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  1. Interleukin (IL)-21 is a cytokine that controls the functional activity of effector T helper cells and the differentiation of Th17 cells, and promotes B-cell differentiation. To test whether IL-21 participates...

    Authors: Kwi Young Kang, Hyun-Ok Kim, Seung-Ki Kwok, Ji Hyeon Ju, Kyung-Su Park, Dong-Il Sun, Joo Yeon Jhun, Hye Jwa Oh, Sung-Hwan Park and Ho-Youn Kim
    Citation: Arthritis Research & Therapy 2011 13:R179
    Content type: Research article Published on:

  2. Although osteoarthritis (OA) commonly involves multiple joints, no widely accepted method for quantifying whole-body OA burden exists. Therefore, our aim was to apply factor analytic methods to radiographic OA...

    Authors: Amanda E Nelson, Robert F DeVellis, Jordan B Renner, Todd A Schwartz, Philip G Conaghan, Virginia B Kraus and Joanne M Jordan
    Citation: Arthritis Research & Therapy 2011 13:R176
    Content type: Research article Published on:

  3. Systemic lupus erythematosus (SLE) patients have lower bone mineral density and increased fracture risk when compared with healthy individuals, due to distinct factors and mechanisms. Bone remodeling is a tigh...

    Authors: Diana Carmona-Fernandes, Maria José Santos, Inês Pedro Perpétuo, João Eurico Fonseca and Helena Canhão
    Citation: Arthritis Research & Therapy 2011 13:R175
    Content type: Research article Published on:

  4. Zostavax, a live attenuated vaccine, has been approved in the United States for use in older individuals to reduce the risk and severity of herpes zoster (HZ), also known as shingles. The vaccine is contraindi...

    Authors: Jie Zhang, Elizabeth Delzell, Fenglong Xie, John W Baddley, Claire Spettell, Raechele M Mcmahan, Joaquim Fernandes, Lang Chen, Kevin Winthrop and Jeffrey R Curtis
    Citation: Arthritis Research & Therapy 2011 13:R174
    Content type: Research article Published on:

  5. No randomised, controlled trials have been conducted to date on the efficacy of psychological and pharmacological treatments of pain catastrophising (PC) in patients with fibromyalgia. Our aim in this study wa...

    Authors: Marta Alda, Juan V Luciano, Eva Andrés, Antoni Serrano-Blanco, Baltasar Rodero, Yolanda López del Hoyo, Miquel Roca, Sergio Moreno, Rosa Magallón and Javier García-Campayo
    Citation: Arthritis Research & Therapy 2011 13:R173
    Content type: Research article Published on:

  6. In the present study, we analysed in detail nuclear autoantibodies and their associations in systemic sclerosis (SSc) patients included in the German Network for Systemic Scleroderma Registry.

    Authors: Rudolf Mierau, Pia Moinzadeh, Gabriela Riemekasten, Inga Melchers, Michael Meurer, Frank Reichenberger, Michael Buslau, Margitta Worm, Norbert Blank, Rüdiger Hein, Ulf Müller-Ladner, Annegret Kuhn, Cord Sunderkötter, Aaron Juche, Christiane Pfeiffer, Christoph Fiehn…
    Citation: Arthritis Research & Therapy 2011 13:R172
    Content type: Research article Published on:

  7. Back pain, a significant source of morbidity in our society, is related to the degenerative changes of the intervertebral disc. At present, the treatment of disc disease consists of therapies that are aimed at...

    Authors: Ravi K Ponnappan, Dessislava Z Markova, Paul JD Antonio, Hallie B Murray, Alexander R Vaccaro, Irving M Shapiro, D Greg Anderson, Todd J Albert and Makarand V Risbud
    Citation: Arthritis Research & Therapy 2011 13:R171
    Content type: Research article Published on:

  8. In this study, we investigated possible aberrations of monocytes from patients with primary Sjögren's syndrome (pSS). We focused on B-cell-activating factor of the TNF family (BAFF) and IL-6 because they are b...

