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  1. Recently an association between a genetic variation in TRAF1/C5 and mortality from sepsis or cancer was found in rheumatoid arthritis (RA). The most prevalent cause of death, cardiovascular disease, may have been...

    Authors: Jessica AB van Nies, Rute B Marques, Stella Trompet, Zuzana de Jong, Fina AS Kurreeman, Rene EM Toes, J Wouter Jukema, Tom WJ Huizinga and Annette HM van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2010 12:R38
    Content type: Research article Published on:

  2. Urokinase-type plasminogen activator (u-PA) has been implicated in fibrinolysis, cell migration, latent cytokine activation, cell activation, T-cell activation, and tissue remodeling, all of which are involved...

    Authors: Andrew D Cook, Christine M De Nardo, Emma L Braine, Amanda L Turner, Ross Vlahos, Kerrie J Way, S Kaye Beckman, Jason C Lenzo and John A Hamilton
    Citation: Arthritis Research & Therapy 2010 12:R37
    Content type: Research article Published on:

  3. The purpose of this study was to examine the diagnostic performance of autoantibodies against citrullinated peptides/proteins (ACPA) and to determine the prevalence of HLA-DRB1 shared epitope alleles (SE) in A...

    Authors: Madeleine Singwe-Ngandeu, Axel Finckh, Sylvette Bas, Jean-Marie Tiercy and Cem Gabay
    Citation: Arthritis Research & Therapy 2010 12:R36
    Content type: Research article Published on:

  4. The long-term course of rheumatoid arthritis (RA) in terms of health status is not well understood, nor is the degree of effectiveness of biologic therapy in the community. We modeled the progression of loss o...

    Authors: Frederick Wolfe and Kaleb Michaud
    Citation: Arthritis Research & Therapy 2010 12:R35
    Content type: Research article Published on:

  5. Oxygen is a critical parameter proposed to modulate the functions of chondrocytes ex-vivo as well as in damaged joints. This article investigates the effect of low (more physiological) oxygen percentage on the bi...

    Authors: Simon Ströbel, Marko Loparic, David Wendt, Andreas D Schenk, Christian Candrian, Raija LP Lindberg, Florina Moldovan, Andrea Barbero and Ivan Martin
    Citation: Arthritis Research & Therapy 2010 12:R34
    Content type: Research article Published on:

  6. Synovial hyperplasia is a main feature of rheumatoid arthritis pathology that leads to cartilage and bone damage in the inflamed joints. Impaired apoptosis of resident synoviocytes is pivotal in this process. ...

    Authors: Samuel García, Myriam Liz, Juan J Gómez-Reino and Carmen Conde
    Citation: Arthritis Research & Therapy 2010 12:R33
    Content type: Research article Published on:

  7. Anti-neutrophil cytoplasmic antibody (ANCA) - associated vasculitis (AAV) is a life-threatening autoimmune disease characterized by an antibody-mediated glomerulonephritis and necrotizing vasculitis. Apart fro...

    Authors: Benjamin Wilde, Marielle Thewissen, Jan Damoiseaux, Pieter van Paassen, Oliver Witzke and Jan Willem Cohen Tervaert
    Citation: Arthritis Research & Therapy 2010 12:204
    Content type: Review Published on:

  8. Signal transduction pathways regulate the production and function of many cytokines implicated in immune-mediated diseases. Targeting these enzymes with small molecule inhibitors represents a fertile field for...

    Authors: Gary S Firestein
    Citation: Arthritis Research & Therapy 2010 12:109
    Content type: Editorial Published on:

  10. Tyrosine kinases are key mediators of multiple signaling pathways implicated in rheumatoid arthritis (RA). We previously demonstrated that imatinib mesylate--a Food and Drug Administration (FDA)-approved, anti...

