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  1. The presence of rheumatoid factor (RF), anti-carbamylated protein antibodies (anti-CarP) and antibodies against citrullinated protein and peptides (ACPA) precedes the onset of symptoms of rheumatoid arthritis ...

    Authors: Mikael Brink, Monika Hansson, Linda Mathsson-Alm, Priyantha Wijayatunga, Marije K. Verheul, Leendert A. Trouw, Rikard Holmdahl, Johan Rönnelid, Lars Klareskog and Solbritt Rantapää-Dahlqvist
    Citation: Arthritis Research & Therapy 2016 18:43
    Content type: Research article Published on:

  3. In systemic sclerosis (SSc), peripheral vasculopathy is characterized by a progressive and irreversible loss of capillaries following endothelial cell injury, due to defects in both vascular repair and expecte...

    Authors: Mirko Manetti, Serena Guiducci and Marco Matucci-Cerinic
    Citation: Arthritis Research & Therapy 2016 18:36
    Content type: Editorial Published on:

  4. Fibromyalgia (FM) is a chronic, centralized pain condition characterized by alterations in the functional, chemical, and structural brain networks responsible for sensory and mood processing. Transcranial dire...

    Authors: Chelsea M. Cummiford, Thiago D. Nascimento, Bradley R. Foerster, Daniel J. Clauw, Jon-Kar Zubieta, Richard E. Harris and Alexandre F. DaSilva
    Citation: Arthritis Research & Therapy 2016 18:40
    Content type: Research article Published on:

  5. In this study, we assessed whether clinical and ultrasonography (US)-based remission could be used to select patients with rheumatoid arthritis (RA) eligible to taper and discontinue anti-TNF-α therapy after a...

    Authors: Stefano Alivernini, Giusy Peluso, Anna Laura Fedele, Barbara Tolusso, Elisa Gremese and Gianfranco Ferraccioli
    Citation: Arthritis Research & Therapy 2016 18:39
    Content type: Research article Published on:

  6. In this study, the Spondyloarthritis Research Consortium Canada (SPARCC) scoring method was used to compare treatment methods in patients with axial spondyloarthritis (SpA), a form of sacroiliitis. MRI abnorma...

    Authors: Yang Cui, Jinping Zheng, Xiao Zhang, Hui Zeng and Riqiang Luo
    Citation: Arthritis Research & Therapy 2016 18:38
    Content type: Research article Published on:

  7. Age, C-Reactive Protein (CRP) and autoantibodies (Abs) are associated with worse prognosis in patients with recent-onset inflammatory polyarthritis (EPA). Serum 14-3-3η protein is a joint-derived biomarker tha...

    Authors: Nathalie Carrier, Anthony Marotta, Artur J. de Brum-Fernandes, Patrick Liang, Ariel Masetto, Henri A. Ménard, Walter P. Maksymowych and Gilles Boire
    Citation: Arthritis Research & Therapy 2016 18:37
    Content type: Research article Published on:

  8. Ankylosing spondylitis (AS) is an immune-mediated arthritis particularly targeting the spine and pelvis and is characterised by inflammation, osteoproliferation and frequently ankylosis. Current treatments tha...

    Authors: Hsu-Wen Tseng, Miranda E. Pitt, Tibor T. Glant, Allan F. McRae, Tony J. Kenna, Matthew A. Brown, Allison R. Pettit and Gethin P. Thomas
    Citation: Arthritis Research & Therapy 2016 18:35
    Content type: Research article Published on:

  9. Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis. Here, tofacitinib safety and efficacy data from a long-term extension study in Japanese patients are presented.

    Authors: Hisashi Yamanaka, Yoshiya Tanaka, Tsutomu Takeuchi, Naonobu Sugiyama, Hirotoshi Yuasa, Shigeyuki Toyoizumi, Yosuke Morishima, Tomohiro Hirose and Samuel Zwillich
    Citation: Arthritis Research & Therapy 2016 18:34
    Content type: Research article Published on:

  10. Patients with rheumatoid arthritis (RA) suffer from co-morbidities that contribute to a shortened lifespan. Inflammation is important for the development of cardiovascular disease, but little is known on its r...

