Cortical remodeling during menopause, rheumatoid arthritis, glucocorticoid and bisphosphonate therapy
© BioMed Central Ltd 2013
Published: 21 March 2013
Bone mass, bone geometry and its changes are based on trabecular and cortical bone remodeling. Whereas the effects of estrogen loss, rheumatoid arthritis (RA), glucocorticoid (GC) and bisphosphonate (BP) on trabecular bone remodeling have been well described, the effects of these conditions on the cortical bone geometry are less known. The present review will report current knowledge on the effects of RA, GC and BP on cortical bone geometry and its clinical relevance. Estrogen deficiency, RA and systemic GC lead to enhanced endosteal bone resorption. While in estrogen deficiency and under GC therapy endosteal resorption is insufficiently compensated by periosteal apposition, RA is associated with some periosteal bone apposition resulting in a maintained load-bearing capacity and stiffness. In contrast, BP treatment leads to filling of endosteal bone cavities at the epiphysis; however, periosteal apposition at the bone shaft seems to be suppressed. In summary, estrogen loss, RA and GC show similar effects on endosteal bone remodeling with an increase in bone resorption, whereas their effect on periosteal bone remodeling may differ. Despite over 50 years of GC therapy and over 25 years of PB therapy, there is still need for better understanding of the skeletal effects of these drugs as well as of inflammatory disease such as RA on cortical bone remodeling.
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by destruction of periarticular bone and cartilage and soft-tissue damage, leading to impaired joint function . Bone erosion, periarticular osteopenia and systemic bone loss, are central features of RA . In a recent cross-sectional study we found that RA patients had thinner cortices at the shafts of the tibia, radius and metacarpal bone, and that the outer diameter of the metacarpal bone was increased. Disease severity, measured by the extent of erosions and the cumulative dose of glucocorticoids (GCs), correlated negatively with shaft cortical thickness . However, despite increased outer circumference and thinner cortical shaft, the calculated load-bearing capacity (strength strain index) of long bone shafts was not impaired in RA patients and adaptation to muscular strength remained unchanged .
In the last years, several case studies have linked RA with increased risk of bone shaft fractures at the metatarsal, tibial and femoral bones [5–7]. Since these fractures occur without previous trauma, and are not at typical locations for osteoporosis-associated fractures, they are called insufficiency or atypical fractures. The reasons for these fractures are not yet known, but associated factors are estrogen deficiency, RA, diabetes, GC therapy and treatment with anti-resorptive drugs, such as bisphosphonates (BPs). In a recent report of summarized clinical data on cases with shaft fractures associated with BP, the task force of the American Society for Bone Mineral Research  found that patients with atypical fractures of the femur had a higher number of comorbid conditions such as RA (odds ratio = 16.5) and underwent therapy with GC (odds ratio = 5.2) .
Findings of a potential association of BP with insufficiency fractures are in strong contrast to the actual therapy concept and impede the clinician's decision-making in treating RA patients on GCs with BP therapy. Hence, there is a need to elucidate the effect of RA, BP and GC (and their combination) on long-term adaptation of bone geometry and bone mineral density.
Physiology of adaptation of bone geometry
Various factors influence adaptation of bone geometry. These factors include the menopause, GC therapy and treatment with anti-resorptive drugs, as well as diseases such as RA, hyperparathyroidism, diabetes mellitus, hypophosphatasia and vitamin D deficiency and mechanical factors such as weight. In the following paragraphs, current knowledge on the main factors causing bone loss and potentially leading to fractures in patients with RA will be summarized and resulting research questions highlighted.
Estrogen loss during the menopause is the most common cause of fractures in older people. Trabecular bone loss occurs years before the menopause; at the onset of estrogen decline, a phase of rapid bone loss starts, leading to loss of an approximate mean of 10% of bone at the spine and about 5% at the hip over a period of 5 years [14, 15]. This phase is characterized by bone resorption, leading to trabecular thinning and perforation, resulting in a loss of connectivity . This initial acute phase-the high-turnover phase-is followed by a long-lasting period of slower bone loss where the dominant microarchitecture change is trabecular thinning and increased cortical porosity .
