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  1. To examine the effects of tumour necrosis factor (TNF) blocking therapy on the levels of early mitochondrial genome alterations and oxidative stress.

    Authors: Monika Biniecka, Aisling Kennedy, Chin T Ng, Ting C Chang, Emese Balogh, Edward Fox, Douglas J Veale, Ursula Fearon and Jacintha N O'Sullivan
    Citation: Arthritis Research & Therapy 2011 13:R121
    Content type: Research article Published on:

  2. Anti-RNA polymerase III (RNAP III) antibodies are highly specific markers of scleroderma (systemic sclerosis, SSc) and associated with a rapidly progressing subset of SSc. The clinical presentation of anti-RNA...

    Authors: Angela Ceribelli, Malgorzata E Krzyszczak, Yi Li, Steven J Ross, Jason YF Chan, Edward KL Chan, Rufus W Burlingame, Tyler T Webb, Michael R Bubb, Eric S Sobel, Westley H Reeves and Minoru Satoh
    Citation: Arthritis Research & Therapy 2011 13:R119
    Content type: Research article Published on:

  3. Aortitis is a general term denoting inflammation of the aortic wall. Various infectious and non-infectious diseases can be complicated by aortitis; in addition, isolated idiopathic aortitis has also been descr...

    Authors: Nicolò Pipitone and Carlo Salvarani
    Citation: Arthritis Research & Therapy 2011 13:119
    Content type: Editorial Published on:

  4. Diagnosis of antiphospholipid syndrome (APS) still remains a laboratory challenge due to the great diversity of antiphospholipid antibodies (aPL) and their significance regarding APS-diagnostic criteria.

    Authors: Karl Egerer, Dirk Roggenbuck, Thomas Büttner, Barbara Lehmann, Annushka Kohn, Philipp von Landenberg, Rico Hiemann, Eugen Feist, Gerd-Rüdiger Burmester and Thomas Dörner
    Citation: Arthritis Research & Therapy 2011 13:R118
    Content type: Research article Published on:

  5. Mortality in systemic lupus erythematosus (SLE) patients is influenced by an increased occurrence of severe cardiovascular complications. Statins have been proven to protect a wide spectrum of SLE patients fro...

    Authors: Wojciech Plazak, Krzysztof Gryga, Hanna Dziedzic, Lidia Tomkiewicz-Pajak, Malgorzata Konieczynska, Piotr Podolec and Jacek Musial
    Citation: Arthritis Research & Therapy 2011 13:R117
    Content type: Research article Published on:

  6. Acid phosphatase locus 1 (ACP1) encodes a low molecular weight phosphotyrosine phosphatase implicated in a number of different biological functions in the cell. The aim of this study was to determine the contribu...

    Authors: María Teruel, Jose-Ezequiel Martin, Carlos González-Juanatey, Raquel López-Mejias, Jose A Miranda-Filloy, Ricardo Blanco, Alejandro Balsa, Dora Pascual-Salcedo, Luis Rodriguez-Rodriguez, Benjamin Fernández-Gutierrez, Ana M Ortiz, Isidoro González-Alvaro, Carmen Gómez-Vaquero, Nunzio Bottini, Javier Llorca, Miguel A González-Gay…
    Citation: Arthritis Research & Therapy 2011 13:R116
    Content type: Research article Published on:

  8. MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded RNAs about 21 nucleotides in length. miRNAs have been shown to regulate gene expression and thus influence a wide range of physiological and patho...

    Authors: Angela Ceribelli, Bing Yao, Paul R Dominguez-Gutierrez, Md A Nahid, Minoru Satoh and Edward KL Chan
    Citation: Arthritis Research & Therapy 2011 13:229
    Content type: Review Published on:

  9. The aim was to determine the effect of the Bruton tyrosine kinase (Btk)-selective inhibitor PCI-32765, currently in Phase I/II studies in lymphoma trials, in arthritis and immune-complex (IC) based animal mode...

