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  1. The objective of our study was to identify the significance of the subtypes of dendritic cell (DC), specifically myeloid DCs (mDCs) and plasmacytoid DCs (pDCs), in rheumatoid arthritis (RA) pathogenesis throug...

    Authors: Christophe Richez, Thierry Schaeverbeke, Chantal Dumoulin, Joël Dehais, Jean-François Moreau and Patrick Blanco
    Citation: Arthritis Research & Therapy 2009 11:R100
    Content type: Research article Published on:

  2. Rheumatoid arthritis (RA) is a heterogeneous disease and its underlying molecular mechanisms are still poorly understood. Because previous microarray studies have only focused on long-standing (LS) RA compared...

    Authors: Thierry Lequerré, Carine Bansard, Olivier Vittecoq, Céline Derambure, Martine Hiron, Maryvonne Daveau, François Tron, Xavier Ayral, Norman Biga, Isabelle Auquit-Auckbur, Gilles Chiocchia, Xavier Le Loët and Jean-Philippe Salier
    Citation: Arthritis Research & Therapy 2009 11:R99
    Content type: Research article Published on:

  3. B cells and antigen-presenting cells express a group of intracellular Toll-like receptors (TLRs) that recognize nucleic acids and can be accessed only when apoptotic debris or immune complexes are internalized...

    Authors: Zheng Liu and Anne Davidson
    Citation: Arthritis Research & Therapy 2009 11:116
    Content type: Editorial Published on:

  5. Recent guidelines pertaining to exercise for individuals with osteoarthritis have been released. These guidelines have been based primarily on studies of knee-joint osteoarthritis. The current study was focuse...

    Authors: Peter J McNair, Marion A Simmonds, Mark G Boocock and Peter J Larmer
    Citation: Arthritis Research & Therapy 2009 11:R98
    Content type: Research article Published on:

  6. Rheumatoid arthritis (RA) is more common in females than males and sex steroid hormones may in part explain this difference. We conducted a case–control study nested within two prospective studies to determine...

    Authors: Elizabeth W Karlson, Lori B Chibnik, Monica McGrath, Shun-Chiao Chang, Brendan T Keenan, Karen H Costenbader, Patricia A Fraser, Shelley Tworoger, Susan E Hankinson, I-Min Lee, Julie Buring and Immaculata De Vivo
    Citation: Arthritis Research & Therapy 2009 11:R97
    Content type: Research article Published on:

  8. The molecular mechanisms underlying cartilage destruction in osteoarthritis are poorly understood. Proteolysis is a key feature in the turnover and degradation of cartilage extracellular matrix where the focus...

    Authors: Tracey E Swingler, Jasmine G Waters, Rosemary K Davidson, Caroline J Pennington, Xose S Puente, Clare Darrah, Adele Cooper, Simon T Donell, Geoffrey R Guile, Wenjia Wang and Ian M Clark
    Citation: Arthritis Research & Therapy 2009 11:R96
    Content type: Research article Published on:

  9. Since current treatment options for patients suffering from active rheumatoid arthritis (RA) remain inadequate, especially for those unresponsive to disease-modifying antirheumatic drugs (DMARDs), new and impr...

    Authors: Jacques Tebib, Xavier Mariette, Pierre Bourgeois, René-Marc Flipo, Philippe Gaudin, Xavier Le Loët, Paul Gineste, Laurent Guy, Colin D Mansfield, Alain Moussy, Patrice Dubreuil, Olivier Hermine and Jean Sibilia
    Citation: Arthritis Research & Therapy 2009 11:R95
    Content type: Research article Published on:

  10. Tumor necrosis factor (TNF) antagonists are approved worldwide for the treatment of rheumatoid arthritis (RA). Clinical experience revealed that TNF-blocking therapy is effective for only approximately two thi...

    Authors: Cornelis L Verweij
    Citation: Arthritis Research & Therapy 2009 11:115
    Content type: Editorial Published on:

  11. Magnetic resonance imaging (MRI) may reveal rheumatoid arthritis (RA) changes in the feet when hands are normal. The purpose of this study was to determine the sensitivity, specificity, positive predictive val...

    Authors: Matthew L Mundwiler, Paul Maranian, Douglas H Brown, Jeffrey M Silverman, Daniel Wallace, Dinesh Khanna, James Louie, Daniel E Furst and Michael H Weisman
    Citation: Arthritis Research & Therapy 2009 11:R94
    Content type: Research article Published on:

  12. Glomerular microthrombosis (GMT) is a common vascular change in patients with lupus nephritis (LN). The mechanism underlying GMT is largely unknown. Although several studies have reported the association of an...

