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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Integrative analysis of single-cell and bulk transcriptome data reveal the significant role of macrophages in lupus nephritis

Fig. 2

Results of scRNA-seq data analysis of lupus nephritis (LN). (A) Uniform manifold approximation and projection (UMAP) plot of the scRNA-seq data of LN with cell type annotations. (B) Heatmap of the expression of differentially expressed genes (DEGs) identified from the bulk transcriptome in each cell cluster from scRNA-seq data of LN. (C) ssGSEA scores of each cell cluster in LN for the bulk transcriptome DEGs. (D) Heatmap of the cellular signaling pathway of each immune cell cluster in LN and normal kidney tissue. (E) Results of the trajectory analysis of macrophages in LN, showing the distribution of macrophage subtypes alongside the pseudotime. (F) The heatmap of marker genes alongside the evolution of macrophages in LN

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Arthritis Research & Therapy

ISSN: 1478-6362

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