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  1. Soluble biglycan (sBGN) and soluble decorin (sDCN), are two closely related essential components of extracellular matrix which both have been shown to possess proinflammatory properties. We studied whether sBG...

    Authors: Goncalo Barreto, Antti Soininen, Pekka Ylinen, Jerker Sandelin, Yrjö T. Konttinen, Dan C. Nordström and Kari K. Eklund
    Citation: Arthritis Research & Therapy 2015 17:379
    Content type: Research article Published on:

  2. Ankylosing spondylitis (AS) is an inflammatory disease associated with new bone formation and an increased risk of osteoporosis and fractures. The negative effects of AS on bone microarchitecture and strength ...

    Authors: Nisha Nigil Haroon, Eva Szabo, Janet M. Raboud, Heather Mcdonald-Blumer, Lydia Fung, Robert G. Josse, Robert D. Inman and Angela M. Cheung
    Citation: Arthritis Research & Therapy 2015 17:377
    Content type: Research article Published on:

  3. Patients with rheumatoid arthritis (RA) have shared care between rheumatologists and general practitioners (GPs). Rheumatologists guide immunosuppressive therapy, whilst GPs rely on analgesia and glucocorticoi...

    Authors: Rachel J. Black, Rebecca M. Joseph, Benjamin Brown, Mohammad Movahedi, Mark Lunt and William G. Dixon
    Citation: Arthritis Research & Therapy 2015 17:375
    Content type: Research article Published on:

  4. Rheumatoid arthritis fibroblast-like synovial cells (RA-FLS) show resistance to methotrexate (MTX) treatment. To better understand the mechanisms of this resistance, RA-FLS and osteoarthritis fibroblast-like s...

    Authors: Ke Xu, Yong-song Cai, She-Min Lu, Xiao-li Li, Lin Liu, Zhong Li, Hui Liu and Peng Xu
    Citation: Arthritis Research & Therapy 2015 17:374
    Content type: Research article Published on:

  5. The extent of lung involvement visualized by high-resolution computed tomography (HRCT) is a predictor of decline in forced vital capacity (FVC) in scleroderma–interstitial lung disease. Our objective was to e...

    Authors: Dinesh Khanna, Vivek Nagaraja, Chi-hong Tseng, Fereidoun Abtin, Robert Suh, Grace Kim, Athol Wells, Daniel E. Furst, Philip J. Clements, Michael D. Roth, Donald P. Tashkin and Jonathan Goldin
    Citation: Arthritis Research & Therapy 2015 17:372
    Content type: Research article Published on:

  6. Chronic low back pain (LBP) is the most common cause of disability worldwide. New ideas surrounding LBP are emerging that are based on interactions between mechanical, biological and chemical influences on the...

    Authors: Abbie L. A. Binch, Ashley A. Cole, Lee M. Breakwell, Antony L. R. Michael, Neil Chiverton, Laura B. Creemers, Alison K. Cross and Christine L. Le Maitre
    Citation: Arthritis Research & Therapy 2015 17:370
    Content type: Research article Published on:

  9. To identify baseline radiographic features that predict hip osteoarthritis (HOA) progression, and to explore differences in these associations by race.

    Authors: Bridget Foley, Rebecca J. Cleveland, Jordan B. Renner, Joanne M. Jordan and Amanda E. Nelson
    Citation: Arthritis Research & Therapy 2015 17:366
    Content type: Research article Published on:

  10. Neutrophil activation induces citrullination of intracellular targets of anticitrullinated peptide antibodies (ACPA), which are specific for rheumatoid arthritis (RA). Citrullinated fibrinogen is bound by ACPA...

    Authors: Nathalie E. Blachère, Salina Parveen, John Fak, Mayu O. Frank and Dana E. Orange
    Citation: Arthritis Research & Therapy 2015 17:369
    Content type: Research article Published on:

  11. Medication decision-making poses a challenge for a significant proportion of patients. This is an even more challenging for patients who have complex, rare, immune conditions that affect them at a young age an...

    Authors: Jasvinder A. Singh, Haiyan Qu, Jinoos Yazdany, Winn Chatham and Richard Shewchuk
    Citation: Arthritis Research & Therapy 2015 17:367
    Content type: Research article Published on:

  12. Ro52 is an interferon-inducible protein of the tripartite motif family. Antibodies against Ro52 have been described in patients with different autoimmune diseases, such as systemic lupus erythematosus and Sjög...

