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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Impaired immune tolerance mediated by reduced Tfr cells in rheumatoid arthritis linked to gut microbiota dysbiosis and altered metabolites

Fig. 6

The analysis of gut microbiota-derived metabolites in new-onset patients with RA. A The KEGG pathway enrichment analysis of the differentially abundant metabolites. Four pathways including biosynthesis of unsaturated fatty acids (P < 0.001), arginine biosynthesis (P = 0.012), and tryptophan metabolism (P = 0.012), as well as alanine, aspartate, and glutamate metabolism (P = 0.004) were the main pathways related to RA in the top twenty pathways. B The correlation heatmap of the eleven differentially abundant metabolites involved in the four mainly altered pathway and indicators of RA. C The ROC curve of biomarker analysis for arachidonic acid. (RA: rheumatoid arthritis; HCs: healthy controls; KEGG: Kyoto Encyclopedia of Genes and Genomes; ROC: receiver operating characteristic; AUC: area under curve; CI: confidence interval)

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Arthritis Research & Therapy

ISSN: 1478-6362

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