Ever since Philip S Hench was awarded the Nobel Prize in Physiology or Medicine in 1950 for introducing glucocorticoids into clinical medicine, its mode of action and its application in the treatment of rheumatic diseases continues to be studied. Articles in this supplement look at what we have learned about the use of glucocorticoids in rheumatic diseases, and how insulin resistance, common in chronic inflammatory systemic diseases, serves as an example to demonstrate the complex crosstalk of the endocrine, nervous and immune systems.
Volume 16 Supplement 2
At the interface between immunology and endocrinology in rheumatic diseases
Reviews
Edited by Rainer Straub
This supplement was proposed, developed and commissioned by Arthritis Research & Therapy and was funded by an educational grant from Horizon Pharma Inc. All published articles were independently prepared by the authors and have undergone peer review in accordance with the journal’s standard policies and processes. Horizon Pharma Inc had no input into the topics covered or the articles themselves. The Supplement Editor was appointed by the journal and declares that they have no competing interests.
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Citation: Arthritis Research & Therapy 2014 16(Suppl 2):I1
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The supplementary therapeutic DMARD role of low-dose glucocorticoids in rheumatoid arthritis
The management of rheumatoid arthritis (RA) is primarily based on the use of disease-modifying antirheumatic drugs (DMARDs), mainly comprising synthetic chemical compounds (that is, methotrexate or leflunomide...
Citation: Arthritis Research & Therapy 2014 16(Suppl 2):S1 -
The value of glucocorticoid co-therapy in different rheumatic diseases - positive and adverse effects
Glucocorticoids play a pivotal role in the management of many inflammatory rheumatic diseases. The therapeutic effects range from pain relief in arthritides, to disease-modifying effects in early rheumatoid ar...
Citation: Arthritis Research & Therapy 2014 16(Suppl 2):S2 -
Circadian rhythms in rheumatology - a glucocorticoid perspective
The hypothalamic-pituitary-adrenal (HPA) axis plays an important role in regulating and controlling immune responses. Dysfunction of the HPA axis has been implicated in the pathogenesis of rheumatoid arthritis...
Citation: Arthritis Research & Therapy 2014 16(Suppl 2):S3 -
Insulin resistance, selfish brain, and selfish immune system: an evolutionarily positively selected program used in chronic inflammatory diseases
Insulin resistance (IR) is a general phenomenon of many physiological states, disease states, and diseases. IR has been described in diabetes mellitus, obesity, infection, sepsis, trauma, painful states such a...
Citation: Arthritis Research & Therapy 2014 16(Suppl 2):S4
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