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  1. Persistent expansion of circulating CD4+ effector memory T cells (TEM) in patients with granulomatosis with polyangiitis (GPA) suggests their fundamental role in disease pathogenesis. Recent studies have shown th...

    Authors: Lucas L. Lintermans, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa and Wayel H. Abdulahad
    Citation: Arthritis Research & Therapy 2017 19:136
    Content type: Research article Published on:

  2. Pulmonary arterial hypertension (PAH) is one of the most relevant causes of death in systemic sclerosis. The aims of this study were to analyse the recently published DETECT algorithm comparing it with Europea...

    Authors: Alfredo Guillén-Del Castillo, Eduardo L. Callejas-Moraga, Gabriela García, José F. Rodríguez-Palomares, Antonio Román, Cristina Berastegui, Manuel López-Meseguer, Enric Domingo, Vicente Fonollosa-Plá and Carmen Pilar Simeón-Aznar
    Citation: Arthritis Research & Therapy 2017 19:135
    Content type: Research article Published on:

  3. Systemic sclerosis (SSc) is characterized by fibrosis of the skin and internal organs. Although the involvement of connective tissue growth factor (CTGF/CCN2) has been well-documented in SSc fibrosis, the ther...

    Authors: Katsunari Makino, Tomoko Makino, Lukasz Stawski, Kenneth E. Lipson, Andrew Leask and Maria Trojanowska
    Citation: Arthritis Research & Therapy 2017 19:134
    Content type: Research article Published on:

  4. Some abnormalities in nailfold videocapillaroscopy (NVC), such as the presence of micro-haemorrhages (MHEs), micro-thromboses (MTs), giant capillaries (GCs) and reduction in the number of capillaries (nCs), su...

    Authors: Romina Andracco, Rosaria Irace, Eleonora Zaccara, Serena Vettori, Wanda Maglione, Antonella Riccardi, Francesca Pignataro, Roberta Ferrara, Domenico Sambataro, Gianluca Sambataro, Claudio Vitali, Gabriele Valentini and Nicoletta Del Papa
    Citation: Arthritis Research & Therapy 2017 19:133
    Content type: Research article Published on:

  5. Cardiovascular disease (CVD) is the main cause of death in systemic lupus erythematous (SLE) patients. The Framingham score underestimates the risk for CVD in this population. Our study aimed to determine whet...

    Authors: Gillian Divard, Rachid Abbas, Camille Chenevier-Gobeaux, Noémie Chanson, Brigitte Escoubet, Marie-Paule Chauveheid, Antoine Dossier, Thomas Papo, Monique Dehoux and Karim Sacre
    Citation: Arthritis Research & Therapy 2017 19:132
    Content type: Research article Published on:

  6. Hand osteoarthritis is a common condition characterised by joint pain and muscle weakness. These factors are thought to contribute to ongoing disability. Some evidence exists that resistance training decreases...

    Authors: Nicoló Edoardo Magni, Peter John McNair and David Andrew Rice
    Citation: Arthritis Research & Therapy 2017 19:131
    Content type: Research article Published on:

  7. Patient registry data serves an increasing role in drug safety and comparative effectiveness research, but registry databases often do not contain confounder information measured at the same time that treatmen...

    Authors: Daniel H. Solomon, Nancy A. Shadick, Michael E. Weinblatt, Agnes Zak, Michelle Frits and Jessica M. Franklin
    Citation: Arthritis Research & Therapy 2017 19:130
    Content type: Research article Published on:

  8. Relapse of disease is frequent in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). It is unclear whether persistent ANCA when starting maintenance therapy increases the risk of relapse. W...

    Authors: Matthew David Morgan, Matthew Szeto, Michael Walsh, David Jayne, Kerstin Westman, Niels Rasmussen, Thomas F. Hiemstra, Oliver Flossmann, Annelies Berden, Peter Höglund and Lorraine Harper
    Citation: Arthritis Research & Therapy 2017 19:129
    Content type: Research article Published on:

  10. We determined the prevalence of anti-nuclear autoantibodies (ANAs) in the German adult population and examined the association between ANAs and cardiovascular and metabolic disorders.