Thinning of the cortical shaft thickness of the radius and tibia is associated with an increased fracture risk . In estrogen-treated women, loss of bone strength was partially prevented  and the risk of vertebral and hip fracture incidence in postmenopausal women declined . In summary, estrogen deficiency leads to thinning and loss of bony trabeculae as well as increased endosteal resorption and impaired periosteal bone apposition, resulting in a net loss of bone with diminished strength to compression and bending.
RA is a chronic inflammatory joint disease characterized by destruction of periarticular bone and cartilage and soft-tissue damage, leading to impaired joint function . The general consensus is that the pathogenic process of bone loss in RA patients is due to the abundance of osteoclasts . Bone erosion, periarticular osteopenia and systemic bone loss are central features of RA . Chronic inflammatory diseases such as RA cause skeletal breakdown and enhance the risk of nontraumatic fractures [27, 28]. Approximately 25% of patients with early RA show an osteopenic bone mineral density at the spine or hip before the onset of therapy, and 10% have osteoporosis [29–32]. A large case-control study based on the British General Practice Research Database has shown that RA doubles the risk of hip and vertebral fractures, supporting the concept that the effect of RA is independent and additive to GC .
With a newly established protocol using peripheral quantitative computed tomography (QCT) we investigated the differences in volumetric bone mineral density (BMD) and bone geometry at the metacarpal bone, tibia and radius in 50 female RA patients and compared it with 100 healthy female controls . We found that RA patients had significantly lower trabecular volumetric BMD at the distal epiphyses of the radius (-19%), tibia (-14%) and metacarpal bone (-12%). At the shafts of these bones RA patients had thinner cortices (-7% to-16%), and at the metacarpal shaft the outer diameter was increased by 5% (Figure 2b). The extent of bone erosions and the cumulative dose of GCs correlated negatively with trabecular and total volumetric BMD as well as with shaft cortical thickness . In a subsequent study with 64 RA patients and 128 healthy controls, we assessed factors associated with differences in bone geometry between RA patients and healthy controls. Based on linear models with explanatory variables (muscle cross-sectional area, age, RA status and sex), we found that patients with RA showed a greater age-related decrease in cortical thickness with a concomitant increase in outer bone circumference consistent with an enhanced aging pattern .
These observations suggest that the biological changes of endosteal resorption and periosteal bone apposition found in healthy populations [11, 23, 34] are accelerated in patients with RA. Possible explanations for this process may be inflammation-driven endosteal resorption, which was also found in human juvenile idiopathic arthritis , experimentally induced inflammatory knee arthritis or adjuvant-induced arthritis [36–38]. Similarly, inhibition of bone resorption by the anti-receptor activator of NF-κB ligand antibody denosumab prevented metacarpal shaft bone loss in patients with RA . Periosteal bone formation has been found in human studies  and in animal studies [36–38], with one of these studies observing that periosteal bone formation occurred after the endosteal resorption, when inflammation had already subsided . This observation suggests that periosteal bone formation may be a compensatory mechanism to restore bone strength. In other words, the calculated load-bearing capacity of RA patients was not impaired and adaptation to muscular strength remained unchanged .
In summary, RA is associated with an increased endosteal bone resorption and compensatory periosteal bone formation of the affected shafts leading to a change in geometry with maintained strength. Longitudinal data for the effects of inflammation on bone geometry and volumetric BMD in patients with RA have not yet been published.