    Authors: Lena Innala, Clara Sjöberg, Bozena Möller, Lotta Ljung, Torgny Smedby, Anna Södergren, Staffan Magnusson, Solbritt Rantapää-Dahlqvist and Solveig Wållberg-Jonsson
    Citation: Arthritis Research & Therapy 2016 18:33
    Content type: Research article Published on:

  11. Osteoarthritis (OA) is the commonest chronic disease, with an estimated 9.6 % of men and 18.0 % of women aged over 60 years having symptomatic OA according to the World Health Organisation. Despite this preval...

    Authors: Blandine Poulet and Frank Beier
    Citation: Arthritis Research & Therapy 2016 18:32
    Content type: Editorial Published on:

  12. The impact of male sex as a determinant of health outcomes in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) is controversial. The primary objective of this study was to evaluate the e...

    Authors: Christopher R. Pasarikovski, John T. Granton, Adrienne M. Roos, Saghar Sadeghi, Amie T. Kron, John Thenganatt, Jakov Moric, Cathy Chau and Sindhu R. Johnson
    Citation: Arthritis Research & Therapy 2016 18:30
    Content type: Research article Published on:

  13. Subchondral bone marrow lesions (BMLs) play a key role in the pathogenesis of osteoarthritis (OA) and are associated with pain and structural progression in knee OA. However, little is known about clinical sig...

    Authors: Benny Antony, Alison Venn, Flavia Cicuttini, Lyn March, Leigh Blizzard, Terence Dwyer, Andrew Halliday, Marita Cross, Graeme Jones and Changhai Ding
    Citation: Arthritis Research & Therapy 2016 18:31
    Content type: Research article Published on:

  14. The aims of the present study were to determine the relationship between bone destruction and bone formation in the delayed-type hypersensitivity arthritis (DTHA) model and to evaluate the effect of receptor a...

    Authors: Sara Marie Atkinson, Janine Bleil, René Maier, Anja A. Kühl, Mette Thorn, Kyle Serikawa, Brian Fox, Kim Kruse, Claus Haase, Søren Skov, Anneline Nansen and Uta Syrbe
    Citation: Arthritis Research & Therapy 2016 18:28
    Content type: Research article Published on:

  15. Autoantibody profiles represent important patient stratification markers in systemic sclerosis (SSc). Here, we performed serum-immunoprecipitations with patient antibodies followed by mass spectrometry (LC-MS/...

    Authors: Michael E. Johnson, Andrew V. Grassetti, Jaclyn N. Taroni, Shawn M. Lyons, Devin Schweppe, Jessica K. Gordon, Robert F. Spiera, Robert Lafyatis, Paul J. Anderson, Scott A. Gerber and Michael L. Whitfield
    Citation: Arthritis Research & Therapy 2016 18:27
    Content type: Research article Published on:

  16. During pregnancy, many patients with rheumatoid arthritis (RA) experience disease improvement, whereas patients with ankylosing spondylitis often suffer from persistent active disease. Here we investigated whe...

    Authors: Manuela Tham, Gabriele R. Schlör, Daniel Yerly, Christina Mueller, Daniel Surbek, Peter M. Villiger and Frauke Förger
    Citation: Arthritis Research & Therapy 2016 18:26
    Content type: Research article Published on:

  17. The Rheumatoid Arthritis Impact of Disease (RAID) score was developed as a European League Against Rheumatism initiative to obtain a patient reported outcome score for clinical trials in patients with rheumato...

    Authors: Marieke M. ter Wee, Lilian H. van Tuyl, Birgit S. Blomjous, Willem F. Lems, Maarten Boers and Caroline B. Terwee
    Citation: Arthritis Research & Therapy 2016 18:22
    Content type: Research article Published on:

  18. As an initial step in the development of a local therapeutic to treat osteoarthritis (OA), a number of agents were tested for their ability to block activation of inflammation through nuclear factor κ-light-ch...

    Authors: Erica M. TenBroek, Laurie Yunker, Mae Foster Nies and Alison M. Bendele
    Citation: Arthritis Research & Therapy 2016 18:24
    Content type: Research article Published on:

  19. Early suppression of disease activity in (rheumatoid) arthritis (RA) patients may result in drug-free remission and prevent damage. We assessed 2-year clinical and radiological outcomes of two disease activity...