    Authors: Manas K. Akmatov, Nadja Röber, Wolfgang Ahrens, Dieter Flesch-Janys, Julia Fricke, Halina Greiser, Kathrin Günther, Rudolf Kaaks, Yvonne Kemmling, Bastian Krone, Jakob Linseisen, Christa Meisinger, Susanne Moebus, Nadia Obi, Carlos A. Guzman, Karsten Conrad…
    Citation: Arthritis Research & Therapy 2017 19:127
    Content type: Research article Published on:

  11. Studies have shown that structural lesions may be present in patients with non-radiographic axial spondyloarthritis (nr-axSpA). However, the relevance of structural lesions in these patients is unclear, partic...

    Authors: Walter P. Maksymowych, Stephanie Wichuk, Maxime Dougados, Heather Jones, Annette Szumski, Jack F. Bukowski, Lisa Marshall and Robert G. Lambert
    Citation: Arthritis Research & Therapy 2017 19:126
    Content type: Research article Published on:

  12. Our previous study found that circulating and urinary levels of high mobility group box-1 (HMGB1) were closely associated with disease activity in patients with antineutrophil cytoplasmic antibody (ANCA)-assoc...

    Authors: Hui Deng, Chen Wang, Dong-Yuan Chang, Nan Hu, Min Chen and Ming-Hui Zhao
    Citation: Arthritis Research & Therapy 2017 19:125
    Content type: Research article Published on:

  13. Increasing evidences indicate that an unbalance between tryptases and their endogenous inhibitors, leading to an increased proteolytic activity, is implicated in the pathophysiology of rheumatoid arthritis. Th...

    Authors: Alexandre Denadai-Souza, Camilla Moreira Ribeiro, Corinne Rolland, Anne Thouard, Céline Deraison, Cristoforo Scavone, Daniel Gonzalez-Dunia, Nathalie Vergnolle and Maria Christina Werneck Avellar
    Citation: Arthritis Research & Therapy 2017 19:124
    Content type: Research article Published on:

  14. An association has been suggested between gout and erectile dysfunction (ED), however studies quantifying the risk of ED amongst gout patients are lacking. We aimed to precisely determine the population-level ...

    Authors: Alyshah Abdul Sultan, Christian Mallen, Richard Hayward, Sara Muller, Rebecca Whittle, Matthew Hotston and Edward Roddy
    Citation: Arthritis Research & Therapy 2017 19:123
    Content type: Research article Published on:

    The Editorial to this article has been published in Arthritis Research & Therapy 2017 19:184

  15. Pulmonary arterial hypertension (PAH) is a leading cause of mortality in systemic sclerosis (SSc). We sought to determine survival, predictors of mortality, and health-related quality of life (HRQoL) related t...

    Authors: Kathleen Morrisroe, Wendy Stevens, Molla Huq, David Prior, Jo Sahhar, Gene-Siew Ngian, David Celermajer, Jane Zochling, Susanna Proudman and Mandana Nikpour
    Citation: Arthritis Research & Therapy 2017 19:122
    Content type: Research article Published on:

  16. The receptor activator of NF-κB ligand (RANKL), a member of the TNF ligand superfamily, is known to regulate bone metabolism. The expression of each component of the RANK/RANKL/osteoprotegerin (OPG) system in ...

    Authors: Norihiko Takegami, Koji Akeda, Junichi Yamada, Tomohiko Sano, Koichiro Murata, Jenny Huang, Koichi Masuda and Akihiro Sudo
    Citation: Arthritis Research & Therapy 2017 19:121
    Content type: Research article Published on:

  17. This study reports the clinical and pathological features of 12 cases of primary Sjogren syndrome (pSS) with renal involvement presenting with proximal tubular dysfunction in a single center, and investigates ...

