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Volume 5 Supplement 4

Targeting B cells in autoimmune diseases

Reviews

Edited by Peter E Lipsky and Ravinder N Maini

Supported by an educational grant from Roche Pharmaceuticals

  1. The role of B cells in rheumatoid arthritis (RA) has been debated for decades. However, recent clinical trial data indicating that depletion of B cells in RA patients is of therapeutic benefit has validated th...

    Authors: Thomas J Oligino and Stacie A Dalrymple
    Citation: Arthritis Res Ther 2003 5(Suppl 4):S7
    Content type: Review Published on:

  2. The CD20 cell marker appears early in the process of B cell development. In this review we focus on the results of attempts to utilize B cell depletion based on the use of a chimeric monoclonal antibody (MAb) ...

    Authors: Claire Gorman, Maria Leandro and David Isenberg
    Citation: Arthritis Res Ther 2003 5(Suppl 4):S17
    Content type: Review Published on:

  4. Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease characterized by the differentiation of short- and long-lived immunoglobulin secreting plasma cells that secrete pathogenic autoa...

    Authors: Amrie C Grammer and Peter E Lipsky
    Citation: Arthritis Res Ther 2003 5(Suppl 4):S22
    Content type: Review Published on:

  5. B lymphocytes play several critical roles in the pathogenesis of rheumatoid arthritis. They are the source of the rheumatoid factors and anticitrullinated protein antibodies, which contribute to immune complex...

    Authors: Gregg J Silverman and Dennis A Carson
    Citation: Arthritis Res Ther 2003 5(Suppl 4):S1
    Content type: Review Published on:
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    Journal Impact Factor: 4.4
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Arthritis Research & Therapy

ISSN: 1478-6362

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