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  1. Rheumatoid arthritis (RA) is frequently complicated with infections. The aim of our study was to evaluate vaccination response in patients with RA after B-cell depletion by using rituximab.

    Authors: Maria Rehnberg, Mikael Brisslert, Sylvie Amu, Kiandoht Zendjanchi, Gunilla HÃ¥wi and Maria I Bokarewa
    Citation: Arthritis Research & Therapy 2010 12:R111
    Content type: Research article Published on:

  2. Rheumatology patients frequently note the occurrence of stressful or traumatic life events prior to the onset of their illness and/or a relationship between stress and disease flares. For our patients, identif...

    Authors: Afton L Hassett and Daniel J Clauw
    Citation: Arthritis Research & Therapy 2010 12:123
    Content type: Editorial Published on:

  3. Neutrophils and monocytes play an important role in overt inflammation in chronic inflammatory joint diseases such as rheumatoid arthritis (RA). The sympathetic nervous system (SNS) inhibits many neutrophil/mo...

    Authors: Birgit Riepl, Susanne Grässel, Reiner Wiest, Martin Fleck and Rainer H Straub
    Citation: Arthritis Research & Therapy 2010 12:R110
    Content type: Research article Published on:

  4. T-helper (Th) lymphocytes contribute to arthritis pathogenesis by helping B cells to produce antibodies, by producing cytokines that activate effector cells involved in the destruction of cartilage and bone, a...

    Authors: Thomas Kamradt and Oliver Frey
    Citation: Arthritis Research & Therapy 2010 12:122
    Content type: Editorial Published on:

  5. Informed consent is not only for documenting a patient's acceptance of enrolling in a clinical trial. It currently is the patient's and, we propose, should also be the public's main source of information regar...

    Authors: Yusuf Yazici and Hasan Yazici
    Citation: Arthritis Research & Therapy 2010 12:121
    Content type: Commentary Published on:

  6. Infliximab is a chimeric monoclonal antibody against tumor necrosis factor alpha (TNF-α) that has been introduced recently for Behçet's disease (BD) patients who were resistant to standard treatment. The aim o...

    Authors: Antonina Accardo-Palumbo, Anna Rita Giardina, Francesco Ciccia, Angelo Ferrante, Alfonso Principato, Rosalia Impastato, Ennio Giardina and Giovanni Triolo
    Citation: Arthritis Research & Therapy 2010 12:R109
    Content type: Research article Published on:

  7. Peptidylarginine deiminases (PADs) convert arginine within a peptide (peptidylarginine) into peptidylcitrulline. Citrullination by human PADs is important in normal physiology and inflammation. Porphyromonas ging...

    Authors: Pamela Mangat, Natalia Wegner, Patrick J Venables and Jan Potempa
    Citation: Arthritis Research & Therapy 2010 12:209
    Content type: Review Published on:

  8. Systemic lupus erythematosus (SLE) is characterized by B cell hyper-activation and auto-reactivity resulting in pathogenic auto-antibody generation. The phenotypic analysis of blood B cell subsets can be used ...

    Authors: Beatriz Rodríguez-Bayona, Ana Ramos-Amaya, José J Pérez-Venegas, Carmen Rodríguez and José A Brieva
    Citation: Arthritis Research & Therapy 2010 12:R108
    Content type: Research article Published on:

  9. Type 4 phosphodiesterases (PDE4) play an important role in immune cells through the hydrolysis of the second messenger, cAMP. Inhibition of PDE4 has previously been shown to suppress immune and inflammatory re...

    Authors: Fiona E McCann, Andrew C Palfreeman, Melanie Andrews, Dany P Perocheau, Julia J Inglis, Peter Schafer, Marc Feldmann, Richard O Williams and Fionula M Brennan
    Citation: Arthritis Research & Therapy 2010 12:R107
    Content type: Research article Published on:

  10. Systemic lupus erythematosus (SLE) is a clinically and serologically complex disease that demonstrates clinical, epidemiological and genetic differences among racial and ethnic groups. Some autoantibodies are ...

    Authors: R Hal Scofield
    Citation: Arthritis Research & Therapy 2010 12:120
    Content type: Editorial Published on:

  11. The importance of mechanical signals in normal and inflamed cartilage is well established. Chondrocytes respond to changes in the levels of proinflammatory cytokines and mechanical signals during inflammation....

