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  6. Binding immunoglobulin protein (BiP) has previously shown powerful anti-inflammatory properties in the collagen-induced arthritis (CIA) model, where a single dose of BiP has proved to be both a long-term proph...

    Authors: Kaoru Yoshida, Akira Ochiai, Hiroaki Matsuno, Gabriel S Panayi and Valerie M Corrigall
    Citation: Arthritis Research & Therapy 2011 13:R149
    Content type: Research article Published on:

  7. Autoinflammatory diseases are characterized by seemingly unprovoked episodes of inflammation, without high titers of autoantibodies or antigen-specific T cells, and derive from genetic variants of the innate i...

    Authors: Qingping Yao, Lan Zhou, Philip Cusumano, Nilanjana Bose, Melissa Piliang, Bijal Jayakar, Le-Chu Su and Bo Shen
    Citation: Arthritis Research & Therapy 2011 13:R148
    Content type: Research article Published on:

  8. The Health Assessment Questionnaire Disability Index (HAQ) and the SF-36 PF-10, among other instruments, yield sensitive and valid Disability (Physical Function) endpoints. Modern techniques, such as Item Resp...

    Authors: James F Fries, Eswar Krishnan, Matthias Rose, Bharathi Lingala and Bonnie Bruce
    Citation: Arthritis Research & Therapy 2011 13:R147
    Content type: Research article Published on:

  9. Osteoarthritis (OA) is a common cause of disability in older adults. We have previously reported that an agonist for subtypes EP2 of the prostaglandin E2 receptor (an EP2 agonist) promotes the regeneration of ...

    Authors: Hiroto Mitsui, Tomoki Aoyama, Moritoshi Furu, Kinya Ito, Yonghui Jin, Takayuki Maruyama, Toshiya Kanaji, Shinsei Fujimura, Hikaru Sugihara, Akio Nishiura, Takanobu Otsuka, Takashi Nakamura and Junya Toguchida
    Citation: Arthritis Research & Therapy 2011 13:R146
    Content type: Research article Published on:

  10. The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression.

    Authors: Manoj Ramachandran, Prim Achan, Donald M Salter, Dan L Bader and Tina T Chowdhury
    Citation: Arthritis Research & Therapy 2011 13:R145
    Content type: Research article Published on:

  11. Ossification of the ligamentum flavum (OLF) of the spine is associated with serious neurologic compromise, but the pathomechanism of this process remains unclear. The objective of this study was to investigate...

    Authors: Kenzo Uchida, Takafumi Yayama, Hong-Xin Cai, Hideaki Nakajima, Daisuke Sugita, Alexander Rodríguez Guerrero, Shigeru Kobayashi, Ai Yoshida, Ke-Bing Chen and Hisatoshi Baba
    Citation: Arthritis Research & Therapy 2011 13:R144
    Content type: Research article Published on:

  12. Autoimmune inflammation is a characteristic feature of rheumatoid arthritis (RA) and other autoimmune diseases. In the natural course of human autoimmune diseases, it is rather difficult to pinpoint the precis...

    Authors: Hua Yu, Changwan Lu, Ming T Tan and Kamal D Moudgil
    Citation: Arthritis Research & Therapy 2011 13:R143
    Content type: Research article Published on:

  13. Dupuytren's disease (DD) is an ill-defined fibroproliferative disorder of the palm of the hands leading to digital contracture. DD commonly occurs in individuals of northern European extraction. Cellular compo...

    Authors: Samrina Rehman, Royston Goodacre, Philip J Day, Ardeshir Bayat and Hans V Westerhoff
    Citation: Arthritis Research & Therapy 2011 13:238
    Content type: Review Published on:

  14. Traumatic joint injury damages cartilage and causes adjacent joint tissues to release inflammatory cytokines, increasing the risk of developing osteoarthritis. The main objective of this study was to determine...

    Authors: Yihong CS Lu, Christopher H Evans and Alan J Grodzinsky
    Citation: Arthritis Research & Therapy 2011 13:R142
    Content type: Research article Published on:

  15. The efficacy and safety of tocilizumab in patients with rheumatoid arthritis have been evaluated in a comprehensive phase 3 program. Patients from these randomized trials could receive tocilizumab treatment in...