    Authors: Hui Zheng, Yi Chen, Wen Ao, Yan Shen, Xiao-wei Chen, Min Dai, Xiao-dong Wang, Yu-cheng Yan and Cheng-de Yang
    Citation: Arthritis Research & Therapy 2009 11:R93
    Content type: Research article Published on:

  13. Aggrecanase cleavage at the 392Glu-393Ala bond in the interglobular domain (IGD) of aggrecan, releasing N-terminal 393ARGS fragments, is an early key event in arthritis and joint injuries. Here, we use a quantita...

    Authors: Staffan Larsson, L Stefan Lohmander and André Struglics
    Citation: Arthritis Research & Therapy 2009 11:R92
    Content type: Research article Published on:

  14. Chemokines and their receptors control immune cell migration during infections as well as in autoimmune responses. A 32 bp deletion in the gene of the chemokine receptor CCR5 confers protection against HIV inf...

    Authors: Manuela Rossol, Matthias Pierer, Sybille Arnold, Gernot Keyßer, Harald Burkhardt, Christoph Baerwald and Ulf Wagner
    Citation: Arthritis Research & Therapy 2009 11:R91
    Content type: Research article Published on:

  15. Imaging is a helpful tool for clinicians to evaluate diseases that induce chronic joint inflammation. Chronic gout is associated with changes in joint structures that may be evaluated with diverse imaging tech...

    Authors: Fernando Perez-Ruiz, Nicola Dalbeth, Aranzazu Urresola, Eugenio de Miguel and Naomi Schlesinger
    Citation: Arthritis Research & Therapy 2009 11:232
    Content type: Review Published on:

  18. The aim was to investigate the relationship of cartilage loss (change in medial femorotibial cartilage thickness measured with magnetic resonance imaging (MRI)) with compartment-specific baseline radiographic ...

    Authors: Felix Eckstein, Wolfgang Wirth, Martin I Hudelmaier, Susanne Maschek, Wolfgang Hitzl, Bradley T Wyman, Michael Nevitt, Marie-Pierre Hellio Le Graverand and David Hunter
    Citation: Arthritis Research & Therapy 2009 11:R90
    Content type: Research article Published on:

  21. Recent epidemiologic studies have implicated smoking as an environmental risk factor for the development of rheumatoid arthritis (RA). The aim of the present study is the evaluation of the role of cigarette sm...

    Authors: Sofia S Lindblad, Piotr Mydel, Ing-Marie Jonsson, Robert M Senior, Andrej Tarkowski and Maria Bokarewa
    Citation: Arthritis Research & Therapy 2009 11:R88
    Content type: Research article Published on:

  22. Autoantibodies against C1q correlate with lupus nephritis. We compared titers of anti-C1q and anti-dsDNA in 70 systemic lupus erythematosus patients with (n = 15) or without (n = 55) subsequent biopsy-proven l...

    Authors: Olivier C Meyer, Pascale Nicaise-Roland, Nolwenn Cadoudal, Sabine Grootenboer-Mignot, Elisabeth Palazzo, Gilles Hayem, Philippe Dieudé and Sylvie Chollet-Martin
    Citation: Arthritis Research & Therapy 2009 11:R87
    Content type: Research article Published on:

  23. Racial and ethnic disparities in rates of total joint replacement have been described, but little work has been done in well-established migrant groups. The aim of this study was to compare the rates of primar...

    Authors: Yuanyuan Wang, Julie A Simpson, Anita E Wluka, Donna M Urquhart, Dallas R English, Graham G Giles, Stephen Graves and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2009 11:R86
    Content type: Research article Published on:

  24. Recent findings suggest that articular cartilage contains mesenchymal progenitor cells. The aim of this study was to examine the distribution of stem cell markers (Notch-1, Stro-1 and VCAM-1) and of molecules ...

    Authors: Shawn P Grogan, Shigeru Miyaki, Hiroshi Asahara, Darryl D D'Lima and Martin K Lotz
    Citation: Arthritis Research & Therapy 2009 11:R85
    Content type: Research article Published on:

  25. Disturbances in peripheral blood memory B cell subpopulations have been observed in various autoimmune diseases, but have not been fully delineated in rheumatoid arthritis (RA). Additionally, the possible role...

