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  1. The utility of generic health-related quality of life (HRQoL) questionnaires in patients with systemic lupus erythematosus (SLE) is uncertain. We compared the performance of generic (SF36) and specific (SLEQOL...

    Authors: Worawit Louthrenoo, Nuntana Kasitanon, Eric Morand and Rangi Kandane-Rathnayake
    Citation: Arthritis Research & Therapy 2020 22:8
    Content type: Research article Published on:

  2. Following publication of the original article [1], it was brought to our attention that the AOSD Consensus Group was incorrectly tagged and therefore not searchable. The publishers apologize for this error.

    Authors: Serena Colafrancesco, Maria Manara, Alessandra Bortoluzzi, Teodora Serban, Gerolamo Bianchi, Luca Cantarini, Francesco Ciccia, Lorenzo Dagna, Marcello Govoni, Carlomaurizio Montecucco, Roberta Priori, Angelo Ravelli, Paolo Sfriso and Luigi Sinigaglia
    Citation: Arthritis Research & Therapy 2020 22:6
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2019 21:275

  3. To describe successful therapeutic strategies in statin-induced anti-HMGCR myopathy.

    Authors: Alain Meyer, Yves Troyanov, Julie Drouin, Geneviève Oligny-Longpré, Océane Landon-Cardinal, Sabrina Hoa, Baptiste Hervier, Josiane Bourré-Tessier, Anne-Marie Mansour, Sara Hussein, Vincent Morin, Eric Rich, Jean-Richard Goulet, Sandra Chartrand, Marie Hudson, Jessica Nehme…
    Citation: Arthritis Research & Therapy 2020 22:5
    Content type: Research article Published on:

  4. Few studies have investigated patients’ own treatment goals in rheumatoid arthritis (RA). The objective of this real-world, cross-sectional study of US patients with RA was to identify factors that patients be...

    Authors: Kelly Gavigan, W. Benjamin Nowell, Mylene S. Serna, Jeffrey L. Stark, Mohamed Yassine and Jeffrey R. Curtis
    Citation: Arthritis Research & Therapy 2020 22:4
    Content type: Research article Published on:

  5. We aimed to develop a patient-reported outcome measure, in accordance with the US Food and Drug Administration guidance, to capture the impact of systemic sclerosis-related digital ulcers (SSc-DUs) on hand fun...

    Authors: Luc Mouthon, Serge Poiraudeau, Margaret Vernon, Kelly Papadakis, Loïc Perchenet and Dinesh Khanna
    Citation: Arthritis Research & Therapy 2020 22:3
    Content type: Research article Published on:

  6. In the context of the scarcity of biomarkers for knee osteoarthritis (OA), we examined the associations of prevalent and incident OA with the expression levels of serum miRNAs in subjects with and without OA.

    Authors: Jean-Charles Rousseau, Marjorie Millet, Martine Croset, Elisabeth Sornay-Rendu, Olivier Borel and Roland Chapurlat
    Citation: Arthritis Research & Therapy 2020 22:2
    Content type: Research article Published on:

  7. Early differentiation between different types of inflammatory arthritis and subsequent initiation of modern treatments can improve patient outcomes by reducing disease activity and preventing joint damage. Rou...

    Authors: Gurjit S. Kaeley, Catherine Bakewell and Atul Deodhar
    Citation: Arthritis Research & Therapy 2020 22:1
    Content type: Review Published on:

  8. Systemic sclerosis (SSc) is a rare disease with studies limited by small sample sizes. Electronic health records (EHRs) represent a powerful tool to study patients with rare diseases such as SSc, but validated...

    Authors: Lia Jamian, Lee Wheless, Leslie J. Crofford and April Barnado
    Citation: Arthritis Research & Therapy 2019 21:305
    Content type: Research article Published on:

  9. Large vessel vasculitis (LVV) is a type of vasculitis characterized by granulomatous inflammation of medium- and large-sized arteries. Clinical assessment of acute phase reactants has been conventionally used ...

