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  1. Benefits of disease-modifying anti-rheumatic drugs (DMARD) in early rheumatoid arthritis patients (ERAP) will be achieved if patients follow prescribed treatment. Objective was to investigate whether timing of...

    Authors: Irazú Contreras-Yáñez and Virginia Pascual-Ramos
    Citation: Arthritis Research & Therapy 2015 17:177
    Content type: Research article Published on:

  2. The relationship between peripheral tissue characteristics and pain symptoms in soft tissue inflammation is poorly understood. The primary aim of this study was to determine immunohistochemical differences in ...

    Authors: Benjamin John Floyd Dean, Sarah J. B. Snelling, Stephanie G. Dakin, Richard J. Murphy, Muhammad Kassim Javaid and Andrew Jonathan Carr
    Citation: Arthritis Research & Therapy 2015 17:176
    Content type: Research article Published on:

  3. Alternative splicing distinguishes normal and pathologic cells. High levels of oncoprotein survivin recognise patients with severe rheumatoid arthritis (RA). Here, we assess clinical relevance of alternative s...

    Authors: Minna Turkkila, Karin M.E. Andersson, Sylvie Amu, Mikael Brisslert, Malin C. Erlandsson, Sofia Silfverswärd and Maria I. Bokarewa
    Citation: Arthritis Research & Therapy 2015 17:175
    Content type: Research article Published on:

  4. Rheumatoid arthritis–associated autoantibodies (RA-AAB) can be present in serum years before clinical onset of rheumatoid arthritis (RA). It has been hypothesized that initiation of RA-AAB generation occurs at...

    Authors: Koen M J Janssen, Menke J de Smit, Elisabeth Brouwer, Fenne A C de Kok, Jan Kraan, Josje Altenburg, Marije K Verheul, Leendert A Trouw, Arie Jan van Winkelhoff, Arjan Vissink and Johanna Westra
    Citation: Arthritis Research & Therapy 2015 17:174
    Content type: Research article Published on:

  5. The functional relevance of synovial ectopic lymphoid neogenesis (ELN) in rheumatoid arthritis (RA) remains unknown. As ELN correlates with the degree of tissue inflammation, we investigated whether ELN was as...

    Authors: Juan D. Cañete, Raquel Celis, Nataliya Yeremenko, Raimon Sanmartí, Leonie van Duivenvoorde, Julio Ramírez, Iris Blijdorp, Carmen M. García-Herrero, José L. Pablos and Dominique L. Baeten
    Citation: Arthritis Research & Therapy 2015 17:173
    Content type: Research article Published on:

  6. Mouse models have been widely used to elucidate the pathogenic mechanisms of human diseases. The advantages of using these models include the ability to study different stages of the disease with particular re...

    Authors: Naomi I Maria, Petra Vogelsang and Marjan A Versnel
    Citation: Arthritis Research & Therapy 2015 17:172
    Content type: Review Published on:

  8. Studying the factors that control gene expression is of substantial importance for rheumatic diseases with poorly understood etiopathogenesis. In the past, gene expression microarrays have been used to measure...

    Authors: Eugenia G Giannopoulou, Olivier Elemento and Lionel B Ivashkiv
    Citation: Arthritis Research & Therapy 2015 17:167
    Content type: Review Published on:

  9. Numerous observations indicate that rheumatoid arthritis (RA) has a bone marrow component. In parallel, local synovial changes depend on neuronal components of the peripheral sympathetic nervous system. Here, ...

    Authors: Dominique Muschter, Claudia Göttl, Mandy Vogel, Joachim Grifka, Rainer H. Straub and Susanne Grässel
    Citation: Arthritis Research & Therapy 2015 17:169
    Content type: Research article Published on:

  10. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects around 1 % of the human population worldwide. RA diagnosis can be difficult as there is no definitive test for its detection....

    Authors: Galber Rodrigues Araujo, Emília Rezende Vaz, Patricia Tiemi Fujimura, João Eurico Fonseca, Lucélia Maria de Lima, Helena Canhão, Gabriela Venturini, Karina Helena Morais Cardozo, Valdemir Melechco Carvalho, Marcelo Henrique Napimoga, Luiz Ricardo Goulart, João Gonçalves and Carlos Ueira-Vieira
    Citation: Arthritis Research & Therapy 2015 17:168
    Content type: Research article Published on:

  12. In patients with systemic sclerosis (SSc), associated pulmonary arterial hypertension (SSc-APAH) is the leading cause of death. The objective of this prospective screening study was to analyse sensitivity and ...