    Authors: M Margarida Souto-Carneiro, Vijayabhanu Mahadevan, Kazuki Takada, Ruth Fritsch-Stork, Toshihiro Nanki, Margaret Brown, Thomas A Fleisher, Mildred Wilson, Raphaela Goldbach-Mansky and Peter E Lipsky
    Citation: Arthritis Research & Therapy 2009 11:R84
    Content type: Research article Published on:

  26. It was previously shown that lipoxygenase (LO) pathways are important in the rheumatoid arthritis (RA) inflammatory process and that synovial fluid from RA patients contains high amounts of leukotrienes. We th...

    Authors: Karina Roxana Gheorghe, Marina Korotkova, Anca Irinel Catrina, Linda Backman, Erik af Klint, Hans-Erik Claesson, Olof RÃ¥dmark and Per-Johan Jakobsson
    Citation: Arthritis Research & Therapy 2009 11:R83
    Content type: Research article Published on:

  28. We previously described the presence of nerve growth factor receptors in the inflamed synovial compartment. Here we investigated the presence of the corresponding nerve growth factors, with special focus on ne...

    Authors: Christian Barthel, Nataliya Yeremenko, Roland Jacobs, Reinhold E Schmidt, Michael Bernateck, Henning Zeidler, Paul-Peter Tak, Dominique Baeten and Markus Rihl
    Citation: Arthritis Research & Therapy 2009 11:R82
    Content type: Research article Published on:

  29. Arthroscopy is a minimally invasive technique for retrieving synovial biopsies in rheumatology during the past 20 years. Vital for its use is continual evaluation of its safety and efficacy. Important for samp...

    Authors: Erik af Klint, Anca I Catrina, Peter Matt, Petra Neregråd, Jon Lampa, Ann-Kristin Ulfgren, Lars Klareskog and Staffan Lindblad
    Citation: Arthritis Research & Therapy 2009 11:R81
    Content type: Research article Published on:

  30. Disorders that affect glucose metabolism, namely diabetes mellitus (DM), may favor the development and/or progression of osteoarthritis (OA). Thus far, little is known regarding the ability of chondrocytes to ...

    Authors: Susana C Rosa, Juliana Gonçalves, Fernando Judas, Ali Mobasheri, Celeste Lopes and Alexandrina F Mendes
    Citation: Arthritis Research & Therapy 2009 11:R80
    Content type: Research article Published on:

  31. B cells have many different roles in systemic lupus erythematosus (SLE), ranging from autoantigen recognition and processing to effector functions (for example, autoantibody and cytokine secretion). Recent stu...

    Authors: Petar Lenert, Kei Yasuda, Liliana Busconi, Patrice Nelson, Courtney Fleenor, Radhika S Ratnabalasuriar, Peter L Nagy, Robert F Ashman, Ian R Rifkin and Ann Marshak-Rothstein
    Citation: Arthritis Research & Therapy 2009 11:R79
    Content type: Research article Published on:

  32. The purpose of this study was to evaluate serum chondroitin sulfate (CS) and hyaluronic acid (HA) levels and the capability of cartilage repair of full-thickness cartilage defects after treatment with two diff...

    Authors: Korakot Nganvongpanit, Peraphan Pothacharoen, Patama Chaochird, Kasisin Klunklin, Kanawee Warrit, Jongkolnee Settakorn, Nuttaya Pattamapaspong, Sirichai Luevitoonvechkij, Olarn Arpornchayanon, Prachya Kongtawelert and Dumnoensun Pruksakorn
    Citation: Arthritis Research & Therapy 2009 11:R78
    Content type: Research article Published on:

  33. There is a suspicion of increased risk of Epstein-Barr virus (EBV)-associated lymphoproliferations in patients with inflammatory arthritides receiving immunosuppressive drugs. We investigated the EBV load and ...

    Authors: Corinne Miceli-Richard, Nicolas Gestermann, Corinne Amiel, Jérémie Sellam, Marc Ittah, Stephan Pavy, Alejandra Urrutia, Isabelle Girauld, Guislaine Carcelain, Alain Venet and Xavier Mariette
    Citation: Arthritis Research & Therapy 2009 11:R77
    Content type: Research article Published on:

  34. Anti-TNF therapies have revolutionized the treatment of rheumatoid arthritis (RA), a common systemic autoimmune disease involving destruction of the synovial joints. However, in the practice of rheumatology ap...