    Authors: Kotaro Matsumoto, Katsuya Suzuki, Keiko Yoshimoto, Noriyasu Seki, Hideto Tsujimoto, Kenji Chiba and Tsutomu Takeuchi
    Citation: Arthritis Research & Therapy 2019 21:304
    Content type: Research article Published on:

  10. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of various autoantibodies. This disease causes disabling neuropsychiatric symptoms even in the absence of apparent in...

    Authors: Atsushi Nomura, Daisuke Noto, Goh Murayama, Asako Chiba and Sachiko Miyake
    Citation: Arthritis Research & Therapy 2019 21:303
    Content type: Research article Published on:

  12. Systemic sclerosis (SSc), a life-threatening autoimmune disease characterized by vasculopathy. Numerous SSc patients demonstrate gastrointestinal (GI) involvement but the delicate GI bleeding risk remains spar...

    Authors: Yi-Ting Lin, Yun-Shiuan Chuang, Jiunn-Wei Wang and Ping-Hsun Wu
    Citation: Arthritis Research & Therapy 2019 21:301
    Content type: Research article Published on:

  13. Osteoarthritis (OA) is an inflammatory disease of the joints that causes progressive disability in the elderly. Reactive oxygen species (ROS) play an important role in OA development; they may activate the NLR...

    Authors: Zhuming Chen, Huan Zhong, Jinsong Wei, Sien Lin, Zhixian Zong, Fan Gong, Xinqia Huang, Jinhui Sun, Peng Li, Hao Lin, Bo Wei and Jiaqi Chu
    Citation: Arthritis Research & Therapy 2019 21:300
    Content type: Research article Published on:

  14. To determine the frequency and clinical characteristics of systemic sclerosis-related digital ulcers, and associated direct health care costs, quality of life, and survival.

    Authors: Kathleen Morrisroe, Wendy Stevens, Joanne Sahhar, Gene-Siew Ngian, Nava Ferdowsi, Catherine L. Hill, Janet Roddy, Jennifer Walker, Susanna Proudman and Mandana Nikpour
    Citation: Arthritis Research & Therapy 2019 21:299
    Content type: Research article Published on:

  15. Although disease in a majority of rheumatoid arthritis (RA) patients is often initially limited to one or a few joints, currently approved medications including anti-tumor necrosis factor-α antibody (α-TNF) ar...

    Authors: Kiyomitsu Katsumata, Jun Ishihara, Kazuto Fukunaga, Ako Ishihara, Eiji Yuba, Erica Budina and Jeffrey A. Hubbell
    Citation: Arthritis Research & Therapy 2019 21:298
    Content type: Research article Published on:

  16. Angiogenesis is an early event in the pathogenesis of both psoriatic arthritis (PsA) and rheumatoid arthritis (RA); however, there are striking differences in blood vessel morphology and activation between the...

    Authors: S. Fromm, C. C. Cunningham, M. R. Dunne, D. J. Veale, U. Fearon and S. M. Wade
    Citation: Arthritis Research & Therapy 2019 21:297
    Content type: Research article Published on:

  18. CD4+ T cells play critical roles in the pathogenesis of IgG4-related disease (IgG4-RD). The aim of this study was to investigate the TCR repertoire of peripheral blood CD4+ T cells in IgG4-RD.

    Authors: Liwen Wang, Panpan Zhang, Jieqiong Li, Hui Lu, Linyi Peng, Jing Ling, Xuan Zhang, Xiaofeng Zeng, Yan Zhao and Wen Zhang
    Citation: Arthritis Research & Therapy 2019 21:295
    Content type: Research article Published on:

  19. Treatment of patients with Sjögren’s syndrome (SjS) is a clinical challenge with high unmet needs. Gene expression profiling and integrative network-based approaches to complex disease can offer an insight on ...

    Authors: Hong Ki Min, Su-Jin Moon, Kyung-Su Park and Ki-Jo Kim
    Citation: Arthritis Research & Therapy 2019 21:294
    Content type: Research article Published on:

  20. Sporadic inclusion body myositis (sIBM) is clinically characterised by progressive proximal and distal muscle weakness and impaired physical function while skeletal muscle tissue displays abnormal cellular inf...