    Authors: Maria Infantino, Francesca Meacci, Valentina Grossi, Maurizio Benucci, Gabriella Morozzi, Elio Tonutti, Marilina Tampoia, Antonina Ott, Wolfgang Meyer, Fabiola Atzeni, Piercarlo Sarzi-Puttini, Mariangela Manfredi and Nicola Bizzaro
    Citation: Arthritis Research & Therapy 2015 17:365
    Content type: Research article Published on:

  13. HLA-B*35 is associated with increased risk of developing pulmonary hypertension in SSc patients. We previously reported that HLA-B*35 induces endothelial cell dysfunction via activation of ER stress/UPR and up...

    Authors: Stefania Lenna, Shervin Assassi, G. Alessandra Farina, Julio C. Mantero, Raffaella Scorza, Robert Lafyatis, Harrison W. Farber and Maria Trojanowska
    Citation: Arthritis Research & Therapy 2015 17:363
    Content type: Research article Published on:

  14. Evidence is accumulating that a preclinical phase is present before the onset of clinical signs and symptoms of rheumatoid arthritis (RA). This phase represents an important therapeutic window within which int...

    Authors: Tao-Hsiang Yang, Peng-Yang Hsu, Menghsiao Meng and Che-Chun Su
    Citation: Arthritis Research & Therapy 2015 17:364
    Content type: Research article Published on:

  15. Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Tofacitinib modulates the signaling of cytokines that are integral to lymphocyte activation, proliferation, and fun...

    Authors: Vibeke Strand, Sima Ahadieh, Jonathan French, Jamie Geier, Sriram Krishnaswami, Sujatha Menon, Tina Checchio, Thomas G. Tensfeldt, Elaine Hoffman, Richard Riese, Mary Boy and Juan J. Gómez-Reino
    Citation: Arthritis Research & Therapy 2015 17:362
    Content type: Research article Published on:

  16. In recent decades, low-level laser therapy (LLLT) has been widely used to relieve pain caused by different musculoskeletal disorders. Though widely used, its reported therapeutic outcomes are varied and confli...

    Authors: ZeYu Huang, Jun Ma, Jing Chen, Bin Shen, FuXing Pei and Virginia Byers Kraus
    Citation: Arthritis Research & Therapy 2015 17:360
    Content type: Research article Published on:

  17. During osteoarthritis and following surgical procedures, the environment of the knee is rich in proinflammatory cytokines such as IL-1. Introduction of tissue-engineered cartilage constructs to a chemically ha...

    Authors: Andrea R. Tan, Curtis D. VandenBerg, Mukundan Attur, Steven B. Abramson, Martin M Knight, J. Chloe Bulinski, Gerard A. Ateshian, James L Cook and Clark T. Hung
    Citation: Arthritis Research & Therapy 2015 17:361
    Content type: Research article Published on:

  18. Gene expression profiling is rapidly becoming a useful and informative tool in a much needed area of research. Identifying patients as to whether they will respond or not to a given treatment before prescripti...

    Authors: Samantha Louise Smith, Stephen Eyre, Annie Yarwood, Kimme Hyrich, Ann W. Morgan, A. G. Wilson, John Isaacs, Darren Plant and Anne Barton
    Citation: Arthritis Research & Therapy 2015 17:359
    Content type: Research article Published on:

  19. In women with rheumatoid arthritis (RA) it has been observed that during pregnancy a majority of patients experience amelioration, but after delivery a relapse of the disease is common. However, there are few ...

    Authors: Mitra Pikwer, Cecilia Orellana, Henrik Källberg, Andreas Pikwer, Carl Turesson, Lars Klareskog, Lars Alfredsson, Saedis Saevarsdottir and Camilla Bengtsson
    Citation: Arthritis Research & Therapy 2015 17:358
    Content type: Research article Published on:

  20. Patients with rheumatoid arthritis (RA) treated with abatacept (ABT) are at increased risk for vaccine-preventable infections. The aim of the present study is to evaluate the humoral response to 23-valent pneu...

    Authors: Kiyoshi Migita, Yukihiro Akeda, Manabu Akazawa, Shigeto Tohma, Fuminori Hirano, Haruko Ideguchi, Hideko Kozuru, Yuka Jiuchi, Ryutaro Matsumura, Eiichi Suematsu, Tomoya Miyamura, Shunsuke Mori, Takahiro Fukui, Yasumori Izumi, Nozomi Iwanaga, Hiroshi Tsutani…
    Citation: Arthritis Research & Therapy 2015 17:357
    Content type: Research article Published on:

  21. Despite the broad spectrum of antirheumatic drugs, RA is still not well controlled in up to 30-50 % of patients. Inhibition of JAK kinases by means of the pan-JAK inhibitor tofacitinib has demonstrated to be e...

