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Volume 16 Supplement 2

At the interface between immunology and endocrinology in rheumatic diseases

Reviews

Edited by Rainer Straub

This supplement was proposed, developed and commissioned by Arthritis Research & Therapy and was funded by an educational grant from Horizon Pharma Inc. All published articles were independently prepared by the authors and have undergone peer review in accordance with the journal’s standard policies and processes. Horizon Pharma Inc had no input into the topics covered or the articles themselves. The Supplement Editor was appointed by the journal and declares that they have no competing interests.

Ever since Philip S Hench was awarded the Nobel Prize in Physiology or Medicine in 1950 for introducing glucocorticoids into clinical medicine, its mode of action and its application in the treatment of rheumatic diseases continues to be studied. Articles in this supplement look at what we have learned about the use of glucocorticoids in rheumatic diseases, and how insulin resistance, common in chronic inflammatory systemic diseases, serves as an example to demonstrate the complex crosstalk of the endocrine, nervous and immune systems.

  2. The management of rheumatoid arthritis (RA) is primarily based on the use of disease-modifying antirheumatic drugs (DMARDs), mainly comprising synthetic chemical compounds (that is, methotrexate or leflunomide...

    Authors: Maurizio Cutolo, Cornelia M Spies, Frank Buttgereit, Sabrina Paolino and Carmen Pizzorni
    Citation: Arthritis Research & Therapy 2014 16(Suppl 2):S1
    Content type: Review Published on:

  3. Glucocorticoids play a pivotal role in the management of many inflammatory rheumatic diseases. The therapeutic effects range from pain relief in arthritides, to disease-modifying effects in early rheumatoid ar...

    Authors: Marlies C van der Goes, Johannes W Jacobs and Johannes W Bijlsma
    Citation: Arthritis Research & Therapy 2014 16(Suppl 2):S2
    Content type: Review Published on:

  4. The hypothalamic-pituitary-adrenal (HPA) axis plays an important role in regulating and controlling immune responses. Dysfunction of the HPA axis has been implicated in the pathogenesis of rheumatoid arthritis...

    Authors: Cornelia M Spies, Rainer H Straub, Maurizio Cutolo and Frank Buttgereit
    Citation: Arthritis Research & Therapy 2014 16(Suppl 2):S3
    Content type: Review Published on:

  5. Insulin resistance (IR) is a general phenomenon of many physiological states, disease states, and diseases. IR has been described in diabetes mellitus, obesity, infection, sepsis, trauma, painful states such a...

    Authors: Rainer H Straub
    Citation: Arthritis Research & Therapy 2014 16(Suppl 2):S4
    Content type: Review Published on:
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