    Authors: Kasper Yde Jensen, Mikkel Jacobsen, Henrik Daa Schrøder, Per Aagaard, Jakob Lindberg Nielsen, Anders Nørkær Jørgensen, Eleanor Boyle, Rune Dueholm Bech, Sofie Rosmark, Louise Pyndt Diederichsen and Ulrik Frandsen
    Citation: Arthritis Research & Therapy 2019 21:293
    Content type: Research article Published on:

  21. To examine the ability of takinib, a selective transforming growth factor beta-activated kinase 1 (TAK1) inhibitor, to reduce the severity of murine type II collagen-induced arthritis (CIA), and to affect func...

    Authors: Scott A. Scarneo, Liesl S. Eibschutz, Phillip J. Bendele, Kelly W. Yang, Juliane Totzke, Philip Hughes, David A. Fox and Timothy A. J. Haystead
    Citation: Arthritis Research & Therapy 2019 21:292
    Content type: Research article Published on:

  23. Systemic sclerosis is a multisystem inflammatory and vascular lesion leading to extensive tissue fibrosis. A reversible S-adenosyl-l-homocysteine hydrolase (SAHH) inhibitor, DZ2002, modulates the pathologic pr...

    Authors: Zongwang Zhang, Yanwei Wu, Bing Wu, Qing Qi, Heng Li, Huimin Lu, Chen Fan, Chunlan Feng, Jianping Zuo, Lili Niu and Wei Tang
    Citation: Arthritis Research & Therapy 2019 21:290
    Content type: Research article Published on:

  24. The prevalence of osteoarthritis (OA) increases with obesity, with up to two thirds of the elderly obese population affected by OA of the knee. The metabolic syndrome (MetS), frequently associated with central...

    Authors: Bruce M. Dickson, Anke J. Roelofs, Justin J. Rochford, Heather M. Wilson and Cosimo De Bari
    Citation: Arthritis Research & Therapy 2019 21:289
    Content type: Review Published on:

  25. Antibodies and upregulated cytokines and chemokines predate the onset of rheumatoid arthritis (RA) symptoms. We aimed to identify the pathways related to the early processes leading to RA development, as well ...

    Authors: Mikael Brink, Anders Lundquist, Andrey Alexeyenko, Kristina Lejon and Solbritt Rantapää-Dahlqvist
    Citation: Arthritis Research & Therapy 2019 21:288
    Content type: Research article Published on:

  26. Identification of universal biomarkers to predict systemic lupus erythematosus (SLE) flares is challenging due to the heterogeneity of the disease. Several biomarkers have been reported. However, the data of v...

    Authors: Nopparat Ruchakorn, Pintip Ngamjanyaporn, Thanitta Suangtamai, Thanuchporn Kafaksom, Charin Polpanumas, Veerachat Petpisit, Trairak Pisitkun and Prapaporn Pisitkun
    Citation: Arthritis Research & Therapy 2019 21:287
    Content type: Research article Published on:

  27. Systemic sclerosis is a systemic connective tissue disease characterized by endothelium damage, fibrosis, and subsequent atrophy of the skin. Perioral fibrosis produces a characteristic microstomia together wi...

    Authors: Roberto Pirrello, Barbara Verro, Giulia Grasso, Piero Ruscitti, Adriana Cordova, Roberto Giacomelli, Francesco Ciccia and Giuliana Guggino
    Citation: Arthritis Research & Therapy 2019 21:286
    Content type: Research article Published on:

  28. Biosimilar infliximab has the potential for appreciable cost savings compared to its reference biologic, but dose escalation is common and increases costs. We compared frequency of dose escalation and associat...

    Authors: Jeffrey R. Curtis, Fenglong Xie, Jonathan Kay and Joel D Kallich
    Citation: Arthritis Research & Therapy 2019 21:285
    Content type: Research article Published on:

  29. Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis and bone destruction at the joints, causing pain and motor disturbance. Despite the better control of inflammation and join...

