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  1. The T allele of a single nucleotide polymorphism (SNP: rs2544390) in lipoprotein receptor-related protein 2 (LRP2) is associated with higher serum urate and risk of gout in Japanese individuals. SNP rs2544390 als...

    Authors: Humaira Rasheed, Amanda Phipps-Green, Ruth Topless, Jade E Hollis-Moffatt, Jennie Harré Hindmarsh, Christopher Franklin, Nicola Dalbeth, Peter B Jones, Douglas HN White, Lisa K Stamp and Tony R Merriman
    Citation: Arthritis Research & Therapy 2013 15:R177
    Content type: Research article Published on:

  3. Systemic lupus erythematosus (SLE) is a chronic inflammatory condition with multisystem involvement. One of the key features of the disease is the upregulation of type I interferons, resulting in the so-called...

    Authors: Dana Kidder, Hannah E Richards, Paul A Lyons and Paul R Crocker
    Citation: Arthritis Research & Therapy 2013 15:R175
    Content type: Research article Published on:

  4. Our understanding of autoimmunity is skewed considerably towards the late stages of overt disease and chronic inflammation. Defining the targeted organ’s role during emergence of autoimmune diseases is, howeve...

    Authors: Nicolas Delaleu, Cuong Q Nguyen, Kidane M Tekle, Roland Jonsson and Ammon B Peck
    Citation: Arthritis Research & Therapy 2013 15:R174
    Content type: Research article Published on:

  5. The aim of this study was to investigate patient reported outcomes (PROs) of functional ability and health related quality of life (HRQoL) in patients with early (rheumatoid) arthritis during one year of remis...

    Authors: Lotte Heimans, Kirsten VC Wevers-de Boer, KK Michel Koudijs, Karen Visser, Yvonne P Goekoop-Ruiterman, Joop B Harbers, Gerda M Steup-Beekman, Leroy R Lard, Bernard AM Grillet, Tom WJ Huizinga and Cornelia F Allaart
    Citation: Arthritis Research & Therapy 2013 15:R173
    Content type: Research article Published on:

  7. Primary Sjögren’s syndrome (pSS) is an autoimmune disorder affecting exocrine glands; however, a subgroup of pSS patients experience systemic extra-glandular involvement leading to a worsening of disease progn...

    Authors: Francesco Carubbi, Paola Cipriani, Alessandra Marrelli, Paola Di Benedetto, Piero Ruscitti, Onorina Berardicurti, Ilenia Pantano, Vasiliki Liakouli, Saverio Alvaro, Alessia Alunno, Antonio Manzo, Francesco Ciccia, Roberto Gerli, Giovanni Triolo and Roberto Giacomelli
    Citation: Arthritis Research & Therapy 2013 15:R172
    Content type: Research article Published on:

  8. The objective of the study was to investigate the impact of newer biologic treatments including rituximab, abatacept and tocilizumab on antibody response following pneumococcal vaccination using a 7-valent con...

    Authors: Meliha Crnkic Kapetanovic, Tore Saxne, Göran Jönsson, Lennart Truedsson and Pierre Geborek
    Citation: Arthritis Research & Therapy 2013 15:R171
    Content type: Research article Published on:

  9. Rheumatoid arthritis, currently regarded as a complex multifactorial disease, was initially characterized as such at the turn of the 19th century. Ever since, multiple lines of investigation have attempted to ...

    Authors: Jose U Scher and Steven B Abramson
    Citation: Arthritis Research & Therapy 2013 15:122
    Content type: Editorial Published on:

  10. We previously reported that IL-29, a newly described member of interferon (IFN) family, was overexpressed in blood and synovium of rheumatoid arthritis (RA) patients and triggered proinflammatory cytokine IL-6...

    Authors: Lingxiao Xu, Xiaoke Feng, Wenfeng Tan, Weijuan Gu, Dunming Guo, Miaojia Zhang and Fang Wang
    Citation: Arthritis Research & Therapy 2013 15:R170
    Content type: Research article Published on:

  11. Mesenchymal stem cells (MSCs) represent promising applications in rheumatoid arthritis (RA). However, the inflammatory niche in the RA synovium could adversely affect MSC function. This study was designed to i...

    Authors: Zhengzheng Zhang, Yuanjing Ding, Weiping Li, Bin Song and Rui Yang
    Citation: Arthritis Research & Therapy 2013 15:R169
    Content type: Research article Published on:

  13. Osteoarthritis is becoming more problematic as the population ages. Recent reports suggest that the benefit of anti-inflammatory drugs is unimpressive and the incidence of side effects is worrying. Low-level l...