    Authors: Alba Llop-Guevara, Mónica Porras, Carla Cendón, Irene Di Ceglie, Francesco Siracusa, Federica Madarena, Vagelis Rinotas, Lluís Gómez, Peter L. van Lent, Eleni Douni, Hyun Dong Chang, Thomas Kamradt and Juan Román
    Citation: Arthritis Research & Therapy 2015 17:356
    Content type: Research article Published on:

  22. In this study, we investigated whether an abnormal hypothalamic-pituitary-adrenal (HPA) axis response to psychosocial stress at 18 years of age is associated with musculoskeletal (MS) pain alone and MS pain co...

    Authors: Markus Paananen, Peter O’Sullivan, Leon Straker, Darren Beales, Pieter Coenen, Jaro Karppinen, Craig Pennell and Anne Smith
    Citation: Arthritis Research & Therapy 2015 17:355
    Content type: Research article Published on:

  23. Authors: Jolien Suurmond, Annemarie L. Dorjée, Mariëtte R. Boon, Edward F. Knol, Tom W. J. Huizinga, René E. M. Toes and Annemie J. M. Schuerwegh
    Citation: Arthritis Research & Therapy 2015 17:354
    Content type: Retraction Note Published on:

    The original article was published in Arthritis Research & Therapy 2011 13:R150

  24. The article by Seror et al. in Arthritis Research & Therapy reports data from the 15 French patients in the open-label BELISS (Efficacy and Safety of Belimumab in Subjects With Primary Sjögren's Syndrome, NCT0116...

    Authors: Simon J. Bowman and Benjamin A. Fisher
    Citation: Arthritis Research & Therapy 2015 17:351
    Content type: Editorial Published on:

  25. Triamcinolone acetonide (TA) is used for osteoarthritis management to reduce pain, and pre-clinical studies have shown that TA limits osteophyte formation. Osteophyte formation is known to be facilitated by sy...

    Authors: Michiel Siebelt, Nicoline Korthagen, Wu Wei, Harald Groen, Yvonne Bastiaansen-Jenniskens, Christina Müller, Jan Hendrik Waarsing, Marion de Jong and Harrie Weinans
    Citation: Arthritis Research & Therapy 2015 17:352
    Content type: Research article Published on:

  26. Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. PRG4 has a homeostatic multifaceted role in the joint. PRG4 intra-articular treatme...

    Authors: Ali Alquraini, Steven Garguilo, Gerard D’Souza, Ling X. Zhang, Tannin A. Schmidt, Gregory D. Jay and Khaled A. Elsaid
    Citation: Arthritis Research & Therapy 2015 17:353
    Content type: Research article Published on:

  27. The formation of bony spurs and ankylosis is a key pathognomic feature in ankylosing spondylitis (AS) and results in functional impairment. The aim of this study was to investigate the role of IL-32γ in osteob...

    Authors: Eun-Ju Lee, Eun-Jin Lee, Yeon-Ho Chung, Da-Hyun Song, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Tae-Hwan Kim, Ye-Soo Park, Soo-Hyun Kim, Eun-Ju Chang and Yong-Gil Kim
    Citation: Arthritis Research & Therapy 2015 17:350
    Content type: Research article Published on:

  29. Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease affecting predominantly females. To discover additional genetic risk variants for SLE on the X chromosome, we performed a follow-up...

    Authors: Zhengwei Zhu, Zhuoyuan Liang, Herty Liany, Chao Yang, Leilei Wen, Zhiming Lin, Yujun Sheng, Yan Lin, Lei Ye, Yuyan Cheng, Yan Chang, Lu Liu, Lulu Yang, Yinjuan Shi, Changbing Shen, Fusheng Zhou…
    Citation: Arthritis Research & Therapy 2015 17:349
    Content type: Research article Published on:

  30. Patient preferences contribute to marked racial disparities in the utilization of total knee replacement (TKR). The objectives of this study were to identify the determinants of knee osteoarthritis (OA) patien...

    Authors: C. Kent Kwoh, Ernest R. Vina, Yona K. Cloonan, Michael J. Hannon, Robert M. Boudreau and Said A. Ibrahim
    Citation: Arthritis Research & Therapy 2015 17:348
    Content type: Research article Published on:

  32. The primary complaint of patients with hand osteoarthritis (OA) is frequently the inelegant appearance of their hands. Only one study has been conducted to assess the magnitude of and identify the determinants...

