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  2. Systemic lupus erythematosus (SLE) is a highly heterogeneous disorder, characterized by differences in autoantibody profile, serum cytokines, and clinical manifestations. SLE-associated autoantibodies and high...

    Authors: Silvia N Kariuki, Beverly S Franek, Akaash A Kumar, Jasmine Arrington, Rachel A Mikolaitis, Tammy O Utset, Meenakshi Jolly, Mary K Crow, Andrew D Skol and Timothy B Niewold
    Citation: Arthritis Research & Therapy 2010 12:R151
    Content type: Research article Published on:

  4. There is growing evidence that interleukin 17 (IL-17) producing T cells are involved in the pathogenesis of systemic lupus erythematosus (SLE). Previous studies showed that increased percentages of T-cell subs...

    Authors: Sebastian Dolff, Daniel Quandt, Benjamin Wilde, Thorsten Feldkamp, Fan Hua, Xin Cai, Christof Specker, Andreas Kribben, Cees GM Kallenberg and Oliver Witzke
    Citation: Arthritis Research & Therapy 2010 12:R150
    Content type: Research article Published on:

  5. Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initia...

    Authors: Sindhu T Mohanty, Lucksy Kottam, Alessandra Gambardella, Martin J Nicklin, Les Coulton, David Hughes, Anthony G Wilson, Peter I Croucher and Ilaria Bellantuono
    Citation: Arthritis Research & Therapy 2010 12:R149
    Content type: Research article Published on:

  6. The purpose of this study was theevaluation of synovial effusion (SE), synovial fluid (SF) and synovial tissue (ST) biomarkers in relation to disease activity indexes to assess the response to intraarticular (...

    Authors: Ugo Fiocco, Paolo Sfriso, Francesca Oliviero, Pascale Roux-Lombard, Elena Scagliori, Luisella Cozzi, Francesca Lunardi, Fiorella Calabrese, Maristella Vezzù, Serena Dainese, Beatrice Molena, Anna Scanu, Roberto Nardacchione, Leopoldo Rubaltelli, Jean Michel Dayer and Leonardo Punzi
    Citation: Arthritis Research & Therapy 2010 12:R148
    Content type: Research article Published on:

  7. The objective of this study was to evaluate the efficacy of intravenous (i.v.) injection of liposomally encapsulated dexamethasone phosphate (DxM-P) in comparison to free DxM-P in rats with established adjuvan...

    Authors: Rebecca Anderson, Angels Franch, Margarida Castell, Francisco J Perez-Cano, Rolf Bräuer, Dirk Pohlers, Mieczyslaw Gajda, Alexandros P Siskos, Theodora Katsila, Constantin Tamvakopoulos, Una Rauchhaus, Steffen Panzner and Raimund W Kinne
    Citation: Arthritis Research & Therapy 2010 12:R147
    Content type: Research article Published on:

  8. The TAM (tyro 3, axl, mer) kinases are key regulators of innate immunity and are important in the phagocytosis of apoptotic cells. Gas6 and protein S are ligands for these TAM kinases and bind to phosphatidyl ...

    Authors: Chang-Hee Suh, Brendan Hilliard, Sophia Li, Joan T Merrill and Philip L Cohen
    Citation: Arthritis Research & Therapy 2010 12:R146
    Content type: Research article Published on:

  9. The objective of this study was to assess natural microbial agents, history and risk factors for total joint arthroplasty (TJA) infections in patients receiving tumor necrosis factor (TNF)α-blockers, through t...

    Authors: Mélanie Gilson, Laure Gossec, Xavier Mariette, Dalenda Gherissi, Marie-Hélène Guyot, Jean-Marie Berthelot, Daniel Wendling, Christian Michelet, Pierre Dellamonica, Florence Tubach, Maxime Dougados and Dominique Salmon
    Citation: Arthritis Research & Therapy 2010 12:R145
    Content type: Research article Published on:

  10. Previous research suggests patients with rheumatoid arthritis (RA) may receive suboptimal care with respect to preventive tests and services. We evaluated the proportion of older Americans with RA, psoriatic a...

