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  1. Adenosine is a purine nucleoside implicated in the regulation of the innate and adaptive immune systems, acting through its interaction with four cell surface receptors: A1, A2A, A2B, and A3. There is intense int...

    Authors: Alessandra Bortoluzzi, Fabrizio Vincenzi, Marcello Govoni, Melissa Padovan, Annalisa Ravani, Pier Andrea Borea and Katia Varani
    Citation: Arthritis Research & Therapy 2016 18:192
    Content type: Research article Published on:

  2. Heparin-induced thrombocytopenia is caused by antibodies (Abs) specific to platelet factor 4 (PF4)/heparin complexes. In this study, we evaluated the rates of seroconversion of anti-PF4/heparin Ab between pati...

    Authors: Masahiro Izumi, Tatsuya Sakai, Atsunori Shirakawa, Hideko Kozuru, Yuka Jiuchi, Yasumori Izumi, Tomohiko Asahara, Kenji Kumagai, Masaaki Mawatari, Makoto Osaki, Satoru Motokawa and Kiyoshi Migita
    Citation: Arthritis Research & Therapy 2016 18:191
    Content type: Research article Published on:

  3. Although B cell depletion with rituximab (RTX) is an effective treatment strategy in rheumatoid arthritis (RA), one third of patients do not achieve remission or low disease activity (LDA). Thus, identifying p...

    Authors: Martin H. Stradner, Christian Dejaco, Kerstin Brickmann, Winfried B. Graninger and Hans Peter Brezinschek
    Citation: Arthritis Research & Therapy 2016 18:190
    Content type: Research article Published on:

  4. In rheumatoid arthritis, prediction of response to TNF-alpha inhibitor (TNFi) treatment would be of clinical value. This study aims to discover miRNAs that predict response and aims to replicate results of two...

    Authors: Bart V. J. Cuppen, Marzia Rossato, Ruth D. E. Fritsch-Stork, Arno N. Concepcion, Yolande Schenk, Johannes W. J. Bijlsma, Timothy R. D. J. Radstake and Floris P. J. G. Lafeber
    Citation: Arthritis Research & Therapy 2016 18:189
    Content type: Research article Published on:

  5. Interleukin-21 (IL-21) is a T-cell-derived cytokine whose receptor is expressed on a variety of cells and therefore might have pleiotropic roles in the pathogenesis of rheumatoid arthritis (RA). In this study,...

    Authors: Koji Sakuraba, Akiko Oyamada, Kenjiro Fujimura, Rosanne Spolski, Yukihide Iwamoto, Warren J. Leonard, Yasunobu Yoshikai and Hisakata Yamada
    Citation: Arthritis Research & Therapy 2016 18:188
    Content type: Research article Published on:

  6. Chromogranin-A (CgA) is a secretory protein processed into peptides that regulate angiogenesis and vascular cells activation, migration and proliferation. These processes may influence arterial inflammation an...

    Authors: Enrico Tombetti, Barbara Colombo, Maria Chiara Di Chio, Silvia Sartorelli, Maurizio Papa, Annalaura Salerno, Enrica Paola Bozzolo, Elisabetta Tombolini, Giulia Benedetti, Claudia Godi, Chiara Lanzani, Patrizia Rovere-Querini, Alessandro Del Maschio, Alessandro Ambrosi, Francesco De Cobelli, Maria Grazia Sabbadini…
    Citation: Arthritis Research & Therapy 2016 18:187
    Content type: Research article Published on:

  7. Gene therapy has the potential to provide long-term production of therapeutic proteins in the joints of osteoarthritis (OA) patients. The objective of this study was to analyse the therapeutic potential of dis...

    Authors: Mathijs G. A. Broeren, Marieke de Vries, Miranda B. Bennink, Onno J. Arntz, Peter L. E M. van Lent, Peter M. van der Kraan, Wim B. van den Berg, Frank H. J. van den Hoogen, Marije I. Koenders and Fons A. J. van de Loo
    Citation: Arthritis Research & Therapy 2016 18:186
    Content type: Research article Published on:

  8. Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel, widely expressed in neuronal cells and involved in nociception and neurogenic inflammation. We showed recently that TRPA1...