    Authors: Audrey Neuprez, Olivier Bruyère, Emmanuel Maheu, Nadia Dardenne, Nansa Burlet, Pieter D’Hooghe, Stéphan Distèche and Jean-Yves Reginster
    Citation: Arthritis Research & Therapy 2015 17:346
    Content type: Research article Published on:

  33. Patients with rheumatoid arthritis (RA) can be separated into two major subpopulations based on the absence or presence of serum anti-citrullinated protein antibodies (ACPAs). The more severe disease course in...

    Authors: Sandra M. J. Paulissen, Jan Piet van Hamburg, Nadine Davelaar, Heleen Vroman, Johanna M. W. Hazes, Pascal H. P. de Jong and Erik Lubberts
    Citation: Arthritis Research & Therapy 2015 17:344
    Content type: Research article Published on:

  34. The effect of certolizumab pegol (CZP) on patient-reported outcomes (PROs) was investigated in 1063 patients with rheumatoid arthritis (RA) from the REALISTIC trial (double-blind, placebo-controlled to week 12...

    Authors: Janet Pope, Clifton O. Bingham III, Roy M. Fleischmann, Maxime Dougados, Elena M. Massarotti, Jürgen Wollenhaupt, Benjamin Duncan, Geoffroy Coteur and Michael E. Weinblatt
    Citation: Arthritis Research & Therapy 2015 17:343
    Content type: Research article Published on:

  35. The presence of the HLA-B*27 allele is a major risk factor for the development of ankylosing spondylitis (AS), which causes chronic inflammation of the spine and other sites. We investigated residual effects outs...

    Authors: Kwangwoo Kim, So-Young Bang, Seunghun Lee, Hye-Soon Lee, Seung-Cheol Shim, Young Mo Kang, Chang-Hee Suh, Celi Sun, Swapan K. Nath, Sang-Cheol Bae and Tae-Hwan Kim
    Citation: Arthritis Research & Therapy 2015 17:342
    Content type: Research article Published on:

  36. The aim of this study was to examine whether circulating levels of the proinflammatory glycoprotein tenascin-C (TNC) are useful as an activity-specific or predictive biomarker in systemic lupus erythematosus (...

    Authors: Jakub Závada, Michal Uher, Radka Svobodová, Marta Olejárová, Markéta Hušáková, Hana Ciferská, Hana Hulejová, Michal Tomčík, Ladislav Šenolt and Jiří Vencovský
    Citation: Arthritis Research & Therapy 2015 17:341
    Content type: Research article Published on:

  37. The programmed cell death 1 (PD-1) protein is a critical regulator of T-cell activation and is also an important therapeutic target for autoimmune diseases. Little is known about the regulation and functional ...

    Authors: Cuiping Liu, Juean Jiang, Li Gao, Xiaoting Wang, Xiaohan Hu, Min Wu, Jian Wu, Ting Xu, Qin Shi and Xueguang Zhang
    Citation: Arthritis Research & Therapy 2015 17:340
    Content type: Research article Published on:

  38. Anti-carbamylated protein (anti-CarP) antibodies have been described in rheumatoid arthritis (RA) and arthralgia patients at risk of developing RA. To what extent these autoantibodies are specific for RA is un...

    Authors: Jing Shi, Hanna W. van Steenbergen, Jessica A. B. van Nies, E. W. Nivine Levarht, Tom W. J. Huizinga, Annette H. M. van der Helm-van Mil, René E. M. Toes and Leendert A. Trouw
    Citation: Arthritis Research & Therapy 2015 17:339
    Content type: Research article Published on:

  39. Granulomatosis with polyangiitis (GPA) is a rare systemic vasculitis. While aetiology is unknown the prominent respiratory involvement suggests inhaled antigens may be involved. The aim of this study was to id...

    Authors: Lisa K. Stamp, Peter T. Chapman, Janine Francis, Lutz Beckert, Christopher Frampton, Richard A. Watts and John L. O’Donnell
    Citation: Arthritis Research & Therapy 2015 17:333
    Content type: Research article Published on:

  40. The non-histone nuclear protein high mobility group box protein-1 (HMGB1) is typically associated with nucleosomes, but may shuttle between the nucleus and the cytoplasm, and under some conditions also be rele...

    Authors: Lina Wirestam, Hanna Schierbeck, Thomas Skogh, Iva Gunnarsson, Lars Ottosson, Helena Erlandsson-Harris, Jonas Wetterö and Christopher Sjöwall
    Citation: Arthritis Research & Therapy 2015 17:338
    Content type: Research article Published on:

  42. The role of CD3−CD56+ natural killer (NK) cells in granulomatosis with polyangiitis (GPA) is poorly understood. Recently, it has been shown that peripheral blood NK cells can kill renal microvascular endotheli...

