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  1. In the absence of head-to-head trials, analysis of available data from randomized clinical trials allows for comparison of the efficacy of biologic agents for the treatment of rheumatoid arthritis. Methotrexat...

    Authors: Yusuf Yazici
    Citation: Arthritis Research & Therapy 2012 14:104
    Content type: Editorial Published on:

  2. The c-Jun N-terminal kinase (JNK) is a key regulator of matrix metalloproteinase (MMP) and cytokine production in rheumatoid arthritis (RA) and JNK deficiency markedly protects mice in animal models of arthrit...

    Authors: Sang-il Lee, David L Boyle, Andres Berdeja and Gary S Firestein
    Citation: Arthritis Research & Therapy 2012 14:R38
    Content type: Research article Published on:

  3. Systematic lupus erythematosus (SLE) is a complex disease for which molecular diagnostics are limited and pathogenesis is not clearly understood. Important information is provided in this regard by identificat...

    Authors: Erik A Korte, Patrick M Gaffney and David W Powell
    Citation: Arthritis Research & Therapy 2012 14:204
    Content type: Review Published on:

  4. Patients with systemic lupus erythematosus (SLE) have a greatly increased risk of cardiovascular disease. There is growing interest in the link between vascular damage and lupus-specific inflammatory factors. ...

    Authors: Sahena Haque, M Yvonne Alexander and Ian N Bruce
    Citation: Arthritis Research & Therapy 2012 14:203
    Content type: Review Published on:

  5. Fibromyalgia (FM) is an idiopathic disease characterized by widespread pain and a myriad of symptoms. Symptoms are diverse and include not only pain but also anxiety, depression, orthostatic intolerance, and c...

    Authors: J Derek Kingsley
    Citation: Arthritis Research & Therapy 2012 14:103
    Content type: Editorial Published on:

  6. Erectile dysfunction (ED) is common in men with systemic sclerosis (SSc) but the demographics, risk factors and treatment coverage for ED are not well known.

    Authors: Chingching Foocharoen, Alan Tyndall, Eric Hachulla, Edoardo Rosato, Yannick Allanore, Dominique Farge-Bancel, Paola Caramaschi, Paolo Airó, Starovojtova M Nikolaevna, José António Pereira da Silva, Bojana Stamenkovic, Gabriela Riemekasten, Simona Rednic, Jean Sibilia, Piotr Wiland, Ingo Tarner…
    Citation: Arthritis Research & Therapy 2012 14:R37
    Content type: Research article Published on:

  7. High mobility group box 1 protein (HMGB1) is a nuclear DNA binding protein acting as a pro-inflammatory mediator following extracellular release. HMGB1 has been increasingly recognized as a pathogenic mediator...

    Authors: Agneta Zickert, Karin Palmblad, Birgitta Sundelin, Sangeeta Chavan, Kevin J Tracey, Annette Bruchfeld and Iva Gunnarsson
    Citation: Arthritis Research & Therapy 2012 14:R36
    Content type: Research article Published on:

  8. Fibronectin is one of the most abundant proteins present in the inflamed joint. Here, we characterized the citrullination of fibronectin in the joints of rheumatoid arthritis (RA) patients and studied the prev...

    Authors: Joyce JBC van Beers, Annemiek Willemze, Judith Stammen-Vogelzangs, Jan W Drijfhout, René EM Toes and Ger J M Pruijn
    Citation: Arthritis Research & Therapy 2012 14:R35
    Content type: Research article Published on:

  9. Biological markers specifically reflecting pathological processes may add value in the assessment of inter-individual variations in the course of rheumatoid arthritis (RA). The current study was undertaken to ...

    Authors: Serena Bugatti, Antonio Manzo, Francesca Benaglio, Catherine Klersy, Barbara Vitolo, Monica Todoerti, Garifallia Sakellariou, Carlomaurizio Montecucco and Roberto Caporali
    Citation: Arthritis Research & Therapy 2012 14:R34
    Content type: Research article Published on:

  10. Interleukin-10 (IL-10) producing B cells, also known as regulatory B (Breg) cells, play a key role in controlling autoimmunity. Our laboratory and others have demonstrated a pivotal role for Bregs in rheumatol...