    Authors: Lotte Heimans, Gülşah Akdemir, Kirsten V. C. Wevers-de Boer, Yvonne P. Goekoop-Ruiterman, Esmeralda T. Molenaar, Johannes H. L. M. van Groenendael, Andreas J. Peeters, Gerda M. Steup-Beekman, Leroy R. Lard, Peter B. J. de Sonnaville, Bernard A. M. Grillet, Tom W. J. Huizinga and Cornelia F. Allaart
    Citation: Arthritis Research & Therapy 2016 18:23
    Content type: Research article Published on:

  20. One potential mechanism for early superficial cartilage wear in normal joints is alteration of the lubricant content and quality of synovial fluid. The purpose of this study was to determine if the concentrati...

    Authors: Michele M. Temple-Wong, Shuwen Ren, Phu Quach, Bradley C. Hansen, Albert C. Chen, Akihiko Hasegawa, Darryl D. D’Lima, Jim Koziol, Koichi Masuda, Martin K. Lotz and Robert L. Sah
    Citation: Arthritis Research & Therapy 2016 18:18
    Content type: Research article Published on:

  21. CT-P13 (Remsima®, Inflectra®) is a biosimilar of the infliximab reference product (RP; Remicade®) and is approved in Europe and elsewhere, mostly for the same indications as RP. The aim of this study was to co...

    Authors: Won Park, Dae Hyun Yoo, Janusz Jaworski, Jan Brzezicki, Andriy Gnylorybov, Vladimir Kadinov, Irmgadt Goecke Sariego, Carlos Abud-Mendoza, William Jose Otero Escalante, Seong Wook Kang, Daina Andersone, Francisco Blanco, Seung Suh Hong, Sun Hee Lee and Jürgen Braun
    Citation: Arthritis Research & Therapy 2016 18:25
    Content type: Research article Published on:

  22. Evaluating lymphocytic infiltration of minor salivary gland biopsy in primary Sjögren’s syndrome is challenging. We developed and evaluated a digital method for quantifying B and T lymphocytes in whole minor s...

    Authors: Sebastian Costa, Sacha Schutz, Divi Cornec, Arnaud Uguen, Isabelle Quintin-Roué, Agnès Lesourd, Jean-Marie Berthelot, Eric Hachulla, Pierre-Yves Hatron, Vincent Goeb, Olivier Vittecoq, Jacques Olivier Pers, Pascale Marcorelles, Alain Saraux and Valérie Devauchelle-Pensec
    Citation: Arthritis Research & Therapy 2016 18:21
    Content type: Research article Published on:

  23. Systemic sclerosis (SSc)-related interstitial lung disease (ILD) has phenotypic similarities to lung involvement in idiopathic interstitial pneumonia (IIP). We aimed to assess whether genetic susceptibility lo...

    Authors: Minghua Wu, Shervin Assassi, Gloria A. Salazar, Claudia Pedroza, Olga Y. Gorlova, Wei V. Chen, Julio Charles, Miranda L. Taing, Kelley Liao, Fredrick M. Wigley, Laura K. Hummers, Ami A. Shah, Monique Hinchcliff, Dinesh Khanna, Elena Schiopu, Kristine Phillips…
    Citation: Arthritis Research & Therapy 2016 18:20
    Content type: Research article Published on:

  24. IL6-related T cell activation and TNFα-dependent cell proliferation are major targets of therapy in the RA synovium. We investigated whether expression of these pathways in RA synovial biopsies is associated w...

    Authors: Aurélie De Groof, Julie Ducreux, Frances Humby, Adrien Nzeusseu Toukap, Valérie Badot, Costantino Pitzalis, Frédéric A. Houssiau, Patrick Durez and Bernard R. Lauwerys
    Citation: Arthritis Research & Therapy 2016 18:19
    Content type: Research article Published on:

  25. Rheumatoid arthritis (RA) is characterized by gradual joint destruction. Tocilizumab (TCZ) significantly suppresses symptoms, however not all patients are protected from joint damage. We investigated whether e...