    Authors: Christian Nagel, Philipp Henn, Nicola Ehlken, Antonello D’Andrea, Norbert Blank, Eduardo Bossone, Anke Böttger, Christoph Fiehn, Christine Fischer, Hanns-Martin Lorenz, Frank Stöckl, Ekkehard Grünig and Benjamin Egenlauf
    Citation: Arthritis Research & Therapy 2015 17:165
    Content type: Research article Published on:

  13. The aim of this study was to investigate possible differences in the organisation of the motor cortex in people with knee osteoarthritis (OA) and whether there is an association between cortical organisation a...

    Authors: Camille J. Shanahan, Paul W. Hodges, Tim V. Wrigley, Kim L. Bennell and Michael J. Farrell
    Citation: Arthritis Research & Therapy 2015 17:164
    Content type: Research article Published on:

  14. Fibromyalgia (FM) is characterized by persistent widespread pain, increased pain sensitivity and tenderness. Muscle strength in women with FM is reduced compared to healthy women. The aim of this study was to ...

    Authors: Anette Larsson, Annie Palstam, Monika Löfgren, Malin Ernberg, Jan Bjersing, Indre Bileviciute-Ljungar, Björn Gerdle, Eva Kosek and Kaisa Mannerkorpi
    Citation: Arthritis Research & Therapy 2015 17:161
    Content type: Research article Published on:

  15. Type 17 T helper cells and interleukin (IL)-17 play important roles in the pathogenesis of human and murine arthritis. Although there is a clear link between IL-17 and granulocyte macrophage colony-stimulating...

    Authors: Annemarie E. M. van Nieuwenhuijze, Fons A. van de Loo, Birgitte Walgreen, Miranda Bennink, Monique Helsen, Liduine van den Bersselaar, Ian P. Wicks, Wim B. van den Berg and Marije I. Koenders
    Citation: Arthritis Research & Therapy 2015 17:163
    Content type: Research article Published on:

  16. Pediatric systemic lupus erythematosus (pSLE) patients often initially present with more active and severe disease than adults, including a higher frequency of lupus nephritis. Specific autoantibodies, includi...

    Authors: D. James Haddon, Vivian K. Diep, Jordan V. Price, Cindy Limb, Paul J. Utz and Imelda Balboni
    Citation: Arthritis Research & Therapy 2015 17:162
    Content type: Research article Published on:

  17. Systemic sclerosis is an autoimmune disease characterized by inflammation and fibrosis of the skin and internal organs. We sought to assess the clinical and molecular effects associated with response to intrav...

    Authors: Eliza F. Chakravarty, Viktor Martyanov, David Fiorentino, Tammara A. Wood, David James Haddon, Justin Ansel Jarrell, Paul J. Utz, Mark C. Genovese, Michael L. Whitfield and Lorinda Chung
    Citation: Arthritis Research & Therapy 2015 17:159
    Content type: Research article Published on:

  18. Sclerostin (SOST), a soluble antagonist of Wnt signaling, is expressed in chondrocytes and contributes to chondrocytes’ hypertrophic differentiation; however its role in osteoarthritis (OA) pathogenesis is not...

    Authors: Ioanna Papathanasiou, Fotini Kostopoulou, Konstantinos N. Malizos and Aspasia Tsezou
    Citation: Arthritis Research & Therapy 2015 17:160
    Content type: Research article Published on:

  19. Takayasu arteritis (TA) and giant cell arteritis (GCA) are large vessel vasculitides (LVV) that usually present as granulomatous inflammation in arterial walls. High mobility group box 1 (HMGB1) is a nuclear p...

    Authors: Alexandre W. S. de Souza, Kornelis S. M. van der Geest, Elisabeth Brouwer, Frederico A. G. Pinheiro, Ana Cecília Diniz Oliveira, Emília Inoue Sato, Luis Eduardo C. Andrade, Marc Bijl, Johanna Westra and Cees G. M. Kallenberg
    Citation: Arthritis Research & Therapy 2015 17:158
    Content type: Research article Published on:

  20. This study evaluated various remission criteria in abatacept plus methotrexate (MTX)-treated patients with early rheumatoid arthritis (RA). We aimed to investigate the time to, and sustainability of, remission...

    Authors: Josef S. Smolen, Jürgen Wollenhaupt, Juan J. Gomez-Reino, Walter Grassi, Corine Gaillez, Coralie Poncet, Manuela Le Bars and Rene Westhovens
    Citation: Arthritis Research & Therapy 2015 17:157
    Content type: Research article Published on:

  21. There is reasonable evidence that folic acid 5–10 mg per week leads to reduction in methotrexate (MTX) toxicity in rheumatoid arthritis (RA). However, this is based on studies conducted with lower MTX dosage t...

