Fig. 6
Transcription factors (TFs) predicted to bind at the DMR. A Schematic representation of the 16 CpGs and of 10 TFs predicted to bind at or close to the CpGs. cg26736200 (CpG8) and cg26661922 (CpG13) are highlighted. The TFs are marked by grey rectangles with the direction of the arrows within the rectangles indicating the DNA strand the TF is predicted to bind to (arrows pointing to the left = antisense strand, arrows pointing to the right = sense strand). TF heterodimers are denoted by a double colon (::) between two TFs. B Expression levels (TPM, transcripts per million) of the TFs in cartilage chondrocytes from 10 OA patients. Triangles represent individual samples. Box plots show the median, 25th and 75th percentiles, and minimum and maximum values