    Authors: Michael H Schiff, Joel M Kremer, Angelika Jahreis, Emma Vernon, John D Isaacs and Ronald F van Vollenhoven
    Citation: Arthritis Research & Therapy 2011 13:R141
    Content type: Research article Published on:

  16. Cathepsin K is a recently discovered cysteine protease which cleaves the triple helical domains of type I to II collagen. It has been shown to be up-regulated in synovial tissue from osteoarthritic and rheumat...

    Authors: Helen E Gruber, Jane A Ingram, Gretchen L Hoelscher, Natalia Zinchenko, H James Norton and Edward N Hanley Jr
    Citation: Arthritis Research & Therapy 2011 13:R140
    Content type: Research article Published on:

  17. Infection is a major cause of morbidity and mortality in patients with rheumatoid arthritis (RA). The objective of this study was to perform a systematic review and meta-analysis of the effect of glucocorticoi...

    Authors: William G Dixon, Samy Suissa and Marie Hudson
    Citation: Arthritis Research & Therapy 2011 13:R139
    Content type: Research article Published on:

  18. Rheumatoid arthritis (RA) is a chronic autoimmune disease with episodic flares in affected joints. However, how arthritic flare occurs only in select joints during a systemic autoimmune disease remains an enig...

    Authors: Jie Li, Quan Zhou, Ronald W Wood, Igor Kuzin, Andrea Bottaro, Christopher T Ritchlin, Lianping Xing and Edward M Schwarz
    Citation: Arthritis Research & Therapy 2011 13:R138
    Content type: Research article Published on:

  19. Despite tremendous advances in the therapy of rheumatoid arthritis (RA), there remains interest in oral agents that may offer benefits that are similar to, or better than, those of biologic therapies. In their...

    Authors: Eric M Ruderman and Richard M Pope
    Citation: Arthritis Research & Therapy 2011 13:125
    Content type: Editorial Published on:

  20. Microvascular disease is a prominent feature of systemic sclerosis (SSc) and leads to Raynaud's phenomenon, pulmonary arterial hypertension, and scleroderma renal crisis. The presence of macrovascular disease ...

    Authors: Gene-Siew Ngian, Joanne Sahhar, Ian P Wicks and Sharon Van Doornum
    Citation: Arthritis Research & Therapy 2011 13:237
    Content type: Review Published on:

  21. Tumor necrosis factor-α (TNFα) has received significant attention as a mediator of lumbar radiculopathy, with interest in TNF antagonism to treat radiculopathy. Prior studies have demonstrated that TNF antagon...

    Authors: Kyle D Allen, Mohammed F Shamji, Brian A Mata, Mostafa A Gabr, S Michael Sinclair, Daniel O Schmitt, William J Richardson and Lori A Setton
    Citation: Arthritis Research & Therapy 2011 13:R137
    Content type: Research article Published on:

  22. In addition to its direct proinflammatory activity, extracellular high mobility group box protein 1 (HMGB1) can strongly enhance the cytokine response evoked by other proinflammatory molecules, such as lipopol...

    Authors: Heidi Wähämaa, Hanna Schierbeck, Hulda S Hreggvidsdottir, Karin Palmblad, Anne-Charlotte Aveberger, Ulf Andersson and Helena Erlandsson Harris
    Citation: Arthritis Research & Therapy 2011 13:R136
    Content type: Research article Published on:

  24. Although people with knee and hip osteoarthritis (OA) seek treatment because of pain, many of these individuals have commonly co-occurring symptoms (for example, fatigue, sleep problems, mood disorders). The p...

    Authors: Susan L Murphy, Angela K Lyden, Kristine Phillips, Daniel J Clauw and David A Williams
    Citation: Arthritis Research & Therapy 2011 13:R135
    Content type: Research article Published on:

  25. Last October, the 7th meeting of the Global Arthritis Research Network was held in Zurich, Switzerland. European and American experts who have made major recent contributions to molecular biology got together ...

