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  1. Rheumatoid arthritis exhibits diurnal variation in symptoms, with patients suffering with increased painful joint stiffness in the early morning. This correlates with an early morning rise in circulating level...

    Authors: Julie E Gibbs and David W Ray
    Citation: Arthritis Research & Therapy 2013 15:205
    Content type: Review Published on:

  2. Fibroblast-like synoviocytes (FLSs) are a major cell population of the pannus that invades adjacent cartilage and bone in rheumatoid arthritis (RA). The study was undertaken to determine the effect of interleu...

    Authors: Seon-Yeong Lee, Seung-Ki Kwok, Hye-Jin Son, Jun-Geol Ryu, Eun-Kyung Kim, Hye-Jwa Oh, Mi-La Cho, Ji Hyeon Ju, Sung-Hwan Park and Ho-Youn Kim
    Citation: Arthritis Research & Therapy 2013 15:R31
    Content type: Research article Published on:

  4. Mutations in the NLRP3 gene are associated with the dominantly inherited cryopyrin-associated periodic syndrome (CAPS). The significance of the V198M variant is unclear; it has been reported in association with v...

    Authors: Dorota M Rowczenio, Hadija Trojer, Tonia Russell, Anna Baginska, Thirusha Lane, Nicola M Stewart, Julian D Gillmore, Philip N Hawkins, Patricia Woo, Bozena Mikoluc and Helen J Lachmann
    Citation: Arthritis Research & Therapy 2013 15:R30
    Content type: Research article Published on:

  5. Anterior cruciate ligament (ACL) degeneration is observed in most osteoarthritis (OA)-affected knee joints. However, the specific spatial and temporal relations of these changes and their association with extr...

    Authors: Akihiko Hasegawa, Hiroyuki Nakahara, Mitsuo Kinoshita, Hiroshi Asahara, James Koziol and Martin K Lotz
    Citation: Arthritis Research & Therapy 2013 15:R29
    Content type: Research article Published on:

  6. Increased expression of aggrecanase-1 (ADAMTS-4) has emerged as an important factor in osteoarthritis (OA) and other joint diseases. This study aimed to determine whether the expression of ADAMTS-4 in human ch...

    Authors: Tetsuya Matsukawa, Tadahiro Sakai, Tomo Yonezawa, Hideki Hiraiwa, Takashi Hamada, Motoshige Nakashima, Yohei Ono, Shinya Ishizuka, Hiroyuki Nakahara, Martin K Lotz, Hiroshi Asahara and Naoki Ishiguro
    Citation: Arthritis Research & Therapy 2013 15:R28
    Content type: Research article Published on:

  7. The aim of this study was to assess a novel approach for the quantification of finger joint space narrowing and joint destruction in patients with rheumatoid arthritis (RA) focusing on the peripheral hand arti...

    Authors: Alexander Pfeil, Peter Oelzner, Klaus Bornholdt, Andreas Hansch, Gabriele Lehmann, Diane M Renz, Gunter Wolf and Joachim Böttcher
    Citation: Arthritis Research & Therapy 2013 15:R27
    Content type: Research article Published on:

  8. This study investigated whether the calcineurin inhibitor, tacrolimus, suppresses receptor activator of NF-κB ligand (RANKL) expression in fibroblast-like synoviocytes (FLS) through regulation of IL-6/Janus ac...

    Authors: Jung-Yoon Choe, Ki-Yeun Park, Sung-Hoon Park, Sang-Il Lee and Seong-Kyu Kim
    Citation: Arthritis Research & Therapy 2013 15:R26
    Content type: Research article Published on:

  9. B cells are believed to be central to the disease process in systemic lupuserythematosus (SLE), making them a target for new therapeutic intervention. In recentyears there have been many publications regarding...

    Authors: Venkat Reddy, David Jayne, David Close and David Isenberg
    Citation: Arthritis Research & Therapy 2013 15(Suppl 1):S2
    Content type: Review Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  10. B cell abnormalities contribute to the development and progress of autoimmune disease.Traditionally, the role of B cells in autoimmune disease was thought to be predominantly limited tothe production of autoan...

    Authors: Ioannis Kalampokis, Ayumi Yoshizaki and Thomas F Tedder
    Citation: Arthritis Research & Therapy 2013 15(Suppl 1):S1
    Content type: Review Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  12. In phase-3 clinical trials, the interleukin (IL-1) blocker, rilonacept (IL-1 Trap), demonstrated efficacy for gout flare prevention during initiation of urate-lowering therapy. This trial evaluated rilonacept ...