GC use, quantified either by daily or cumulative dosage, is strongly related to an increased fracture risk [40, 41]. Prednisone equivalent >5 mg daily is associated with vertebral fractures in postmenopausal women within the first 6 months of treatment . The relative risk for fractures in GC users in a general practice research database is 2.86 (95% confidence interval = 2.31 to 3.16) for the spine and 2.01 (95% confidence interval = 1.47 to 2.29) for the hip compared with subjects not using GCs . The areal BMD at the lumbar spine and hip showed an up to 12% increased bone loss in GC users compared with in nonusers of similar age and sex . A meta-analysis of the relationship between areal BMD changes and fractures showed that low areal BMD was associated with a relative risk of 1.48 for vertebral fractures and 1.41 for hip fractures . Further, it has been shown that fractures occurred at a younger age in male GC users compared with nonusers at comparable areal BMD . This finding indicates that GCs not only lead to decreased areal BMD, but fractures occur at an even higher rate than that expected based on areal BMD. One can therefore speculate that there is not only a loss in bone mass but also in bone quality in GC users. The effects of GC on bone cells include early and quick induction of osteoclastogenesis leading to in creased bone resorption as well as apoptosis of osteo blasts and osteocyts .
Histomorphometric analyses showed trabecular thinning and reduced osteoid thickness, a marker for osteoblastic activity in GC users [46, 47]. At the iliac crest, cortical porosity and Haversian canal density were higher in patients treated with GCs . Using QCT of the spine, rapid decline of vertebral trabecular volumetric BMD was found upon GC treatment with subsequent recovery following discontinuation . Thinning of the cortical shell at the distal radius was found by peripheral QCT [50, 51] and at the proximal femur by QCT . Consistent with these results, GC administration to ovariectomized sheep showed that the cortical width and cortical bone area were reduced by 7 to 8% and the marrow area increased by 8% in GC-treated animals compared with controls (Figure 2a) . Trabecular bone formation in the GC-treated animals decreased by 68% after 2 months and by 90% after 4 months. The apparent trabecular BMD and compressive stiffness were reduced by 34% and 55%, respectively. The results are consistent with a substantially reduced bone formation in the cortical and trabecular bone and reduced cortical width due to increased endosteal resorption. Impaired cortical bone remodeling together with increased cortical porosity bears the potential for increased fracture risk at appendicular bone sites such as the femur and tibia [48, 53].
In summary, BMD and bone quality are reduced upon GC treatment due to increased endosteal resorption, cortical porosity and impaired periosteal apposition. Longitudinal data on bone shaft geometry changes in GC-treated patients, however, are as yet absent.
BP therapy is the strategy of choice for prevention and treatment of bone loss and fractures associated with osteoporosis. Current clinical practice treats patients on high-dose long-term GC therapy with BP to prevent bone loss. BP therapy has been shown to reduce the relative risk for new vertebral and hip fractures in postmenopausal women by 70% and 50%, respectively, over 3 years . Indications for treatment with BPs are a quantitative estimate of the 10-year probability of a major osteoporotic fracture (clinical spine, hip, forearm or shoulder) exceeding 15 to 30% [55–57], inadequate vertebral fracture or GC therapy depending on the risk category .
BPs accumulate in the bone's hydroxyapatite mineral phase, particularly at sites of active resorption [59, 60]-where the nitrogen-containing BPs enter osteoclasts and reduce resorption by initiating early osteoclast death . Recent retro spective studies and case reports suggest that long-term BP therapy may result in the suppression of bone turn over and confer a predisposition to increased bone fragility, with an increased risk of atypical fractures . The number of atypical fractures is low-corresponding to an incidence of subtrochanteric fractures of 3 per 10,000 person-years-compared with the overall incidence of hip fractures (103 per 10,000 person-years) . Nevertheless, long-term BP use is more likely and the duration of BP use longer in patients with sub trochanteric and femoral shaft fractures compared with patients with typical osteoporotic hip fracture [63, 64]. Hip fracture incidence declined by 12.8% from 1996 to 2007, since BPs were approved, whereas the number of subtrochanteric and femoral shaft fractures remained stable or even increased in the same period . This coincidence made the US Food and Drug Administration issue an alert with a warning about the 'possible risk of rare atypical femur fractures associated with BP treatment in osteoporosis patients' .