    Authors: Betty Y Chang, Min Mei Huang, Michelle Francesco, Jun Chen, Jeremy Sokolove, Padmaja Magadala, William H Robinson and Joseph J Buggy
    Citation: Arthritis Research & Therapy 2011 13:R115
    Content type: Research article Published on:

  10. Mouse models of rheumatoid arthritis (RA) have proven critical for identifying genetic and cellular mechanisms of the disease. Upon discovering mice in our breeding colony that had spontaneously developed infl...

    Authors: Iris A Adipue, Joel T Wilcox, Cody King, Carolyn AY Rice, Katherine M Shaum, Cory M Suard, Elri ten Brink, Stephen D Miller and Eileen J McMahon
    Citation: Arthritis Research & Therapy 2011 13:R114
    Content type: Research article Published on:

  11. The receptor for advanced glycation end-products (RAGE) has been implicated in the pathogenesis of arthritis. We conducted this study to determine the effect of interleukin (IL)-17 on the expression and produc...

    Authors: Yu-Jung Heo, Hye-Jwa Oh, Young Ok Jung, Mi-La Cho, Seon-Yeong Lee, Jun-Geol Yu, Mi-Kyung Park, Hae-Rim Kim, Sang-Heon Lee, Sung-Hwan Park and Ho-Youn Kim
    Citation: Arthritis Research & Therapy 2011 13:R113
    Content type: Research article Published on:

  12. The purpose of this observational study was to analyze the rates, characteristics and associated risk factors of severe infections in patients with systemic autoimmune diseases (SAD) who were treated off-label...

    Authors: Cándido Díaz-Lagares, Roberto Pérez-Alvarez, Francisco J García-Hernández, María M Ayala-Gutiérrez, José Luis Callejas, Agustín Martínez-Berriotxoa, Javier Rascón, Luis Caminal-Montero, Albert Selva-O'Callaghan, Joaquim Oristrell, Carmen Hidalgo, Ricardo Gómez-de-la-Torre, Luis Sáez, Jesús Canora-Lebrato, María-Teresa Camps, Norberto Ortego-Centeno…
    Citation: Arthritis Research & Therapy 2011 13:R112
    Content type: Research article Published on:

  13. Single nucleotide polymorphisms (SNPs) of transforming growth factor β (TGF-β) and IL-6 genes (respectively, 869C/T and -174G/C) have been associated with radiographic severity of bone-erosive damage in patien...

    Authors: Fulvia Ceccarelli, Carlo Perricone, Martina Fabris, Cristiano Alessandri, Annamaria Iagnocco, Cinzia Fabro, Elena Pontarini, Salvatore De Vita and Guido Valesini
    Citation: Arthritis Research & Therapy 2011 13:R111
    Content type: Research article Published on:

  14. Clinical trials provided controversial results on whether the injection of hyaluronan preparations into osteoarthritic joints reduces pain. Problems of clinical studies may be the substantial placebo effects o...

    Authors: Michael Karl Boettger, Diana Kümmel, Andrew Harrison and Hans-Georg Schaible
    Citation: Arthritis Research & Therapy 2011 13:R110
    Content type: Research article Published on:

  15. The pathogenesis of systemic lupus erythematosus (SLE) is complex, and the resulting disease manifestations are heterogeneous. Cytokine dysregulation is pervasive, and their protein and gene expression profile...

    Authors: Noam Jacob and William Stohl
    Citation: Arthritis Research & Therapy 2011 13:228
    Content type: Review Published on:

  16. The difficulty in predicting the consequences of interactions between different cytokine networks has increased with the expansion of the T helper (Th) cell universe and the discovery of numerous B lymphocyte-...

    Authors: Pierre Youinou and Jacques-Olivier Pers
    Citation: Arthritis Research & Therapy 2011 13:227
    Content type: Review Published on:

  18. The liver is often overlooked as a target organ, with pathology either secondary to an underlying disease or due to the toxicity of therapies and the medical complications of extrahepatic diseases. It is thus ...

    Authors: Carlo Selmi, Maria De Santis and M Eric Gershwin
    Citation: Arthritis Research & Therapy 2011 13:226
    Content type: Review Published on:

  22. Management of patients with inflammatory rheumatic disease and a history of (or even a current) malignant disease poses some particular challenges. As direct evidence of the risk of (recurrent or de novo) maligna...