    Authors: Michael R Hamblin
    Citation: Arthritis Research & Therapy 2013 15:120
    Content type: Editorial Published on:

  14. Intervertebral disc degeneration (IDD) is a common orthopedic disease associated with mechanical changes that may result in significant pain. Current treatments for IDD mainly depend on conservative therapies ...

    Authors: Shan-Zheng Wang, Yun-Feng Rui, Qi Tan and Chen Wang
    Citation: Arthritis Research & Therapy 2013 15:220
    Content type: Review Published on:

  15. B lymphocytes might play a pathogenic role in dermal fibrosis in systemic sclerosis (SSc). B-cell activating factor (BAFF), a key cytokine for B-cell activation, is increased in the serum and the skin of patie...

    Authors: Antoine François, Emmanuel Chatelus, Dominique Wachsmann, Jean Sibilia, Seiamak Bahram, Ghada Alsaleh and Jacques-Eric Gottenberg
    Citation: Arthritis Research & Therapy 2013 15:R168
    Content type: Research article Published on:

  16. The aim of this study was to test the naturally occurring organosulfur compound dipropyltetrasulfide (DPTTS), found in plants, which has antibiotic and anticancer properties, as a treatment for HOCl-induced sy...

    Authors: Wioleta Marut, Vincent Jamier, Niloufar Kavian, Amélie Servettaz, Paul G Winyard, Paul Eggleton, Awais Anwar, Carole Nicco, Claus Jacob, Christiane Chéreau, Bernard Weill and Frédéric Batteux
    Citation: Arthritis Research & Therapy 2013 15:R167
    Content type: Research article Published on:

  17. Ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) share genetic and clinical features. IBD is associated with the presence of antibodies to a variety of commensal microorganisms including anti-Sacc...

    Authors: Dinny Wallis, Arundip Asaduzzaman, Michael Weisman, Nigil Haroon, Ammepa Anton, Dermot McGovern, Stephan Targan and Robert Inman
    Citation: Arthritis Research & Therapy 2013 15:R166
    Content type: Research article Published on:

  19. Microvascular damage and defective angiogenesis and vasculogenesis have a major role in the pathogenesis of systemic sclerosis (SSc). Epidermal growth factor-like domain 7 (EGFL7) is a proangiogenic molecule w...

    Authors: Mirko Manetti, Serena Guiducci, Eloisa Romano, Jérôme Avouac, Irene Rosa, Barbara Ruiz, Gemma Lepri, Silvia Bellando-Randone, Lidia Ibba-Manneschi, Yannick Allanore and Marco Matucci-Cerinic
    Citation: Arthritis Research & Therapy 2013 15:R165
    Content type: Research article Published on:

  20. The aim of this study was to evaluate the safety, pharmacokinetics, and clinical response of brodalumab (AMG 827), a human, anti-IL-17 receptor A (IL-17RA) monoclonal antibody in subjects with moderate-to-seve...

    Authors: David A Martin, Melvin Churchill, Luis Felipe Flores-Suarez, Mario H Cardiel, Daniel Wallace, Richard Martin, Kristine Phillips, Jeffrey L Kaine, Hua Dong, David Salinger, Erin Stevens, Chris B Russell and James B Chung
    Citation: Arthritis Research & Therapy 2013 15:R164
    Content type: Research article Published on:

  21. The inherent low oxygen tension in normal cartilage has implications on inflammatory conditions associated with osteoarthritis (OA). Biomechanical signals will additionally contribute to changes in tissue remo...

    Authors: Eleanor Parker, Sandrine Vessillier, Belinda Pingguan-Murphy, Wan Abu Baker Wan Abas, Dan L Bader and Tina T Chowdhury
    Citation: Arthritis Research & Therapy 2013 15:R163
    Content type: Research article Published on:

  22. In many patients with rheumatoid arthritis (RA) subclinical disease activity can be detected with ultrasound (US), especially using power Doppler US (PDUS). However, PDUS may be highly dependent on the type of...

    Authors: David F Ten Cate, Jolanda J Luime, Myrthe van der Ven, Johanna MW Hazes, Klazina Kooiman, Nico de Jong and Johannes G Bosch
    Citation: Arthritis Research & Therapy 2013 15:R162
    Content type: Research article Published on:

  23. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterised by the autoinflammation and necrosis of blood vessel walls. The renal involvement is commonly characterised by a pauci-im...