    Authors: Varun Dhir, Amit Sandhu, Jasbinder Kaur, Benzeeta Pinto, Phani Kumar, Prabhdeep Kaur, Nidhi Gupta, Ankita Sood, Aman Sharma and Shefali Sharma
    Citation: Arthritis Research & Therapy 2015 17:156
    Content type: Research article Published on:

  22. We have previously identified endogenously citrullinated peptides derived from fibrinogen in rheumatoid arthritis (RA) synovial tissues. In this study, we have investigated the auto-antigenicity of four of tho...

    Authors: Cátia Fernandes-Cerqueira, Elena Ossipova, Sunithi Gunasekera, Monika Hansson, Linda Mathsson, Anca I. Catrina, Yngve Sommarin, Lars Klareskog, Karin Lundberg, Johan Rönnelid, Ulf Göransson and Per-Johan Jakobsson
    Citation: Arthritis Research & Therapy 2015 17:155
    Content type: Research article Published on:

  23. Interleukin (IL)-21 is a key cytokine in autoimmune diseases such as systemic lupus erythematosus (SLE) by its regulation of autoantibody production and inflammatory responses. The objective of this study is t...

    Authors: Tue Kruse Rasmussen, Thomas Andersen, Rasmus Otkjær Bak, Gloria Yiu, Christian Møller Sørensen, Kristian Stengaard-Pedersen, Jacob Giehm Mikkelsen, Paul Joseph Utz, Christian Kanstrup Holm and Bent Deleuran
    Citation: Arthritis Research & Therapy 2015 17:154
    Content type: Research article Published on:

  25. We performed a systematic review of prognostic factors for the progression of symptomatic knee osteoarthritis (OA), defined as increase in pain, decline in physical function or total joint replacement.

    Authors: Alex N. Bastick, Jos Runhaar, Janneke N. Belo and Sita M.A. Bierma-Zeinstra
    Citation: Arthritis Research & Therapy 2015 17:152
    Content type: Research article Published on:

  26. Vagus nerve stimulation (VNS) exerts beneficial anti-inflammatory effects in various animal models of inflammation, including collagen-induced arthritis, and is implicated in representing a novel therapy for r...

    Authors: Matthijs Kox, Lucas T. van Eijk, Tim Verhaak, Tim Frenzel, Harmke D. Kiers, Jelle Gerretsen, Johannes G. van der Hoeven, Lilian Kornet, Avram Scheiner and Peter Pickkers
    Citation: Arthritis Research & Therapy 2015 17:150
    Content type: Research article Published on:

  27. Patients undergoing immunosuppressive therapy are at increased risk of infection. Community-acquired pneumonia and invasive pneumococcal disease account for substantial morbidity and mortality in this populati...

    Authors: Lara Fischer, Patricia Francis Gerstel, Antoine Poncet, Claire-Anne Siegrist, Emmanuel Laffitte, Cem Gabay, Joerg Dieter Seebach and Camillo Ribi
    Citation: Arthritis Research & Therapy 2015 17:151
    Content type: Research article Published on:

  28. In rheumatoid arthritis (RA) patients receiving immunosuppressive treatments, vaccination against Streptococcus pneumoniae is recommended. The objective of the study was to evaluate the effects of tacrolimus (TAC...

    Authors: Kiyoshi Migita, Yukihiro Akeda, Manabu Akazawa, Shigeto Tohma, Fuminori Hirano, Haruko Ideguchi, Ryutaro Matsumura, Eiichi Suematsu, Tomoya Miyamura, Shunsuke Mori, Takahiro Fukui, Yasumori Izumi, Nozomi Iwanaga, Hiroshi Tsutani, Kouichirou Saisyo, Takao Yamanaka…
    Citation: Arthritis Research & Therapy 2015 17:149
    Content type: Research article Published on:

  29. A minimal clinically important difference (MCID) is an important concept used to determine whether a medical intervention improves perceived outcomes in patients. Prior to the introduction of the concept in 19...

    Authors: Sharan K Rai, Jinoos Yazdany, Paul R Fortin and J Antonio Aviña-Zubieta
    Citation: Arthritis Research & Therapy 2015 17:143
    Content type: Review Published on:

  30. Vasculitides are classified by the size, type and location of the predominantly involved vessels and by their primary or secondary nature. Their treatment depends on the type of vasculitis, its etiology (when ...