    Authors: Elina Nummenmaa, Mari Hämäläinen, Lauri J. Moilanen, Erja-Leena Paukkeri, Riina M. Nieminen, Teemu Moilanen, Katriina Vuolteenaho and Eeva Moilanen
    Citation: Arthritis Research & Therapy 2016 18:185
    Content type: Research article Published on:

  9. Apoptotic cell-based therapies have been proposed to treat chronic inflammatory diseases. The aim of this study was to investigate the effect of intravenous (i.v.) apoptotic cell infusion in ongoing collagen-i...

    Authors: Francis Bonnefoy, Anna Daoui, Séverine Valmary-Degano, Eric Toussirot, Philippe Saas and Sylvain Perruche
    Citation: Arthritis Research & Therapy 2016 18:184
    Content type: Research article Published on:

  10. The aim was to estimate the impact of individual risk factors and treatment with various disease-modifying antirheumatic drugs (DMARDs) on the incidence of myocardial infarction (MI) in patients with rheumatoi...

    Authors: Yvette Meissner, Angela Zink, Jörn Kekow, Karin Rockwitz, Anke Liebhaber, Silke Zinke, Kerstin Gerhold, Adrian Richter, Joachim Listing and Anja Strangfeld
    Citation: Arthritis Research & Therapy 2016 18:183
    Content type: Research article Published on:

  11. Excessive autoantibody production characterizing systemic lupus erythematosus (SLE) occurs irrespective of the disease’s clinical status and is linked to increased lymphocyte apoptosis. Herein, we tested the h...

    Authors: Vassilis L. Souliotis, Konstantinos Vougas, Vassilis G. Gorgoulis and Petros P. Sfikakis
    Citation: Arthritis Research & Therapy 2016 18:182
    Content type: Research article Published on:

  12. Quantitative measurement of knee joint effusion by ultrasonography has not been well established; however, a categorical measurement (e.g., a ≥4-mm-deep suprapatellar pouch) is recommended. Therefore, the curr...

    Authors: Daisuke Chiba, Eiichi Tsuda, Shugo Maeda, Eiji Sasaki, Ippei Takahashi, Shigeyuki Nakaji and Yasuyuki Ishibashi
    Citation: Arthritis Research & Therapy 2016 18:181
    Content type: Research article Published on:

  13. The inhibitory CTLA-4 molecule is a crucial regulator of immune responses and a target for therapeutic intervention in both autoimmunity and cancer. In particular, CTLA-4 is important in controlling antigen-sp...

    Authors: Lekh N. Dahal, Neil Basu, Hazem Youssef, Rahul C. Khanolkar, Robert N. Barker, Lars P. Erwig and Frank J. Ward
    Citation: Arthritis Research & Therapy 2016 18:180
    Content type: Research article Published on:

  14. In rheumatoid arthritis (RA) bone marrow edema (BME, osteitis) and anti-citrullinated protein antibodies (ACPA) are associated with radiographic progression. ACPA have been associated with BME, but it is unkno...

    Authors: Debbie M. Boeters, Wouter P. Nieuwenhuis, Marije K. Verheul, Elize C. Newsum, Monique Reijnierse, René E. M. Toes, Leendert A. Trouw and Annette H. M. van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2016 18:179
    Content type: Research article Published on:

  15. Patients with psoriatic arthritis (PsA) are at an increased risk for cardiovascular (CV) disease.  The aim of this study was to identify the frequency of carotid plaque in asymptomatic patients with psoriatic ...

    Authors: Michael Lucke, William Messner, Esther S. H. Kim and M. Elaine Husni
    Citation: Arthritis Research & Therapy 2016 18:178
    Content type: Research article Published on:

  16. Staphylococcus aureus (SA) is a commensal bacterium representing one of the most important components of the skin microbiome, mostly isolated in the anterior nares. A higher rate of SA...