    Authors: Anne C. Bay-Jensen, Adam Platt, Anne Sofie Siebuhr, Claus Christiansen, Inger Byrjalsen and Morten A. Karsdal
    Citation: Arthritis Research & Therapy 2016 18:13
    Content type: Research article Published on:

  26. There is increasing evidence that the non-neuronal cholinergic system might be of importance for the pathology of rheumatoid arthritis. The role of M3 muscarinic acetylcholine receptor (M3R) in this regard has...

    Authors: Janet Beckmann, Nicole Dittmann, Iris Schütz, Jochen Klein and Katrin Susanne Lips
    Citation: Arthritis Research & Therapy 2016 18:17
    Content type: Research article Published on:

  27. The effect of circumstances and exposures early in life on the risk of developing ankylosing spondylitis (AS) is largely unknown. The purpose of this study was to determine whether perinatal characteristics pr...

    Authors: Ulf Lindström, Helena Forsblad-d’Elia, Johan Askling, Lars Erik Kristensen, Elisabeth Lie, Sofia Exarchou and Lennart Jacobsson
    Citation: Arthritis Research & Therapy 2016 18:16
    Content type: Research article Published on:

  28. Synovial fibroblasts play a key role in joint destruction and regulation of the inflammatory infiltrate in established rheumatoid arthritis (RA). The mechanisms by which this occurs in the earliest stages of R...

    Authors: Maria Juarez, Helen M. McGettrick, Dagmar Scheel-Toellner, Lorraine Yeo, Julia Spengler, Banesa de Paz, Rowan Hardy, Mark Cooper, Karim Raza, Christopher D. Buckley and Andrew Filer
    Citation: Arthritis Research & Therapy 2016 18:14
    Content type: Research article Published on:

  29. Studies of Caucasian patients with rheumatoid arthritis (RA) to identify genetic biomarkers of anti-tumor necrosis factor (TNF) response have used response at a single time point as the phenotype with which si...

    Authors: Kyoko Honne, Ingileif Hallgrímsdóttir, Chunsen Wu, Ronnie Sebro, Nicholas P. Jewell, Takeo Sakurai, Masahiro Iwamoto, Seiji Minota and Damini Jawaheer
    Citation: Arthritis Research & Therapy 2016 18:12
    Content type: Research article Published on:

  30. Autoreactive B cells are crucial players in the pathogenesis of rheumatoid arthritis (RA). Autoantibodies specific for citrullinated proteins (ACPA), present in the serum of approximately 60–70 % of patients, ...

    Authors: Judit Pozsgay, Fruzsina Babos, Katalin Uray, Anna Magyar, Gergő Gyulai, Éva Kiss, György Nagy, Bernadette Rojkovich, Ferenc Hudecz and Gabriella Sármay
    Citation: Arthritis Research & Therapy 2016 18:15
    Content type: Research article Published on:

  31. MicroRNAs (miRNAs) are small, non-coding RNAs that mediate mRNA cleavage, translational repression or mRNA destabilisation and are around 22–25 nucleotides in length via partial complementary binding to the 3′...

    Authors: Steven O’Reilly
    Citation: Arthritis Research & Therapy 2016 18:11
    Content type: Review Published on:

  32. Synovial infiltration of monocytes is commonly associated with inflammation in rheumatoid arthritis (RA). Toll-like receptors (TLRs) are innate sensors that recognize cell debris and microbial components in ho...

    Authors: Patricia Lacerte, Alexandre Brunet, Benoit Egarnes, Benjamin Duchêne, Jacques P. Brown and Jean Gosselin
    Citation: Arthritis Research & Therapy 2016 18:10
    Content type: Research article Published on:

  33. Caspase-8 is required for extrinsic apoptosis, but is also central for preventing a pro-inflammatory receptor interacting protein kinase (RIPK) 3–mixed lineage kinase domain-like (MLKL)-dependent cell death pa...

    Authors: Vitaliya Sagulenko, Kate E. Lawlor and James E. Vince
    Citation: Arthritis Research & Therapy 2016 18:4
    Content type: Editorial Published on:

  34. Primary Sjögren’s syndrome (pSS) is a systemic rheumatic disease in which gastrointestinal (GI) symptoms are common. Faecal calprotectin (FC) is a non-invasive biomarker that has been suggested to discriminate...

