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Volume 9 Supplement 2

Advances in systemic sclerosis and related fibrotic and vascular conditions

Reviews

Edited by Carol M Black, Christopher P Denton, Steffen Gay, Lars C Huber and James R Seibold

This supplement has been supported by an educational grant from Actelion Pharmaceuticals Ltd

  1. Angiogenesis is important in the pathogenesis of systemic inflammatory rheumatic diseases, a family of related disorders that includes rheumatoid arthritis and systemic sclerosis. Rheumatoid arthritis is the r...

    Authors: Alisa E Koch and Oliver Distler

    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S3

    Content type: Review

    Published on:

  2. Fibrosis, characterized by excessive extracellular matrix accumulation, is a common feature of many connective tissue diseases, notably scleroderma (systemic sclerosis). Experimental studies suggest that a com...

    Authors: Thomas Krieg, David Abraham and Robert Lafyatis

    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S4

    Content type: Review

    Published on:

  3. A number of genetic loci have been identified that appear to be associated with systemic sclerosis (SSc; scleroderma). There is mounting evidence suggesting that these genetic associations may in fact be assoc...

    Authors: Maureen D Mayes and Maria Trojanowska

    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S5

    Content type: Review

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  4. The precise aetiology of systemic sclerosis (SSc) remains elusive, but significant advances over the past few years have improved our understanding of the underlying pathogenic processes and identified key pat...

    Authors: Christopher P Denton

    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S6

    Content type: Review

    Published on:

  5. The pathogenesis of systemic sclerosis (SSc) is complex and largely unclear. The clinical heterogeneity of the disease and its progression over a number of years makes the choice of endpoints in the design of ...

    Authors: Marco Matucci-Cerinic, Virginia D Steen, Daniel E Furst and James R Seibold

    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S7

    Content type: Review

    Published on:

  6. Pulmonary involvement is common in sarcoidosis, an immune-mediated inflammatory disorder that is characterized by non-caseating granulomas in tissue. Sarcoid patients with advanced pulmonary disease, especiall...

    Authors: Robert P Baughman

    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S8

    Content type: Review

    Published on:

  7. Systemic vasculitis, an inflammatory necrotizing disease of the blood vessel walls, can occur secondary to autoimmune diseases, including connective tissue diseases. Various pathogenic mechanisms have been imp...

    Authors: Loic Guillevin and Thomas Dörner

    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S9

    Content type: Review

    Published on:

  8. Despite advances in elucidating the pathogenic factors responsible for its development, systemic sclerosis remains complex and poorly understood, and treatment options are limited. Multidisciplinary collaborat...

    Authors: Lewis J Rubin, Carol M Black, Christopher P Denton and James R Seibold

    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S10

    Content type: Review

    Published on:

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