    Authors: Jing Wang, Yubing Wen, Mengyu Zhou, Xiaoxiao Shi, Lanping Jiang, Mingxi Li, Yang Yu, Xuemei Li, Xuewang Li, Wen Zhang, Andrew L. Lundquist and Limeng Chen
    Citation: Arthritis Research & Therapy 2017 19:120
    Content type: Research article Published on:

  18. Exosomes are thought to play an important role in exchanging information between cells. The proteins and lipids in exosomes play roles in mediating inflammatory and autoimmune diseases. The aim of this study w...

    Authors: Jihyung Yoo, Sang Kwang Lee, Mikyung Lim, Donghyuk Sheen, Eun-Hye Choi and Soon Ae Kim
    Citation: Arthritis Research & Therapy 2017 19:119
    Content type: Research article Published on:

  19. The Assessment of SpondyloArthritis international Society (ASAS) definition of a positive family history (PFH) of spondyloarthritis (SpA) includes the following diseases in first- or second-degree relatives: a...

    Authors: Zineb Ez-Zaitouni, Andrea Hilkens, Laure Gossec, Inger Jorid Berg, Robert Landewé, Roberta Ramonda, Maxime Dougados, Désirée van der Heijde and Floris van Gaalen
    Citation: Arthritis Research & Therapy 2017 19:118
    Content type: Research article Published on:

  20. Microscopic polyangiitis (MPA), which is classified as an anti-neutrophil cytoplasmic antibody (ANCA)-associated small vessel vasculitis, is one of the most frequent primary vasculitides in Japan. We earlier n...

    Authors: Akihiro Ishizu, Utano Tomaru, Sakiko Masuda, Ken-ei Sada, Koichi Amano, Masayoshi Harigai, Yasushi Kawaguchi, Yoshihiro Arimura, Kunihiro Yamagata, Shoichi Ozaki, Hiroaki Dobashi, Sakae Homma, Yasunori Okada, Hitoshi Sugiyama, Joichi Usui, Naotake Tsuboi…
    Citation: Arthritis Research & Therapy 2017 19:117
    Content type: Research article Published on:

  21. Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby ...

    Authors: Melissa B. Aldrich, Fred C. Velasquez, Sunkuk Kwon, Ali Azhdarinia, Kenneth Pinkston, Barrett R. Harvey, Wenyaw Chan, John C. Rasmussen, Russell F. Ross, Caroline E. Fife and E. M. Sevick-Muraca
    Citation: Arthritis Research & Therapy 2017 19:116
    Content type: Research article Published on:

  22. Rheumatoid arthritis (RA) consists of two syndromes, one autoantibody-positive and one autoantibody-negative. Existing data on the relation between age of onset and prevalence of autoantibodies were conflictin...

    Authors: Debbie M. Boeters, Lukas Mangnus, Sofia Ajeganova, Elisabet Lindqvist, Björn Svensson, René E. M. Toes, Leendert A. Trouw, Tom W. J. Huizinga, Francis Berenbaum, Jacques Morel, Solbritt Rantapää-Dahlqvist and Annette H. M. van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2017 19:115
    Content type: Research article Published on:

  23. Folate receptor β (FRβ) is involved in facilitating cellular uptake of folates and anti-folates (such as methotrexate (MTX)). In rheumatoid arthritis, FRβ is expressed on synovial macrophages and recently has ...

    Authors: Durga M. S. H. Chandrupatla, Gerrit Jansen, Ricardo Vos, Mariska Verlaan, Qingshou Chen, Philip S. Low, Albert D. Windhorst, Adriaan A. Lammertsma, Conny J. van der Laken and Carla F. M. Molthoff
    Citation: Arthritis Research & Therapy 2017 19:114
    Content type: Research article Published on:

  24. Lipid profiles appear to be altered in rheumatoid arthritis (RA) patients because of disease activity and inflammation. Cholesterol efflux capacity (CEC), which is the ability of high-density lipoprotein chole...

    Authors: Beatriz Tejera-Segura, María Macía-Díaz, José David Machado, Antonia de Vera-González, Jose A. García-Dopico, José M. Olmos, José L. Hernández, Federico Díaz-González, Miguel A. González-Gay and Iván Ferraz-Amaro
    Citation: Arthritis Research & Therapy 2017 19:113
    Content type: Research article Published on:

  25. Dysregulated transforming growth factor β (TGFβ) signaling is implicated in osteoarthritis development, making normalizing TGFβ signaling a possible therapy. Theoretically, this can be achieved with small mole...