    Authors: Kristofer Andréasson, Bodil Ohlsson and Thomas Mandl
    Citation: Arthritis Research & Therapy 2016 18:9
    Content type: Research article Published on:

  35. Fingolimod (FTY720) is an immunomodulating drug that inhibits sphingosine-1-phosphate binding and blocks T-cell egress from lymph nodes. We analyzed the effect of FTY720 on the autoimmune T- and B-cell respons...

    Authors: David C. Miller, Karen B. Whittington, David D. Brand, Karen A. Hasty and Edward F. Rosloniec
    Citation: Arthritis Research & Therapy 2016 18:8
    Content type: Research article Published on:

  36. The effect of cold temperature on arthritis symptoms is unclear. The aim of this study was to investigate how environmental cold affects pain and blood flow in mono-arthritic mice, and examine a role for trans...

    Authors: Elizabeth S. Fernandes, Fiona A. Russell, Khadija M. Alawi, Claire Sand, Lihuan Liang, Robin Salamon, Jennifer V. Bodkin, Aisah A. Aubdool, Matthew Arno, Clive Gentry, Sarah-Jane Smillie, Stuart Bevan, Julie E. Keeble, Marzia Malcangio and Susan D. Brain
    Citation: Arthritis Research & Therapy 2016 18:7
    Content type: Research article Published on:

  37. The transient receptor potential ankyrin 1 (TRPA1) is a calcium-permeable cation channel that is expressed on capsaicin-sensitive sensory neurons, endothelial and inflammatory cells. It is activated by a varie...

    Authors: Ádám Horváth, Valéria Tékus, Melinda Boros, Gábor Pozsgai, Bálint Botz, Éva Borbély, János Szolcsányi, Erika Pintér and Zsuzsanna Helyes
    Citation: Arthritis Research & Therapy 2016 18:6
    Content type: Research article Published on:

  38. To determine whether optimal use of serial measurements of serum levels of soluble cell adhesion molecules (CAM) can improve monitoring of disease activity in SLE.

    Authors: Myles J. Lewis, Simon Vyse, Adrian M. Shields, Lu Zou, Munther Khamashta, Patrick A. Gordon, Costantino Pitzalis, Timothy J. Vyse and David P. D’Cruz
    Citation: Arthritis Research & Therapy 2016 18:5
    Content type: Research article Published on:

  39. Many intervertebral disc diseases cause low back pain (LBP). Proinflammatory cytokines and matrix metalloproteinases (MMPs) participate in disc pathology. In this study, we examined levels of serum cytokines a...

    Authors: Kathryn T. Weber, D. Olivier Alipui, Cristina P. Sison, Ona Bloom, Shaheda Quraishi, M. Chris Overby, Mitchell Levine and Nadeen O. Chahine
    Citation: Arthritis Research & Therapy 2016 18:3
    Content type: Research article Published on:

  40. Recent studies found that the circulating high-mobility group box 1 (HMGB1) levels could reflect the disease activity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). HMGB1 could prim...

    Authors: Yun-Hua Ma, Tian-tian Ma, Chen Wang, Huan Wang, Dong-Yuan Chang, Min Chen and Ming-Hui Zhao
    Citation: Arthritis Research & Therapy 2016 18:2
    Content type: Research article Published on:

  41. Since the 2002 Dusseldorf meeting, one new agent, Benlysta, has been approved by the US Food and Drug Administration for systemic lupus erythematosus. Experiences from the field in conducting trials of all the...

    Authors: Chan-Bum Choi, Matthew H. Liang and Sang-Cheol Bae
    Citation: Arthritis Research & Therapy 2016 18:1
    Content type: Review Published on:

  42. Pristane-treated mice chronically produce high levels of anti-ribonucleoprotein/Smith (anti-Sm/RNP) and other lupus autoantibodies. The present study addressed how these autoantibody levels are maintained over...

