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  1. Events normally taking place in the terminal chondrocyte differentiation in the growth plate are also observed during osteoarthritis (OA) development, suggesting that molecules, such as Wnts and bone morphogen...

    Authors: Ioanna Papathanasiou, Konstantinos N Malizos and Aspasia Tsezou
    Citation: Arthritis Research & Therapy 2012 14:R82
    Content type: Research article Published on:

  2. Osteoarthritis (OA) results in pain and disability; however, preclinical OA models often focus on joint-level changes. Gait analysis is one method used to evaluate both preclinical OA models and OA patients. T...

    Authors: Kyle D Allen, Brian A Mata, Mostafa A Gabr, Janet L Huebner, Samuel B Adams Jr, Virginia B Kraus, Daniel O Schmitt and Lori A Setton
    Citation: Arthritis Research & Therapy 2012 14:R78
    Content type: Research article Published on:

  3. Juvenile idiopathic arthritis (JIA) is a heterogeneous disease characterized by chronic joint inflammation of unknown cause in children. JIA is an autoimmune disease and small numbers of autoantibodies have be...

    Authors: David S Gibson, Ji Qiu, Eliseo A Mendoza, Kristi Barker, Madeleine E Rooney and Joshua LaBaer
    Citation: Arthritis Research & Therapy 2012 14:R77
    Content type: Research article Published on:

  4. Staphylococcus aureus is a common cause of bacterial arthritis, which is associated with progressive bone loss in affected joints. We recently showed that S. aureus infection also induces a significant systemic b...

    Authors: Inger Gjertsson, Marie K Lagerquist, Erik Kristiansson, Hans Carlsten and Catharina Lindholm
    Citation: Arthritis Research & Therapy 2012 14:R76
    Content type: Research article Published on:

  5. miR-146a is one of the first identified miRNAs expressed differentially in osteoarthritis (OA) cartilage. However, the role it plays in OA pathogenesis is not clear. The aim of this study is to identify a mole...

    Authors: Jing Li, Jingang Huang, Liming Dai, Degang Yu, Qian Chen, Xiaoling Zhang and Kerong Dai
    Citation: Arthritis Research & Therapy 2012 14:R75
    Content type: Research article Published on:

  6. Synovial tissue macrophages play a key role in chronic inflammatory arthritis, but the contribution of different macrophage subsets in this process remains largely unknown. The main in vitro polarized macrophage ...

    Authors: Carmen A Ambarus, Troy Noordenbos, Maria JH de Hair, Paul P Tak and Dominique LP Baeten
    Citation: Arthritis Research & Therapy 2012 14:R74
    Content type: Research article Published on:

  8. Chemokine receptors play an important role in mediating the recruitment of T cells to inflammatory sites. Previously, small proportions of circulating Th1-type CCR5+ and Th2-type CCR3+ cells have been shown in...

    Authors: Ursula Fagin, Silke Pitann, Wolfgang L Gross and Peter Lamprecht
    Citation: Arthritis Research & Therapy 2012 14:R73
    Content type: Research article Published on:

  9. Articular cartilage (AC) is an avascular tissue with precise polarity and organization. The three distinct zones are: surface, middle and deep. The production and accumulation of the superficial zone protein (...

    Authors: José A Andrades, Shirley C Motaung, Pedro Jiménez-Palomo, Silvia Claros, José M López-Puerta, José Becerra, Thomas M Schmid and A Hari Reddi
    Citation: Arthritis Research & Therapy 2012 14:R72
    Content type: Research article Published on:

  11. Positron Emission Tomography - Computer Tomography (PET-CT) is an interesting imaging technique to visualize Ankylosing Spondylitis (AS) activity using specific PET tracers. Previous studies have shown that th...

    Authors: Stefan TG Bruijnen, Mignon AC van der Weijden, Joannes P Klein, Otto S Hoekstra, Ronald Boellaard, J Christiaan van Denderen, Ben AC Dijkmans, Alexandre E Voskuyl, Irene E van der Horst-Bruinsma and Conny J van der Laken
    Citation: Arthritis Research & Therapy 2012 14:R71
    Content type: Research article Published on:

  12. The therapeutic response to a drug treatment is a mixture of direct pharmacological action and placebo effect. Therefore, harnessing the positive aspects of the placebo effect and reducing the negative ones co...

    Authors: Alison Watson, Andrea Power, Christopher Brown, Wael El-Deredy and Anthony Jones
    Citation: Arthritis Research & Therapy 2012 14:206
    Content type: Review Published on:

  13. Fleishaker and colleagues reported on a double-blind placebo controlled clinical trial of a C-C chemokine-receptor type 5 (CCR5) antagonist, maraviroc, in rheumatoid arthritis (RA) patients with inadequate res...