    Authors: Keiko Yoshimoto, Maiko Tanaka, Masako Kojima, Yumiko Setoyama, Hideto Kameda, Katsuya Suzuki, Kensei Tsuzaka, Yoko Ogawa, Kazuo Tsubota, Tohru Abe and Tsutomu Takeuchi
    Citation: Arthritis Research & Therapy 2011 13:R170
    Content type: Research article Published on:

  9. The purpose of this study was to examine data from the Johnston County Osteoarthritis (OA) Project for independent associations of educational attainment, occupation and community poverty with tibiofemoral kne...

    Authors: Leigh F Callahan, Rebecca J Cleveland, Jack Shreffler, Todd A Schwartz, Britta Schoster, Randy Randolph, Jordan B Renner and Joanne M Jordan
    Citation: Arthritis Research & Therapy 2011 13:R169
    Content type: Research article Published on:

  11. Minocycline and doxycycline are safe and moderately effective disease-modifying anti-rheumatic drugs (DMARDs) in the treatment of early, DMARD-naïve rheumatoid arthritis (RA), although little is known about th...

    Authors: Christopher J Smith, Harlan Sayles, Ted R Mikuls and Kaleb Michaud
    Citation: Arthritis Research & Therapy 2011 13:R168
    Content type: Research article Published on:

  12. Fatigue is prevalent in primary Sjögren's syndrome (pSS), and contributes to the considerably reduced health related quality of life in this disease. The symptom is included in proposed disease activity and ou...

    Authors: Karstein Haldorsen, Ingvar Bjelland, Anne Isine Bolstad, Roland Jonsson and Johan Gorgas Brun
    Citation: Arthritis Research & Therapy 2011 13:R167
    Content type: Research article Published on:

  13. T cell abnormalities have been associated with the pathogenesis of systemic sclerosis (SSc). Recently, besides T helper (Th)17 cells, the Th22 subset has been identified in humans. Our purpose was to investiga...

    Authors: Marie-Elise Truchetet, Nicolò C Brembilla, Elisa Montanari, Yannick Allanore and Carlo Chizzolini
    Citation: Arthritis Research & Therapy 2011 13:R166
    Content type: Research article Published on:

  14. Degeneration of the interverterbral disk is as a cause of low-back pain is increasing. To gain insight into relationships between biological processes, structural alterations and behavioral pain, we created an...

    Authors: Jae-Sung Kim, Jeffrey S Kroin, Xin Li, Howard S An, Asokumar Buvanendran, Dongyao Yan, Kenneth J Tuman, Andre J van Wijnen, Di Chen and Hee-Jeong Im
    Citation: Arthritis Research & Therapy 2011 13:R165
    Content type: Research article Published on:

  15. The purpose of this study was to analyze the cellular expressions of pro-resorptive cytokines in gouty tophus tissues, to determine the capacity of monosodium urate monohydrate (MSU) crystals to induce these c...

    Authors: Sung-Ji Lee, Kwang-Il Nam, Hye-Mi Jin, Young-Nan Cho, Song-Eun Lee, Tae-Jong Kim, Shin-Seok Lee, Seung-Jung Kee, Keun-Bae Lee, Nacksung Kim and Yong-Wook Park
    Citation: Arthritis Research & Therapy 2011 13:R164
    Content type: Research article Published on:

  16. The diagnosis of ankylosing spondylitis is made from a combination of clinical features and the presence of radiographic evidence that may be detected only after many years of inflammatory back pain. It is not...

    Authors: Facundo Las Heras, Ralph S DaCosta, Kenneth PH Pritzker, Nigil Haroon, George Netchev, Hing Wo Tsui, Basil Chiu, W Mark Erwin, Florence WL Tsui and Robert D Inman
    Citation: Arthritis Research & Therapy 2011 13:R163
    Content type: Research article Published on:

  17. Human cytomegalovirus (HCMV) infection has been implicated in the development of autoimmunity, including systemic lupus erythematosus (SLE). Previously we reported that HCMV phosphoprotein 65 (pp65) could indu...