A causal relationship between BP use and atypical femur fractures has not been established, but preclinical data evaluating the effects of BPs lend biologic plausibility to a potential association with long-term BP use. Of special interest was the finding that patients with femoral shaft fractures had a higher number of comorbid conditions-for example, diabetes mellitus, RA (odds ratio = 16.5) and concomitant use of additional antiresorptive agent (such as estrogen, raloxifene or calcitonin) or systemic GCs (odds ratio = 5.2)-than those with typical hip fractures . This association is striking since guidelines suggest treating patients with RA undergoing GC treatment with BPs, either preventative to alleviate GC-induced osteoporosis or as therapy of already established osteoporosis . In a recent longitudinal study using high-resolution computed tomography to measure the effect of alendronate treatment in postmenopausal women with low BMD, changes in trabecular and endosteal compartments at the epiphyses of tibia and radius were found . Particularly at the weight-bearing tibia, a filling of endosteal bone cavities was found with a concomitant decrease in the medullary area . At the tibia shaft, however, increased medullary area with unaltered periosteal circumference was seen in postmenopausal RA patients treated with alendronate  (Figure 2c).
In summary, the positive effects of BP therapy in reducing fracture risk are undoubted; in patients with comorbid conditions such as RA and GC use, however, BPs seem to be associated with atypical femoral fractures, for which the reason is not yet known. The recent reports of the potential association of BPs with atypical femur shaft fractures and the recommendations to treat RA patients on GCs with BP therapy are in stark contrast to the prevailing advice and therefore impede the clinician's decision-making in treating a large proportion of RA patients. Further research is needed to address these questions.
Current knowledge about the adaptation of bone shaft geometry to effects of estrogen deficiency, RA and systemic GC therapy suggests an enhanced endosteal bone resorption. While in estrogen deficiency and under GC therapy this endosteal resorption is insufficiently compensated by periosteal apposition (Figure 2a), in the RA it seems to be compensated by increased periosteal bone apposition (Figure 2b) resulting in a maintained load-bearing capacity and stiffness. BP therapy results in filling of endosteal bone cavities and hence reduction of the endosteal diameter at the epiphysis. However, periosteal apposition upon BP treatment in patients with osteoporosis has not yet been seen (Figure 2c). More so, studies elucidating the effect of BP treatment on the bone geometry of patients with RA are missing. Further, the effects of concomitant use of GCs and BPs on the bone shaft's inner and outer bone envelope are unexplored. There is a need for answering these questions, and studies that further clarify the effect of GCs and BPs (and their combination) on bone geometry and fragility will shed some light on these points.
Rheumatology key messages
Estrogen loss, RA and GC show increased endosteal resorption of bone shaft.
Periosteal bone remodeling of the bone shaft may be increased under inflammatory conditions.
Studies are needed to elucidate the effect of BP on periosteal apposition under inflammatory conditions.
bone mineral density
quantitative computed tomography
The authors would like to thank Prisca Eser for editing the manuscript.