    Authors: Jeffrey R Curtis, Tarun Arora, Pongthorn Narongroeknawin, Allison Taylor, Clifton O Bingham III, Jack Cush, Kenneth G Saag, Monika Safford and Elizabeth Delzell
    Citation: Arthritis Research & Therapy 2010 12:R144
    Content type: Research article Published on:

  11. The present study objective was to evaluate the incidence of methotrexate (MTX)-specific liver lesions from the analysis of a liver biopsy of inflammatory arthritis patients with elevated liver enzymes.

    Authors: Emilie Quintin, Jean-Yves Scoazec, Hubert Marotte and Pierre Miossec
    Citation: Arthritis Research & Therapy 2010 12:R143
    Content type: Research article Published on:

  12. Anti-tumor necrosis factor (TNF)-α biotherapies have considerably changed the treatment of rheumatoid arthritis (RA). However, serious infections are a major concern in patients with rheumatic diseases treated...

    Authors: Jean-Luc Davignon, Jean-Frédéric Boyer, Bénédicte Jamard, Delphine Nigon, Arnaud Constantin and Alain Cantagrel
    Citation: Arthritis Research & Therapy 2010 12:R142
    Content type: Research article Published on:

  13. Remission was a rare event, even in the most advanced rheumatology clinics, until recent times. However, in the early 1990s, it was chosen as the treatment goal and the primary outcome measure for the Finnish ...

    Authors: Tuulikki Sokka and Heidi Mäkinen
    Citation: Arthritis Research & Therapy 2010 12:129
    Content type: Editorial Published on:

  14. Interleukin-6 (IL-6) is a key player in systemic arthritis, involved in inflammation and joint destruction. IL-6 signalling has also been revealed in nerve cells. Recently, IL-6 and in particular IL-6 together...

    Authors: Michael K Boettger, Johannes Leuchtweis, Diana Kümmel, Mieczyslaw Gajda, Rolf Bräuer and Hans-Georg Schaible
    Citation: Arthritis Research & Therapy 2010 12:R140
    Content type: Research article Published on:

  15. Although obesity is a modifiable risk factor for knee osteoarthritis (OA), the effect of weight gain on knee structure in young and healthy adults has not been examined. The aim of this study was to examine th...

    Authors: Sharon L Brennan, Flavia M Cicuttini, Julie A Pasco, Margaret J Henry, Yuanyuan Wang, Mark A Kotowicz, Geoff C Nicholson and Anita E Wluka
    Citation: Arthritis Research & Therapy 2010 12:R139
    Content type: Research article Published on:

  16. Chondroitin sulfate (CS) and glucosamine sulfate (GS) are symptomatic slow-acting drugs for osteoarthritis (OA) widely used in clinic. Despite their widespread use, knowledge of the specific molecular mechanis...

    Authors: Valentina Calamia, Cristina Ruiz-Romero, Beatriz Rocha, Patricia Fernández-Puente, Jesús Mateos, Eulàlia Montell, Josep Vergés and Francisco J Blanco
    Citation: Arthritis Research & Therapy 2010 12:R138
    Content type: Research article Published on:

  17. Dendritic cells (DCs) are capable of inducing immunity or tolerance. Previous studies have suggested plasmacytoid DCs (pDCs) are pathogenic in systemic lupus erythematosus (SLE). However, the functional charac...

    Authors: Ou Jin, Sushma Kavikondala, Mo-Yin Mok, Lingyun Sun, Jieruo Gu, Rong Fu, Albert Chan, Joseph Yeung, Yingjie Nie and Chak-Sing Lau
    Citation: Arthritis Research & Therapy 2010 12:R137
    Content type: Research article Published on:

  18. Rheumatoid arthritis (RA) is a systemic disease manifested by chronic inflammation in multiple articular joints, including the knees and small joints of the hands and feet. We have developed a unique modificat...

    Authors: Bo Tang, David L Cullins, Jing Zhou, Janice A Zawaski, Hyelee Park, David D Brand, Karen A Hasty, M Waleed Gaber, John M Stuart, Andrew H Kang and Linda K Myers
    Citation: Arthritis Research & Therapy 2010 12:R136
    Content type: Research article Published on:

  19. Interleukin-32 (IL-32) is a recently described cytokine that is a strong inducer of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, IL-1β, IL-6, and IL-8. The expression of this cytokine is h...