    Authors: Priyangi M Perera, Ewa Wypasek, Shashi Madhavan, Birgit Rath-Deschner, Jie Liu, Jin Nam, Bjoern Rath, Yan Huang, James Deschner, Nicholas Piesco, Chuanyue Wu and Sudha Agarwal
    Citation: Arthritis Research & Therapy 2010 12:R106
    Content type: Research article Published on:

  12. Standard measurements used to assess murine models of rheumatoid arthritis, notably paw thickness and clinical score, do not align well with certain aspects of disease severity as assessed by histopathology. W...

    Authors: Jeffrey D Peterson, Timothy P LaBranche, Kristine O Vasquez, Sylvie Kossodo, Michele Melton, Randall Rader, John T Listello, Mark A Abrams and Thomas P Misko
    Citation: Arthritis Research & Therapy 2010 12:R105
    Content type: Research article Published on:

  14. Lung involvement is a common extra-articular manifestation of rheumatoid arthritis (RA) that confers significant morbidity and mortality. The objective of the present study is to assess which respiratory sympt...

    Authors: Dimitrios A Pappas, Jon T Giles, Geoffrey Connors, Noah Lechtzin, Joan M Bathon and Sonye K Danoff
    Citation: Arthritis Research & Therapy 2010 12:R104
    Content type: Research article Published on:

  15. Toll-like receptors (TLRs) are involved in both innate and adaptive immune responses and are likely to play a complex role in the pathogenesis of human rheumatoid arthritis (RA) and experimental arthritis. The...

    Authors: Liesu Meng, Wenhua Zhu, Congshan Jiang, Xiaojing He, Weikun Hou, Fang Zheng, Rikard Holmdahl and Shemin Lu
    Citation: Arthritis Research & Therapy 2010 12:R103
    Content type: Research article Published on:

  19. The immune modulatory role of estrogens in inflammation is complex. Both pro- and anti-inflammatory effects of estrogens have been described. Estrogens bind both estrogen receptor (ER)α and β. The contribution...

    Authors: John Dulos, Peter Vijn, Cindy van Doorn, Claudia L Hofstra, Desiree Veening-Griffioen, Jan de Graaf, Fred A Dijcks and Annemieke MH Boots
    Citation: Arthritis Research & Therapy 2010 12:R101
    Content type: Research article Published on:

  20. Chondrocytes experience a hypertonic environment compared with plasma (280 mOsm) due to the high fixed negative charge density of cartilage. Standard isolation of chondrocytes removes their hypertonic matrix, ...

    Authors: Anna E van der Windt, Esther Haak, Ruud HJ Das, Nicole Kops, Tim JM Welting, Marjolein MJ Caron, Niek P van Til, Jan AN Verhaar, Harrie Weinans and Holger Jahr
    Citation: Arthritis Research & Therapy 2010 12:R100
    Content type: Research article Published on:

  22. Articular calcification correlates with osteoarthritis (OA) severity but its exact role in the disease process is unclear. In examining OA meniscal cell function, Sun and colleagues have shown recently that me...

    Authors: Paul A MacMullan and Geraldine M McCarthy
    Citation: Arthritis Research & Therapy 2010 12:116
    Content type: Editorial Published on:

  23. Anti-centromere antibodies (ACA) are useful biomarkers in the diagnosis of systemic sclerosis (SSc). ACA are found in 20 to 40% of SSc patients and, albeit with lower prevalence, in patients with other systemi...

    Authors: Michael Mahler, Liesbeth Maes, Daniel Blockmans, Rene Westhovens, Xavier Bossuyt, Gabriela Riemekasten, Sandra Schneider, Falk Hiepe, Andreas Swart, Irmgard Gürtler, Karl Egerer, Margrit Fooke and Marvin J Fritzler
    Citation: Arthritis Research & Therapy 2010 12:R99
    Content type: Research article Published on:

  24. Ultrasonography (US) has better sensitivity than clinical evaluation for the detection of synovitis in early rheumatoid arthritis (RA). Patients presenting with arthralgia and a positive anti-citrullinated pro...

    Authors: Lotte A van de Stadt, Wouter H Bos, Marlies Meursinge Reynders, Helen Wieringa, Franktien Turkstra, Conny J van der Laken and Dirkjan van Schaardenburg
    Citation: Arthritis Research & Therapy 2010 12:R98
    Content type: Research article Published on:

  25. Though remission is currently a treatment goal in patients with rheumatoid arthritis (RA), the number of patients who achieve and sustain remission in daily practice is still small. It is suggested that early ...