- Stach CM, Bäuerle M, Englbrecht M, Kronke G, Engelke K, Manger B, Schett G: Periarticular bone structure in rheumatoid arthritis patients and healthy individuals assessed by high-resolution computed tomography. Arthritis Rheum. 2010, 62: 330-339.PubMedGoogle Scholar
- Kamen DL, Alele JD: Skeletal manifestations of systemic autoimmune diseases. Curr Opin Endocrinol Diabetes Obes. 2010, 17: 540-545. 10.1097/MED.0b013e328340533d.View ArticlePubMedGoogle Scholar
- Aeberli D, Eser P, Bonel H, Widmer J, Caliezi G, Varisco PA, Möller B, Villiger PM: Reduced trabecular bone mineral density and cortical thickness accompanied by increased outer bone circumference in metacarpal bone of rheumatoid arthritis patients: a cross-sectional study. Arthritis Res Ther. 2010, 12: R119-10.1186/ar3056.PubMed CentralView ArticlePubMedGoogle Scholar
- Eser P, Aeberli D, Widmer J, Möller B, Villiger PM: Abnormal bone geometry at the metacarpal bone shaft of rheumatoid arthritis patients with maintained muscle-bone relationship. Arthritis Care Res (Hoboken). 2011, 63: 383-389. 10.1002/acr.20541.View ArticleGoogle Scholar
- Kay LJ, Holland TM, Platt PN: Stress fractures in rheumatoid arthritis: a case series and case-control study. Ann Rheum Dis. 2004, 63: 1690-1692. 10.1136/ard.2003.010322.PubMed CentralView ArticlePubMedGoogle Scholar
- Shane E, Burr D, Ebeling PR, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster D, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Koval K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O'Keefe R, Papapoulos S, Sen HT, van der Meulen MC, Weinstein RS, Whyte M, American Society for Bone and Mineral Research: Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2010, 25: 2267-2294. 10.1002/jbmr.253.View ArticlePubMedGoogle Scholar
- Mäenpää HM, Soini I, Lehto MU, Belt EA: Insufficiency fractures in patients with chronic inflammatory joint diseases. Clin Exp Rheumatol. 2002, 20: 77-79.PubMedGoogle Scholar
- Girgis CM, Sher D, Seibel MJ: Atypical femoral fractures and bisphosphonate use. N Engl J Med. 2010, 362: 1848-1849. 10.1056/NEJMc0910389.View ArticlePubMedGoogle Scholar
- Seeman E: The growth and age-related origins of bone fragility in men. Calcif Tissue Int. 2004, 75: 100-109.PubMedGoogle Scholar
- Parfitt AM: The two faces of growth: benefits and risks to bone integrity. Osteoporos Int. 1994, 4: 382-398. 10.1007/BF01622201.View ArticlePubMedGoogle Scholar
- Ruff CB, Hayes WC: Subperiosteal expansion and cortical remodeling of the human femur and tibia with aging. Science. 1982, 217: 945-948. 10.1126/science.7112107.View ArticlePubMedGoogle Scholar
- Ruff CB, Hayes WC: Sex differences in age-related remodeling of the femur and tibia. J Orthop Res. 1988, 6: 886-896. 10.1002/jor.1100060613.View ArticlePubMedGoogle Scholar
- Ahlborg HG, Johnell O, Turner CH, Rannevik G, Karlsson MK: Bone loss and bone size after menopause. N Engl J Med. 2003, 349: 327-334. 10.1056/NEJMoa022464.View ArticlePubMedGoogle Scholar
- Riggs BL, Wahner HW, Melton LJ, Richelson LS, Judd HL, Offord KP: Rates of bone loss in the appendicular and axial skeletons of women. Evidence of substantial vertebral bone loss before menopause. J Clin Invest. 1986, 77: 1487-1491. 10.1172/JCI112462.PubMed CentralView ArticlePubMedGoogle Scholar
- Riggs BL, Melton LJ, Robb RA, Camp JJ, Atkinson EJ, McDaniel L, Amin S, Rouleau PA, Khosla S: A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. J Bone Miner Res. 2008, 23: 205-214.PubMed CentralView ArticlePubMedGoogle Scholar
