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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Integrative analysis of single-cell and bulk transcriptome data reveal the significant role of macrophages in lupus nephritis

Fig. 1

Results of bulk transcriptome analysis for lupus nephritis (LN). (A) Heatmap of bulk transcriptome differentially expressed genes (DEGs) between LN and normal kidney tissues. (B) Volcano plot of the bulk transcriptome DEGs between LN and normal kidney tissues. (C) Bubble plot of the results of gene ontology (GO) enrichment analysis of the DEGs. (D, E) Interferon (IFN) signature genes were significantly upregulated in LN samples compared with in normal kidney samples. (F) The infiltration abundance of up to 22 types of immune cells imputed from bulk transcriptomes of LN and control samples using the CIBERSORT method. (G) Correlation matrix of the 22 immune cell types and the IFN scores of LN samples. (H) The linear correlations between IFN signature genes and macrophage abundance in LN samples. * p-value less than 0.05

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Arthritis Research & Therapy

ISSN: 1478-6362

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