset RA patients. And the ratio of c-Tfh/c-Tfr cells was increased in new-onset RA patients. The new-onset patients with RA had a higher percentage of c-Tfh cells but a lower percentage of c-Tfr cells than those in HCs. A The comparison in the number of CD4+ T cells. B The comparison in the number of Th17 cells. C The comparison in the percent of Th17 cells. D The comparison in the number of Treg cells. E The comparison in the percent of Treg cells. F The comparison in the number of c-Tfr cells. G The comparison in the percent of c-Tfr cells. H The comparison in the number of c-Tfh cells. I The comparison in the percent of c-Tfh cells. J The comparison in the ratio of Th17/Treg. K The comparison in the ratio of c-Tfh/c-Tfr. (Th17: helper T 17 cells; Treg: regulatory T cells; Tfr: follicular regulatory T cells; Tfh: follicular helper T cells; RA: rheumatoid arthritis; HCs: healthy controls)

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Arthritis Research & Therapy

ISSN: 1478-6362

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