- Eriksen EF, Hodgson SF, Eastell R, Cedel SL, O'Fallon WM, Riggs BL: Cancellous bone remodeling in type I (postmenopausal) osteoporosis: quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels. J Bone Miner Res. 1990, 5: 311-319. 10.1002/jbmr.5650050402.View ArticlePubMedGoogle Scholar
- Seeman E, Delmas PD: Bone quality-the material and structural basis of bone strength and fragility. N Engl J Med. 2006, 354: 2250-2261. 10.1056/NEJMra053077.View ArticlePubMedGoogle Scholar
- Khosla S: Update on estrogens and the skeleton. J Clin Endocrinol Metab. 2010, 95: 3569-3577. 10.1210/jc.2010-0856.PubMed CentralView ArticlePubMedGoogle Scholar
- Manolagas SC: Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. 2000, 21: 115-137. 10.1210/er.21.2.115.PubMedGoogle Scholar
- Manolagas SC, Kousteni S, Jilka RL: Sex steroids and bone. Recent Prog Horm Res. 2002, 57: 385-409. 10.1210/rp.57.1.385.View ArticlePubMedGoogle Scholar
- Clowes JA, Riggs BL, Khosla S: The role of the immune system in the pathophysiology of osteoporosis. Immunol Rev. 2005, 208: 207-227. 10.1111/j.0105-2896.2005.00334.x.View ArticlePubMedGoogle Scholar
- Vedi S, Purdie DW, Ballard P, Bord S, Cooper AC, Compston JE: Bone remodeling and structure in postmenopausal women treated with long-term, high-dose estrogen therapy. Osteoporos Int. 1999, 10: 52-58. 10.1007/s001980050194.View ArticlePubMedGoogle Scholar
- Szulc P, Seeman E, Duboeuf F, Sornay-Rendu E, Delmas PD: Bone fragility: failure of periosteal apposition to compensate for increased endocortical resorption in postmenopausal women. J Bone Miner Res. 2006, 21: 1856-1863. 10.1359/jbmr.060904.View ArticlePubMedGoogle Scholar
- Stein EM, Liu XS, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Zhang C, Yin PT, Cosman F, Nieves J, Guo XE, Shane E: Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures. J Bone Miner Res. 2010, 25: 2572-2581. 10.1002/jbmr.152.PubMed CentralView ArticlePubMedGoogle Scholar
- Cauley JA, Robbins J, Chen Z, Cummings SR, Jackson RD, LaCroix AZ, LeBoff M, Lewis CE, McGowan J, Neuner J, Pettinger M, Stefanick ML, Wactawski-Wende J, Watts NB, Women's Health Initiative Investigators: Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial. JAMA. 2003, 290: 1729-1738. 10.1001/jama.290.13.1729.View ArticlePubMedGoogle Scholar
- Gravallese EM, Harada Y, Wang JT, Gorn AH, Thornhill TS, Goldring SR: Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol. 1998, 152: 943-951.PubMed CentralPubMedGoogle Scholar
- Spector TD, Hall GM, McCloskey EV, Kanis JA: Risk of vertebral fracture in women with rheumatoid arthritis. BMJ. 1993, 306: 558-10.1136/bmj.306.6877.558.PubMed CentralView ArticlePubMedGoogle Scholar
- Bernstein CN, Blanchard JF, Leslie W, Wajda A, Yu BN: The incidence of fracture among patients with inflammatory bowel disease. A population based cohort study. Ann Intern Med. 2000, 133: 795-799.View ArticlePubMedGoogle Scholar
- Güler-Yüksel M, Bijsterbosch J, Goekoop-Ruiterman YP, de Vries-Bouwstra JK, Ronday HK, Peeters AJ, de Jonge-Bok JM, Breedveld FC, Dijkmans BA, Allaart CF, Lems WF: Bone mineral density in patients with recently diagnosed, active rheumatoid arthritis. Ann Rheum Dis. 2007, 66: 1508-1512. 10.1136/ard.2007.070839.PubMed CentralView ArticlePubMedGoogle Scholar