    Authors: Robert A Terkeltaub, H Ralph Schumacher, John D Carter, Herbert SB Baraf, Robert R Evans, Jian Wang, Shirletta King-Davis and Steven P Weinstein
    Citation: Arthritis Research & Therapy 2013 15:R25
    Content type: Research article Published on:

  13. Stresses and strains are major factors influencing growth, remodeling and repair of musculoskeletal tissues. Therefore, knowledge of forces and deformation within bones and joints is critical to gain insight i...

    Authors: Darryl D D'Lima, Benjamin J Fregly and Clifford W Colwell Jr
    Citation: Arthritis Research & Therapy 2013 15:203
    Content type: Review Published on:

  15. Systemic lupus erythematosus is a chronic relapsing autoimmune disease that primarilyafflicts women, and both a genetic predisposition and appropriate environmentalexposures are required for lupus to develop a...

    Authors: Dipak R Patel and Bruce C Richardson
    Citation: Arthritis Research & Therapy 2013 15:201
    Content type: Review Published on:

  16. Fibroblast-like synoviocytes (FLS) play a central role in defining the stromal environment in inflammatory joint diseases. Despite a growing use of FLS isolated from murine inflammatory models, a detailed char...

    Authors: Rowan S Hardy, Claudia Hülso, Yingling Liu, Sylvia J Gasparini, Colette Fong-Yee, Jinwen Tu, Shihani Stoner, Paul M Stewart, Karim Raza, Mark S Cooper, Markus J Seibel and Hong Zhou
    Citation: Arthritis Research & Therapy 2013 15:R24
    Content type: Research article Published on:

  17. Early degeneration of the intervertebral disc (IVD) involves a change in cellular differentiation from notochordal cells (NCs) in the nucleus pulposus (NP) to chondrocyte-like cells (CLCs). The purpose of this...

    Authors: Lucas A Smolders, Björn P Meij, David Onis, Frank M Riemers, Niklas Bergknut, Richard Wubbolts, Guy CM Grinwis, Martin Houweling, Marian JA Groot Koerkamp, Dik van Leenen, Frank CP Holstege, Herman AW Hazewinkel, Laura B Creemers, Louis C Penning and Marianna A Tryfonidou
    Citation: Arthritis Research & Therapy 2013 15:R23
    Content type: Research article Published on:

  18. Cell therapy is a rapidly growing area of research for the treatment of osteoarthritis (OA). This work is aimed to investigate the efficacy of intra-articular adipose-derived stromal cell (ASC) injection in th...

    Authors: Giovanna Desando, Carola Cavallo, Federica Sartoni, Lucia Martini, Annapaola Parrilli, Francesca Veronesi, Milena Fini, Roberto Giardino, Andrea Facchini and Brunella Grigolo
    Citation: Arthritis Research & Therapy 2013 15:R22
    Content type: Research article Published on:

  20. Familial Mediterranean fever (FMF) is an auto-inflammatory disease characterized by recurrent attacks of fever and serositis. Limited data suggest that the prevalence of sacroiliitis is increased in patients w...

    Authors: Servet Akar, Ozgul Soysal, Ali Balci, Dilek Solmaz, Vedat Gerdan, Fatos Onen, Mehmet Tunca and Nurullah Akkoc
    Citation: Arthritis Research & Therapy 2013 15:R21
    Content type: Research article Published on:

  21. Mammalian immune responses are intended to eradicate microbial pathogens and thus protect individuals from the harmful effects of such infections. However, unresolved inflammation can be devastating to the hos...

    Authors: Ruozhen Hu and Ryan M O'Connell
    Citation: Arthritis Research & Therapy 2013 15:202
    Content type: Review Published on:

  22. The hallmarks of IgG4-related disease (IgG4-RD) are lymphoplasmacytic tissue infiltration with a predominance of IgG4-positive plasma cells, accompanied by fibrosis, obliterative phlebitis, dacryoadenitis, and...

    Authors: Takao Koike
    Citation: Arthritis Research & Therapy 2013 15:103
    Content type: Editorial Published on:

  23. Rituximab (RTX) therapy of rheumatoid arthritis (RA) exhibits enhanced effectiveness in seropositive patients. Using patient sera, we tested if this improved efficacy was associated with enhanced RTX mediated ...