    Authors: Ghada Alsaleh, Laetitia Sparsa, Emmanuel Chatelus, Mathieu Ehlinger, Jacques-Eric Gottenberg, Dominique Wachsmann and Jean Sibilia
    Citation: Arthritis Research & Therapy 2010 12:R135
    Content type: Research article Published on:

  20. The purpose of this study was to investigate whether single-voxel (SV) proton magnetic resonance spectroscopy (MRS), diffusion-weighted imaging (DWI), and diffusion tensor imaging (DTI) detected differences be...

    Authors: Nicolas Fayed, Javier Garcia-Campayo, Rosa Magallón, Helena Andrés-Bergareche, Juan V Luciano, Eva Andres and Julián Beltrán
    Citation: Arthritis Research & Therapy 2010 12:R134
    Content type: Research article Published on:

  21. The purpose of this study was to investigate the profile of histone deacetylase (HDAC) expression in the synovial tissue of rheumatoid arthritis (RA) compared with that of normal control and osteoarthritis (OA...

    Authors: Tomoko Kawabata, Keiichiro Nishida, Koji Takasugi, Hiroko Ogawa, Kenei Sada, Yasutaka Kadota, Junko Inagaki, Satoshi Hirohata, Yoshifumi Ninomiya and Hirofumi Makino
    Citation: Arthritis Research & Therapy 2010 12:R133
    Content type: Research article Published on:

  22. Rheumatoid arthritis (RA) is an inflammatory disease, which results in destruction of the joint. The presence of immune complexes (IC) in serum and synovial fluid of RA patients might contribute to this articu...

    Authors: Katleen Van Steendam, Kelly Tilleman, Marlies De Ceuleneer, Filip De Keyser, Dirk Elewaut and Dieter Deforce
    Citation: Arthritis Research & Therapy 2010 12:R132
    Content type: Research article Published on:

  23. Circulating endothelial cells are increased in patients affected by systemic sclerosis (SSc) and their number strongly correlates with vascular damage. The effects of iloprost in systemic sclerosis are only pa...

    Authors: Elisa Tinazzi, Marzia Dolcino, Antonio Puccetti, Antonella Rigo, Ruggero Beri, Maria Teresa Valenti, Roberto Corrocher and Claudio Lunardi
    Citation: Arthritis Research & Therapy 2010 12:R131
    Content type: Research article Published on:

  24. Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of os...

    Authors: Timothy M Griffin, Beverley Fermor, Janet L Huebner, Virginia B Kraus, Ramona M Rodriguiz, William C Wetsel, Li Cao, Lori A Setton and Farshid Guilak
    Citation: Arthritis Research & Therapy 2010 12:R130
    Content type: Research article Published on:

  25. Interleukin (IL)-27 is a novel member of the IL-6/IL-12 family cytokines that are produced early by antigen-presenting cells in T helper (Th)1-mediated inflammation. Elevated expression of IL-27 has been detec...

    Authors: Chun K Wong, Da P Chen, Lai S Tam, Edmund K Li, Yi B Yin and Christopher WK Lam
    Citation: Arthritis Research & Therapy 2010 12:R129
    Content type: Research article Published on:

  26. Recent accumulating evidence indicates a crucial involvement of macrophage lineage in the pathogenesis of systemic sclerosis (SSc). To analyze the assembly of the monocyte/macrophage population, we evaluated t...

    Authors: Nobuyo Higashi-Kuwata, Masatoshi Jinnin, Takamitsu Makino, Satoshi Fukushima, Yuji Inoue, Faith C Muchemwa, Yuji Yonemura, Yoshihiro Komohara, Motohiro Takeya, Hiroaki Mitsuya and Hironobu Ihn
    Citation: Arthritis Research & Therapy 2010 12:R128
    Content type: Research article Published on:

  27. Osteoarthritis (OA) and rheumatoid arthritis (RA) are characterised by joint inflammation and cartilage degradation. Although mesenchymal stem cell (MSC)-like progenitors are resident in the superficial zone o...

    Authors: Constanze Buhrmann, Ali Mobasheri, Ulrike Matis and Mehdi Shakibaei
    Citation: Arthritis Research & Therapy 2010 12:R127
    Content type: Research article Published on:

  28. The microdialysis method was applied to the human knee joint with osteoarthritis (OA) in order to reveal changes in biochemical markers of cartilage and inflammation, intraarticularly and in the synovium, in r...