    Authors: Fabrizio Conti, Fulvia Ceccarelli, Giancarlo Iaiani, Carlo Perricone, Alessandra Giordano, Luigino Amori, Francesca Miranda, Laura Massaro, Viviana Antonella Pacucci, Simona Truglia, Gabriella Girelli, Azis Fakeri, Gloria Taliani, Chiara Temperoni, Francesca Romana Spinelli, Cristiano Alessandri…
    Citation: Arthritis Research & Therapy 2016 18:177
    Content type: Research article Published on:

  17. Fibromyalgia (FM) affects approximately 1–3 % of the general population. Fatigue limits the work ability and social life of patients with FM. A few studies of physical exercise have included measures of fatigu...

    Authors: Anna Ericsson, Annie Palstam, Anette Larsson, Monika Löfgren, Indre Bileviciute-Ljungar, Jan Bjersing, Björn Gerdle, Eva Kosek and Kaisa Mannerkorpi
    Citation: Arthritis Research & Therapy 2016 18:176
    Content type: Research article Published on:

  18. The aim of this study was to evaluate the clinical manifestations and prevalence of familial Mediterranean fever (FMF) in Japanese patients with unexplained fever and rheumatic manifestations.

    Authors: Kiyoshi Migita, Yasumori Izumi, Yuka Jiuchi, Nozomi Iwanaga, Chieko Kawahara, Kazunaga Agematsu, Akihiro Yachie, Junya Masumoto, Keita Fujikawa, Satoshi Yamasaki, Tadashi Nakamura, Yoshifumi Ubara, Tomohiro Koga, Yoshikazu Nakashima, Toshimasa Shimizu, Masataka Umeda…
    Citation: Arthritis Research & Therapy 2016 18:175
    Content type: Research article Published on:

  19. In contrast to rheumatoid arthritis (RA), no systematic investigation of diurnal variation has been carried out in polymyalgia rheumatica (PMR). The aim of the study was to provide the often-requested document...

    Authors: Henrik Galbo and Lisbeth Kall
    Citation: Arthritis Research & Therapy 2016 18:174
    Content type: Research article Published on:

  20. The relationship between lung and joint inflammation in rheumatoid arthritis is poorly understood. Lung inflammation with resultant protein citrullination may trigger anti-citrullinated protein antibodies, inf...

    Authors: Mandar Bawadekar, Annette Gendron-Fitzpatrick, Ryan Rebernick, Daeun Shim, Thomas F. Warner, Anthony P. Nicholas, Lennart K. A. Lundblad, Paul R. Thompson and Miriam A. Shelef
    Citation: Arthritis Research & Therapy 2016 18:173
    Content type: Research article Published on:

  21. The unfolded protein response (UPR) is activated following an endoplasmic reticulum (ER) stress. The aim of this study was to investigate the global expression of UPR genes in human OA chondrocytes in induced ...

    Authors: Ying-Hua Li, Ginette Tardif, David Hum, Mohit Kapoor, Hassan Fahmi, Jean-Pierre Pelletier and Johanne Martel-Pelletier
    Citation: Arthritis Research & Therapy 2016 18:172
    Content type: Research article Published on:

  22. The formation of destructive hypercellular pannus is critical to joint damage in rheumatoid arthritis (RA). The collagen triple helix repeat containing 1 (CTHRC1) protein expressed by activated stromal cells o...

    Authors: Mohammed Talha Shekhani, Toni S. Forde, Altynai Adilbayeva, Mohamed Ramez, Askhat Myngbay, Yergali Bexeitov, Volkhard Lindner and Vyacheslav A. Adarichev
    Citation: Arthritis Research & Therapy 2016 18:171
    Content type: Research article Published on:

  23. According to EULAR recommendations, biologic DMARDs (bDMARDs) such as tumor necrosis factor inhibitor, tocilizumab (TCZ), and abatacept (ABT) are in parallel when prescribing to rheumatoid arthritis (RA) patie...

    Authors: Seiji Nakamura, Katsuya Suzuki, Hiroshi Iijima, Yuko Hata, Chun Ren Lim, Yohei Ishizawa, Hideto Kameda, Koichi Amano, Kenichi Matsubara, Ryo Matoba and Tsutomu Takeuchi
    Citation: Arthritis Research & Therapy 2016 18:159
    Content type: Research article Published on:

  24. Inhomogeneity of immune cell distribution in the synovial sublining layer was analyzed in order to improve our mechanistic understanding of synovial inflammation and explore potential refinements for histologi...