    Authors: Corisande Baldwin, Simon Carette and Christian Pagnoux
    Citation: Arthritis Research & Therapy 2015 17:138
    Content type: Review Published on:

  31. Joint destruction, as evidenced by radiographic findings, is a significant problem for patients suffering from rheumatoid arthritis and psoriatic arthritis. Inherently irreversible and frequently progressive, ...

    Authors: Angela Mc Ardle, Brian Flatley, Stephen R. Pennington and Oliver FitzGerald
    Citation: Arthritis Research & Therapy 2015 17:141
    Content type: Review Published on:

  33. The control of differentiation of mesenchymal stromal/stem cells (MSCs) is crucial for tissue engineering strategies employing MSCs. The purpose of this study was to investigate whether the transcriptional co-...

    Authors: Alexandra Karystinou, Anke J Roelofs, Anna Neve, Francesco P Cantatore, Henning Wackerhage and Cosimo De Bari
    Citation: Arthritis Research & Therapy 2015 17:147
    Content type: Research article Published on:

  34. Systemic sclerosis (SSc) is a connective tissue disorder characterised by the development of skin fibrosis. Our current understanding of the disease pathogenesis is incomplete and the study of SSc is hindered,...

    Authors: Nadira Ruzehaji, Jerome Avouac, Muriel Elhai, Maxime Frechet, Camelia Frantz, Barbara Ruiz, Joerg H. Distler and Yannick Allanore
    Citation: Arthritis Research & Therapy 2015 17:145
    Content type: Research article Published on:

  35. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of the joints and bones. Omega-3 (ω3) fatty acid supplementation has been associated with a decreased production of inflammatory cytokines...

    Authors: Caroline Morin, Pierre U Blier and Samuel Fortin
    Citation: Arthritis Research & Therapy 2015 17:142
    Content type: Research article Published on:

  36. Our previous proteomic study on fibroblast-like synoviocytes (FLSs) derived from the synovial tissues found that the expression of KIAA1199 was higher in rheumatoid arthritis (RA) patients than in healthy cont...

    Authors: Xinyu Yang, Pengcheng Qiu, Bingbing Chen, Yaoyao Lin, Zhonghao Zhou, Renshan Ge, Hai Zou, Jianmin Wang and Jianguang Wang
    Citation: Arthritis Research & Therapy 2015 17:140
    Content type: Research article Published on:

  37. Recently, a great interest has arisen for salivary gland ultrasonography (SGUS) as a valuable tool for the assessment of major salivary gland involvement in primary Sjögren’s syndrome (pSS. The aims of this st...

    Authors: Chiara Baldini, Nicoletta Luciano, Gaia Tarantini, Rachele Pascale, Francesca Sernissi, Marta Mosca, Davide Caramella and Stefano Bombardieri
    Citation: Arthritis Research & Therapy 2015 17:146
    Content type: Research article Published on:

  38. Dupuytren’s contracture (DC) is a chronic fibroproliferative disease of the hand, which is characterized by uncontrolled proliferation of atypical myofibroblasts at the cellular level. We hypothesized that spe...

    Authors: Janeli Viil, Katre Maasalu, Kristina Mäemets-Allas, Liis Tamming, Kadi Lõhmussaar, Mikk Tooming, Sulev Ingerpuu, Aare Märtson and Viljar Jaks
    Citation: Arthritis Research & Therapy 2015 17:144
    Content type: Research article Published on:

  40. Strategies for biological repair and regeneration of the intervertebral disc (IVD) by cell and tissue engineering are promising, but few have made it into a clinical setting. Recombinant human bone morphogenet...

    Authors: Nicole Willems, Frances C Bach, Saskia G M Plomp, Mattie HP van Rijen, Jeannette Wolfswinkel, Guy CM Grinwis, Clemens Bos, Gustav J Strijkers, Wouter JA Dhert, Björn P Meij, Laura B Creemers and Marianna A Tryfonidou
    Citation: Arthritis Research & Therapy 2015 17:137
    Content type: Research article Published on:

  41. T cells play an important role in the pathogenesis of systemic lupus erythematosus (SLE). Clonal expansion of T cells correlating with disease activity has been observed in peripheral blood (PB) of SLE subject...

