Table 3 Causal effects of ankylosing spondylitis on immune cells

Ankylosing spondylitis

CD8 on HLA DR + CD8 + T cell

Inverse variance weighted

6

4.46E − 05

1.029 (1.015, 1.043)

MR-Egger

6

0.119

1.022 (1.000, 1.045)

Weighted median

6

2.81E − 05

1.031 (1.016, 1.045)

Weighted mode

6

0.011

1.031 (1.015, 1.047)

CD3 on HLA DR + CD8 + T cell

Inverse variance weighted

6

1.99E − 04

0.974 (0.961, 0.988)

MR-Egger

6

0.032

0.964 (0.943, 0.986)

Weighted median

6

1.31E − 04

0.971 (0.956, 0.986)

Weighted mode

6

0.012

0.970 (0.955, 0.985)

CD8 + natural killer T %lymphocyte

Inverse variance weighted

6

1.92E − 04

0.973 (0.959, 0.987)

MR-Egger

6

0.120

0.978 (0.956, 0.999)

Weighted median

6

5.62E − 04

0.974 (0.959, 0.989)

Weighted mode

6

0.024

0.974 (0.959, 0.990)

IgD on IgD + CD24 + B cell

Inverse variance weighted

6

1.20E − 04

0.973 (0.960, 0.987)

MR-Egger

6

0.052

0.970 (0.950, 0.991)

Weighted median

6

1.67E − 04

0.972 (0.958, 0.987)

Weighted mode

6

0.012

0.970 (0.955, 0.985)

CD8 + natural killer T %T cell

Inverse variance weighted

6

1.65E − 04

0.973 (0.959, 0.987)

MR-Egger

6

0.101

0.976 (0.955, 0.998)

Weighted median

6

6.83E − 04

0.973 (0.958, 0.989)

Weighted mode

6

0.021

0.974 (0.959, 0.989)

IgD on IgD + CD38 − unswitched memory B cell

Inverse variance weighted

6

3.02E − 05

0.962 (0.945, 0.980)

MR-Egger

6

0.164

0.976 (0.948, 1.003)

Weighted median

6

1.11E − 04

0.964 (0.946, 0.982)

Weighted mode

6

0.013

0.964 (0.946, 0.982)