    Authors: Johanna Mucke, Annika Hoyer, Ralph Brinks, Ellen Bleck, Thomas Pauly, Matthias Schneider and Stefan Vordenbäumen
    Citation: Arthritis Research & Therapy 2016 18:170
    Content type: Research article Published on:

  26. Plasma exchange (PLEX) has been used routinely for treatment of severe renal vasculitis and/or alveolar haemorrhage (AH) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), but the long...

    Authors: Doubravka Frausová, Zdenka Hrušková, Věra Lánská, Jana Lachmanová and Vladimír Tesař
    Citation: Arthritis Research & Therapy 2016 18:168
    Content type: Research article Published on:

  27. The aim of this study was to elucidate the function of circulating follicular helper T (Tfh) cell subsets in helping B cells in patients with active, untreated IgG4-related disease (IgG4-RD) and determine thei...

    Authors: Mitsuhiro Akiyama, Hidekata Yasuoka, Kunihiro Yamaoka, Katsuya Suzuki, Yuko Kaneko, Harumi Kondo, Yoshiaki Kassai, Keiko Koga, Takahiro Miyazaki, Rimpei Morita, Akihiko Yoshimura and Tsutomu Takeuchi
    Citation: Arthritis Research & Therapy 2016 18:167
    Content type: Research article Published on:

  28. Joint surface injury, a known risk factor for osteoarthritis, triggers synovial hyperplasia, which involves proliferation of mesenchymal stromal/stem cells (MSCs). Whether these proliferative MSCs are resident...

    Authors: Ana Sergijenko, Anke J. Roelofs, Anna H. K. Riemen and Cosimo De Bari
    Citation: Arthritis Research & Therapy 2016 18:166
    Content type: Research article Published on:

  29. The type I interferon (IFN) signature in rheumatoid arthritis (RA) has shown clinical relevance in relation to disease onset and therapeutic response. Identification of the cell type(s) contributing to this IF...

    Authors: Tamarah D. de Jong, Joyce Lübbers, Samina Turk, Saskia Vosslamber, Elise Mantel, Hetty J. Bontkes, Conny J. van der Laken, Johannes W. Bijlsma, Dirkjan van Schaardenburg and Cornelis L. Verweij
    Citation: Arthritis Research & Therapy 2016 18:165
    Content type: Research article Published on:

  30. The aim of the present study was to describe prevalence and trends in the incidence of gout and patterns of urate-lowering treatment (ULT) in the Western Swedish Health Care Region (WSHCR) from 2002 to 2012.

    Authors: Mats Dehlin, Panagiota Drivelegka, Valgerdur Sigurdardottir, Anna Svärd and Lennart T. H. Jacobsson
    Citation: Arthritis Research & Therapy 2016 18:164
    Content type: Research article Published on:

  31. Diagnosing systemic juvenile idiopathic arthritis (SJIA) can be extremely challenging if typical arthritis is lacking. A variety of biomarkers have been described for the diagnosis and management of SJIA. Howe...

    Authors: Faekah Gohar, Christoph Kessel, Miha Lavric, Dirk Holzinger and Dirk Foell
    Citation: Arthritis Research & Therapy 2016 18:163
    Content type: Research article Published on:

  32. Recent achievement in genetics and epigenetics has led to the exploration of the pathogenesis of systemic lupus erythematosus (SLE). Identification of differentially expressed genes and their regulatory mechan...

    Authors: Honglin Zhu, Wentao Mi, Hui Luo, Tao Chen, Shengxi Liu, Indu Raman, Xiaoxia Zuo and Quan-Zhen Li
    Citation: Arthritis Research & Therapy 2016 18:162
    Content type: Research article Published on:

  33. It has been previously hypothesized that oral microbes may be an etiological link between rheumatoid arthritis (RA) and periodontal disease. However, the mechanistic basis of this association is incompletely u...

    Authors: Sasanka Chukkapalli, Mercedes Rivera-Kweh, Prashasnika Gehlot, Irina Velsko, Indraneel Bhattacharyya, S. John Calise, Minoru Satoh, Edward K. L. Chan, Joseph Holoshitz and Lakshmyya Kesavalu
    Citation: Arthritis Research & Therapy 2016 18:161
    Content type: Research article Published on:

  34. Serum levels of calprotectin, a major S100 leucocyte protein, are associated with disease activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients. Higher drug trough serum levels are assoc...