    Authors: Jonathan D Jones, Irene Shyu, Marianna M Newkirk and William FC Rigby
    Citation: Arthritis Research & Therapy 2013 15:R20
    Content type: Research article Published on:

  24. Osteoarthritis (OA) is the most common degenerative joint disease that is involved in the degradation of articular cartilage. The exact etiology of OA is not completely understood. CCN4 is related to up-regula...

    Authors: Chun-Han Hou, Chih-Hsin Tang, Chin-Jung Hsu, Sheng-Mon Hou and Ju-Fang Liu
    Citation: Arthritis Research & Therapy 2013 15:R19
    Content type: Research article Published on:

  25. Osteopontin (OPN) has been implicated as a mediator of Th17 regulation via type I interferon (IFN) receptor signaling and in macrophage activity at sites of tissue repair. This study assessed whether increased...

    Authors: Ornella J Rullo, Jennifer MP Woo, Miriam F Parsa, Alice DC Hoftman, Paul Maranian, David A Elashoff, Timothy B Niewold, Jennifer M Grossman, Bevra H Hahn, Maureen McMahon, Deborah K McCurdy and Betty P Tsao
    Citation: Arthritis Research & Therapy 2013 15:R18
    Content type: Research article Published on:

  26. Autoantibodies may be found years before an autoimmune disease becomes clinically apparent. For systemic lupus erythematosus (SLE), those to RNA-binding proteins, to phospholipids, and to double-stranded DNA, ...

    Authors: Martin Aringer and Edward Vital
    Citation: Arthritis Research & Therapy 2013 15:102
    Content type: Editorial Published on:

  27. To investigate how markers of β-cell secretion (proinsulin-processing metabolites) are expressed in rheumatoid arthritis (RA) patients and their potential relation with the insulin resistance (IR) observed in ...

    Authors: Iván Ferraz-Amaro, Jose A García-Dopico, Lilian Medina-Vega, Miguel A González-Gay and Federico Díaz-González
    Citation: Arthritis Research & Therapy 2013 15:R17
    Content type: Research article Published on:

  28. The diagnostic, predictive and prognostic role of anti-cyclic citrullinated peptide (CCP) antibodies in rheumatoid arthritis (RA) patients is widely accepted. Moreover, detection of these antibodies in subject...

    Authors: Nicola Bizzaro, Elena Bartoloni, Gabriella Morozzi, Stefania Manganelli, Valeria Riccieri, Paola Sabatini, Matteo Filippini, Marilina Tampoia, Antonella Afeltra, Giandomenico Sebastiani, Claudia Alpini, Vittorio Bini, Onelia Bistoni, Alessia Alunno and Roberto Gerli
    Citation: Arthritis Research & Therapy 2013 15:R16
    Content type: Research article Published on:

  29. Geng and colleagues consolidate and detail the role of cartilage oligomeric matrix protein (COMP) as a (potential) autoantigen in experimental and human arthritis, a finding also supported by the detection of ...

    Authors: Raimund W Kinne
    Citation: Arthritis Research & Therapy 2013 15:101
    Content type: Editorial Published on:

  30. Behcet's disease (BD) is a multi-systemic disorder with muco-cutaneous, ocular, arthritic, vascular or central nervous system involvement. The role of γδ T cells is implicated in BD. The activation status of γ...

    Authors: Gunes Parlakgul, Ekin Guney, Burak Erer, Zeki Kılıcaslan, Haner Direskeneli, Ahmet Gul and Guher Saruhan-Direskeneli
    Citation: Arthritis Research & Therapy 2013 15:R15
    Content type: Research article Published on:

  31. Radiographic damage is one of the core outcomes in axial SpA and is usually assessed with the modified Stoke Ankylosing Spondylitis (AS) Spine Score (mSASSS). Alternatively, the Radiographic AS Spinal Score (R...

    Authors: Sofia Ramiro, Astrid van Tubergen, Carmen Stolwijk, Robert Landewé, Filip van de Bosch, Maxime Dougados and Désirée van der Heijde
    Citation: Arthritis Research & Therapy 2013 15:R14
    Content type: Research article Published on:

  32. Interleukin (IL)-33 is a cytokine of the IL-1 family, which signals through the ST2 receptor. Previous work suggested implication of the IL-33/ST2 axis in the pathogenesis of human and mouse arthritis. Here, w...