    Authors: Arjan van Caam, Wojciech Madej, Amaya Garcia de Vinuesa, Marie-José Goumans, Peter ten Dijke, Esmeralda Blaney Davidson and Peter van der Kraan
    Citation: Arthritis Research & Therapy 2017 19:112
    Content type: Research article Published on:

  26. Obesity is associated with worse disease activity and drug responses in patients with rheumatoid arthritis (RA). However, the immunological mechanisms responsible for the relationship between RA and obesity ha...

    Authors: Hirofumi Shoda, Yasuo Nagafuchi, Yumi Tsuchida, Keiichi Sakurai, Shuji Sumitomo, Keishi Fujio and Kazuhiko Yamamoto
    Citation: Arthritis Research & Therapy 2017 19:111
    Content type: Research article Published on:

  27. An increasing number of studies show how changes in intracellular metabolic pathways alter tumor and immune cell function. However, little information about metabolic changes in other cell types, including syn...

    Authors: Marta F. Bustamante, Ricard Garcia-Carbonell, Katrijn D. Whisenant and Monica Guma
    Citation: Arthritis Research & Therapy 2017 19:110
    Content type: Review Published on:

  28. In the current context of personalized medicine, one of the major challenges in the management of rheumatoid arthritis (RA) is to identify biomarkers that predict drug responsiveness. From the European APPRAIS...

    Authors: C. Derambure, G. Dzangue-Tchoupou, C. Berard, N. Vergne, M. Hiron, M. A. D’Agostino, P. Musette, O. Vittecoq and T. Lequerré
    Citation: Arthritis Research & Therapy 2017 19:109
    Content type: Research article Published on:

  29. In the present study, we explored the risk factors for relapse after discontinuation of biologic disease-modifying antirheumatic drug (bDMARD) therapy in patients with rheumatoid arthritis (RA) whose ultrasoun...

    Authors: Shin-ya Kawashiri, Keita Fujikawa, Ayako Nishino, Akitomo Okada, Toshiyuki Aramaki, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Takahisa Suzuki, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Akinari Mizokami, Hideki Nakamura, Tomoki Origuchi…
    Citation: Arthritis Research & Therapy 2017 19:108
    Content type: Research article Published on:

  30. We aimed to investigate the clinical characteristics of 411 Chinese Takayasu’s arteritis (TAK) patients using a retrospective analysis.

    Authors: Jing Li, Fei Sun, Zhe Chen, Yunjiao Yang, Jiuliang Zhao, Mengtao Li, Xinping Tian and Xiaofeng Zeng
    Citation: Arthritis Research & Therapy 2017 19:107
    Content type: Research article Published on:

  31. The endocannabinoid system has been shown to reduce inflammatory flares and pain in rodent models of arthritis. A limitation of endocannabinoids is that they are rapidly denatured by hydrolysing enzymes such a...

    Authors: Jason J. McDougall, Milind M. Muley, Holly T. Philpott, Allison Reid and Eugene Krustev
    Citation: Arthritis Research & Therapy 2017 19:106
    Content type: Research article Published on:

  32. The angiopoietin(Ang)/Tie2 system is a key regulator of vascular biology. The expression of membrane bound (mb) Tie2 and Ang-1 ensures vessel stability, whereas Ang-2, inducible by vascular endothelial growth ...

    Authors: Falk Moritz, Janine Schniering, Jörg H. W. Distler, Renate E. Gay, Steffen Gay, Oliver Distler and Britta Maurer
    Citation: Arthritis Research & Therapy 2017 19:105
    Content type: Research article Published on:

  33. Little is known about gene expression changes induced by pregnancy in women with rheumatoid arthritis (RA) and healthy women because the few studies previously conducted did not have pre-pregnancy samples avai...