    Authors: Yohsuke Oto, Yukari Takahashi, Daitaro Kurosaka and Fusao Kato
    Citation: Arthritis Research & Therapy 2019 21:284
    Content type: Research article Published on:

  30. The inflammatory cascade in the rheumatoid arthritis (RA) synovium is modulated by a variety of cytokine and chemokine networks; however, the roles of IL-26, in RA pathogenesis, are poorly defined. Here, we in...

    Authors: Kyung-Ann Lee, Kyoung-Woon Kim, Bo-Mi Kim, Ji-Yeon Won, Hong Ki Min, Dhong Won Lee, Hae-Rim Kim and Sang-Heon Lee
    Citation: Arthritis Research & Therapy 2019 21:283
    Content type: Research article Published on:

  31. 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a promising tool for diagnosing relapsing polychondritis (RP). However, its usefulness in assessing RP with airway involv....

    Authors: Yunxiang Zeng, Minfang Li, Sheng Chen, Lin Lin, Shiyue Li, Jianxing He and Jinlin Wang
    Citation: Arthritis Research & Therapy 2019 21:282
    Content type: Research article Published on:

  32. To compare the efficacy, serum drug concentrations, immunogenicity, and safety of FKB327 with the adalimumab reference product (RP) in combination with methotrexate in patients with moderate-to-severe, active ...

    Authors: Mark C. Genovese, Josephine Glover, Maria Greenwald, Wieslawa Porawska, Elias Chalouhi El Khouri, Eva Dokoupilova, Juan Ignacio Vargas, Mykola Stanislavchuk, Herbert Kellner, Elena Baranova, Nobuhito Matsunaga and Rieke Alten
    Citation: Arthritis Research & Therapy 2019 21:281
    Content type: Research article Published on:

  33. The patients with RA benefit from early identification soon after the first clinical symptoms appear. The 2010 ACR/EULAR classification criteria were developed to fulfill this need and their application has be...

    Authors: Cristina Regueiro, Lorena Rodríguez-Martínez, Laura Nuño, Ana M. Ortiz, Alejandro Villalba, Dora Pascual-Salcedo, Ana Martínez-Feito, Isidoro González-Alvaro, Alejandro Balsa and Antonio Gonzalez
    Citation: Arthritis Research & Therapy 2019 21:280
    Content type: Research article Published on:

    The Letter to this article has been published in Arthritis Research & Therapy 2020 22:85

  34. Bilateral hands including proximal interphalangeal joints (PIPJs) are recommended on physical, X-ray radiographic, or ultrasonographic examination by clinical guidelines of rheumatoid arthritis (RA), but MRI s...

    Authors: Ying-Qian Mo, Ze-Hong Yang, Jun-Wei Wang, Qian-Hua Li, Xin-Yun Du, T. W. Huizinga, X. M. E. Matthijssen, Guang-Zi Shi, Jun Shen and Lie Dai
    Citation: Arthritis Research & Therapy 2019 21:279
    Content type: Research article Published on:

  35. Type V collagen (Col V) has the potential to become an autoantigen and has been associated with the pathogenesis of systemic sclerosis (SSc). We characterized serological, functional, and histopathological fea...

    Authors: Walcy Rosolia Teodoro, Zelita Aparecida de Jesus Queiroz, Lais Araujo dos Santos, Sergio Catanozi, Antonio dos Santos Filho, Cleonice Bueno, Margarete B. G. Vendramini, Sandra de Morais Fernezlian, Esmeralda M. Eher, Percival D. Sampaio-Barros, Sandra Gofinet Pasoto, Fernanda Degobbi T. Q. S. Lopes, Ana Paula Pereira Velosa and Vera Luiza Capelozzi
    Citation: Arthritis Research & Therapy 2019 21:278
    Content type: Research article Published on:

  36. In the last few years, anti-CD20 antibody rituximab profoundly changed the therapeutic landscape of granulomatosis with polyangiitis (GPA). Here, we investigated whether natural killer (NK) cells may play a ro...

