Evelyn Houtman received a Master’s degree in Biomedical Sciences from the University of Leiden and is currently finalizing her PhD research in the osteoarthritis group of the Biomedical Data Sciences department at the Leiden University Medical Centre (LUMC). Her PhD project focused on setting up human aged osteochondral explant models in which osteoarthritis (OA) is induced by relevant triggers such as mechanical stress, inflammation and thyroid signaling. The major strengths of this ex vivo model is that it considers aged, preserved, human tissues of a heterogeneous OA patient population prone to OA onset allowing for development of different treatment modalities. To study mechano-pathology of OA in the osteochondral compartment of aged human tissues, the model was further exploited by performing RNA sequencing after injurious mechanical stress. Her overall research goal is to translate acquired knowledge of genome wide genetic and transcriptomic datasets of human OA in reliable human biomimetic OA models. Ultimately, to advance OA clinical development towards effective disease modifying OA treatments. During her PhD, she was awarded the OARSI Belt and Road scholarship to perform a part of her research abroad at the KU Leuven. Outside of work, Evelyn enjoys cooking/baking, cycling, mountain biking, and reading fiction.
Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants
Evelyn Houtman et al.
Arthritis Research & Therapy 2021 23:215
Published on: 16 August 2021