    Authors: Ida C Helmark, Ulla R Mikkelsen, Jens Børglum, Anders Rothe, Marie CH Petersen, Ove Andersen, Henning Langberg and Michael Kjaer
    Citation: Arthritis Research & Therapy 2010 12:R126
    Content type: Research article Published on:

  29. Total cholesterol (TC) and blood pressure (BP) are likely to take a dynamic course over time in patients with systemic lupus erythematosus (SLE). This would have important implications in terms of using single...

    Authors: Mandana Nikpour, Dafna D Gladman, Dominique Ibanez, Paula J Harvey and Murray B Urowitz
    Citation: Arthritis Research & Therapy 2010 12:R125
    Content type: Research article Published on:

  31. Joint trauma can lead to a spectrum of acute lesions, including osteochondral fractures, ligament or meniscus tears and damage to the articular cartilage. This is often associated with intraarticular bleeding ...

    Authors: Martin K Lotz
    Citation: Arthritis Research & Therapy 2010 12:211
    Content type: Review Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2010 12:408

  32. Nitric oxide (NO) has been shown to regulate T cell functions under physiological conditions, but overproduction of NO may contribute to T lymphocyte dysfunction. NO-dependent tissue injury has been implicated...

    Authors: György Nagy, Agnes Koncz, Tiffany Telarico, David Fernandez, Barbara Érsek, Edit Buzás and András Perl
    Citation: Arthritis Research & Therapy 2010 12:210
    Content type: Review Published on:

  35. Avascular necrosis of the femoral head (ANFH) occurs variably after exposure to corticosteroids. Microvascular thrombosis is a common pathological finding. Since systemic thrombophilia is only weakly linked wi...

    Authors: Mohammad Amin Kerachian, Denis Cournoyer, Edward J Harvey, Terry Y Chow, Louis R Bégin, Ayoub Nahal and Chantal Séguin
    Citation: Arthritis Research & Therapy 2010 12:R124
    Content type: Research article Published on:

  36. Previous observations suggest that active systemic juvenile idiopathic arthritis (sJIA) is associated with a prominent erythropoiesis gene-expression signature. The aim of this study was to determine the assoc...

    Authors: Claas H Hinze, Ndate Fall, Sherry Thornton, Jun Q Mo, Bruce J Aronow, Gerlinde Layh-Schmitt, Thomas A Griffin, Susan D Thompson, Robert A Colbert, David N Glass, Michael G Barnes and Alexei A Grom
    Citation: Arthritis Research & Therapy 2010 12:R123
    Content type: Research article Published on:

  37. Early treatment of rheumatoid arthritis (RA) has been shown to retard the development of joint damage for a period of up to 5 years. The aim of this study was to evaluate the radiologic progression beyond that...

    Authors: Vappu Rantalaiho, Markku Korpela, Leena Laasonen, Hannu Kautiainen, Salme Järvenpää, Pekka Hannonen, Marjatta Leirisalo-Repo, Harri Blåfield, Kari Puolakka, Anna Karjalainen and Timo Möttönen
    Citation: Arthritis Research & Therapy 2010 12:R122
    Content type: Research article Published on:

  39. Autoantibodies against mutated and citrullinated vimentin (MCV) represent a novel diagnostic marker for rheumatoid arthritis (RA). Recently, an increased sensitivity for anti-MCV compared to autoantibodies aga...

    Authors: Franziska Renger, Holger Bang, Eugen Feist, Gert Fredenhagen, Alexander Natusch, Marina Backhaus, Gerd-R Burmester and Karl Egerer
    Citation: Arthritis Research & Therapy 2010 12:R120
    Content type: Research article Published on:

  40. The objective of this study was to assess three-dimensional bone geometry and density at the epiphysis and shaft of the third meta-carpal bone of rheumatoid arthritis (RA) patients in comparison to healthy con...

    Authors: Daniel Aeberli, Prisca Eser, Harald Bonel, Jolanda Widmer, Gion Caliezi, Pierre-Alain Varisco, Burkhard Möller and Peter M Villiger
    Citation: Arthritis Research & Therapy 2010 12:R119
    Content type: Research article Published on:

  41. Intervention with mesenchymal stem cells (MSCs) represents a promising therapeutic tool in treatment-refractory autoimmune diseases. A new report by Schurgers and colleagues in a previous issue of Arthritis Resea...