    Authors: Matthias Brock, Michelle Trenkmann, Maria Filkova, Hossein Hemmatazad, Emmanuel Karouzakis, Fabienne Niederer, Kerstin Klein and Steffen Gay
    Citation: Arthritis Research & Therapy 2011 13:303
    Content type: Meeting report Published on:

  26. In anti-neutrophil cytoplasmic autoantibody-associated vasculitides (AAV), several observations support a key role of T-helper cells (CD4+ T cells) in disease pathophysiology. An expanded population of effector m...

    Authors: Wayel H Abdulahad, Peter Lamprecht and Cees GM Kallenberg
    Citation: Arthritis Research & Therapy 2011 13:236
    Content type: Review Published on:

  28. The reviews in this series on Sjögren syndrome provide an up-to-date summary and perspectives on the pathogenesis of this interesting entity with glandular and frequently systemic manifestations, the value of ...

    Authors: Thomas Dörner
    Citation: Arthritis Research & Therapy 2011 13:123
    Content type: Editorial Published on:

  30. Interstitial pulmonary fibrosis (IPF) is a frequent manifestation in patients with connective tissue disorders (CTD). Recently the ultrasound (US) criterion validity for its assessment has been proposed; howev...

    Authors: Marwin Gutierrez, Fausto Salaffi, Marina Carotti, Marika Tardella, Carlos Pineda, Chiara Bertolazzi, Elisabetta Bichisecchi, Emilio Filippucci and Walter Grassi
    Citation: Arthritis Research & Therapy 2011 13:R134
    Content type: Research article Published on:

  31. The aim of our study was to analyze the influence of the CCR5Δ32 polymorphism in the risk of cardiovascular (CV) events and subclinical atherosclerosis among patients with rheumatoid arthritis (RA).

    Authors: Luis Rodríguez-Rodríguez, Carlos González-Juanatey, Mercedes García-Bermúdez, Tomas R Vázquez-Rodríguez, Jose A Miranda-Filloy, Benjamin Fernández-Gutiérrez, Javier Llorca, Javier Martin and Miguel A González-Gay
    Citation: Arthritis Research & Therapy 2011 13:R133
    Content type: Research article Published on:

  33. Co-morbidity and mortality due to cardiovascular disease (CVD) are increased in patients with rheumatoid arthritis (RA). Most published studies in this field are retrospective or cross sectional. We investigat...

    Authors: Lena Innala, Bozena Möller, Lotta Ljung, Staffan Magnusson, Torgny Smedby, Anna Södergren, Marie-Louise Öhman, Solbritt Rantapää-Dahlqvist and Solveig Wållberg-Jonsson
    Citation: Arthritis Research & Therapy 2011 13:R131
    Content type: Research article Published on:

  34. High expression of folate receptors is characteristic for the effector cell population of synovial macrophages in synovial inflammation. A new drug conjugate, EC0746, targets the folate inhibitor aminopterin t...

    Authors: Christoph Fiehn
    Citation: Arthritis Research & Therapy 2011 13:122
    Content type: Editorial Published on:

  35. Cartilage degeneration driven by catabolic stimuli is a critical pathophysiological process in osteoarthritis (OA). We have defined fibroblast growth factor 2 (FGF-2) as a degenerative mediator in adult human ...

    Authors: Dongyao Yan, Di Chen, Simon M Cool, Andre J van Wijnen, Katalin Mikecz, Gillian Murphy and Hee-Jeong Im
    Citation: Arthritis Research & Therapy 2011 13:R130
    Content type: Research article Published on:

  36. Innate defence regulator (IDR) peptides are synthetic cationic peptides, variants of naturally occurring innate immune effector molecules known as host defence peptides. IDR peptides were recently demonstrated...

    Authors: Emily Turner-Brannen, Ka-Yee Choi, Dustin ND Lippert, John P Cortens, Robert EW Hancock, Hani El-Gabalawy and Neeloffer Mookherjee
    Citation: Arthritis Research & Therapy 2011 13:R129
    Content type: Research article Published on:

  38. Sumoylation is involved in nucleolus-nucleoplasm transport of DNA topoisomerase I (topo I), which may associate with changes of cellular and topo I functions. Skin fibroblasts of patients with systemic scleros...