    Authors: Dharma R Thapa, Raffi Tonikian, Chao Sun, Mei Liu, Andrea Dearth, Michelle Petri, Francois Pepin, Ryan O Emerson and Ann Ranger
    Citation: Arthritis Research & Therapy 2015 17:132
    Content type: Research article Published on:

  42. We evaluated the safety of current treatment regimens for patients with RA and HBV in a large US cohort.

    Authors: Mary Jane Burton, Jeffrey R Curtis, Shuo Yang, Lang Chen, Jasvinder A Singh, Ted R Mikuls, Kevin L Winthrop and John W Baddley
    Citation: Arthritis Research & Therapy 2015 17:136
    Content type: Research article Published on:

  43. For patients with rheumatoid arthritis (RA) whose treatment with a tumour necrosis factor inhibitor (TNFi) is failing, several biological treatment options are available. Often, another TNFi or a biological wi...

    Authors: Sofie HM Manders, Wietske Kievit, Eddy Adang, Herman L Brus, Hein J Bernelot Moens, Andre Hartkamp, Lidy Hendriks, Elisabeth Brouwer, Henk Visser, Harald E Vonkeman, Jos Hendrikx, Tim L Jansen, Rene Westhovens, Mart AFJ van de Laar and Piet LCM van Riel
    Citation: Arthritis Research & Therapy 2015 17:134
    Content type: Research article Published on:

  44. Clinical synovitis is often associated with damage to bone and cartilage. Previous data have suggested that joint erosions (JE) are more prevalent than joint space narrowing (JSN) and that the two processes ar...

    Authors: Robert Landewé, Josef S Smolen, Stefan Florentinus, Su Chen, Benoît Guérette and Désirée van der Heijde
    Citation: Arthritis Research & Therapy 2015 17:133
    Content type: Research article Published on:

  45. Despite growing evidence that large intergenic noncoding RNAs (lincRNAs) can regulate gene expression and widely take part in normal physiological and disease conditions, our knowledge of systemic lupus erythe...

    Authors: Yanfang Wu, Feifei Zhang, Jianyang Ma, Xiaoyan Zhang, Lingling Wu, Bo Qu, Shiwei Xia, Shunle Chen, Yuanjia Tang and Nan Shen
    Citation: Arthritis Research & Therapy 2015 17:131
    Content type: Research article Published on:

  46. A multitude of reports have delineated the risks of using non-steroidal anti-inflammatory drugs but have not been totally congruent. Meta-analyses of randomized controlled trials sometimes concur regarding gas...

    Authors: Lee S. Simon
    Citation: Arthritis Research & Therapy 2015 17:130
    Content type: Editorial Published on:

  47. Increasing evidences have demonstrated that activation of alternative complement pathway plays an important role in the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). ...

    Authors: Su-Fang Chen, Feng-Mei Wang, Zhi-Ying Li, Feng Yu, Ming-Hui Zhao and Min Chen
    Citation: Arthritis Research & Therapy 2015 17:129
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2017 19:82

  48. The pleiotropic cytokine interleukin-6 (IL-6) plays an important role in the pathogenesis of different diseases, including rheumatoid arthritis (RA). ALX-0061 is a bispecific Nanobody® with a high affinity and...

    Authors: Maarten Van Roy, Cedric Ververken, Els Beirnaert, Sven Hoefman, Joost Kolkman, Michel Vierboom, Elia Breedveld, Bert ‘t Hart, Sofie Poelmans, Lieselot Bontinck, Alex Hemeryck, Sandy Jacobs, Judith Baumeister and Hans Ulrichts
    Citation: Arthritis Research & Therapy 2015 17:135
    Content type: Research article Published on:

  49. It has previously been shown that an increased number of antibodies against citrullinated peptides/proteins (ACPA) predate the onset of rheumatoid arthritis (RA). Over time antibody positivity expands, involvi...

    Authors: Heidi Kokkonen, Mikael Brink, Monika Hansson, Ewa Lassen, Linda Mathsson-Alm, Rikard Holmdahl, Johan Rönnelid, Lars Klareskog and Solbritt Rantapää-Dahlqvist
    Citation: Arthritis Research & Therapy 2015 17:125
    Content type: Research article Published on:

  50. The aim of present study is to inverstigate the association between antibody levels after vaccination with 7-valent pneumococcal conjugate vaccine (PCV7) and subsequent serious pneumococcal infections in rheum...

    Authors: Johanna Nagel, Pierre Geborek, Tore Saxne, Göran Jönsson, Martin Englund, Ingemar F Petersson, Jan-Åke Nilsson, Lennart Truedsson and Meliha C Kapetanovic
    Citation: Arthritis Research & Therapy 2015 17:124
    Content type: Research article Published on:
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Arthritis Research & Therapy

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