    Authors: Wolfgang Hueber, Beren H Tomooka, Franak Batliwalla, Wentian Li, Paul A Monach, Robert J Tibshirani, Ronald F Van Vollenhoven, Jon Lampa, Kazuyoshi Saito, Yoshiya Tanaka, Mark C Genovese, Lars Klareskog, Peter K Gregersen and William H Robinson
    Citation: Arthritis Research & Therapy 2009 11:R76
    Content type: Research article Published on:

  35. The aim of this study was to examine seroconversion and the relationship with age and inflammation of autoantibodies in a large group of patients attending an outpatient rheumatology clinic.

    Authors: Jennie Ursum, Wouter H Bos, Rob J van de Stadt, Ben AC Dijkmans and Dirkjan van Schaardenburg
    Citation: Arthritis Research & Therapy 2009 11:R75
    Content type: Research article Published on:

  36. Osteoarthritis is characterized by the progressive destruction of cartilage in the articular joints. Novel therapies that promote resurfacing of exposed bone in focal areas are of interest in osteoarthritis be...

    Authors: Pascale Simard, Hugo Galarneau, Sébastien Marois, Daniel Rusu, Caroline D Hoemann, Patrice E Poubelle, Hani El-Gabalawy and Maria JG Fernandes
    Citation: Arthritis Research & Therapy 2009 11:R74
    Content type: Research article Published on:

  37. Patients with polymyalgia rheumatica have been shown to have an increased risk of peripheral arterial disease on longitudinal follow-up. Possible explanations for this include premature atherosclerosis related...

    Authors: Frances A Borg and Bhaskar Dasgupta
    Citation: Arthritis Research & Therapy 2009 11:111
    Content type: Editorial Published on:

  38. The rheumatoid arthritis-specific Work Productivity Survey (WPS-RA) measures the impact of rheumatoid arthritis (RA) and treatment on patient productivity within and outside the home. It contains nine question...

    Authors: Jane T Osterhaus, Oana Purcaru and Lance Richard
    Citation: Arthritis Research & Therapy 2009 11:R73
    Content type: Research article Published on:

  39. Juvenile idiopathic arthritis (JIA) is a disease characterized by chronic joint inflammation, caused by a deregulated immune response. In patients with JIA, heat shock proteins (HSPs) are highly expressed in t...

    Authors: Yvonne Vercoulen, Nienke H van Teijlingen, Ismé M de Kleer, Sylvia Kamphuis, Salvatore Albani and Berent J Prakken
    Citation: Arthritis Research & Therapy 2009 11:231
    Content type: Review Published on:

  42. During the past 10 years we have experienced very significant developments in our understanding of bone biology, and this has improved our abilities to both diagnose and treat patients with osteoporosis. This ...

    Authors: Nancy E Lane and Wei Yao
    Citation: Arthritis Research & Therapy 2009 11:228
    Content type: Review Published on:

  43. Osteoarthritis is often a progressive and disabling disease, which occurs in the setting of a variety of risk factors – such as advancing age, obesity, and trauma – that conspire to incite a cascade of pathoph...

    Authors: Steven B Abramson and Mukundan Attur
    Citation: Arthritis Research & Therapy 2009 11:227
    Content type: Review Published on:

  44. For a long time, genetic studies of complex diseases were most successfully conducted in animal models. However, the field of genetics is now rapidly evolving, and human genetics has also started to produce st...

    Authors: Emma Ahlqvist, Malin Hultqvist and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2009 11:226
    Content type: Review Published on:

  46. As the cellular component of articular cartilage, chondrocytes are responsible for maintaining in a low-turnover state the unique composition and organization of the matrix that was determined during embryonic...

    Authors: Mary B Goldring and Kenneth B Marcu
    Citation: Arthritis Research & Therapy 2009 11:224
    Content type: Review Published on:

  48. Conventional corticosteroid suspensions for the intra-articular treatment of arthritis suffer from limitations such as crystal formation or rapid clearance from the joint. The purpose of this study was to inve...

    Authors: Nicoleta Butoescu, Christian A Seemayer, Gaby Palmer, Pierre-André Guerne, Cem Gabay, Eric Doelker and Olivier Jordan
    Citation: Arthritis Research & Therapy 2009 11:R72
    Content type: Research article Published on:

  50. The major risk factor for osteoarthritis (OA) is aging, but the mechanisms underlying this risk are only partly understood. Age-related accumulation of advanced glycation end products (AGEs) can activate chond...

    Authors: Zafar Rasheed, Arivarasu N Anbazhagan, Nahid Akhtar, Sangeetha Ramamurthy, Frank R Voss and Tariq M Haqqi
    Citation: Arthritis Research & Therapy 2009 11:R71
    Content type: Research article Published on:
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Arthritis Research & Therapy

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