    Authors: Ricardo T Paniagua, Anna Chang, Melissa M Mariano, Emily A Stein, Qian Wang, Tamsin M Lindstrom, Orr Sharpe, Claire Roscow, Peggy P Ho, David M Lee and William H Robinson
    Citation: Arthritis Research & Therapy 2010 12:R32
    Content type: Research article Published on:

  12. The goal of this study is to analyze the potential immunosuppressive properties of mesenchymal stem cells (MSC) on T cell proliferation and in collagen-induced arthritis (CIA). An additional aim is to investig...

    Authors: Evelien Schurgers, Hilde Kelchtermans, Tania Mitera, Lies Geboes and Patrick Matthys
    Citation: Arthritis Research & Therapy 2010 12:R31
    Content type: Research article Published on:

  14. Bisphosphonates are the most commonly used drugs for the prevention and treatment of osteoporosis. Although a recent FDA review of the results of clinical trials reported no clear link between bisphosphonates ...

    Authors: Seo Young Kim, Min Jung Kim, Suzanne M Cadarette and Daniel H Solomon
    Citation: Arthritis Research & Therapy 2010 12:R30
    Content type: Research article Published on:

  15. The interaction between the immune and skeletal systems is evidenced by the bone loss observed in autoimmune diseases such as rheumatoid arthritis. In this paper we describe a new mechanism by which the immune...

    Authors: Iannis E Adamopoulos, Cheng-chi Chao, Richard Geissler, Drake Laface, Wendy Blumenschein, Yoichiro Iwakura, Terrill McClanahan and Edward P Bowman
    Citation: Arthritis Research & Therapy 2010 12:R29
    Content type: Research article Published on:

  16. This study was undertaken to determine whether the anti-osteoarthritis drug pentosan polysulfate (PPS) influenced mesenchymal precursor cell (MPC) proliferation and differentiation.

    Authors: Peter Ghosh, Jiehua Wu, Susan Shimmon, Andrew CW Zannettino, Stan Gronthos and Silviu Itescu
    Citation: Arthritis Research & Therapy 2010 12:R28
    Content type: Research article Published on:

  17. Angiogenesis and vasculogenesis are critical in rheumatoid arthritis (RA) as they could be a key issue for chronic synovitis. Contradictory results have been published regarding circulating endothelial progeni...

    Authors: Vanina Jodon de Villeroché, Jérome Avouac, Aurélie Ponceau, Barbara Ruiz, André Kahan, Catherine Boileau, Georges Uzan and Yannick Allanore
    Citation: Arthritis Research & Therapy 2010 12:R27
    Content type: Research article Published on:

  18. Dectin-1, a pattern recognition receptor expressed by the innate immune system, is known to be a major receptor inducing Th17-type adaptive immune responses that have been demonstrated to mediate autoimmunity....

    Authors: Theo S Plantinga, Jaap Fransen, Nozomi Takahashi, Rinke Stienstra, Piet L van Riel, Wim B van den Berg, Mihai G Netea and Leo AB Joosten
    Citation: Arthritis Research & Therapy 2010 12:R26
    Content type: Research article Published on:

  20. The aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis has not been well defined. Here we review two factors which may play a role in the pathogenesis of the disease: genet...

    Authors: Lisa C Willcocks, Paul A Lyons, Andrew J Rees and Kenneth GC Smith
    Citation: Arthritis Research & Therapy 2010 12:202
    Content type: Review Published on:

  21. Management of osteoarthritis (OA) includes the use of non-pharmacological and pharmacological therapies. Although walking is commonly recommended for reducing pain and increasing physical function in people wi...

    Authors: Norman TM Ng, Kristiann C Heesch and Wendy J Brown
    Citation: Arthritis Research & Therapy 2010 12:R25
    Content type: Research article Published on:

  22. Development of cell therapies for repairing the intervertebral disc is limited by the lack of a source of healthy human disc cells. Stem cells, particularly mesenchymal stem cells, are seen as a potential sour...