    Authors: Xiaodong Zhou, Wei Lin, Filemon K Tan, Shervin Assassi, Mavin J Fritzler, Xinjian Guo, Roozbeh Sharif, Tom Xia, Syeling Lai and Frank C Arnett
    Citation: Arthritis Research & Therapy 2011 13:R128
    Content type: Research article Published on:

  39. Susceptibility for giant cell arteritis increases with chronological age, in parallel with age-related restructuring of the immune system and age-induced remodeling of the vascular wall. Immunosenescence resul...

    Authors: Shalini V Mohan, Y Joyce Liao, Jonathan W Kim, Jörg J Goronzy and Cornelia M Weyand
    Citation: Arthritis Research & Therapy 2011 13:231
    Content type: Review Published on:

  40. Postural instability and falls are increasingly recognized problems in patients with fibromyalgia (FM). The purpose of this study was to determine whether FM patients, compared to age-matched healthy controls ...

    Authors: Kim D Jones, Laurie A King, Scott D Mist, Robert M Bennett and Fay B Horak
    Citation: Arthritis Research & Therapy 2011 13:R127
    Content type: Research article Published on:

  42. The objective of this study was to investigate the effects of tumor necrosis factor (TNF)-α inhibitors on circulating T helper-type 17 (Th17) cells and Th17-related cytokines in patients with rheumatoid arthri...

    Authors: Der-Yuan Chen, Yi-Ming Chen, Hsin-Hua Chen, Chia-Wei Hsieh, Chi-Chen Lin and Joung-Liang Lan
    Citation: Arthritis Research & Therapy 2011 13:R126
    Content type: Research article Published on:

  43. AMG 108 is a fully human, immunoglobulin subclass G2 (IgG2) monoclonal antibody that binds the human interleukin-1 (IL-1) receptor type 1, inhibiting the activity of IL-1a and IL-1b. In preclinical studies, IL...

    Authors: Stanley B Cohen, Susanna Proudman, Alan J Kivitz, Francis X Burch, John P Donohue, Deborah Burstein, Yu-Nien Sun, Christopher Banfield, Michael S Vincent, Liyun Ni and Debra J Zack
    Citation: Arthritis Research & Therapy 2011 13:R125
    Content type: Research article Published on:

  44. Expression of TXNDC5, which is induced by hypoxia, stimulates cell proliferation and angiogenesis. Our previous study detected increased TXNDC5 expression in the synovial tissues of rheumatoid arthritis (RA) p...

    Authors: Xiaotian Chang, Yan Zhao, Xinfeng Yan, Jihong Pan, Kehua Fang and Lin Wang
    Citation: Arthritis Research & Therapy 2011 13:R124
    Content type: Research article Published on:

  47. Articular tissues are capable of producing a range of eicosanoid mediators, each of which has individual biological effects and may be affected by anti-inflammatory treatment. We set out to develop and evaluat...

    Authors: Janny C de Grauw, Chris HA van de Lest and Paul René van Weeren
    Citation: Arthritis Research & Therapy 2011 13:R123
    Content type: Research article Published on:

  48. Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting synovial joints. Therapies blocking tumor necrosis factor-alpha (TNFα) are now routinely used in the management of RA. However, a significa...

    Authors: Flavia Calmon-Hamaty, Bernard Combe, Michael Hahne and Jacques Morel
    Citation: Arthritis Research & Therapy 2011 13:232
    Content type: Review Published on:

  49. The aim of this study was to examine the serum levels of S100 proteins and to evaluate their role in patients with recent-onset rheumatoid arthritis (RA).

    Authors: Lucie Andrés Cerezo, Heřman Mann, Ondřej Pecha, Lenka Pleštilová, Karel Pavelka, Jiří Vencovský and Ladislav Šenolt
    Citation: Arthritis Research & Therapy 2011 13:R122
    Content type: Research article Published on:

  50. Intervertebral disc (IVD) degeneration is associated with proteolytic degradation of the extracellular matrix, and its repair requires both the production of extracellular matrix and the downregulation of prot...

    Authors: Fackson Mwale, Koichi Masuda, Rajeswari Pichika, Laura M Epure, Tomoaki Yoshikawa, Aseem Hemmad, Peter J Roughley and John Antoniou
    Citation: Arthritis Research & Therapy 2011 13:R120
    Content type: Research article Published on:
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