    Authors: Ao-Ho Hsieh, Yí-Jyun Jhou, Chung-Ting Liang, Mingi Chang and Shih-Lien Wang
    Citation: Arthritis Research & Therapy 2011 13:R162
    Content type: Research article Published on:

  18. Rheumatoid arthritis (RA) is a chronic disease associated with inflammation and destruction of bone and cartilage. Although inhibition of TNFα is widely used to treat RA, a significant number of patients do no...

    Authors: Luke L Gompels, Nasser M Malik, Leigh Madden, Pei Jin, Marc Feldmann, H Michael Shepard and Ewa M Paleolog
    Citation: Arthritis Research & Therapy 2011 13:R161
    Content type: Research article Published on:

  20. The revised shared epitope (SE) concept in rheumatoid arthritis (RA) is based on the presence (S) or absence (X) of the SE RAA amino acid motif at positions 72 to 74 of the third hypervariable region of the va...

    Authors: Pieter WA Meyer, Bridget Hodkinson, Mahmood Ally, Eustasius Musenge, Ahmed A Wadee, Heidi Fickl, Mohammed Tikly and Ronald Anderson
    Citation: Arthritis Research & Therapy 2011 13:R160
    Content type: Research article Published on:

  21. The concept of osteoimmunology is based on growing insight into the links between the immune system and bone at the anatomical, vascular, cellular, and molecular levels. In both rheumatoid arthritis (RA) and a...

    Authors: Piet Geusens and Willem F Lems
    Citation: Arthritis Research & Therapy 2011 13:242
    Content type: Review Published on:

  23. Synovitis and subchondral bone turnover are associated with pain in osteoarthritis. Bisphosphonates provide tools for investigating these pathogenic mechanisms and also may have therapeutic potential. Translat...

    Authors: David A Walsh and Victoria Chapman
    Citation: Arthritis Research & Therapy 2011 13:128
    Content type: Editorial Published on:

  24. Fibroblast growth factor 2 (FGF2) is a highly abundant growth factor found within the pericellular matrix of articular chondrocytes, but studies investigating its role have been conflicting. The paper reported...

    Authors: Tonia L Vincent
    Citation: Arthritis Research & Therapy 2011 13:127
    Content type: Editorial Published on:

  25. Cardiovascular disease (CVD) is the leading cause of death in patients with inflammatory polyarthritis (IP), especially in seropositive disease. In established rheumatoid arthritis (RA), insulin resistance (IR...

    Authors: Hoda Mirjafari, Tracey M Farragher, Suzanne MM Verstappen, Allen Yates, Diane Bunn, Tarnya Marshall, Mark Lunt, Deborah PM Symmons and Ian N Bruce
    Citation: Arthritis Research & Therapy 2011 13:R159
    Content type: Research article Published on:

  26. Chemerin is a chemotactic agonist identified as a ligand for ChemR23 that is expressed on macrophages and dendritic cells (DCs). In this study, we analyzed the expression of chemerin and ChemR23 in the synoviu...

    Authors: Kayoko Kaneko, Yoshishige Miyabe, Aiko Takayasu, Shin Fukuda, Chie Miyabe, Masashi Ebisawa, Waka Yokoyama, Kaori Watanabe, Toshio Imai, Kenzo Muramoto, Yuya Terashima, Takahiko Sugihara, Kouji Matsushima, Nobuyuki Miyasaka and Toshihiro Nanki
    Citation: Arthritis Research & Therapy 2011 13:R158
    Content type: Research article Published on:

  27. Systemic lupus erythematosus (SLE) is an autoimmune disease accompanied by a disturbed T-cell balance skewed towards effector T-cells, in particular Th17-cells. The novel cytokine interleukin-21 (IL-21) is sug...

    Authors: Sebastian Dolff, Wayel H Abdulahad, Johanna Westra, Berber Doornbos-van der Meer, Pieter C Limburg, Cees GM Kallenberg and Marc Bijl
    Citation: Arthritis Research & Therapy 2011 13:R157
    Content type: Research article Published on:

  28. Previous studies have shown that traditional risk factors such as hypercholesterolemia and hypertension account for only a small proportion of the dramatically increased risk of atherosclerotic coronary artery...