- Kanis JA, Burlet N, Cooper C, Delmas PD, Reginster JY, Borgstrom F, Rizzoli R, European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO): European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2008, 19: 399-428. 10.1007/s00198-008-0560-z.PubMed CentralView ArticlePubMedGoogle Scholar
- Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E: FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int. 2008, 19: 385-397. 10.1007/s00198-007-0543-5.PubMed CentralView ArticlePubMedGoogle Scholar
- Kanis JA, McCloskey EV, Johansson H, Strom O, Borgstrom F, Oden A, National Osteoporosis Guideline Group: Case finding for the management of osteoporosis with FRAX-assessment and intervention thresholds for the UK. Osteoporos Int. 2008, 19: 1395-1408. 10.1007/s00198-008-0712-1.View ArticlePubMedGoogle Scholar
- van Staa TP, Geusens P, Bijlsma JW, Leufkens HG, Cooper C: Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis. Arthritis Rheum. 2006, 54: 3104-3112. 10.1002/art.22117.View ArticlePubMedGoogle Scholar
- Russo CR, Lauretani F, Seeman E, Bartali B, Bandinelli S, Di Iorio A, Guralnik J, Ferrucci L: Structural adaptations to bone loss in aging men and women. Bone. 2006, 38: 112-118. 10.1016/j.bone.2005.07.025.View ArticlePubMedGoogle Scholar
- Roth J, Linge M, Tzaribachev N, Schweizer R, Kuemmerle-Deschner J: Musculoskeletal abnormalities in juvenile idiopathic arthritis-a 4-year longitudinal study. Rheumatology (Oxford). 2007, 46: 1180-1184. 10.1093/rheumatology/kem100.View ArticleGoogle Scholar
- Bogoch E, Gschwend N, Bogoch B, Rahn B, Perren S: Juxtaarticular bone loss in experimental inflammatory arthritis. J Orthop Res. 1988, 6: 648-656. 10.1002/jor.1100060505.View ArticlePubMedGoogle Scholar
- Bogoch E, Gschwend N, Bogoch B, Rahn B, Perren S: Changes in the metaphysis and diaphysis of the femur proximal to the knee in rabbits with experimentally induced inflammatory arthritis. Arthritis Rheum. 1989, 32: 617-624. 10.1002/anr.1780320516.View ArticlePubMedGoogle Scholar
- Yu Y, Xiong Z, Lv Y, Qian Y, Jiang S, Tian Y: In vivo evaluation of early disease progression by X-ray phase-contrast imaging in the adjuvant-induced arthritic rat. Skeletal Radiol. 2006, 35: 156-164. 10.1007/s00256-005-0026-8.View ArticlePubMedGoogle Scholar
- Sharp JT, Tsuji W, Ory P, Harper-Barek C, Wang H, Newmark R: Denosumab prevents metacarpal shaft cortical bone loss in patients with erosive rheumatoid arthritis. Arthritis Care Res (Hoboken). 2010, 62: 537-544. 10.1002/acr.20172.View ArticleGoogle Scholar
- Van Staa TP, Leufkens HG, Abenhaim L, Zhang B, Cooper C: Use of oral corticosteroids and risk of fractures. J Bone Miner Res. 2000, 15: 993-1000. 10.1359/jbmr.2000.15.6.993.View ArticlePubMedGoogle Scholar
- van Staa TP, Leufkens HG, Abenhaim L, Zhang B, Cooper C: Oral corticosteroids and fracture risk: relationship to daily and cumulative doses. Rheumatology (Oxford). 2000, 39: 1383-1389. 10.1093/rheumatology/39.12.1383.View ArticleGoogle Scholar
- van Staa TP, Leufkens HG, Cooper C: The epidemiology of corticosteroidinduced osteoporosis: a meta-analysis. Osteoporos Int. 2002, 13: 777-787. 10.1007/s001980200108.View ArticlePubMedGoogle Scholar
- Marshal l D, Johnell O, Wedel H: Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ. 1996, 312: 1254-1259. 10.1136/bmj.312.7041.1254.View ArticleGoogle Scholar
- Hayashi K, Yamamoto M, Murakawa Y, Yamauchi M, Kaji H, Yamaguchi T, Sugimoto T: Bone fragility in male glucocorticoid-induced osteoporosis is not defined by bone mineral density. Osteoporos Int. 2009, 20: 1889-1894. 10.1007/s00198-009-0901-6.View ArticlePubMedGoogle Scholar