    Authors: Dana E. Goin, Mette Kiel Smed, Lior Pachter, Elizabeth Purdom, J. Lee Nelson, Hanne Kjærgaard, Jørn Olsen, Merete Lund Hetland, Vibeke Zoffmann, Bent Ottesen and Damini Jawaheer
    Citation: Arthritis Research & Therapy 2017 19:104
    Content type: Research article Published on:

  34. The aim was to investigate CD4+T-cell subsets, immune cells and their cytokine profiles in blood and synovial compartments in rheumatoid arthritis (RA) and inflammatory osteoarthritis (OA) to define specific immu...

    Authors: Alessandra Penatti, Federica Facciotti, Roberta De Matteis, Paola Larghi, Moira Paroni, Antonella Murgo, Orazio De Lucia, Massimiliano Pagani, Luca Pierannunzii, Marcello Truzzi, Andreea Ioan-Facsinay, Sergio Abrignani, Jens Geginat and Pier Luigi Meroni
    Citation: Arthritis Research & Therapy 2017 19:103
    Content type: Research article Published on:

  35. To investigate the risk of first-time acute coronary syndrome (ACS), stroke and venous thromboembolism (VTE) in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA) and undifferentiated spondyl...

    Authors: Karin Bengtsson, Helena Forsblad-d’Elia, Elisabeth Lie, Eva Klingberg, Mats Dehlin, Sofia Exarchou, Ulf Lindström, Johan Askling and Lennart T. H. Jacobsson
    Citation: Arthritis Research & Therapy 2017 19:102
    Content type: Research article Published on:

  36. B cell depletion with rituximab (RTX) is approved for treatment of rheumatoid arthritis (RA) and ANCA-associated vasculitides (AAV). Recently, RTX has been shown to be effective in AAV maintenance therapy, but...

    Authors: Jens Thiel, Marta Rizzi, Marie Engesser, Ann-Kathrin Dufner, Arianna Troilo, Raquel Lorenzetti, Reinhard E. Voll and Nils Venhoff
    Citation: Arthritis Research & Therapy 2017 19:101
    Content type: Research article Published on:

  37. Macrophages may present two distinct phenotypes indicated as M1 and M2 under different stimuli. M1 and M2 macrophages have divergent functions that range from enhancement of inflammation for M1 to tissue repai...

    Authors: Alexandre Wagner Silva de Souza, Mirjan van Timmeren, Jan-Stephan Sanders, Coen Stegeman, Peter Heeringa, Cees G. M. Kallenberg and Johanna Westra
    Citation: Arthritis Research & Therapy 2017 19:100
    Content type: Research article Published on:

  38. Magnetic resonance imaging (MRI) and computed tomography (CT) angiography have now largely replaced interventional angiography in the diagnoses and follow up of Takayasu arteritis (TAK) but data on the effects...

    Authors: Birgir Gudbrandsson, Øyvind Molberg and Øyvind Palm
    Citation: Arthritis Research & Therapy 2017 19:99
    Content type: Research article Published on:

  39. Osteoarthritis has a high prevalence in people with high bone mineral density (BMD). Nevertheless, whether high systemic BMD predates early structural features of knee osteoarthritis is unclear. This study exa...

    Authors: Andrew J. Teichtahl, Yuanyuan Wang, Anita E. Wluka, Boyd J. Strauss, Joseph Proietto, John B. Dixon, Graeme Jones and Flavia M. Cicuttini
    Citation: Arthritis Research & Therapy 2017 19:98
    Content type: Research article Published on:

  40. Regulatory T cells (Tregs) play a role in the suppression of inflammation in autoimmune diseases, and lymphocyte activation gene 3 (LAG3) was reported as a marker of interleukin (IL)-10-producing Tregs. We aim...

    Authors: Shinichiro Nakachi, Shuji Sumitomo, Yumi Tsuchida, Haruka Tsuchiya, Masanori Kono, Rika Kato, Keiichi Sakurai, Norio Hanata, Yasuo Nagafuchi, Shoko Tateishi, Hiroko Kanda, Tomohisa Okamura, Kazuhiko Yamamoto and Keishi Fujio
    Citation: Arthritis Research & Therapy 2017 19:97
    Content type: Research article Published on:

  41. In this study, we sought to compare the performance of spondyloarthritis (SpA) classification criteria sets in an international SpA cohort with patients included from five continents around the world.