    Authors: Doris Urlaub, Shuyang Zhao, Norbert Blank, Raoul Bergner, Maren Claus, Theresa Tretter, Hanns-Martin Lorenz, Carsten Watzl and Wolfgang Merkt
    Citation: Arthritis Research & Therapy 2019 21:277
    Content type: Research article Published on:

  37. The prevalence of lupus nephritis (LN) remains high despite various emerging monoclonal antibodies against with targeting systemic lupus erythematosus (SLE). Renal fibrosis is the main feature of late stage LN...

    Authors: Junjun Luan, Jingqi Fu, Chengjie Chen, Congcong Jiao, Weiwei Kong, Yixiao Zhang, Qing Chang, Yanqiu Wang, Detian Li, Gabor G. Illei, Jeffrey B. Kopp, Jingbo Pi and Hua Zhou
    Citation: Arthritis Research & Therapy 2019 21:276
    Content type: Research article Published on:

  38. Adult-onset Still’s disease (AOSD) is a rare inflammatory condition characterized by fever, rash, and arthritis. Because of its rarity, clinical trials are inherently small and often uncontrolled. Our objectiv...

    Authors: Serena Colafrancesco, Maria Manara, Alessandra Bortoluzzi, Teodora Serban, Gerolamo Bianchi, Luca Cantarini, Francesco Ciccia, Lorenzo Dagna, Marcello Govoni, Carlomaurizio Montecucco, Roberta Priori, Angelo Ravelli, Paolo Sfriso and Luigi Sinigaglia
    Citation: Arthritis Research & Therapy 2019 21:275
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2020 22:6

  39. We wished to determine bone alterations in systemic sclerosis (SSc) patients by conventional densitometry (DXA), peripheral quantitative computed tomography (pQCT), and bone biomarkers.

    Authors: Ágnes Horváth, Edit Végh, Anita Pusztai, Zsófia Pethő, Attila Hamar, Monika Czókolyová, Harjit Pal Bhattoa, Gábor Nagy, Balázs Juhász, Katalin Hodosi, Andrea Domján, Zoltán Szekanecz, Gabriella Szücs and Szilvia Szamosi
    Citation: Arthritis Research & Therapy 2019 21:274
    Content type: Research article Published on:

  40. To describe the association of age, sex and body mass index with the rate of change of tibial knee cartilage volume over 10.7 years in a community-based sample of older adults.

    Authors: Guoqi Cai, Matthew Jiang, Flavia Cicuttini and Graeme Jones
    Citation: Arthritis Research & Therapy 2019 21:273
    Content type: Research article Published on:

  41. To evaluate the effect of upadacitinib on patient-reported outcomes (PROs) in patients with RA who had an inadequate response to csDMARDs.

    Authors: Vibeke Strand, Janet Pope, Namita Tundia, Alan Friedman, Heidi S. Camp, Aileen Pangan, Arijit Ganguli, Mahesh Fuldeore, Debbie Goldschmidt and Michael Schiff
    Citation: Arthritis Research & Therapy 2019 21:272
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2020 22:137

  42. Hypermethylation of gene promoters has been regarded as an epigenetic regulator for gene inactivation in the development of several diseases. In the current study, we aimed to explore how long noncoding RNA X-...

    Authors: Hongwei Chen, Shengdi Yang and Ruyi Shao
    Citation: Arthritis Research & Therapy 2019 21:271
    Content type: Research article Published on:

  43. Models to predict disease course and long-term outcome based on clinical characteristics at disease onset may guide early treatment strategies in juvenile idiopathic arthritis (JIA). Before a prediction model ...