    Authors: Wolfgang Merkt, Prisca Sturm, Felix Lasitschka, Theresa Tretter, Carsten Watzl, Daniel Saure, Michael Hundemer, Vedat Schwenger, Norbert Blank, Hanns-Martin Lorenz and Adelheid Cerwenka
    Citation: Arthritis Research & Therapy 2015 17:337
    Content type: Research article Published on:

  43. Interleukin-6 (IL-6) is an important mediator of inflammation. In addition to cells involved in inflammation, sensory nociceptive neurons express the IL-6 signal-transducer glycoprotein 130 (gp130). These neur...

    Authors: Matthias Ebbinghaus, Gisela Segond von Banchet, Julia Massier, Mieczyslaw Gajda, Rolf Bräuer, Michaela Kress and Hans-Georg Schaible
    Citation: Arthritis Research & Therapy 2015 17:334
    Content type: Research article Published on:

  44. Primary hip osteoarthritis, radiographic as well as symptomatic, is highly associated with increasing age in both genders. However, little is known about the mechanisms behind this, in particular if this incre...

    Authors: Søren Glud Skousgaard, Jacob Hjelmborg, Axel Skytthe, Lars Peter Andreas Brandt, Sören Möller and Søren Overgaard
    Citation: Arthritis Research & Therapy 2015 17:336
    Content type: Research article Published on:

  45. Leptin has a prominent role in the development and maintenance of acute and chronic inflammatory states such as rheumatoid arthritis (RA) and obesity. Nevertheless, the association of serum leptin (sLep) and s...

    Authors: Eduardo Gómez-Bañuelos, Rosa Elena Navarro-Hernández, Fernanda Corona-Meraz, Perla Monserrat Madrigal-Ruíz, Beatríz Teresita Martín-Marquez, Oscar Enrique Pizano-Martinez, Jorge Aguilar-Arreola, Paul Jacob Perez-Cruz, Hector Macias-Reyes, Laura Gonzalez-Lopez, Jorge Ivan Gamez-Nava, Mario Salazar-Páramo and Monica Vazquez-del Mercado
    Citation: Arthritis Research & Therapy 2015 17:335
    Content type: Research article Published on:

  46. Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by microvascular damage, inflammation, and fibrosis. It has become increasingly evident that platelets, beyond regulating hemostasis, are ...

    Authors: Daniela Hirigoyen, Paula I. Burgos, Veronica Mezzano, Josefina Duran, Magaly Barrientos, Claudia G. Saez, Olga Panes, Diego Mezzano and Mirentxu Iruretagoyena
    Citation: Arthritis Research & Therapy 2015 17:332
    Content type: Research article Published on:

  47. Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. NLRP3 inflammasome activation, reactive oxygen species (ROS) and mononuclear leukocyte infiltration in the kidney have been shown t...

    Authors: Shuk-Man Ka, Jung-Chen Lin, Tsai-Jung Lin, Feng-Cheng Liu, Louis Kuoping Chao, Chen-Lung Ho, Li-Tzu Yeh, Huey-Kang Sytwu, Kuo-Feng Hua and Ann Chen
    Citation: Arthritis Research & Therapy 2015 17:331
    Content type: Research article Published on:

  48. The aim of this study was to assess the efficacy and safety of tumor necrosis factor (TNF)-α inhibition with infliximab (IFX) in treating recurrent and disabling chronic sciatica pain associated with post-oper...

    Authors: Christelle Nguyen, Clémence Palazzo, Sophie Grabar, Antoine Feydy, Katherine Sanchez, Nathalie Zee, Laurent Quinquis, Myriam Ben Boutieb, Michel Revel, Marie-Martine Lefèvre-Colau, Serge Poiraudeau and François Rannou
    Citation: Arthritis Research & Therapy 2015 17:330
    Content type: Research article Published on:

  49. High-frequency ultrasound offers a potential for objective and quantitative assessment of skin thickness and skin echogenicity in systemic sclerosis (SSc). Few studies have however assessed the longitudinal ch...

    Authors: Roger Hesselstrand, Johanna Carlestam, Marie Wildt, Gunnel Sandqvist and Kristofer Andréasson
    Citation: Arthritis Research & Therapy 2015 17:329
    Content type: Research article Published on:
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Arthritis Research & Therapy

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