    Authors: Hans U Scherer, Melissa van Pel and René EM Toes
    Citation: Arthritis Research & Therapy 2010 12:126
    Content type: Editorial Published on:

  42. Tissue fibrosis and vascular disease are hallmarks of systemic sclerosis (SSc). Transforming growth factor β (TGFβ) is a key-player in fibroblast activation and tissue fibrosis in SSc. In contrast to fibrosis,...

    Authors: Angelika Horn and Jörg HW Distler
    Citation: Arthritis Research & Therapy 2010 12:125
    Content type: Editorial Published on:

  44. The function of interleukin-18 (IL-18) was investigated in pertinent animal models of rodent rheumatoid arthritis (RA) to determine its proinflammatory and monocyte recruitment properties.

    Authors: Jeffrey H Ruth, Christy C Park, M Asif Amin, Charles Lesch, Hubert Marotte, Shiva Shahrara and Alisa E Koch
    Citation: Arthritis Research & Therapy 2010 12:R118
    Content type: Research article Published on:

  45. Tumor necrosis factor (TNF) antagonists reduce the signs and symptoms of spondyloarthritides, including ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Our objective was to evaluate the effectivenes...

    Authors: Martin Rudwaleit, Filip Van den Bosch, Martina Kron, Sonja Kary and Hartmut Kupper
    Citation: Arthritis Research & Therapy 2010 12:R117
    Content type: Research article Published on:

  46. The single nucleotide polymorphism (SNP) rs6822844 within the KIAA1109-TENR-IL2-IL21 gene cluster has been associated with rheumatoid arthritis (RA). Other variants within this cluster, including rs17388568 that ...

    Authors: Jade E Hollis-Moffatt, Michael Chen-Xu, Ruth Topless, Nicola Dalbeth, Peter J Gow, Andrew A Harrison, John Highton, Peter BB Jones, Michael Nissen, Malcolm D Smith, Andre van Rij, Gregory T Jones, Lisa K Stamp and Tony R Merriman
    Citation: Arthritis Research & Therapy 2010 12:R116
    Content type: Research article Published on:

  47. Anti-cyclic citrullinated peptide autoantibodies (anti-CCP) are the most specific serologic marker for rheumatoid arthritis (RA). Genetic polymorphisms in a citrullinating (or deiminating) enzyme, peptidyl arg...

    Authors: So-Young Bang, Tae-Un Han, Chan-Bum Choi, Yoon-Kyoung Sung, Sang-Cheol Bae and Changwon Kang
    Citation: Arthritis Research & Therapy 2010 12:R115
    Content type: Research article Published on:

  48. Intraarticular administration of autologous conditioned serum (ACS) recently demonstrated some clinical effectiveness in treatment of osteoarthritis (OA). The current study aims to evaluate the in vitro effects o...

    Authors: Marijn Rutgers, Daniël BF Saris, Wouter JA Dhert and Laura B Creemers
    Citation: Arthritis Research & Therapy 2010 12:R114
    Content type: Research article Published on:

  49. To identify independent predictors of radiographic progression in psoriatic arthritis (PsA) for patients treated with adalimumab or placebo in the Adalimumab Effectiveness in PsA Trial (ADEPT).

    Authors: Dafna D Gladman, Philip J Mease, Ernest HS Choy, Christopher T Ritchlin, Renee J Perdok and Eric H Sasso
    Citation: Arthritis Research & Therapy 2010 12:R113
    Content type: Research article Published on:

  50. Increasing evidence support the regulatory role of leptin in osteoarthritis (OA). As high circulating concentrations of leptin disrupt the physiological function of the adipokine in obese individuals, the curr...

    Authors: Stéphane Pallu, Pierre-Jean Francin, Cécile Guillaume, Pascale Gegout-Pottie, Patrick Netter, Didier Mainard, Bernard Terlain and Nathalie Presle
    Citation: Arthritis Research & Therapy 2010 12:R112
    Content type: Research article Published on:
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Arthritis Research & Therapy

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