    Authors: Natalie A Carter, Elizabeth C Rosser and Claudia Mauri
    Citation: Arthritis Research & Therapy 2012 14:R32
    Content type: Research article Published on:

  11. Atacicept is a soluble, fully human, recombinant fusion protein that inhibits B cell-stimulating factors APRIL (a proliferation-inducing ligand) and BLyS (B-lymphocyte stimulator). The APRIL- LN study aimed to...

    Authors: Ellen M Ginzler, Stephen Wax, Anand Rajeswaran, Samuel Copt, Jan Hillson, Eleanor Ramos and Nora G Singer
    Citation: Arthritis Research & Therapy 2012 14:R33
    Content type: Research article Published on:

  12. Mesenchymal stem cells (MSCs) can differentiate into various connective tissue cells. Several techniques have been used for the clinical application of MSCs in articular cartilage repair; however, there are ma...

    Authors: Mitsuhiko Sato, Kenzo Uchida, Hideaki Nakajima, Tsuyoshi Miyazaki, Alexander Rodriguez Guerrero, Shuji Watanabe, Sally Roberts and Hisatoshi Baba
    Citation: Arthritis Research & Therapy 2012 14:R31
    Content type: Research article Published on:

  13. At present, there is no reliable tool for predicting disease outcome in patients with rheumatoid arthritis (RA). We previously demonstrated an association between specific baseline biomarkers/clinical measures...

    Authors: Mark Houseman, Catherine Potter, Nicola Marshall, Rachel Lakey, Tim Cawston, Ian Griffiths, Steven Young-Min and John D Isaacs
    Citation: Arthritis Research & Therapy 2012 14:R30
    Content type: Research article Published on:

  14. Neuromedin U (NMU) is a neuropeptide with pro-inflammatory activity. The primary goal of this study was to determine if NMU promotes autoantibody-induced arthritis. Additional studies addressed the cellular so...

    Authors: Sindhuja M Rao, Jennifer L Auger, Philippe Gaillard, Ralph Weissleder, Etsuko Wada, Richard Torres, Masayasu Kojima, Christophe Benoist, Diane Mathis and Bryce A Binstadt
    Citation: Arthritis Research & Therapy 2012 14:R29
    Content type: Research article Published on:

  15. Low copy number (CN) of the Fc gamma receptor 3B (FCGR3B) gene has been associated with systemic autoimmune disease. This receptor for IgG is present almost exclusively on neutrophils and plays a role in their in...

    Authors: Scott W Graf, Sue Lester, Johannes C Nossent, Catherine L Hill, Susanna M Proudman, Anita Lee and Maureen Rischmueller
    Citation: Arthritis Research & Therapy 2012 14:R28
    Content type: Research article Published on:

  17. HLA-B*51 and HLA-B*52 are two close human leukocyte antigen (HLA) allele groups with minor amino acid differences. However, they are associated with two different vasculitides (HLA-B*51 in Behçet's disease and HL...

    Authors: Ziver Sahin, Muge Bıcakcıgil, Kenan Aksu, Sevil Kamali, Servet Akar, Fatos Onen, Omer Karadag, Zeynep Ozbalkan, Askin Ates, Huseyin TE Ozer, Vuslat Yilmaz, Emire Seyahi, Mehmet A Ozturk, Ayse Cefle, Veli Cobankara, A Mesut Onat…
    Citation: Arthritis Research & Therapy 2012 14:R27
    Content type: Research article Published on:

  18. Subchondral bone cysts (SBC) have been identified in patients with knee osteoarthritis (OA) as a cause of greater pain, loss of cartilage and increased chance of joint replacement surgery. Few studies monitor ...

    Authors: David D McErlain, Veronica Ulici, Mark Darling, Joseph S Gati, Vasek Pitelka, Frank Beier and David W Holdsworth
    Citation: Arthritis Research & Therapy 2012 14:R26
    Content type: Research article Published on:

  19. Autoreactivity to histones is a pervasive feature of several human autoimmune disorders, including systemic lupus erythematosus (SLE). Specific post-translational modifications (PTMs) of histones within neutro...

    Authors: Chih Long Liu, Stephanie Tangsombatvisit, Jacob M Rosenberg, Gil Mandelbaum, Emily C Gillespie, Or P Gozani, Ash A Alizadeh and Paul J Utz
    Citation: Arthritis Research & Therapy 2012 14:R25
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2012 14:403

  21. Progression of joint damage despite appropriate therapy remains a significant problem for patients with rheumatoid arthritis (RA). This study was undertaken to identify profiles of immune response that correla...