    Authors: Katarzyna Elandt and Daniel Aletaha
    Citation: Arthritis Research & Therapy 2011 13:223
    Content type: Review Published on:

  23. Renal co-morbidity is common in patients with rheumatic disease based on regular assessment of serum and urine parameters of renal function. When patients present with both arthritis and renal abnormalities th...

    Authors: Hans-Joachim Anders and Volker Vielhauer
    Citation: Arthritis Research & Therapy 2011 13:222
    Content type: Review Published on:

  25. The present study investigates the association between single nucleotide polymorphisms (SNPs) in the chitinase 3-like 1 (CHI3L1) gene and serum concentrations of YKL-40 in Danish patients with rheumatoid arthriti...

    Authors: Kaspar R Nielsen, Rudi Steffensen, Martin Boegsted, John Baech, Soeren Lundbye-Christensen, Merete L Hetland, Sophine B Krintel, Hans E Johnsen, Mette Nyegaard and Julia S Johansen
    Citation: Arthritis Research & Therapy 2011 13:R109
    Content type: Research article Published on:

  26. Substantial effort has been devoted for devising effective and safe interventions to reduce preventable hospital admissions in chronic disease patients. In rheumatoid arthritis (RA), identifying risk factors f...

    Authors: George S Metsios, Antonios Stavropoulos-Kalinoglou, Gareth J Treharne, Alan M Nevill, Aamer Sandoo, Vasileios F Panoulas, Tracey E Toms, Yiannis Koutedakis and George D Kitas
    Citation: Arthritis Research & Therapy 2011 13:R108
    Content type: Research article Published on:

  27. Immunological studies of giant cell arteritis (GCA) suggest that a triggering antigen of unknown nature could generate a specific immune response. We thus decided to detect autoantibodies directed against endo...

    Authors: Alexis Régent, Hanadi Dib, Kim H Ly, Christian Agard, Mathieu C Tamby, Nicolas Tamas, Babette Weksler, Christian Federici, Cédric Broussard, Loïc Guillevin and Luc Mouthon
    Citation: Arthritis Research & Therapy 2011 13:R107
    Content type: Research article Published on:

  28. CD25+ FOXP3+ CD4+ regulatory T cells (Tregs) are induced by transforming growth factor β (TGFβ) and further expanded by retinoic acid (RA). We have previously shown that this process was defective in T cells from...

    Authors: Eric S Sobel, Todd M Brusko, Ed J Butfiloski, Wei Hou, Shiwu Li, Carla M Cuda, Ariana N Abid, Westley H Reeves and Laurence Morel
    Citation: Arthritis Research & Therapy 2011 13:R106
    Content type: Research article Published on:

  29. A proportion of patients receiving infliximab have antibodies toward infliximab (ATI), which are associated with increased risk of infusion reaction and reduced response to treatment. We studied the associatio...

    Authors: Emilie Ducourau, Denis Mulleman, Gilles Paintaud, Delphine Chu Miow Lin, Francine Lauféron, David Ternant, Hervé Watier and Philippe Goupille
    Citation: Arthritis Research & Therapy 2011 13:R105
    Content type: Research article Published on:

  30. IFN-gamma inducible protein-10 (CXCL10), a member of the CXC chemokine family, and its receptor CXCR3 contribute to the recruitment of T cells from the blood stream into the inflamed joints and have a crucial ...

    Authors: Eun Young Lee, MiRan Seo, Yong-Sung Juhnn, Jeong Yeon Kim, Yoo Jin Hong, Yun Jong Lee, Eun Bong Lee and Yeong Wook Song
    Citation: Arthritis Research & Therapy 2011 13:R104
    Content type: Research article Published on:

  31. Toll-like receptors (TLRs) are likely to play crucial roles in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to determine the key TLRs in synovium and explore their roles in the acti...

    Authors: Wenhua Zhu, Liesu Meng, Congshan Jiang, Xiaojing He, Weikun Hou, Peng Xu, Heng Du, Rikard Holmdahl and Shemin Lu
    Citation: Arthritis Research & Therapy 2011 13:R103
    Content type: Research article Published on:

  32. The past decade has witnessed significant progress in revealing an important role for IL-17 in the pathogenesis of several immune-mediated inflammatory diseases. Recent studies have provided new insights into ...