    Authors: Mandana Nikpour, Murray B Urowitz, Dominique Ibanez, Paula J Harvey and Dafna D Gladman
    Citation: Arthritis Research & Therapy 2011 13:R156
    Content type: Research article Published on:

  29. Lupus nephritis is a major cause of morbidity and mortality in patients with systemic lupus erythematosus. The general consensus is that 60% of lupus patients will develop clinically relevant nephritis at some...

    Authors: Ramesh Saxena, Tina Mahajan and Chandra Mohan
    Citation: Arthritis Research & Therapy 2011 13:240
    Content type: Review Published on:

  30. Osteoarthritis (OA) is a degenerative joint disease characterized by progressive loss of articular cartilage, subchondral bone sclerosis, osteophyte formation, and synovial inflammation, causing substantial ph...

    Authors: Manon C Zweers, Tineke N de Boer, Joël van Roon, Johannes WJ Bijlsma, Floris PJG Lafeber and Simon C Mastbergen
    Citation: Arthritis Research & Therapy 2011 13:239
    Content type: Review Published on:

  31. Administrative claims data have not commonly been used to study the clinical effectiveness of medications for rheumatoid arthritis (RA) because of the lack of a validated algorithm for this outcome. We created...

    Authors: Jeffrey R Curtis, John W Baddley, Shuo Yang, Nivedita Patkar, Lang Chen, Elizabeth Delzell, Ted R Mikuls, Kenneth G Saag, Jasvinder Singh, Monika Safford and Grant W Cannon
    Citation: Arthritis Research & Therapy 2011 13:R155
    Content type: Research article Published on:

  32. An unidentified population of peripheral blood mononuclear cells (PBMCs) express Ras guanine nucleotide releasing protein 4 (RasGRP4). The aim of our study was to identify the cells in human blood that express...

    Authors: Toko Hashimoto, Shinsuke Yasuda, Hideyuki Koide, Hiroshi Kataoka, Tetsuya Horita, Tatsuya Atsumi and Takao Koike
    Citation: Arthritis Research & Therapy 2011 13:R154
    Content type: Research article Published on:

  33. The goals of this study were (i) to compare the prevalence of focal knee abnormalities, the mean cartilage T2 relaxation time, and the spatial distribution of cartilage magnetic resonance (MR) T2 relaxation times...

    Authors: Gabby B Joseph, Thomas Baum, Julio Carballido-Gamio, Lorenzo Nardo, Warapat Virayavanich, Hamza Alizai, John A Lynch, Charles E McCulloch, Sharmila Majumdar and Thomas M Link
    Citation: Arthritis Research & Therapy 2011 13:R153
    Content type: Research article Published on:

  34. While the importance and magnitude of the burden of low back pain upon the individual is well recognized, a systematic understanding of the impact of the condition on individuals is currently hampered by the l...

    Authors: Rachelle Buchbinder, Roy Batterham, Gerald Elsworth, Clermont E Dionne, Emma Irvin and Richard H Osborne
    Citation: Arthritis Research & Therapy 2011 13:R152
    Content type: Research article Published on:

  35. A consequence of knee joint osteoarthritis (OA) is an inability to fully activate the quadriceps muscles, a problem termed arthrogenic muscle inhibition (AMI). AMI leads to marked quadriceps weakness that impa...

    Authors: David A Rice, Peter J McNair and Gwyn N Lewis
    Citation: Arthritis Research & Therapy 2011 13:R151
    Content type: Research article Published on:

  36. Mast cells have been implicated to play a functional role in arthritis, especially in autoantibody-positive disease. Among the cytokines involved in rheumatoid arthritis (RA), IL-17 is an important inflammator...

    Authors: Jolien Suurmond, Annemarie L Dorjée, Mariëtte R Boon, Edward F Knol, Tom WJ Huizinga, René EM Toes and Annemie JM Schuerwegh
    Citation: Arthritis Research & Therapy 2011 13:R150
    Content type: Research article Published on:

    The Retraction Note to this article has been published in Arthritis Research & Therapy 2015 17:354

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