Cartilage destruction in early rheumatoid arthritis patients correlates with CD21−/low double-negative B cells

Table 1 Baseline characteristics of patients with early and established RA and HD

Characteristics	RA N = 76	HD N = 28	RA N = 32	RA N = 63	Est RA N = 5
	All patients		Radiographs	Available CD27IgD data	SF
Female, n (%)	54 (71)	19 (68)	24 (75)	44 (70)	2 (40)
Age, year	54 (15)	55 (15)	55 (17)	52 (16)	62 (18)
Symptom duration (months)	6 (5)	NA	6 (4)	6 (5)	87 (74)^a
Smoking, n (%)	11 (14)	NA	2 (6)	9 (14)	ND^b
CDAI	28 (59)	NA	30 (14)	30 (12)	ND^b
CRP, mg/L	24 (36)	NA	29 (44)	25 (39)	ND^b
ESR, mm/h	33 (27)	NA	36 (29)	34 (29)	ND^b
TJC68	19 (10)	NA	14 (10)	16 (10)	ND^b
SJC66	16 (6)	NA	12 (7)	12 (6)	ND^b
TJC28	9 (6)	NA	8 (7)	9 (7)	ND^b
SJC28	9 (5)	NA	9 (5)	9 (5)	ND^b
VAS-GH	58 (21)	NA	61 (20)	61 (20)	ND^b
DAS28-ESR	5 (1)	NA	5 (1)	5 (1)	ND^b
DAS28-CRP	5 (1)	NA	5 (1)	5 (1)	ND^b
ACPA + , n (%)	63 (83)	NA	25 (78)	53 (84)	3 (75)^a
RF + , n (%)	57 (75)	NA	22 (69)	47 (75)	2 (50)^a
ACPA + RF + , n (%)	52(68)	NA	20 (63)	43 (68)	2 (50)^a
ACPA − RF − , n (%)	8 (11)	NA	5 (16)	6 (10)	1 (25)^a

Data are denoted as number of patients as well as proportions (%) for categorical data and means ± standard deviation for continuous data
ACPA anti-citrullinated protein antibody, CDAI Clinical Disease Activity Index, CRP C-reactive protein, DAS28 Disease Activity Score 28 joints, ESR erythrocyte sedimentation rate, NA not applicable, ND not done, RF rheumatoid factor, SF synovial fluid, SJC swollen joint count, TJC tender joint count, VAS-GH visual analogue scale general health
^aTwo different ethical approvals were used to obtain synovial fluid, one of which did not allow clinical data to be analysed, so data were only available for 4 out of 5 patients
^bSynovial fluid was obtained during an outpatient injection clinic and all joints were not assessed and laboratory data were not recorded

ISSN: 1478-6362