    Authors: Audrey Gilson, Mathias Dreger and Jill PG Urban
    Citation: Arthritis Research & Therapy 2010 12:R24
    Content type: Research article Published on:

  23. To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be ...

    Authors: Anna Scanu, Francesca Oliviero, Lyssia Gruaz, Paolo Sfriso, Assunta Pozzuoli, Federica Frezzato, Carlo Agostini, Danielle Burger and Leonardo Punzi
    Citation: Arthritis Research & Therapy 2010 12:R23
    Content type: Research article Published on:

  24. Nucleus pulposus (NP) cells have a phenotype similar to articular cartilage (AC) cells. However, the matrix of the NP is clearly different to that of AC suggesting that specific cell phenotypes exist. The aim ...

    Authors: Ben M Minogue, Stephen M Richardson, Leo AH Zeef, Anthony J Freemont and Judith A Hoyland
    Citation: Arthritis Research & Therapy 2010 12:R22
    Content type: Research article Published on:

  25. This study aimed to investigate whether hydroxynonenal (HNE) depletion is responsible for the switch from cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) to 5-lipoxygenase-activating...

    Authors: Shu-Huang Chen, Hassan Fahmi, Qin Shi and Mohamed Benderdour
    Citation: Arthritis Research & Therapy 2010 12:R21
    Content type: Research article Published on:

  26. A food supplement containing fish oils, urtica dioica, zinc, and vitamin E (Phytalgic®) for osteoarthritis (OA) has now been tested in a placebo-controlled trial for 3 months and according to the authors has a ve...

    Authors: Robin Christensen and Henning Bliddal
    Citation: Arthritis Research & Therapy 2010 12:105
    Content type: Editorial Published on:

  27. Leptin is a peptide hormone with a role in bone metabolism and rheumatic diseases. The subchondral bone tissue plays a prominent role in the pathophysiology of osteoarthritis (OA), related to abnormal osteobla...

    Authors: Marie-Solange Mutabaruka, Mohamed Aoulad Aissa, Aline Delalandre, Martin Lavigne and Daniel Lajeunesse
    Citation: Arthritis Research & Therapy 2010 12:R20
    Content type: Research article Published on:

  29. Synovial fibroblasts from rheumatoid arthritis show resistance to apoptotic stimuli, indicating they may be difficult to treat. To clearly understand these mechanisms of resistance, rheumatoid and osteoarthrit...

    Authors: Yong-Joo Shin, Song-Hee Han, Do-Sung Kim, Geum-Hwa Lee, Wan-Hee Yoo, Yong-Mo Kang, Je-Yong Choi, Yong Chul Lee, Seoung Ju Park, Seul-Ki Jeong, Hyung-Tae Kim, Soo-Wan Chae, Hyun-Ja Jeong, Hyung-Ryong Kim and Han-Jung Chae
    Citation: Arthritis Research & Therapy 2010 12:R19
    Content type: Research article Published on:

  30. Transforming growth factor beta (TGFβ) is a growth factor with many faces. In our osteoarthritis (OA) research we have found that TGFβ can be protective as well as deleterious for articular cartilage. We postu...

    Authors: Peter M van der Kraan, Esmeralda N Blaney Davidson and Wim B van den Berg
    Citation: Arthritis Research & Therapy 2010 12:201
    Content type: Review Published on:

  31. Nuclear factor-κB (NF-κB) transcription factor regulates several cell signaling pathways, such as differentiation and inflammation, which are both altered in osteoarthritis. Inhibitor κB kinase (IKK)α and IKKβ...

    Authors: Anna Scotto d'Abusco, Laura Politi, Cesare Giordano and Roberto Scandurra
    Citation: Arthritis Research & Therapy 2010 12:R18
    Content type: Research article Published on:

  32. Fibromyalgia is a chronic pain syndrome with unknown etiology. Recent studies have shown some evidence demonstrating that oxidative stress may have a role in the pathophysiology of fibromyalgia. However, it is...