    Authors: Tsutomu Takeuchi and Hideto Kameda
    Citation: Arthritis Research & Therapy 2012 14:114
    Content type: Editorial Published on:

  14. The purpose of this study was to replicate genetic factors associated with the susceptibility to Behçet's disease (BD). We conducted a two-stage candidate genes association and functional study, involving 477 ...

    Authors: Shengping Hou, Qinmeng Shu, Zhengxuan Jiang, Yuanyuan Chen, Fuzhen Li, Feilan Chen, Aize Kijlstra and Peizeng Yang
    Citation: Arthritis Research & Therapy 2012 14:R70
    Content type: Research article Published on:

  15. Peroxisome proliferator-activated receptor (PPAR)γ has been shown to exhibit anti-inflammatory and anti-catabolic properties and to be protective in animal models of osteoarthritis (OA). We have previously sho...

    Authors: Sarah-Salwa Nebbaki, Fatima Ezzahra El Mansouri, Hassan Afif, Mohit Kapoor, Mohamed Benderdour, Nicolas Duval, Jean-Pierre Pelletier, Johanne Martel-Pelletier and Hassan Fahmi
    Citation: Arthritis Research & Therapy 2012 14:R69
    Content type: Research article Published on:

  16. A clinical trial of lupus patients with nephritis was established to determine any possible role for Atacicept, a biologic drug that blocks two B-cell-activating factors (BLyS and APRIL). The trial was stopped...

    Authors: David A Isenberg
    Citation: Arthritis Research & Therapy 2012 14:113
    Content type: Editorial Published on:

  17. Remission is an important goal of therapy in rheumatoid arthritis (RA), but data on duration of remission are lacking. Our objective was to describe the duration of remission in RA, assessed by different crite...

    Authors: Femke HM Prince, Vivian P Bykerk, Nancy A Shadick, Bing Lu, Jing Cui, Michelle Frits, Christine K Iannaccone, Michael E Weinblatt and Daniel H Solomon
    Citation: Arthritis Research & Therapy 2012 14:R68
    Content type: Research article Published on:

  18. Reported findings on the relationship between adiposity and atherosclerotic cardiovascular disease (ACVD) risk in rheumatoid arthritis (RA) are contradictory and originate in developed populations. Approximate...

    Authors: Ahmed Solomon, Gavin R Norton, Angela J Woodiwiss and Patrick H Dessein
    Citation: Arthritis Research & Therapy 2012 14:R67
    Content type: Research article Published on:

  19. High-mobility group box 1 protein (HMGB1) is a prototypic alarmin that is released from activated and dying cells. Because of its proinflammatory activities, HMGB1 could mediate key events in the pathogenesis ...

    Authors: David S Pisetsky
    Citation: Arthritis Research & Therapy 2012 14:112
    Content type: Editorial Published on:

  20. The aim of this study was to evaluate an extensive panel of cytokines involved in immune regulation during pregnancy in patients with systemic lupus erythematosus (SLE) and in healthy women.

    Authors: Andrea Doria, Maurizio Cutolo, Anna Ghirardello, Margherita Zen, Danilo Villalta, Angela Tincani, Leonardo Punzi, Luca Iaccarino and Michelle Petri
    Citation: Arthritis Research & Therapy 2012 14:R66
    Content type: Research article Published on:

  21. Interleukin-22 (IL-22) is a cytokine of IL-10 family with significant proliferative effect on different cell lines. Immunopathological role of IL-22 has been studied in rheumatoid arthritis (RA) and psoriasis....

    Authors: Anupam Mitra, Smriti K Raychaudhuri and Siba P Raychaudhuri
    Citation: Arthritis Research & Therapy 2012 14:R65
    Content type: Research article Published on:

  22. The study was undertaken to investigate the interrelation of toll-like receptor (TLR) and interleukin (IL)-17 in the salivary glands of patients with primary Sjogren's syndrome (pSS) and to determine the role ...

    Authors: Seung-Ki Kwok, Mi-La Cho, Yang-Mi Her, Hye-Joa Oh, Mi-Kyung Park, Seon-Yeong Lee, Yun Ju Woo, Ji Hyeon Ju, Kyung-Su Park, Ho-Youn Kim and Sung-Hwan Park
    Citation: Arthritis Research & Therapy 2012 14:R64
    Content type: Research article Published on:

  23. Patellofemoral joint osteoarthritis (OA) is common and leads to pain and disability. However, current classification criteria do not distinguish between patellofemoral and tibiofemoral joint OA. The objective ...

    Authors: George Peat, Rachel C Duncan, Laurence RJ Wood, Elaine Thomas and Sara Muller
    Citation: Arthritis Research & Therapy 2012 14:R63
    Content type: Research article Published on:

  24. Rheumatoid arthritis (RA) is a chronic inflammatory and destructive disease of the joint. The synovial lining consists of two main types of cells: synovial fibroblasts and macrophages. The macrophage-derived c...