    Authors: Shuhong Han, Haoyang Zhuang, Yuan Xu, Pui Lee, Yi Li, Joseph C. Wilson, Osvaldo Vidal, Hong Seok Choi, Yu Sun, Li-Jun Yang and Westley H. Reeves
    Citation: Arthritis Research & Therapy 2015 17:384
    Content type: Research article Published on:

  43. T2 mapping is an MRI method particularly reflective of the collagen arrangement in the cartilage, and diffusion tensor (DT) imaging captures the diffusion of water molecules. Laser-induced photoacoustic measur...

    Authors: Taku Ukai, Masato Sato, Miya Ishihara, Munetaka Yokoyama, Tomonori Takagaki, Genya Mitani, Yoshiki Tani, Tomohiro Yamashita, Yutaka Imai and Joji Mochida
    Citation: Arthritis Research & Therapy 2015 17:383
    Content type: Research article Published on:

  44. B and T cells play a key role in rheumatoid arthritis (RA) pathophysiology. RasGRP1 and RasGRP3 are involved in T and B cell receptors signaling, and belong to gene combination able to predict infliximab respo...

    Authors: Marie-Laure Golinski, Thibault Vandhuick, Céline Derambure, Manuel Fréret, Matthieu Lecuyer, Clément Guillou, Martine Hiron, Olivier Boyer, Xavier Le Loët, Olivier Vittecoq and Thierry Lequerré
    Citation: Arthritis Research & Therapy 2015 17:382
    Content type: Research article Published on:

  45. The lack of specific and sensitive serum and radiographic biomarkers for early diagnosis of osteoarthritis (OA) as well as for monitoring subtle changes in disease activity in clinical trials has hampered the ...

    Authors: Ngee Han Lim, Tonia L. Vincent and Ahuva Nissim
    Citation: Arthritis Research & Therapy 2015 17:376
    Content type: Research article Published on:

  46. Clinical observations indicate that the presence of nucleus pulposus (NP) tissue during spinal fusion hinders the rate of disc ossification. While the underlying mechanism remains unknown, this observation cou...

    Authors: Samantha C. W. Chan, Adel Tekari, Lorin M. Benneker, Paul F. Heini and Benjamin Gantenbein
    Citation: Arthritis Research & Therapy 2015 18:29
    Content type: Research article Published on:

  47. Rheumatoid arthritis (RA) has been known to be associated with increased risk of cardiovascular disease (CVD). The aim of this study was to investigate the effects of Tai Chi exercise on CVD risk in elderly wo...

    Authors: Jeong-Hun Shin, Yonggu Lee, Soon Gil Kim, Bo Youl Choi, Hye-Soon Lee and So-Young Bang
    Citation: Arthritis Research & Therapy 2015 17:380
    Content type: Research article Published on:

  48. The relationship between non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) is currently debated. Using observational data from the South Swedish Arthritis Treatment Group regi...

    Authors: Johan K. Wallman, Meliha C. Kapetanovic, Ingemar F. Petersson, Pierre Geborek and Lars Erik Kristensen
    Citation: Arthritis Research & Therapy 2015 17:378
    Content type: Research article Published on:

  49. In osteoarthritis, chondrocytes adopt an abnormal hypertrophic morphology and upregulate the expression of the extracellular matrix-degrading enzymes, MMP-13 and ADAMTS-5. The activation of the hedgehog signal...

    Authors: Clare L. Thompson, Riana Patel, Terri-Ann N. Kelly, Angus K. T. Wann, Clark T. Hung, J. Paul Chapple and Martin M. Knight
    Citation: Arthritis Research & Therapy 2015 17:373
    Content type: Research article Published on:

  50. Autoantibodies against monomeric C-reactive protein (anti-CRP-Ab) observed in patients with systemic lupus erythematosus (SLE) and lupus nephritis (LN) were suggested to be associated with active LN and a poor...

    Authors: Satu Sinikka Pesickova, Romana Rysava, Martin Lenicek, Libor Vitek, Eliska Potlukova, Zdenka Hruskova, Eva Jancova, Eva Honsova, Jakub Zavada, Marten Trendelenburg and Vladimir Tesar
    Citation: Arthritis Research & Therapy 2015 17:371
    Content type: Research article Published on:
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Arthritis Research & Therapy

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