    Authors: José Inciarte-Mundo, Julio Ramirez, Maria Victoria Hernández, Virginia Ruiz-Esquide, Andrea Cuervo, Sonia Raquel Cabrera-Villalba, Mariona Pascal, Jordi Yagüe, Juan D. Cañete and Raimon Sanmarti
    Citation: Arthritis Research & Therapy 2016 18:160
    Content type: Research article Published on:

  35. Epigenetic changes (i.e., chromatin modifications) occur during chondrogenesis and in osteoarthritis (OA). We investigated the effect of H3K27me3 demethylase inhibition on chondrogenesis and assessed its utili...

    Authors: Clarence Yapp, Andrew J. Carr, Andrew Price, Udo Oppermann and Sarah J. B. Snelling
    Citation: Arthritis Research & Therapy 2016 18:158
    Content type: Research article Published on:

  36. The Trial of Early Aggressive Therapy in Juvenile Idiopathic Arthritis (TREAT trial) was accompanied by a once-in-a-generation sample collection for translational research. In this paper, we report the results...

    Authors: Kaiyu Jiang, Laiping Wong, Ashley D. Sawle, M. Barton Frank, Yanmin Chen, Carol A. Wallace and James N. Jarvis
    Citation: Arthritis Research & Therapy 2016 18:157
    Content type: Research article Published on:

  37. The idiopathic inflammatory myopathies (IIM) are autoimmune diseases characterised by acquired proximal muscle weakness, inflammatory cell infiltrates in muscle and myositis-specific/associated autoantibodies....

    Authors: Joanna E. Parkes, Simon Rothwell, Philip J. Day, Neil J. McHugh, Zoë E. Betteridge, Robert G. Cooper, William E. Ollier, Hector Chinoy and Janine A. Lamb
    Citation: Arthritis Research & Therapy 2016 18:156
    Content type: Research article Published on:

  38. MicroRNA (miRNA) control key elements of mRNA stability and likely contribute to the dysregulated lung gene expression observed in systemic sclerosis associated interstitial lung disease (SSc-ILD). We analyzed...

    Authors: Romy B. Christmann, Alicia Wooten, Percival Sampaio-Barros, Claudia L. Borges, Carlos R. R. Carvalho, Ronaldo A. Kairalla, Carol Feghali-Bostwick, Jessica Ziemek, Yu Mei, Salma Goummih, Jiangning Tan, Diana Alvarez, Daniel J. Kass, Mauricio Rojas, Thiago Lemos de Mattos, Edwin Parra…
    Citation: Arthritis Research & Therapy 2016 18:155
    Content type: Research article Published on:

  39. Authors: Ruben Burgos-Vargas, James Cheng-Chung Wei, Mahboob U. Rahman, Nurullah Akkoc, Syed Atiqul Haq, Mohammed Hammoudeh, Ehab Mahgoub, Ena Singh, Lyndon John Llamado, Khalid Shirazy, Sameer Kotak, Constance Hammond, Ron Pedersen, Qi Shen and Bonnie Vlahos
    Citation: Arthritis Research & Therapy 2016 18:154
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2016 18:132

  40. Pulmonary arterial hypertension (PAH) complicates the course of systemic sclerosis (SSc) and is associated with poor prognosis. The elevation of systolic pulmonary arterial pressure (sPAP) during exercise in p...

    Authors: Rui Baptista, Sara Serra, Rui Martins, Rogério Teixeira, Graça Castro, Maria João Salvador, José António Pereira da Silva, Lèlita Santos, Pedro Monteiro and Mariano Pêgo
    Citation: Arthritis Research & Therapy 2016 18:153
    Content type: Research article Published on:

  42. Osteoarthritis (OA) is a chronic degenerative disease involving multiple physiopathological mechanisms. The increased prevalence of OA after menopause and the presence of estrogen receptors in joint tissues su...