    Authors: Ying Zhang, Weiwei Shi, Sha Tang, Jingyi Li, Shiwei Yin, Xuejing Gao, Li Wang, Liyun Zou, Jinghong Zhao, Yunjian Huang, Lianyu Shan, Abdelilah S Gounni, Yuzhang Wu, Fahuan Yuan and Jingbo Zhang
    Citation: Arthritis Research & Therapy 2013 15:R161
    Content type: Research article Published on:

  24. Dual-energy computed tomography (DECT) has potential for monitoring urate deposition in patients with gout. The aim of this prospective longitudinal study was to analyse measurement error of DECT urate volume ...

    Authors: Ashwin Rajan, Opetaia Aati, Ramanamma Kalluru, Gregory D Gamble, Anne Horne, Anthony J Doyle, Fiona M McQueen and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2013 15:R160
    Content type: Research article Published on:

  25. The aim of this study was to characterize anti-citrullinated peptide antibody (ACPA) serostatus in pre-clinical rheumatoid arthritis (RA) with and without Human Leukocyte Antigen-Shared Epitope (HLA-SE) alleles.

    Authors: Elizabeth V Arkema, Barbara L Goldstein, William Robinson, Jeremy Sokolove, Catriona A Wagner, Susan Malspeis, Bernard Rosner, Francine Grodstein, Elizabeth W Karlson and Karen H Costenbader
    Citation: Arthritis Research & Therapy 2013 15:R159
    Content type: Research article Published on:

  26. HLA-B27 genotyping is commonly used to support a diagnosis of ankylosing spondylitis (AS). A recent study has suggested that HLA-B27 may adversely affect longevity. The objectives of this study were to determine,...

    Authors: Rebecca L Roberts, Mary C Wallace, Gregory T Jones, Andre M van Rij, Tony R Merriman, Andrew Harrison, Douglas White, Lisa K Stamp, Daniel Ching, John Highton and Simon M Stebbings
    Citation: Arthritis Research & Therapy 2013 15:R158
    Content type: Research article Published on:

  27. Our objective was to determine rheumatoid arthritis (RA) patients’ understanding of methotrexate and assess whether knowledge varies by age, education, English language proficiency, or other disease-related fa...

    Authors: Jennifer L Barton, Gabriela Schmajuk, Laura Trupin, Jonathan Graf, John Imboden, Edward H Yelin and Dean Schillinger
    Citation: Arthritis Research & Therapy 2013 15:R157
    Content type: Research article Published on:

  28. In order to target educational needs of patients more effectively, an Austrian-German educational needs assessment tool (OENAT) was developed, the educational needs of patients with rheumatoid arthritis (RA), ...

    Authors: Răzvan G Drăgoi, Mwidimi Ndosi, Martina Sadlonova, Jackie Hill, Mona Duer, Winfried Graninger, Josef Smolen and Tanja A Stamm
    Citation: Arthritis Research & Therapy 2013 15:R156
    Content type: Research article Published on:

  29. Myeloid dendritic cells (mDCs) are potent T cell-activating antigen-presenting cells that have been suggested to play a crucial role in the regulation of immune responses in many disease states, including rheu...

    Authors: Frederique M Moret, Cornelis E Hack, Kim MG van der Wurff-Jacobs, Wilco de Jager, Timothy RDJ Radstake, Floris PJG Lafeber and Joel AG van Roon
    Citation: Arthritis Research & Therapy 2013 15:R155
    Content type: Research article Published on:

  30. Extracellular ATP (eATP) is released by articular chondrocytes under physiological and pathological conditions. High eATP levels cause pathologic calcification, damage cartilage, and mediate pain. We recently ...

    Authors: Ann K Rosenthal, Claudia M Gohr, Elizabeth Mitton-Fitzgerald, Megan K Lutz, George R Dubyak and Lawrence M Ryan
    Citation: Arthritis Research & Therapy 2013 15:R154
    Content type: Research article Published on:

  31. Adult-onset still's disease (AOSD) is a rare systemic inflammatory disorder in which abnormalities in inflammatory cytokines production appear to play a pathophysiological role. Our previous work has reported ...

    Authors: Fang-Fang Wang, Xin-Fang Huang, Nan Shen, Lin Leng, Richard Bucala, Shun-Le Chen and Liang-Jing Lu
    Citation: Arthritis Research & Therapy 2013 15:R65
    Content type: Research article Published on:

  32. We evaluated the associations between bone marrow lesion (BML) volume change and changes in periarticular bone mineral density (paBMD) as well as subchondral sclerosis to determine whether BML change is associ...