    Authors: Pauline Bakker, Anna Moltó, Adrien Etcheto, Filip Van den Bosch, Robert Landewé, Floris van Gaalen, Maxime Dougados and Désirée van der Heijde
    Citation: Arthritis Research & Therapy 2017 19:96
    Content type: Research article Published on:

  42. Risk prediction algorithms increase understanding of which patients are at greatest risk of a harmful outcome. Our goal was to create a clinically useful prediction algorithm for structural progression of knee...

    Authors: Michael P. LaValley, Grace H. Lo, Lori Lyn Price, Jeffrey B. Driban, Charles B. Eaton and Timothy E. McAlindon
    Citation: Arthritis Research & Therapy 2017 19:95
    Content type: Research article Published on:

  44. Prolactin (PRL) reduces joint inflammation, pannus formation, and bone destruction in rats with polyarticular adjuvant-induced arthritis (AIA). Here, we investigate the mechanism of PRL protection against bone...

    Authors: Maria G. Ledesma-Colunga, Norma Adán, Georgina Ortiz, Mariana Solís-Gutiérrez, Fernando López-Barrera, Gonzalo Martínez de la Escalera and Carmen Clapp
    Citation: Arthritis Research & Therapy 2017 19:93
    Content type: Research article Published on:

  45. Tumor necrosis factor inhibitors (TNFi) are common second-line treatments for rheumatoid arthritis (RA). This study was designed to compare the real-world clinical and economic outcomes between patients with R...

    Authors: Michael Grabner, Natalie N. Boytsov, Qing Huang, Xiang Zhang, Tingjian Yan and Jeffrey R. Curtis
    Citation: Arthritis Research & Therapy 2017 19:92
    Content type: Research article Published on:

  46. Abnormal B-cell activation is implicated in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE). The B-cell surface molecule CD22, which regulates activation through the B-cel...

    Authors: Natalia V. Giltiay, Geraldine L. Shu, Anthony Shock and Edward A. Clark
    Citation: Arthritis Research & Therapy 2017 19:91
    Content type: Research article Published on:

  47. An individual patient’s response to a particular drug is influenced by multiple factors, which may include genetic predisposition. Pharmacogenetic studies attempt to discover and estimate the contributions of ...

    Authors: Kristopher A. Standish, C. Chris Huang, Mark E. Curran and Nicholas J. Schork
    Citation: Arthritis Research & Therapy 2017 19:90
    Content type: Research Article Published on:

  48. Lubricin/proteoglycan 4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. Recently, we showed that recombinant human PRG4 (rhPRG4) is a putative ligand for C...

    Authors: Ali Alquraini, Maha Jamal, Ling Zhang, Tannin Schmidt, Gregory D. Jay and Khaled A. Elsaid
    Citation: Arthritis Research & Therapy 2017 19:89
    Content type: Research article Published on:

  49. Utilising fluorescence optical imaging (FOI), the distribution of an intravenously applied colouring agent indocyanine green (ICG) can be analysed with the potential to identify malperfusion by little to no ti...

    Authors: Stefanie Friedrich, Susanne Lüders, Stephanie Gabriele Werner, Anne-Marie Glimm, Gerd-Rüdiger Burmester, Gabriela Riemekasten, Marina Backhaus and Sarah Ohrndorf
    Citation: Arthritis Research & Therapy 2017 19:87
    Content type: Research article Published on:

  50. This study developed and validated a claims-based statistical model to predict rheumatoid arthritis (RA) disease activity, measured by the 28-joint count Disease Activity Score (DAS28).

    Authors: Brian C. Sauer, Chia-Chen Teng, Neil A. Accortt, Zachary Burningham, David Collier, Mona Trivedi and Grant W. Cannon
    Citation: Arthritis Research & Therapy 2017 19:86
    Content type: Research article Published on:
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Arthritis Research & Therapy

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