    Authors: Mario D Cordero, Manuel De Miguel, Ana M Moreno Fernández, Inés M Carmona López, Juan Garrido Maraver, David Cotán, Lourdes Gómez Izquierdo, Pablo Bonal, Francisco Campa, Pedro Bullon, Plácido Navas and José A Sánchez Alcázar
    Citation: Arthritis Research & Therapy 2010 12:R17
    Content type: Research article Published on:

  33. The objective was to evaluate the changes in S100A8 S100A9, and their complex (S100A8/S100A9) in cartilage during the onset of osteoarthritis (OA) as opposed to inflammatory arthritis.

    Authors: Hala Zreiqat, Daniele Belluoccio, Margaret M Smith, Richard Wilson, Lynn A Rowley, Katie Jones, Yogambha Ramaswamy, Thomas Vogl, Johannes Roth, John F Bateman and Christopher B Little
    Citation: Arthritis Research & Therapy 2010 12:R16
    Content type: Research article Published on:

  34. The synovium is a major target tissue in chronic arthritis and is intensively studied at the cellular and molecular level. The aim of this study was to develop flow cytometry for the quantitative analysis of s...

    Authors: Kristel B Van Landuyt, Elena A Jones, Dennis McGonagle, Frank P Luyten and Rik J Lories
    Citation: Arthritis Research & Therapy 2010 12:R15
    Content type: Research article Published on:

  35. Psoriatic arthritis (PsA) is a chronic inflammatory arthritis characterized by bone erosion mediated by osteoclasts (OC). Our previous studies showed an elevated frequency of OC precursors (OCP) in PsA patient...

    Authors: Yahui Grace Chiu, Tianmeng Shao, Changyong Feng, Kofi A Mensah, Michael Thullen, Edward M Schwarz and Christopher T Ritchlin
    Citation: Arthritis Research & Therapy 2010 12:R14
    Content type: Research article Published on:

  36. We have previously demonstrated that ex vivo inhibition of costimulatory molecules on antigen-pulsed dendritic cells (DCs) can be useful for induction of antigen-specific immune deviation and suppression of au...

    Authors: Xiufen Zheng, Motohiko Suzuki, Xusheng Zhang, Thomas E Ichim, Fei Zhu, Hong Ling, Aminah Shunnar, Michael H Wang, Bertha Garcia, Robert D Inman and Wei-Ping Min
    Citation: Arthritis Research & Therapy 2010 12:R13
    Content type: Research article Published on:

  37. Patients with tuberculosis (TB) frequently produce anti-citrullinated protein antibodies (ACPA). The objective of this study is to characterize the citrulline-dependence of the ACPA reactivity in sera of patie...

    Authors: Ori Elkayam, Refael Segal, Daniele Bendayan, Robert van Uitert, Carla Onnekink and Ger JM Pruijn
    Citation: Arthritis Research & Therapy 2010 12:R12
    Content type: Research article Published on:

  38. Cross-regulation between TNF and type I IFN has been postulated to play an important role in autoimmune diseases. Therefore, we determined the effect of TNF blockade in rheumatoid arthritis (RA) on the type I ...

    Authors: Lisa GM van Baarsen, Carla A Wijbrandts, François Rustenburg, Tineke Cantaert, Tineke CTM van der Pouw Kraan, Dominique L Baeten, Ben AC Dijkmans, Paul P Tak and Cornelis L Verweij
    Citation: Arthritis Research & Therapy 2010 12:R11
    Content type: Research article Published on:

  41. To examine the relationship between development or resolution of bone marrow lesions (BMLs) and knee cartilage properties in a 2 year prospective study of asymptomatic middle-aged adults.

    Authors: Miranda L Davies-Tuck, Anita E Wluka, Andrew Forbes, Yuanyuan Wang, Dallas R English, Graham G Giles, Richard O'Sullivan and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2010 12:R10
    Content type: Research article Published on:

  43. In this study we used a mice model of chronic arthritis to evaluate if bone fragility induced by chronic inflammation is associated with an imbalance in bone turnover and also a disorganization of the bone typ...