    Authors: John M Davis III, Keith L Knutson, John A Skinner, Michael A Strausbauch, Cynthia S Crowson, Terry M Therneau, Peter J Wettstein, Eric L Matteson and Sherine E Gabriel
    Citation: Arthritis Research & Therapy 2012 14:R24
    Content type: Research article Published on:

  23. Obesity is one of the major risk factors for the development of osteoarthritis (OA). Although the mechanical factors appear to be critical, recent studies have suggested a role for adipokines in cartilage degr...

    Authors: Raghunatha R Yammani and Richard F Loeser
    Citation: Arthritis Research & Therapy 2012 14:R23
    Content type: Research article Published on:

  24. The idiopathic inflammatory myopathies are rare diseases for which data regarding the natural history, response to therapies and factors affecting mortality are needed. We performed this study to examine the e...

    Authors: Elena Schiopu, Kristine Phillips, Paul M MacDonald, Leslie J Crofford and Emily C Somers
    Citation: Arthritis Research & Therapy 2012 14:R22
    Content type: Research article Published on:

  25. Our aim in the present study was to determine whether a disease-specific self-management program for primary care patients with osteoarthritis (OA) of the knee (the Osteoarthritis of the Knee Self-Management P...

    Authors: Sophie Coleman, N Kathryn Briffa, Graeme Carroll, Charles Inderjeeth, Nicola Cook and Jean McQuade
    Citation: Arthritis Research & Therapy 2012 14:R21
    Content type: Research article Published on:

  26. Protein citrullination is present in the rheumatoid synovium, presumably contributing to the perpetuation of chronic inflammation, in the presence of specific autoimmunity. As a result, the present study exami...

    Authors: Dimitrios Makrygiannakis, Shankar Revu, Marianne Engström, Erik af Klint, Anthony P Nicholas, Ger JM Pruijn and Anca I Catrina
    Citation: Arthritis Research & Therapy 2012 14:R20
    Content type: Research article Published on:

  27. Pulmonary involvement is a known manifestation in patients with ankylosing spondylitis (AS). However, previous studies have been based on small samples and the reported prevalence and associations with typical...

    Authors: Gunnhild Berdal, Silje Halvorsen, Désirée van der Heijde, Morten Mowe and Hanne Dagfinrud
    Citation: Arthritis Research & Therapy 2012 14:R19
    Content type: Research article Published on:

  29. Uveitis, or intraocular inflammatory disease, is a frequent extra-articular manifestation of several forms of arthritis. Despite the frequent co-occurrence of uveitis and arthritis, little is understood of the...

    Authors: Jelena M Kezic, Tibor T Glant, James T Rosenbaum and Holly L Rosenzweig
    Citation: Arthritis Research & Therapy 2012 14:R18
    Content type: Research article Published on:

  30. Developmental exposure to estrogens has been shown to affect the musculoskeletal system. Furthermore, recent studies have shown that environmental exposure to estrogen-like compounds is much higher than origin...

    Authors: Sora Al Rowas, Rami Haddada, Rahul Gawri, Abdul Aziz Al Ma'awi, Lorraine E Chalifour, John Antoniou and Fackson Mwale
    Citation: Arthritis Research & Therapy 2012 14:R17
    Content type: Research article Published on:

  31. The aim of this research was to study molecular changes in the articular cartilage and subchondral bone of the tibial plateau from mice deficient in frizzled-related protein (Frzb) compared to wild-type mice b...

    Authors: Liesbet Lodewyckx, Frédéric Cailotto, Sarah Thysen, Frank P Luyten and Rik J Lories
    Citation: Arthritis Research & Therapy 2012 14:R16
    Content type: Research article Published on:

  32. Cartilage oligomeric matrix protein (COMP) is found at elevated concentrations in sera of patients with joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). We recently showed that COMP ac...

    Authors: Kaisa E Happonen, Tore Saxne, Pierre Geborek, Maria Andersson, Anders A Bengtsson, Roger Hesselstrand, Dick Heinegård and Anna M Blom
    Citation: Arthritis Research & Therapy 2012 14:R15
    Content type: Research article Published on:

  33. Interleukin-34 (IL-34) is a recently defined cytokine, showing a functional overlap with macrophage colony stimulating factor (M-CSF). This study was undertaken to address the expression of IL-34 in rheumatoid...