    Authors: Lydia G Schipper, Jaap Fransen, Alfons A den Broeder and Piet LCM Van Riel
    Citation: Arthritis Research & Therapy 2010 12:R97
    Content type: Research article Published on:

  26. To investigate whether accelerated hand bone mineral density (BMD) loss is associated with progressive joint damage in hands and feet in the first year of rheumatoid arthritis (RA) and whether it is an indepen...

    Authors: Melek Güler-Yüksel, Naomi B Klarenbeek, Yvonne PM Goekoop-Ruiterman, Jeska K de Vries-Bouwstra, Sjoerd M van der Kooij, Andreas H Gerards, H Karel Ronday, Tom WJ Huizinga, Ben AC Dijkmans, Cornelia F Allaart and Willem F Lems
    Citation: Arthritis Research & Therapy 2010 12:R96
    Content type: Research article Published on:

  27. The associations between leptin, interleukin (IL)-6, and hip radiographic osteoarthritis (OA) have not been reported, and their roles in obesity-related hip OA are unclear. The aim of this study was to describ...

    Authors: Oliver P Stannus, Graeme Jones, Stephen J Quinn, Flavia M Cicuttini, Dawn Dore and Changhai Ding
    Citation: Arthritis Research & Therapy 2010 12:R95
    Content type: Research article Published on:

  28. Since remission is now possible in psoriatic arthritis (PsA) we wished to examine remission rates in PsA patients following anti tumour necrosis factor alpha (TNFα) therapy and to examine possible predictors o...

    Authors: Tajvur P Saber, CT Ng, Guillaume Renard, Bernadette M Lynch, Eliza Pontifex, Ceara AE Walsh, Alexia Grier, Marian Molloy, Barry Bresnihan, Oliver FitzGerald, Ursula Fearon and Douglas J Veale
    Citation: Arthritis Research & Therapy 2010 12:R94
    Content type: Research article Published on:

  29. The purpose of this study was to evaluate the effects of L-4F, an apolipoprotein A-1 mimetic peptide, alone or with pravastatin, in apoE-/-Fas-/-C57BL/6 mice that spontaneously develop immunoglobulin G (IgG) auto...

    Authors: Jennifer MP Woo, Zhuofeng Lin, Mohamad Navab, Casey Van Dyck, Yvette Trejo-Lopez, Krystal MT Woo, Hongyun Li, Lawrence W Castellani, Xuping Wang, Noriko Iikuni, Ornella J Rullo, Hui Wu, Antonio La Cava, Alan M Fogelman, Aldons J Lusis and Betty P Tsao
    Citation: Arthritis Research & Therapy 2010 12:R93
    Content type: Research article Published on:

  30. Targeting joint destruction induced by osteoclasts (OCs) is critical for management of patients with rheumatoid arthritis (RA). Since phosphoinositide 3-kinase (PI3-K) plays a critical role in osteoclastogenes...

    Authors: Shoko Toyama, Naoto Tamura, Kazuhiko Haruta, Takeo Karakida, Shigeyuki Mori, Tetsuo Watanabe, Takao Yamori and Yoshinari Takasaki
    Citation: Arthritis Research & Therapy 2010 12:R92
    Content type: Research article Published on:

  31. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoreactive T and B cells, which are believed to be secondary to deficient dendritic cells (DCs). However, whether DC abnormalities...

    Authors: Ying J Nie, Mo Y Mok, Godfrey CF Chan, Albert W Chan, Ou Jin, Sushma Kavikondala, Albert KW Lie and Chak S Lau
    Citation: Arthritis Research & Therapy 2010 12:R91
    Content type: Research article Published on:

  32. More than half of systemic lupus erythematosus (SLE) patients show evidence of excess type I interferon (IFN-I) production, a phenotype associated with renal disease and certain autoantibodies. However, detect...

    Authors: Yi Li, Pui Y Lee, Erinn S Kellner, Matthew Paulus, Juliana Switanek, Yuan Xu, Haoyang Zhuang, Eric S Sobel, Mark S Segal, Minoru Satoh and Westley H Reeves
    Citation: Arthritis Research & Therapy 2010 12:R90
    Content type: Research article Published on:

  33. Stressful events are thought to contribute to the aetiology, maintenance and exacerbation of rheumatic diseases. Given the growing interest in acute stress responses and disease, this review investigates the i...