    Authors: Nataliya Yeremenko and Dominique Baeten
    Citation: Arthritis Research & Therapy 2011 13:115
    Content type: Editorial Published on:

  33. The aim of this study was to develop a clinical-grade, automated, multiplex system for the differential diagnosis and molecular stratification of rheumatoid arthritis (RA).

    Authors: Piyanka E Chandra, Jeremy Sokolove, Berthold G Hipp, Tamsin M Lindstrom, James T Elder, John D Reveille, Heike Eberl, Ursula Klause and William H Robinson
    Citation: Arthritis Research & Therapy 2011 13:R102
    Content type: Research article Published on:

  34. In this study, we aimed to determine the relationship between flow-mediated endothelium-dependent vasodilatation (FMD) and carotid artery intima-media wall thickness (IMT), two surrogate markers of atheroscler...

    Authors: Carlos González-Juanatey, Javier Llorca and Miguel A González-Gay
    Citation: Arthritis Research & Therapy 2011 13:R101
    Content type: Research article Published on:

  35. Postmenopausal osteoporosis may modulate bone response to wear debris. In this article, we evaluate the influence of oestrogen deficiency on experimental particle-induced osteolysis.

    Authors: Christophe Nich, Jean Langlois, Arnaud Marchadier, Catherine Vidal, Martine Cohen-Solal, Hervé Petite and Moussa Hamadouche
    Citation: Arthritis Research & Therapy 2011 13:R100
    Content type: Research article Published on:

  36. Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD). One of the earliest manifestations of CVD is endothelial dysfunction (ED). ED can occur in both the microcircu...

    Authors: Aamer Sandoo, Douglas Carroll, George S Metsios, George D Kitas and Jet JCS Veldhuijzen van Zanten
    Citation: Arthritis Research & Therapy 2011 13:R99
    Content type: Research article Published on:

  37. The aim of this prospective, randomized, controlled, double-blind study was to evaluate the effects of tiludronate (TLN), a bisphosphonate, on structural, biochemical and molecular changes and function in an e...

    Authors: Maxim Moreau, Pascale Rialland, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Daniel Lajeunesse, Christielle Boileau, Judith Caron, Diane Frank, Bertrand Lussier, Jerome RE del Castillo, Guy Beauchamp, Dominique Gauvin, Thierry Bertaim, Dominique Thibaud and Eric Troncy
    Citation: Arthritis Research & Therapy 2011 13:R98
    Content type: Research article Published on:

  38. Pulmonary arterial hypertension (PAH) is a serious complication of systemic sclerosis (SSc). In clinical trials PAH-SSc has been grouped with other forms, including idiopathic PAH. The primary endpoint for mos...

    Authors: Christopher P Denton, Jerome Avouac, Frank Behrens, Daniel E Furst, Ivan Foeldvari, Marc Humbert, Doerte Huscher, Otylia Kowal-Bielecka, Marco Matucci-Cerinic, Peter Nash, Christian F Opitz, David Pittrow, Lewis J Rubin, James R Seibold and Oliver Distler
    Citation: Arthritis Research & Therapy 2011 13:114
    Content type: Commentary Published on:

  39. Endothelins are involved in tissue inflammation, pain, edema and cell migration. Our genome-wide microarray analysis revealed that endothelin-1 (ET-1) and endothelin-2 (ET-2) showed a marked up-regulation in d...

    Authors: Anne-Katja Imhof, Laura Glück, Mieczyslaw Gajda, Rolf Bräuer, Hans-Georg Schaible and Stefan Schulz
    Citation: Arthritis Research & Therapy 2011 13:R97
    Content type: Research article Published on:

  40. Postmenopausal patients with rheumatoid arthritis (RA) are often treated with corticosteroids. Loss of estrogen, the inflammatory disease and exposure to corticosteroids all contribute to the development of os...

    Authors: Ulrika Islander, Caroline Jochems, Alexandra Stubelius, Annica Andersson, Marie K Lagerquist, Claes Ohlsson and Hans Carlsten
    Citation: Arthritis Research & Therapy 2011 13:R96
    Content type: Research article Published on:

  41. In this study, we analysed the number of IL-17+ cells in facet joints, in the peripheral blood (PB) and synovial fluid (SF) of spondyloarthritis (SpA) patients and compared these results with those of patients wi...