    Authors: Seung-Jun Hwang, Bongkun Choi, Soon-Suk Kang, Jae-Ho Chang, Yong-Gil Kim, Yeon-Ho Chung, Dong Hyun Sohn, Min Wook So, Chang-Keun Lee, William H Robinson and Eun-Ju Chang
    Citation: Arthritis Research & Therapy 2012 14:R14
    Content type: Research article Published on:

  34. Bone marrow lesions (BMLs) play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, ...

    Authors: Dawn Doré, Jonathon de Hoog, Graham Giles, Changhai Ding, Flavia Cicuttini and Graeme Jones
    Citation: Arthritis Research & Therapy 2012 14:R13
    Content type: Research article Published on:

  35. Telomere shortening is associated with a number of common age-related diseases. A role of telomere shortening in osteoarthritis (OA) has been suggested, mainly based on the assessment of mean telomere length in e...

    Authors: Maria Harbo, Laila Bendix, Anne-Christine Bay-Jensen, Jesper Graakjaer, Kent Søe, Thomas L Andersen, Per Kjaersgaard-Andersen, Steen Koelvraa and Jean-Marie Delaisse
    Citation: Arthritis Research & Therapy 2012 14:R12
    Content type: Research article Published on:

  36. The purpose of this study was to determine whether maraviroc, a human CC chemokine receptor 5 (CCR5) antagonist, is safe and effective in the treatment of active rheumatoid arthritis (RA) in patients on backgr...

    Authors: Dona L Fleishaker, Juan A Garcia Meijide, Andriy Petrov, Michael David Kohen, Xin Wang, Sujatha Menon, Thomas C Stock, Charles A Mebus, James M Goodrich, Howard B Mayer and Bernhardt G Zeiher
    Citation: Arthritis Research & Therapy 2012 14:R11
    Content type: Research article Published on:

  37. Patients with a history of myocardial infarction (MI) are often at risk for complications, including subsequent MI and death. Use of prognostic markers may aid in preventing these poor outcomes. Hyperuricemia ...

    Authors: Eswar Krishnan, Bhavik J Pandya, Bharathi Lingala, Ali Hariri and Omar Dabbous
    Citation: Arthritis Research & Therapy 2012 14:R10
    Content type: Research article Published on:

  38. Celecoxib, a highly specific cyclooxygenase-2 (COX-2) inhibitor has been reported to have COX-2-independent immunomodulatory effects. However, celecoxib itself has only mild suppressive effects on arthritis. R...

    Authors: Asako Chiba, Miho Mizuno, Chiharu Tomi, Ryohsuke Tajima, Iraide Alloza, Alessandra di Penta, Takashi Yamamura, Koen Vandenbroeck and Sachiko Miyake
    Citation: Arthritis Research & Therapy 2012 14:R9
    Content type: Research article Published on:

  39. Suitable biomarkers are essential for therapeutic strategies in personalized medicine in terms of diagnosis as well as of prognosis. With highly specific biomarkers, it is possible, for example, to identify pa...

    Authors: Christiane Fueldner, Anja Mittag, Jens Knauer, Maria Biskop, Pierre Hepp, Roger Scholz, Ulf Wagner, Ulrich Sack, Frank Emmrich, Attila Tárnok and Joerg Lehmann
    Citation: Arthritis Research & Therapy 2012 14:R8
    Content type: Research article Published on:

  40. Osteoarthritis (OA) is a degenerative disease characterized by cartilage breakdown in the synovial joints. The presence of low-grade inflammation in OA joints is receiving increasing attention, with synovitis ...

    Authors: Dong Hyun Sohn, Jeremy Sokolove, Orr Sharpe, Jennifer C Erhart, Piyanka E Chandra, Lauren J Lahey, Tamsin M Lindstrom, Inyong Hwang, Katherine A Boyer, Thomas P Andriacchi and William H Robinson
    Citation: Arthritis Research & Therapy 2012 14:R7
    Content type: Research article Published on:

  41. Pateclizumab (MLTA3698A) is a humanized mAb against lymphotoxin α (LTα), a transiently expressed cytokine on activated B and T cells (Th1, Th17), which are implicated in rheumatoid arthritis (RA) pathogenesis....