    Authors: Jeffrey B Driban, Grace H Lo, Lori Lyn Price, Jincheng Pang, Eric Miller, Robert J Ward, David J Hunter, Charles B Eaton, John A Lynch and Timothy E McAlindon
    Citation: Arthritis Research & Therapy 2013 15:R153
    Content type: Research article Published on:

  33. Rheumatoid arthritis (RA) is a complex polygenic disease associated with chronic inflammation, accelerated atherosclerosis and increased cardiovascular (CV) mortality. A recent meta-analysis has described the ZC3...

    Authors: Raquel López-Mejías, Fernanda Genre, Mercedes García-Bermúdez, Alfonso Corrales, Carlos González-Juanatey, Javier Llorca, José A Miranda-Filloy, Javier Rueda-Gotor, Ricardo Blanco, Santos Castañeda, Javier Martín and Miguel A González-Gay
    Citation: Arthritis Research & Therapy 2013 15:R152
    Content type: Research article Published on:

  34. T helper (Th)-17 cells are increased in systemic sclerosis (SSc). We therefore assessed whether Th17 cells could modulate the inflammatory and fibrotic responses in dermal fibroblasts from healthy donors (HD) ...

    Authors: Nicolò Costantino Brembilla, Elisa Montanari, Marie-Elise Truchetet, Elena Raschi, Pierluigi Meroni and Carlo Chizzolini
    Citation: Arthritis Research & Therapy 2013 15:R151
    Content type: Research article Published on:

  35. Our recent study indicated that subchondral bone pathogenesis in osteoarthritis (OA) is associated with osteocyte morphology and phenotypic abnormalities. However, the mechanism underlying this abnormality nee...

    Authors: Indira Prasadam, Saba Farnaghi, Jian Q Feng, Wenyi Gu, Samuel Perry, Ross Crawford and Yin Xiao
    Citation: Arthritis Research & Therapy 2013 15:R150
    Content type: Research article Published on:

  36. The aims of this present study were firstly to assess the outcome, including functional course, in anti-Jo1 positive patients with antisynthetase syndrome (ASS), and secondly to determine predictive parameters...

    Authors: Isabelle Marie, Pierre-Yves Hatron, Patrick Cherin, Eric Hachulla, Elisabeth Diot, Olivier Vittecoq, Jean-François Menard, Fabienne Jouen and Stéphane Dominique
    Citation: Arthritis Research & Therapy 2013 15:R149
    Content type: Research article Published on:

  37. Haemophilic arthropathy following recurrent joint bleedings is one of the major disease-related complications in people with haemophilia (PWH), leading to mostly chronic joint pain. Since many antinociceptive ...

    Authors: Michael Karl Boettger, Susanne Krucker, Mieczyslaw Gajda, Hans-Georg Schaible and Thomas Hilberg
    Citation: Arthritis Research & Therapy 2013 15:R148
    Content type: Research article Published on:

  38. This study aimed to characterize the glycophenotype of osteoarthritic cartilage and human chondrocytes.

    Authors: Stefan Toegel, Daniela Bieder, Sabine André, Friedrich Altmann, Sonja M Walzer, Herbert Kaltner, Jochen G Hofstaetter, Reinhard Windhager and Hans-Joachim Gabius
    Citation: Arthritis Research & Therapy 2013 15:R147
    Content type: Research article Published on:

  39. Spleen tyrosine kinase (SYK) is a key integrator of intracellular signals triggered by activated immunoreceptors, including Bcell receptors (BCR) and Fc receptors, which are important for the development and f...

    Authors: Cheng Liao, Jonathan Hsu, Yong Kim, Dong-Qing Hu, Daigen Xu, Jun Zhang, Achal Pashine, John Menke, Toni Whittard, Natasha Romero, Theresa Truitt, Michelle Slade, Christine Lukacs, Johannes Hermann, Mingyan Zhou, Matthew Lucas…
    Citation: Arthritis Research & Therapy 2013 15:R146
    Content type: Research article Published on:

  40. According to genome wide association (GWA) studies as well as candidate gene approaches, Behçet’s disease (BD) is associated with human leukocyte antigen (HLA)-A and HLA-B gene regions. The HLA-B51 has been co...

