Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model

Table 1 RNA-seq results for known hypertrophic genes

	*FC T3*	*P-value T3*	*FC OAvsH*	*P-value OAvsH*	*FC OAvsP*	*P-value OAP*
*ALPL*	*1.71*	*n.s.*	NA	NA	*1.47*	*n.s.*
*COL1A1*	*-3.00*	*2.94 x 10*^-03	*126*	*7.46 x 10*^-22	*1.14*	*n.s.*
*COL10A1*	*-3.90*	*9.22 x 10*^-04	*8.6*	*7.39 x 10*^-08	*-1.33*	*n.s.*
*EPAS1*	*1.59*	*9.58 x 10*^-03	NA	NA	*-1.17*	*3,03 x 10*^-03
*MMP13*	NA	NA	50	*6.07 x 10*^-18	*-1.12*	*n.s.*

Statistical difference for T3 RNA-seq was determined by DESeq analysis. Fold change (FC) and uncorrected P-values are shown for T3 versus control. Data for OA versus healthy (OAvsH) from Karlsson et al. [20]. Data for OA versus preserved (OAvsP) from Coutinho de Almeida et al. [16]
N.s. not significant, NA Not available

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