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Volume 12 Supplement 1

The role of IFN alpha in autoimmune disease


Edited by Jean-Michel Dayer

Publication of the supplement has been supported with funding from MedImmune, LLC.

  1. Type I interferons are pleiotropic cytokines with antiviral, antitumor and immunoregulatory functions. An aspect of their complex biology is the paradox that, depending on context, type I interferons can be an...

    Authors: George D Kalliolias and Lionel B Ivashkiv
    Citation: Arthritis Research & Therapy 2010 12(Suppl 1):S1
  2. Type I interferons play an outstanding role in innate and adaptive immunity by enhancing functions of dendritic cells, inducing differentiation of monocytes, promoting immunoglobulin class switching in B cells...

    Authors: Angélica M Delgado-Vega, Marta E Alarcón-Riquelme and Sergey V Kozyrev
    Citation: Arthritis Research & Therapy 2010 12(Suppl 1):S2
  3. Patients with lupus have a continuous production of IFNα and display an increased expression of IFNα-regulated genes. The reason for the ongoing IFNα synthesis in these patients seems to be an activation of pl...

    Authors: Lars Rönnblom
    Citation: Arthritis Research & Therapy 2010 12(Suppl 1):S3
  4. Recent studies suggest a mechanistic role for molecules induced by type 1 interferons in the pathogenesis of some forms of myositis. For dermatomyositis, evidence that these molecules injure myofibers seems es...

    Authors: Steven A Greenberg
    Citation: Arthritis Research & Therapy 2010 12(Suppl 1):S4
  5. Type I interferons are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Type I interferon-inducible mRNAs are widely and concordantly overexpressed in the periphery and involved tissues of...

    Authors: Yihong Yao, Brandon W Higgs, Laura Richman, Barbara White and Bahija Jallal
    Citation: Arthritis Research & Therapy 2010 12(Suppl 1):S6

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