    Authors: Brinda Emu, Diana Luca, Carolyn Offutt, Jane L Grogan, Bernadette Rojkovich, Marna B Williams, Meina T Tang, Jim Xiao, June H Lee and John C Davis
    Citation: Arthritis Research & Therapy 2012 14:R6
    Content type: Research article Published on:

  42. A subgroup of voltage gated sodium channels including Nav1.8 are exclusively expressed on small diameter primary afferent neurons and are therefore believed to be integral to the neurotransmission of nocicepti...

    Authors: Niklas Schuelert and Jason J McDougall
    Citation: Arthritis Research & Therapy 2012 14:R5
    Content type: Research article Published on:

  43. Findings that African-American race/ethnicity is associated with higher concentrations of serum urate have not been adjusted for possible confounding factors or have not explored this question as a primary out...

    Authors: Angelo L Gaffo, David R Jacobs Jr, Cora E Lewis, Ted R Mikuls and Kenneth G Saag
    Citation: Arthritis Research & Therapy 2012 14:R4
    Content type: Research article Published on:

  44. Inflammatory involvement of the anterior chest wall (ACW) affects the quality of life of patients with spondyloarthritis (SpA), although involvement of the ACW is often neglected on clinical and imaging evalua...

    Authors: Ulrich Weber, Robert GW Lambert, Kaspar Rufibach, Walter P Maksymowych, Juerg Hodler, Anna Zejden, Stefan Duewell, Rudolf O Kissling, Paul L Filipow and Anne G Jurik
    Citation: Arthritis Research & Therapy 2012 14:R3
    Content type: Research article Published on:

  45. An international cohort study of 73 anti-Ku-positive patients with different connective tissue diseases was conducted to differentiate the anti-Ku-positive populations of patients based on their autoantibody p...

    Authors: Katja Lakota, Gerhard G Thallinger, Snezna Sodin-Semrl, Blaz Rozman, Ales Ambrozic, Matija Tomsic, Sonja Praprotnik, Sasa Cucnik, Katjusa Mrak-Poljsak, Angela Ceribelli, Ilaria Cavazzana, Franco Franceschini, Jiri Vencovsky, Laszlo Czirják, Cecilia Varjú, Gunther Steiner…
    Citation: Arthritis Research & Therapy 2012 14:R2
    Content type: Research article Published on:

  46. Several studies have reported that TNFα is substantially increased within skin lesions of patients with discoid lupus erythematosus (DLE), subacute cutaneous lupus erythematosus (SCLE) and dermatomyositis (DM)...

    Authors: Adam S Nabatian, Muhammad M Bashir, Maria Wysocka, Meena Sharma and Victoria P Werth
    Citation: Arthritis Research & Therapy 2012 14:R1
    Content type: Research article Published on:

  47. The relative resistance of non-chondrodystrophic (NCD) canines to degenerative disc disease (DDD) may be due to a combination of anabolic and anti-catabolic factors secreted by notochordal cells within the int...

    Authors: W Mark Erwin, Diana Islam, Robert D Inman, Michael G Fehlings and Florence WL Tsui
    Citation: Arthritis Research & Therapy 2011 13:R215
    Content type: Research article Published on:

  48. Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. The most prominent and consistent...

    Authors: Emily C Baechler, Hatice Bilgic and Ann M Reed
    Citation: Arthritis Research & Therapy 2011 13:249
    Content type: Review Published on:

  49. Several reports have found the onset or activity of inflammatory myopathies to show spatial clustering and seasonal association. We recently detected autoantibodies against melanoma differentiation-associated ...

    Authors: Yoshinao Muro, Kazumitsu Sugiura, Kei Hoshino, Masashi Akiyama and Koji Tamakoshi
    Citation: Arthritis Research & Therapy 2011 13:R214
    Content type: Research article Published on:

  50. The induction of antinuclear antibodies (ANAs) or anti-double-stranded (ds) -DNA antibodies (Abs) after infliximab (IFX) therapy in rheumatoid arthritis (RA) is a well-known phenomenon, but the correlation of ...

    Authors: Naoichiro Yukawa, Takao Fujii, Seiko Kondo-Ishikawa, Hajime Yoshifuji, Daisuke Kawabata, Takaki Nojima, Koichiro Ohmura, Takashi Usui and Tsuneyo Mimori
    Citation: Arthritis Research & Therapy 2011 13:R213
    Content type: Research article Published on:
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Arthritis Research & Therapy

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