    Authors: Marco Antonio Montes-Cano, Marta Conde-Jaldón, José Raul García-Lozano, Lourdes Ortiz-Fernández, Norberto Ortego-Centeno, María Jesús Castillo-Palma, Gerard Espinosa, Genaro Graña-Gil, Miguel Angel González-Gay, Ana Celia Barnosi-Marín, Roser Solans, Patricia Fanlo, Teresa Camps, Santos Castañeda, Juan Sánchez-Bursón, Antonio Núñez-Roldán…
    Citation: Arthritis Research & Therapy 2013 15:R145
    Content type: Research article Published on:

  41. Disability and Physical Function (PF) outcome assessment has had limited ability to measure functional status at the floor (very poor functional abilities) or the ceiling (very high functional abilities). We s...

    Authors: Bonnie Bruce, James Fries, Bharathi Lingala, Yusra Nazar Hussain and Eswar Krishnan
    Citation: Arthritis Research & Therapy 2013 15:R144
    Content type: Research article Published on:

  42. Interferon alpha (IFN-α) has a complex role in autoimmunity, in that it may both enhance and prevent inflammation. We have previously shown that the presence of IFN-α at sensitization protects against subseque...

    Authors: Jaya Prakash Chalise, Sudeep Chenna Narendra, Bhesh Raj Paudyal and Mattias Magnusson
    Citation: Arthritis Research & Therapy 2013 15:R143
    Content type: Research article Published on:

  43. Neutrophils have emerged as important regulators of innate and adaptive immune responses. Recent evidence indicates that neutrophils display marked abnormalities in phenotype and function in various systemic a...

    Authors: Mariana J Kaplan
    Citation: Arthritis Research & Therapy 2013 15:219
    Content type: Review Published on:

  44. Rheumatoid arthritis (RA) is associated with a high cardiovascular disease (CVD) risk, whereas arterial hypertension is a major modifiable CVD risk factor with still unclear prevalence in RA disease. We conduc...

    Authors: Athanase D Protogerou, Demosthenis B Panagiotakos, Evangelia Zampeli, Antonis A Argyris, Katerina Arida, Giorgos D Konstantonis, Christos Pitsavos, George D Kitas and Petros P Sfikakis
    Citation: Arthritis Research & Therapy 2013 15:R142
    Content type: Research article Published on:

  45. Anemia of inflammation (AI) is a common complication of rheumatoid arthritis (RA) and has a negative impact on RA symptoms and quality of life. Upregulation of hepcidin by inflammatory cytokines has been impli...

    Authors: Soken-Nakazawa J Song, Mitsuhiro Iwahashi, Naohisa Tomosugi, Kazuko Uno, Jiro Yamana, Seizou Yamana, Tomoyasu Isobe, Hiroki Ito, Hiroshi Kawabata and Kazuyuki Yoshizaki
    Citation: Arthritis Research & Therapy 2013 15:R141
    Content type: Research article Published on:

  46. Autoantibodies against citrullinated peptides/proteins (ACPA) are found in approximately 75% of the sera of patients with rheumatoid arthritis (RA). The RA-specific ACPA are frequently present prior to disease...

    Authors: Joyce JBC van Beers, Annemiek Willemze, Jeroen J Jansen, Gerard HM Engbers, Martin Salden, Jos Raats, Jan W Drijfhout, Annette HM van der Helm-van Mil, Rene EM Toes and Ger JM Pruijn
    Citation: Arthritis Research & Therapy 2013 15:R140
    Content type: Research article Published on:

  47. Peripheral blood monocytes are no longer regarded as a homogeneous cell population, but can be differentiated both phenotypically and functionally into various subpopulations. In rheumatoid arthritis, the subp...

    Authors: Marco Krasselt, Christoph Baerwald, Ulf Wagner and Manuela Rossol
    Citation: Arthritis Research & Therapy 2013 15:R139
    Content type: Research article Published on:

  49. Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1, which is often used for the treatment of patients with rheum...

    Authors: Fabia Doll, Kathrin Schwager, Teresa Hemmerle and Dario Neri
    Citation: Arthritis Research & Therapy 2013 15:R138
    Content type: Research article Published on:

  50. Two replicate randomized, placebo-controlled six-month trials (RCTs) and an open-label treatment extension (OLE) comprised the pegloticase development program in patients with gout refractory to conventional t...

    Authors: Herbert SB Baraf, Michael A Becker, Sergio R Gutierrez-Urena, Edward L Treadwell, Janitzia Vazquez-Mellado, Claudia D Rehrig, Faith D Ottery, John S Sundy and Robert A Yood
    Citation: Arthritis Research & Therapy 2013 15:R137
    Content type: Research article Published on:
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Arthritis Research & Therapy

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