    Authors: Ya-Ping Xiao, Fa-Ming Tian, Mu-Wei Dai, Wen-Ya Wang, Li-Tao Shao and Liu Zhang
    Citation: Arthritis Research & Therapy 2016 18:151
    Content type: Review Published on:

  43. Lack of validity in osteoarthritis pain models and assessment methods is suspected. Our goal was to 1) assess the repeatability and reproducibility of measurement and the influence of environment, and acclimat...

    Authors: Colombe Otis, Julie Gervais, Martin Guillot, Julie-Anne Gervais, Dominique Gauvin, Catherine Péthel, Simon Authier, Marc-André Dansereau, Philippe Sarret, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Francis Beaudry and Eric Troncy
    Citation: Arthritis Research & Therapy 2016 18:150
    Content type: Research article Published on:

  44. METARTHROS (Metabolic impact on joint and bone disease) is a nationwide German network to investigate the overlap between inflammatory and metabolic diseases. The objective of this study was to compare the bod...

    Authors: Katinka Albrecht, Adrian Richter, Johanna Callhoff, Dörte Huscher, Georg Schett, Anja Strangfeld and Angela Zink
    Citation: Arthritis Research & Therapy 2016 18:149
    Content type: Research article Published on:

  45. During chronic inflammation, immune cells, notably Th17 cells, infiltrate the inflammatory site and interact with local mesenchymal cells. Applied to rheumatoid arthritis (RA), the aim is to study the interact...

    Authors: Mélissa Noack, Ndiémé Ndongo-Thiam and Pierre Miossec
    Citation: Arthritis Research & Therapy 2016 18:148
    Content type: Research article Published on:

  46. Endothelial progenitor cells (EPC) are of major importance in vascular repair under healthy circumstances. Vascular injury in need of repair occurs frequently in ANCA-associated vasculitis (AAV). A specialized...

    Authors: B. Wilde, A. Mertens, S. J. Arends, R. P. Rouhl, R. Bijleveld, J. Huitema, S. A. Timmermans, J. Damoiseaux, O. Witzke, A. M. Duijvestijn, P. van Paassen, R. J. van Oostenbrugge and J. W. Cohen Tervaert
    Citation: Arthritis Research & Therapy 2016 18:147
    Content type: Research article Published on:

  47. Joint trauma, which is frequently related with mechanical overloading of articular cartilage, is a well-established risk for osteoarthritis (OA) development. Additionally, reports show that trauma leads to syn...

    Authors: Wojciech Madej, Pieter Buma and Peter van der Kraan
    Citation: Arthritis Research & Therapy 2016 18:146
    Content type: Research article Published on:

  48. Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). The aim of this study was to explore the safety and efficacy of open-label tofacitinib following blinded treatment ...

    Authors: Mark C. Genovese, Ronald F. van Vollenhoven, Bethanie Wilkinson, Lisy Wang, Samuel H. Zwillich, David Gruben, Pinaki Biswas, Richard Riese, Liza Takiya and Thomas V. Jones
    Citation: Arthritis Research & Therapy 2016 18:145
    Content type: Research article Published on:

  49. Authors: Katerina Chatzidionysiou, Elisabeth Lie, Evgeny Nasonov, Galina Lukina, Merete Lund Hetland, Ulrik Tarp, Ioan Ancuta, Karel Pavelka, Dan C. Nordström, Cem Gabay, Helene Canhão, Matija Tomsic, Piet L. C. M. van Riel, Juan Gomez-Reino, Tore K. Kvien and Ronald F. van Vollenhoven
    Citation: Arthritis Research & Therapy 2016 18:144
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2016 18:50

  50. Interleukin (IL)-33 is a dual cytokine with both an alarmin role and a T helper 2 cell (Th2)-like inducing effect. It is involved in the pathogenesis of rheumatoid arthritis (RA) and its models; we recently de...

    Authors: Sara Khaleghparast Athari, Elodie Poirier, Jérôme Biton, Luca Semerano, Roxane Hervé, Aurélie Raffaillac, Delphine Lemeiter, André Herbelin, Jean-Philippe Girard, Frédéric Caux, Marie-Christophe Boissier and Natacha Bessis
    Citation: Arthritis Research & Therapy 2016 18:143
    Content type: Research article Published on:
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Arthritis Research & Therapy

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