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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence

Fig. 7

Proposed molecular model. A The DMR is part of a transcriptional activator that loops to the shared promoter of WWP2-FL and WWP2-N. In the presence of the OA-risk conferring allele G of rs34195470, the DMR is more highly methylated. This modulates binding of TFs to the DMR and increases its transcriptional activation potential via the recruitment of co-factors. This results in greater relative expression of WWP2-FL and WWP2-N. B In the presence of the OA non-risk conferring allele A of rs34195470, the DMR is less methylated. This results in decreased transcriptional activation potential and decreased relative expression of WWP2-FL and WWP2-N. Methylated CpGs are represented by filled circles; unmethylated CpGs are represented as unfilled circles. WWP2-FL mRNA is represented as longer wavy lines; WWP2-N mRNA is represented as shorter wavy lines

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Arthritis Research & Therapy

ISSN: 1478-6362

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