    Authors: Praxedis Martin, Dominique Talabot-Ayer, Christian Alexander Seemayer, Solenne Vigne, Céline Lamacchia, Emiliana Rodriguez, Axel Finckh, Dirk E Smith, Cem Gabay and Gaby Palmer
    Citation: Arthritis Research & Therapy 2013 15:R13
    Content type: Research article Published on:

  33. Among various lupus renal vascular changes, thrombotic microangiopathy (TMA) presented with the most severe clinical manifestations and high mortality. The pathogenesis of TMA in systemic lupus erythematosus (...

    Authors: Di Song, Li-hua Wu, Feng-mei Wang, Xiao-wei Yang, Di Zhu, Min Chen, Feng Yu, Gang Liu and Ming-hui Zhao
    Citation: Arthritis Research & Therapy 2013 15:R12
    Content type: Research article Published on:

  34. AIRE is a transcriptional regulator playing a functional role in thymocyte education and negative selection by controlling the expression of peripheral antigens in the thymus. Recently, the AIRE gene was identifi...

    Authors: José-Raúl García-Lozano, Belén Torres-Agrela, Marco-Antonio Montes-Cano, Lourdes Ortiz-Fernández, Marta Conde-Jaldón, María Teruel, Alicia García, Antonio Núñez-Roldán, Javier Martín and María-Francisca González-Escribano
    Citation: Arthritis Research & Therapy 2013 15:R11
    Content type: Research article Published on:

  35. Systemic sclerosis (SSc) is more prevalent in women. Our goal is to determine the effects of 17β-estradiol (E2) on the development of fibrosis and to compare circulating levels of estrogens in SSc patients and...

    Authors: Keiko Aida-Yasuoka, Christine Peoples, Hidekata Yasuoka, Pamela Hershberger, Katelynn Thiel, Jane A Cauley, Thomas A Medsger Jr and Carol A Feghali-Bostwick
    Citation: Arthritis Research & Therapy 2013 15:R10
    Content type: Research article Published on:

  36. Long-lasting relapsing or lingering rheumatic musculoskeletal pain (RMSP) is the hallmark of Chikungunya virus (CHIKV) rheumatism (CHIK-R). Little is known on their prognostic factors. The aim of this prognost...

    Authors: Patrick Gérardin, Adrian Fianu, Alain Michault, Corinne Mussard, Karim Boussaïd, Olivier Rollot, Philippe Grivard, Somar Kassab, Eric Bouquillard, Gianandrea Borgherini, Bernard-Alex Gaüzère, Denis Malvy, Gérard Bréart and François Favier
    Citation: Arthritis Research & Therapy 2013 15:R9
    Content type: Research article Published on:

  37. Microcirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement. We assessed coronary microcirculation status by combinin...

    Authors: Alessandra Vacca, Roberta Montisci, Pietro Garau, Paolo Siotto, Matteo Piga, Alberto Cauli, Massimo Ruscazio, Luigi Meloni, Sabino Iliceto and Alessandro Mathieu
    Citation: Arthritis Research & Therapy 2013 15:R8
    Content type: Research article Published on:

  38. Increased rates of cardiovascular disease are implicated in several rheumatologic diseases. Our aim was to characterize dermatomyositis hospitalizations and evaluate cardiovascular-associated mortality in this...

    Authors: Eleni Linos, David Fiorentino, Bharathi Lingala, Eswar Krishnan and Lorinda Chung
    Citation: Arthritis Research & Therapy 2013 15:R7
    Content type: Research article Published on:

  39. Although the safety of celecoxib has been investigated, limited data are available on complications affecting the entire (upper and lower) gastrointestinal (GI) tract, with no patient-level pooled analyses of ...

    Authors: Andrew Moore, Geoffrey Makinson and Chunming Li
    Citation: Arthritis Research & Therapy 2013 15:R6
    Content type: Research article Published on:

  40. Osteoarthritis (OA) is a degenerative joint disease affecting a large population of people. The mechanism of this highly prevalent disease is not fully understood. Currently there is no effective disease-modif...