    Authors: Sabine JM de Brouwer, Floris W Kraaimaat, Fred CGJ Sweep, Marjonne CW Creemers, Timothy RDJ Radstake, Antoinette IM van Laarhoven, Piet LCM van Riel and Andrea WM Evers
    Citation: Arthritis Research & Therapy 2010 12:R89
    Content type: Research article Published on:

  34. A number of occupational risk factors are discussed in relation to the development and progress of knee joint diseases (for example, working in a kneeling or squatting posture, lifting and carrying heavy weigh...

    Authors: André Klussmann, Hansjürgen Gebhardt, Matthias Nübling, Falk Liebers, Emilio Quirós Perea, Wolfgang Cordier, Lars V von Engelhardt, Markus Schubert, Andreas Dávid, Bertil Bouillon and Monika A Rieger
    Citation: Arthritis Research & Therapy 2010 12:R88
    Content type: Research article Published on:

  35. Plasmacytoid dendritic cells (pDCs) play not only a central role in the antiviral immune response in innate host defense, but also a pathogenic role in the development of the autoimmune process by their abilit...

    Authors: Rie Miyamoto, Tomoki Ito, Shosaku Nomura, Ryuichi Amakawa, Hideki Amuro, Yuichi Katashiba, Makoto Ogata, Naoko Murakami, Keiko Shimamoto, Chihiro Yamazaki, Katsuaki Hoshino, Tsuneyasu Kaisho and Shirou Fukuhara
    Citation: Arthritis Research & Therapy 2010 12:R87
    Content type: Research article Published on:

  36. MicroRNAs (miRNAs), endogenous small noncoding RNAs regulating the activities of target mRNAs and cellular processes, are present in human plasma in a stable form. In this study, we investigated whether miRNAs...

    Authors: Koichi Murata, Hiroyuki Yoshitomi, Shimei Tanida, Masahiro Ishikawa, Kohei Nishitani, Hiromu Ito and Takashi Nakamura
    Citation: Arthritis Research & Therapy 2010 12:R86
    Content type: Research article Published on:

  37. Angiotensin-converting enzyme (ACE) 2, a homolog of ACE, converts angiotensin (Ang) II into Ang(1-7), and the vasoprotective effects of Ang(1-7) have been documented. We explored the hypothesis that serum auto...

    Authors: Yuko Takahashi, Shiori Haga, Yukihito Ishizaka and Akio Mimori
    Citation: Arthritis Research & Therapy 2010 12:R85
    Content type: Research article Published on:

  39. Cancer and infections are leading causes of mortality in systemic lupus erythematosus (SLE) after diseases of the circulatory system, and therefore preventing these complications is important. In this study, w...

    Authors: Jinoos Yazdany, Chris Tonner, Laura Trupin, Pantelis Panopalis, Joann Z Gillis, Aimee O Hersh, Laura J Julian, Patricia P Katz, Lindsey A Criswell and Edward H Yelin
    Citation: Arthritis Research & Therapy 2010 12:R84
    Content type: Research article Published on:

  40. Rheumatoid arthritis synovial fibroblasts (RASF) are key players in synovial pathophysiology and are therefore examined extensively in various experimental approaches. We evaluated, whether passaging during cu...

    Authors: Elena Neumann, Birgit Riepl, Anette Knedla, Stephanie Lefèvre, Ingo H Tarner, Joachim Grifka, Jurgen Steinmeyer, Jurgen Schölmerich, Steffen Gay and Ulf Müller-Ladner
    Citation: Arthritis Research & Therapy 2010 12:R83
    Content type: Research article Published on:

  41. The present study examined the effect of collagen fragments on anabolic and catabolic activities by chondrocyte/agarose constructs subjected to dynamic compression.

    Authors: Tina T Chowdhury, Ronny M Schulz, Sonpreet S Rai, Christian B Thuemmler, Nico Wuestneck, Augustinus Bader and Gene A Homandberg
    Citation: Arthritis Research & Therapy 2010 12:R82
    Content type: Research article Published on:

  42. Increasing evidence indicates that microRNAs (miRNAs) play a critical role in the pathogenesis of inflammatory diseases. The aim of the study was to investigate the expression pattern and function of miRNAs in...