    Authors: Joana Caetano-Lopes, Ana M Nery, Helena Canhão, Joana Duarte, Rita Cascão, Ana Rodrigues, Inês P Perpétuo, Saba Abdulghani, Pedro M Amaral, Shimon Sakaguchi, Yrjö T Konttinen, Luís Graça, Maria F Vaz and João E Fonseca
    Citation: Arthritis Research & Therapy 2010 12:R9
    Content type: Research article Published on:

  44. To investigate whether baseline levels of anti-citrullinated protein antibody (ACPA) or IgM rheumatoid factor (IgM-RF) and changes in the year thereafter are associated with disease activity, functional and ra...

    Authors: Jennie Ursum, Wouter H Bos, Nancy van Dillen, Ben AC Dijkmans and Dirkjan van Schaardenburg
    Citation: Arthritis Research & Therapy 2010 12:R8
    Content type: Research article Published on:

  45. Nonsteroidal anti-inflammatory drugs are recommended for the relief of pain associated with hand osteoarthritis (OA) but do not alter the underlying structural changes that contribute to impaired physical func...

    Authors: H Richard Barthel, John H Peniston, Michael B Clark, Morris S Gold and Roy D Altman
    Citation: Arthritis Research & Therapy 2010 12:R7
    Content type: Research article Published on:

  46. Autoantibodies to RNA helicase A (RHA) were reported as a new serological marker of systemic lupus erythematosus (SLE) associated with early stage of the disease. Anti-RHA and other autoantibodies in Mexican S...

    Authors: Monica Vázquez-Del Mercado, Claudia A Palafox-Sánchez, Jose F Muñoz-Valle, Gerardo Orozco-Barocio, Edith Oregon-Romero, Rosa E Navarro-Hernández, Mario Salazar-Páramo, Juan Armendariz-Borunda, Jorge I Gámez-Nava, Laura Gonzalez-Lopez, Jason YF Chan, Edward KL Chan and Minoru Satoh
    Citation: Arthritis Research & Therapy 2010 12:R6
    Content type: Research article Published on:

  47. We used the data of the German biologics register RABBIT, a nationwide prospective cohort study, to investigate the risk of new or recurrent malignancy in patients with rheumatoid arthritis (RA) receiving biol...

    Authors: Anja Strangfeld, Franka Hierse, Rolf Rau, Gerd-Ruediger Burmester, Brigitte Krummel-Lorenz, Winfried Demary, Joachim Listing and Angela Zink
    Citation: Arthritis Research & Therapy 2010 12:R5
    Content type: Research article Published on:

  48. Previous studies have shown that the number of myoblastically differentiated fibroblasts known as myofibroblasts (MFs) is significantly increased in stiff joint capsules, indicating their crucial role in the p...

    Authors: Stefan G Mattyasovszky, Alexander Hofmann, Christoph Brochhausen, Ulrike Ritz, Sebastian Kuhn, Jochen Wollstädter, Hendrik Schulze-Koops, Lars P Müller, Bernhard Watzer and Pol M Rommens
    Citation: Arthritis Research & Therapy 2010 12:R4
    Content type: Research article Published on:

  49. The aim of our study was to investigate the presence of disease activity in the metatarsophalangeal (MTP) joints of the forefoot in rheumatoid arthritis (RA) patients in remission according to the Disease Acti...

    Authors: Marike van der Leeden, Martijn PM Steultjens, Dirkjan van Schaardenburg and Joost Dekker
    Citation: Arthritis Research & Therapy 2010 12:R3
    Content type: Research article Published on:

  50. The Rho family GTPase Rac1 regulates cytoskeletal rearrangements crucial for the recruitment, extravasation and activation of leukocytes at sites of inflammation. Rac1 signaling also promotes the activation an...

    Authors: Joana RF Abreu, Wendy Dontje, Sarah Krausz, Daphne de Launay, Paula B van Hennik, Anne-Marieke van Stalborch, Jean-Paul ten Klooster, Marjolein E Sanders, Kris A Reedquist, Margriet J Vervoordeldonk, Peter L Hordijk and Paul P Tak
    Citation: Arthritis Research & Therapy 2010 12:R2
    Content type: Research article Published on:
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Arthritis Research & Therapy

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