    Authors: Veronika Rypdal, Jaime Guzman, Andrew Henrey, Thomas Loughin, Mia Glerup, Ellen Dalen Arnstad, Kristiina Aalto, Marite Rygg, Susan Nielsen, Troels Herlin, Anders Fasth, Lillemor Berntson, Martin Rypdal and Ellen Nordal
    Citation: Arthritis Research & Therapy 2019 21:270
    Content type: Research article Published on:

  44. PF-06650833 is a potent, selective inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). Two randomized, double-blind, sponsor-open phase 1 studies evaluated the safety, pharmacokinetics, and pharma...

    Authors: Spencer I. Danto, Negin Shojaee, Ravi Shankar P. Singh, Cheryl Li, Steven A. Gilbert, Zorayr Manukyan and Iain Kilty
    Citation: Arthritis Research & Therapy 2019 21:269
    Content type: Research article Published on:

  45. To investigate whether calprotectin (S100A8/A9 or MRP8/14), an inflammatory complex released by monocytes, could indicate residual subclinical inflammation in rheumatoid arthritis (RA) patients who are in stab...

    Authors: Emma C. de Moel, Jürgen Rech, Michael Mahler, Johannes Roth, Thomas Vogl, Anne Schouffoer, Robbert J. Goekoop, Tom W. J. Huizinga, Cornelia F. Allaart, René E. M. Toes, Georg Schett and Diane van der Woude
    Citation: Arthritis Research & Therapy 2019 21:268
    Content type: Research article Published on:

  46. The information concerning non-invasive, easily obtainable, and accurate biomarkers for diagnosis of lupus nephritis (LN) is extremely limited. The aim of this study was to evaluate the diagnostic performance ...

    Authors: Bei Xu, Ya-mei Zhang, Yu-wei Yang, Yun-shuang Liu and Jia-fu Feng
    Citation: Arthritis Research & Therapy 2019 21:267
    Content type: Research article Published on:

  47. Enthesitis is one of the psoriatic arthritis (PsA) domains. Patients with enthesitis are associated with worse outcomes than those without enthesitis. The effect of secukinumab on the resolution of enthesitis ...

    Authors: Laura C. Coates, Johan K. Wallman, Dennis McGonagle, Georg A. Schett, Iain B. McInnes, Philip J. Mease, Lawrence Rasouliyan, Erhard Quebe-Fehling, Darren L. Asquith, Andreas E. R. Fasth, Luminita Pricop and Corine Gaillez
    Citation: Arthritis Research & Therapy 2019 21:266
    Content type: Research article Published on:

  48. Although the short-term effects of tumor necrosis factor alpha (TNF-α) and interleukin-17A (IL-17A) inhibition on the structural changes in psoriatic arthritis (PsA) using high-resolution peripheral quantitati...

    Authors: Dongze Wu, James F. Griffith, Steven H. M. Lam, Priscilla C. H. Wong, Lin Shi, Edmund K. Li, Isaac T. Cheng, Tena K. Li, Vivian W. Hung, Ling Qin and Lai-Shan Tam
    Citation: Arthritis Research & Therapy 2019 21:265
    Content type: Research article Published on:

  49. In the collagen-induced arthritis (CIA) mouse model, inflammation readouts are usually quantified using operator-dependent clinical scoring systems, and no systematic relationship with functional deficits has ...

    Authors: Anne-Laure Mausset-Bonnefont, Maïlys Cren, Rita Vicente, Julie Quentin, Christian Jorgensen, Florence Apparailly and Pascale Louis-Plence
    Citation: Arthritis Research & Therapy 2019 21:264
    Content type: Research article Published on:

  50. Elevated levels of C-reactive protein (CRP) in systemic sclerosis (SSc) have been linked to early inflammatory stages of the disease. This study has been designed to investigate CRP levels longitudinally in a ...

    Authors: Aleksey Mitev, Lisa Christ, Daria Feldmann, Moritz Binder, Kim Möller, Anna-Maria Kanne, Thomas Hügle, Peter M. Villiger, Reinhard E. Voll, Stephanie Finzel and Florian Kollert
    Citation: Arthritis Research & Therapy 2019 21:262
    Content type: Research article Published on:
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Arthritis Research & Therapy

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