    Authors: Jingyi Li, Ying Wan, Qiuye Guo, Liyun Zou, Jinyu Zhang, Yongfei Fang, Jingbo Zhang, Jinjun Zhang, Xiaolan Fu, Hongli Liu, Liwei Lu and Yuzhang Wu
    Citation: Arthritis Research & Therapy 2010 12:R81
    Content type: Research article Published on:

  43. Behçet's disease (BD) is a multisystem inflammatory disorder, in which a T-helper 1 (Th1)-polarized immune response plays a major role in the pathogenic process. We evaluated the regulatory role of natural kil...

    Authors: Yukie Yamaguchi, Hayato Takahashi, Takashi Satoh, Yuka Okazaki, Nobuhisa Mizuki, Kazuo Takahashi, Zenro Ikezawa and Masataka Kuwana
    Citation: Arthritis Research & Therapy 2010 12:R80
    Content type: Research article Published on:

  44. The efficacy and the optimal type and volume of aerobic exercise (AE) in fibromyalgia syndrome (FMS) are not established. We therefore assessed the efficacy of different types and volumes of AE in FMS.

    Authors: Winfried Häuser, Petra Klose, Jost Langhorst, Babak Moradi, Mario Steinbach, Marcus Schiltenwolf and Angela Busch
    Citation: Arthritis Research & Therapy 2010 12:R79
    Content type: Research article Published on:

  45. The aim of the present study was to investigate the association between cardiovascular risk factors and endothelial dysfunction in patients with mixed connective tissue disease (MCTD) and to determine which bi...

    Authors: Pal Soltesz, Daniel Bereczki, Peter Szodoray, Maria T Magyar, Henrietta Der, Istvan Csipo, Agota Hajas, Gyorgy Paragh, Gyula Szegedi and Edit Bodolay
    Citation: Arthritis Research & Therapy 2010 12:R78
    Content type: Research article Published on:

  46. This study is based on the results from a Belgian expanded access program in which patients with active refractory and erosive rheumatoid arthritis (RA) were treated with intravenous infusions of infliximab in...

    Authors: Bert Vander Cruyssen, Patrick Durez, Rene Westhovens and Filip De Keyser
    Citation: Arthritis Research & Therapy 2010 12:R77
    Content type: Research article Published on:

  47. We wanted to assess the importance of the levels of anti-citrullinated peptide antibody (anti-CCP) and immunoglobulin M (IgM) rheumatoid factor (RF) in predicting development of persistent arthritis from undif...

    Authors: Maria D Mjaavatten, Désirée van der Heijde, Till Uhlig, Anne J Haugen, Halvor Nygaard, Göran Sidenvall, Knut Helgetveit and Tore K Kvien
    Citation: Arthritis Research & Therapy 2010 12:R76
    Content type: Research article Published on:

  48. To determine whether IL4R single-nucleotide polymorphisms (SNPs) rs1805010 (I50V) and rs1801275 (Q551R), which have been associated with disease severity in rheumatoid arthritis (RA) patients of European ancestry...

    Authors: Paula I Burgos, Zenoria L Causey, Ashutosh Tamhane, James M Kelley, Elizabeth E Brown, Laura B Hughes, Maria I Danila, Amalia van Everdingen, Doyt L Conn, Beth L Jonas, Leigh F Callahan, Edwin A Smith, Richard D Brasington Jr, Larry W Moreland, Désirée M van der Heijde, Graciela S Alarcón…
    Citation: Arthritis Research & Therapy 2010 12:R75
    Content type: Research article Published on:

  49. Chronic nonbacterial osteomyelitis (CNO) is an inflammatory disorder of unknown etiology. In children and adolescents CNO predominantly affects the metaphyses of the long bones, but lesions can occur at any si...

    Authors: Christine Beck, Henner Morbach, Meinrad Beer, Martin Stenzel, Dennis Tappe, Stefan Gattenlöhner, Ulrich Hofmann, Peter Raab and Hermann J Girschick
    Citation: Arthritis Research & Therapy 2010 12:R74
    Content type: Research article Published on:

  50. Extracellular matrix (ECM) turnover is controlled by the synthetic rate of matrix proteins, including type I collagen, and their enzymatic degradation by matrix metalloproteinases (MMPs). Fibrosis is character...

    Authors: Laurence Goffin, Queralt Seguin-Estévez, Montserrat Alvarez, Walter Reith and Carlo Chizzolini
    Citation: Arthritis Research & Therapy 2010 12:R73
    Content type: Research article Published on:
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Arthritis Research & Therapy

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