Sex-specific disparities in disease activity scores among patients with axial spondyloarthritis and their implications for evaluating the response to tumor necrosis factor alpha inhibitor therapy

Table 5 Comparisons of sex differences in TNFi response using BASDAI and ASDAS, adjusted for variables^a by multivariate logistic regression analysis and inverse probability of treatment weighting (IPTW)

Outcome	Multivariate logistic regression analysis		IPTW
Outcome	OR^d (95% CI)	p-value	OR (95% CI)	p-value
BASDAI criterion^b	1.700 (1.200–2.406)	0.003	1.388 (1.046–1.842)	0.023
ASDAS criterion^c	0.993 (0.678–1.455)	0.973	0.890 (0.648–1.222)	0.471

BASDAI Bath Ankylosing Spondylitis Disease Activity Score, ASDAS Ankylosing Spondylitis Disease Activity Score, IPTW inverse probability of treatment weighting, OR Odds ratio.
^aIncluded variables were age, disease duration, HLA-B27 positivity, radiographic changes, cigarette smoking, peripheral arthritis, uveitis, family history of spondyloarthritis, enthesitis, type of tumor necrosis factor alpha inhibitors, baseline value of each outcome, and the time interval between baseline to the first follow-up.
^bBASDAI criterion: If BASDAI decreases by 50% or more of the baseline, or by two or more, the patient was classified as a responder.
^cASDAS criterion: If ASDAS decreases by 1.1 or more of the baseline, the patient was classified as a responder.
^dThe calculated odds ratio of reaching the response criteria in male patients compared to female patients. Odds ratios above 1.0 indicate that male patients are more likely to be found effective for each criterion, while odds ratios below 1.0 indicate that male patients are less likely to be found effective.

ISSN: 1478-6362