    Authors: Alison M Connor, Nizar Mahomed, Rajiv Gandhi, Edward C Keystone and Stuart A Berger
    Citation: Arthritis Research & Therapy 2012 14:R62
    Content type: Research article Published on:

  25. To determine the validity and reliability of patients' self-performed joint counts compared to joint counts by professional assessors in rheumatoid arthritis (RA) patients in different disease activity states.

    Authors: Helga Radner, Johannes Grisar, Josef S Smolen, Tanja Stamm and Daniel Aletaha
    Citation: Arthritis Res Ther 2012 14:R61
    Content type: Research article Published on:

  26. We have taken advantage of the large screening capacity of a multiplex immunoassay to better define the respective contribution of articular versus systemic cytokines in experimental arthritis.

    Authors: Joseph Paquet, Jean-Christophe Goebel, Camille Delaunay, Astrid Pinzano, Laurent Grossin, Christel Cournil-Henrionnet, Pierre Gillet, Patrick Netter, Jean-Yves Jouzeau and David Moulin
    Citation: Arthritis Research & Therapy 2012 14:R60
    Content type: Research article Published on:

  27. Early detection of atherosclerosis is of major importance to reduce the increased incidence of cardiovascular (CV) complications observed in patients with rheumatoid arthritis (RA). Prospective studies have sh...

    Authors: Miguel A González-Gay and Carlos González-Juanatey
    Citation: Arthritis Research & Therapy 2012 14:105
    Content type: Editorial Published on:

  28. Studies in the spontaneous ankylosis model in aging male DBA/1 mice and in patients with ankylosing spondylitis provide evidence that inflammation and new tissue formation leading to joint or spine ankylosis a...

    Authors: Kirsten Braem, Christophe M Deroose, Frank P Luyten and Rik J Lories
    Citation: Arthritis Research & Therapy 2012 14:R59
    Content type: Research article Published on:

  29. This work aimed at comparing the production of inflammatory and pro- and anti-angiogenic factors by normal/reactive (N/R) or inflammatory (I) areas of the osteoarthritic synovial membrane. The effects of inter...

    Authors: Cécile Lambert, Marianne Mathy-Hartert, Jean-Emile Dubuc, Eulàlia Montell, Josep Vergés, Carine Munaut, Agnès Noël and Yves Henrotin
    Citation: Arthritis Research & Therapy 2012 14:R58
    Content type: Research article Published on:

  30. B-cell depletion has become a common treatment strategy in anti-TNF-refractory rheumatoid arthritis (RA). Although the exact mechanism of how B-cell depletion leads to clinical amelioration in RA remains to be...

    Authors: YK Onno Teng, Gillian Wheater, Vanessa E Hogan, Philip Stocks, EW Nivine Levarht, Tom WJ Huizinga, Rene EM Toes and Jacob M van Laar
    Citation: Arthritis Research & Therapy 2012 14:R57
    Content type: Research article Published on:

  31. Increased frequencies of hyperuricemia and gout have been associated with primary hyperparathyroidism, and recent clinical trials of parathyroid hormone (PTH) have reported hyperuricemic adverse events. We eva...

    Authors: Janet Y Hui, Jee Woong J Choi, David B Mount, Yanyan Zhu, Yuqing Zhang and Hyon K Choi
    Citation: Arthritis Research & Therapy 2012 14:R56
    Content type: Research article Published on:

  32. Magnetic resonance imaging (MRI) has been proven capable of showing inflammatory and structural changes in patients with spondyloarthritis (SpA) and has become widely used in the diagnosis of SpA. Despite this...

    Authors: Bodil Arnbak, Charlotte Leboeuf-Yde and Tue Secher Jensen
    Citation: Arthritis Research & Therapy 2012 14:R55
    Content type: Research article Published on:

  33. Targeting CD74 as the invariant chain of major histocompatibility complexes (MHC) became possible by the availability of a specific humanized monoclonal antibody, milatuzumab, which is under investigation in p...

    Authors: Daniela Frölich, Daniela Blaβfeld, Karin Reiter, Claudia Giesecke, Capucine Daridon, Henrik E Mei, Gerd R Burmester, David M Goldenberg, Abdulagabar Salama and Thomas Dörner
    Citation: Arthritis Research & Therapy 2012 14:R54
    Content type: Research article Published on:

  34. The aim of this study was to evaluate, under real-life conditions, the safety and efficacy of tocilizumab in patients having failed anti-TNFα therapy for spondyloarthritis.

    Authors: Fernando Kemta Lekpa, Cécile Poulain, Daniel Wendling, Martin Soubrier, Michel De Bandt, Jean Marie Berthelot, Philippe Gaudin, Eric Toussirot, Philippe Goupille, Thao Pham, Jérémie Sellam, Rémy Bruckert, Muriel Paul, Valérie Farrenq and Pascal Claudepierre
    Citation: Arthritis Research & Therapy 2012 14:R53
    Content type: Research article Published on:
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Arthritis Research & Therapy

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