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Volume 9 Supplement 1

Basic science, rationale, background and future of denosumab: a RANK ligand inhibitor

Reviews

Edited by Edward M Schwarz and Christopher T Ritchlin

Supported by an unrestricted grant from Amgen Inc.

  1. The discovery of the receptor activator of nuclear factor-κB ligand (RANKL)/RANK/osteoprotegerin (OPG) system and its role in the regulation of bone resorption exemplifies how both serendipity and a logic-base...

    Authors: Brendan F Boyce and Lianping Xing

    Citation: Arthritis Research & Therapy 2007 9(Suppl 1):S1

    Content type: Review

    Published on:

  2. Inflammation and degradation of bone are two closely linked processes. Chronic inflammatory arthritis not only leads to inflammatory bone loss but it also involves local erosion of articular bone. This osteo-d...

    Authors: Georg Schett

    Citation: Arthritis Research & Therapy 2007 9(Suppl 1):S2

    Content type: Review

    Published on:

  3. When the rate of bone resorption exceeds that of bone formation, destruction of bone tissue occurs, resulting in a fragile skeleton. The clinical consequences, namely osteoporosis and fragility fractures, are ...

    Authors: Michael McClung

    Citation: Arthritis Research & Therapy 2007 9(Suppl 1):S3

    Content type: Review

    Published on:

  4. Multiple myeloma, a cancer of plasma cells, is associated with excessive tumor-induced, osteoclast-mediated bone destruction. Hypercalcemia remains the most frequent metabolic complication of myeloma in patien...

    Authors: Babatunde O Oyajobi

    Citation: Arthritis Research & Therapy 2007 9(Suppl 1):S4

    Content type: Review

    Published on:

  5. Establishment of skeletal metastasis involves bidirectional interactions between the tumor cell and the cellular elements in the bone microenvironment. A better understanding of the pathophysiology of bone met...

    Authors: Mandeep S Virk and Jay R Lieberman

    Citation: Arthritis Research & Therapy 2007 9(Suppl 1):S5

    Content type: Review

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  6. Total joint replacement, although considered an excellent surgical procedure, can be complicated by osteolysis induced by implant particles and subsequent aseptic loosening of the implant. The pathogenesis of ...

    Authors: Yousef Abu-Amer, Isra Darwech and John C Clohisy

    Citation: Arthritis Research & Therapy 2007 9(Suppl 1):S6

    Content type: Review

    Published on:

  7. The receptor activator of nuclear factor-κB ligand (RANKL), its cognate receptor RANK, and its natural decoy receptor osteoprotegerin have been identified as the final effector molecules of osteoclastic bone r...

    Authors: Edward M Schwarz and Christopher T Ritchlin

    Citation: Arthritis Research & Therapy 2007 9(Suppl 1):S7

    Content type: Review

    Published on:

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