    Authors: Heiner Appel, René Maier, Peihua Wu, Rebecca Scheer, Axel Hempfing, Ralph Kayser, Andreas Thiel, Andreas Radbruch, Christoph Loddenkemper and Joachim Sieper
    Citation: Arthritis Research & Therapy 2011 13:R95
    Content type: Research article Published on:

  42. Identifying ankylosing spondylitis (AS) patients who are likely to benefit from tumor necrosis factor-alpha (TNF-α) blocking therapy is important, especially in view of the costs and potential side effects of ...

    Authors: Suzanne Arends, Elisabeth Brouwer, Eveline van der Veer, Henk Groen, Martha K Leijsma, Pieternella M Houtman, Tim L Th A Jansen, Cees GM Kallenberg and Anneke Spoorenberg
    Citation: Arthritis Research & Therapy 2011 13:R94
    Content type: Research article Published on:

  43. Epigallocatechin-3-gallate (EGCG) is a bioactive polyphenol of green tea and exerts potent anti-inflammatory effects by inhibiting signaling events and gene expression. Interleukin-1beta (IL-1β) is the princip...

    Authors: Nahid Akhtar and Tariq M Haqqi
    Citation: Arthritis Research & Therapy 2011 13:R93
    Content type: Research article Published on:

  44. The mono- and digalactosyldiacylglycerol (MGDG and DGDG) galactolipids have been purified from the thermophilic blue-green alga Phormidium sp. ETS-05 that colonizes the therapeutic thermal mud of Abano Terme and ...

    Authors: Valentina Ulivi, Manuela Lenti, Chiara Gentili, Gabriele Marcolongo, Ranieri Cancedda and Fiorella Descalzi Cancedda
    Citation: Arthritis Research & Therapy 2011 13:R92
    Content type: Research article Published on:

  46. Hypoxia is a feature of the inflamed synovium in rheumatoid arthritis (RA). Intra-articular injection of hyaluronan (HA) may be considered a potential way to treat RA. However, the exact molecular mechanism of...

    Authors: Li-Wei Chou, John Wang, Pei-Lin Chang and Yueh-Ling Hsieh
    Citation: Arthritis Research & Therapy 2011 13:R90
    Content type: Research article Published on:

  47. Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic synovitis that progresses to destruction of cartilage and bone. Bone marrow (BM) cells have been shown to contribute to this ...

    Authors: Hooi-Ming Lee, Hidehiko Sugino, Chieko Aoki, Yasunori Shimaoka, Ryuji Suzuki, Kensuke Ochi, Takahiro Ochi and Norihiro Nishimoto
    Citation: Arthritis Research & Therapy 2011 13:R89
    Content type: Research article Published on:

  48. Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organ systems. Previous studies have suggested that interferon-lambda 1 (IFN-λ1), a type III interferon, plays an immunomodulatory...

    Authors: Qian Wu, Qingrui Yang, Elaine Lourenco, Hongsheng Sun and Yuanchao Zhang
    Citation: Arthritis Research & Therapy 2011 13:R88
    Content type: Research article Published on:

  49. Assessing the prevalence of, and predictors for, pathologically-confirmed inflammation of the aorta in Denmark, using a nationwide population-based study design.

    Authors: Jean Schmidt, Kaare Sunesen, Jette B Kornum, Pierre Duhaut and Reimar W Thomsen
    Citation: Arthritis Research & Therapy 2011 13:R87
    Content type: Research article Published on:

  50. Fatigue is one of the most disabling symptoms associated with fibromyalgia that greatly impacts quality of life. Fatigue was assessed as a secondary objective in a 2-phase, 24-week study in outpatients with Am...

    Authors: Lesley M Arnold, Fujun Wang, Jonna Ahl, Paula J Gaynor and Madelaine M Wohlreich
    Citation: Arthritis Research & Therapy 2011 13:R86
    Content type: Research article Published on:
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Arthritis Research & Therapy

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