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Volume 8 Supplement 2

Interleukin-6, a pleiotropic cytokine


Edited by Josef Smolen

Supported by an educational grant from Roche Pharmaceuticals

  1. In the late 1960s, the essential role played by T cells in antibody production was reported. This led to our hypothesis that certain molecules would have to be released from T cells to effect the stimulation o...

    Authors: Tadamitsu Kishimoto
    Citation: Arthritis Research & Therapy 2006 8(Suppl 2):S2
  2. Interleukin (IL)-6 is produced at the site of inflammation and plays a key role in the acute phase response as defined by a variety of clinical and biological features such as the production of acute phase pro...

    Authors: Cem Gabay
    Citation: Arthritis Research & Therapy 2006 8(Suppl 2):S3
  3. IL-6 is a pleiotropic cytokine involved in both the initiation and the maintenance of the inflammatory and immunologic responses in certain autoimmune diseases. Blocking of these two complementary functions of...

    Authors: Peter E Lipsky
    Citation: Arthritis Research & Therapy 2006 8(Suppl 2):S4
  4. The therapeutic success of biological agents, especially the tumour necrosis factor (TNF) inhibitors, has opened a new chapter in the book of therapies for rheumatoid arthritis. Nevertheless, more than 50% of ...

    Authors: Josef S Smolen and Ravinder N Maini
    Citation: Arthritis Research & Therapy 2006 8(Suppl 2):S5

    The Erratum to this article has been published in Arthritis Research & Therapy 2006 8:407

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