    Authors: Meina Wang, Erik R Sampson, Hongting Jin, Jia Li, Qiao H Ke, Hee-Jeong Im and Di Chen
    Citation: Arthritis Research & Therapy 2013 15:R5
    Content type: Research article Published on:

  41. Ultrasonography (US) might have an added value to clinical examination in diagnosing early rheumatoid arthritis (RA) and assessing remission of RA. We aimed to clarify the added value of US in RA in these situ...

    Authors: David F Ten Cate, Jolanda J Luime, Nanno Swen, Andreas H Gerards, Mike H De Jager, Natalja M Basoski, Johanna MW Hazes, Cees J Haagsma and Johannes WG Jacobs
    Citation: Arthritis Research & Therapy 2013 15:R4
    Content type: Research article Published on:

  42. A body of studies suggests the role of osteopontin (OPN) in onset and development of osteoarthritis (OA), however, the association between OPN polymorphisms and OA susceptibility as well as its clinical featur...

    Authors: Yongqing Jiang, Meng Yao, Qingpeng Liu and Changwei Zhou
    Citation: Arthritis Research & Therapy 2013 15:R3
    Content type: Research article Published on:

  43. The aim of the present study was to assess the prevalence and characteristics of subclinical arthritis of carpal and metacarpophalangeal joints in patients with systemic sclerosis (SSc).

    Authors: Elif Akbayrak, Robert Dinser, Ulf Müller-Ladner and Ingo H Tarner
    Citation: Arthritis Research & Therapy 2013 15:R2
    Content type: Research article Published on:

  44. The aim of this study was to explore the persistence of an antibody response 1.5 years after vaccination with 7-valent pneumococcal conjugate vaccine in patients with rheumatoid arthritis (RA) or spondyloarthr...

    Authors: Meliha Crnkic Kapetanovic, Tore Saxne, Lennart Truedsson and Pierre Geborek
    Citation: Arthritis Research & Therapy 2013 15:R1
    Content type: Research article Published on:

  45. A growing body of literature has documented the elevated levels of the alarmin HMGB1 in lupus skin and serum. Two recent reports highlight the increased expression of HMGB1 in lupus nephritis, within the disea...

    Authors: Tianfu Wu and Chandra Mohan
    Citation: Arthritis Research & Therapy 2012 14:129
    Content type: Editorial Published on:

  46. T cells of both the CD4 and CD8 lineage are commonly found in affected tissues of patients with idiopathic inflammatory myopathies, but understanding the contribution of these cells to immunopathogenesis remai...

    Authors: Vivianne Malmström, Paulius Venalis and Inka Albrecht
    Citation: Arthritis Research & Therapy 2012 14:230
    Content type: Review Published on:

  47. Potassium voltage-gated channel shaker-related subfamily member 5 (KCNA5) is implicated in vascular tone regulation, and its inhibition during hypoxia produces pulmonary vasoconstriction. Recently, a protectiv...

    Authors: Lara Bossini-Castillo, Carmen P Simeon, Lorenzo Beretta, Jasper Broen, Madelon C Vonk, José Luis Callejas, Patricia Carreira, Luis Rodríguez-Rodríguez, Rosa García-Portales, Miguel A González-Gay, Ivan Castellví, María Teresa Camps, Carlos Tolosa, Esther Vicente-Rabaneda, María Victoria Egurbide, Annemie J Schuerwegh…
    Citation: Arthritis Research & Therapy 2012 14:R273
    Content type: Research article Published on:

  48. The synovial tissue stands at the epicenter of joint pathology in rheumatoid arthritis (RA). As a primary target of the disease, studies on the synovium have provided invaluable insights into the mechanisms in...

    Authors: Serena Bugatti, Antonio Manzo, Roberto Caporali and Carlomaurizio Montecucco
    Citation: Arthritis Research & Therapy 2012 14:229
    Content type: Review Published on:

  50. The current markers of disease activity in Takayasu arteritis (TA) are insufficient for proper assessment. We investigated circulating levels of unacylated and acylated ghrelin, leptin and adiponectin and thei...

    Authors: Hatice Yilmaz, Vedat Gerdan, Didem Kozaci, Dilek Solmaz, Servet Akar, Gercek Can, Aytac Gulcu, Yigit Goktay, Ismail Sari, Merih Birlik, Nurullah Akkoc and Fatos Onen
    Citation: Arthritis Research & Therapy 2012 14:R272
    Content type: Research article Published on:
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Arthritis Research & Therapy

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