- Compston J: Management of glucocorticoid-induced osteoporosis. Nat Rev Rheumatol. 2010, 6: 82-88. 10.1038/nrrheum.2009.259.View ArticlePubMedGoogle Scholar
- Aaron JE, Francis RM, Peacock M, Makins NB: Contrasting microanatomy of idiopathic and corticosteroid-induced osteoporosis. Clin Orthop Relat Res. 1989, 243: 294-305.PubMedGoogle Scholar
- Chappard D, Legrand E, Basle MF, Fromont P, Racineux JL, Rebel A, Audran M: Altered trabecular architecture induced by corticosteroids: a bone histomorphometric study. J Bone Miner Res. 1996, 11: 676-685.View ArticlePubMedGoogle Scholar
- Vedi S, Elkin SL, Compston JE: A histomorphometric study of cortical bone of the iliac crest in patients treated with glucocorticoids. Calcif Tissue Int. 2005, 77: 79-83. 10.1007/s00223-004-0205-y.View ArticlePubMedGoogle Scholar
- Laan RF, van Riel PL, van de Putte LB, van Erning LJ, van't Hof MA, Lemmens JA: Low-dose prednisone induces rapid reversible axial bone loss in patients with rheumatoid arthritis. A randomized, controlled study. Ann Intern Med. 1993, 119: 963-968.View ArticlePubMedGoogle Scholar
- Tsugeno H, Tsugeno H, Fujita T, Goto B, Sugishita T, Hosaki Y, Ashida K, Mitsunobu F, Tanizaki Y, Shiratori Y: Vertebral fracture and cortical bone changes in corticosteroid-induced osteoporosis. Osteoporos Int. 2002, 13: 650-656. 10.1007/s001980200088.View ArticlePubMedGoogle Scholar
- Tsugeno H, Nakai M, Okamoto M, Harada S, Mifune T, Mitsunobu F, Ashida K, Hosaki Y, Tanizaki Y, Tsuji T: Bone mineral density in steroid-dependent asthma assessed by peripheral quantitative computed tomography. Eur Respir J. 1999, 14: 923-927. 10.1034/j.1399-3003.1999.14d32.x.View ArticlePubMedGoogle Scholar
- Lian KC, Lang TF, Keyak JH, Modin GW, Rehman Q, Do L, Lane NE: Differences in hip quantitative computed tomography (QCT) measurements of bone mineral density and bone strength between glucocorticoid-treated and glucocorticoid-naive postmenopausal women. Osteoporos Int. 2005, 16: 642-650. 10.1007/s00198-004-1736-9.View ArticlePubMedGoogle Scholar
- Schorlemmer S, Ignatius A, Claes L, Augat P: Inhibition of cortical and cancellous bone formation in glucocorticoid-treated OVX sheep. Bone. 2005, 37: 491-496. 10.1016/j.bone.2005.05.002.View ArticlePubMedGoogle Scholar
- Black DM, Delmas PD, Eastell R, Reid IR, Boonen S, Cauley JA, Cosman F, Lakatos P, Leung PC, Man Z, Mautalen C, Mesenbrink P, Hu H, Caminis J, Tong K, Rosario-Jansen T, Krasnow J, Hue TF, Sellmeyer D, Eriksen EF, Cummings SR, HORIZON Pivotal Fracture Trial: Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med. 2007, 356: 1809-1822. 10.1056/NEJMoa067312.View ArticlePubMedGoogle Scholar
- Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern B, Siminoski K, Leslie WD, Scientific dvisory Council of Osteoporosis Canada: 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ. 2010, 182: 1864-1873.PubMed CentralView ArticlePubMedGoogle Scholar
- Lippune r K: Osteoporosis-whom to treat? The importance of FRAX(R) in Switzerland. Ther Umsch. 2012, 69: 207-213. 10.1024/0040-5930/a000275.View ArticleGoogle Scholar
- Dawson-Hughes B, Looker AC, Tosteson AN, Johansson H, Kanis JA, Melton LJ: The potential impact of new National Osteoporosis Foundation guidance on treatment patterns. Osteoporos Int. 2010, 21: 41-52. 10.1007/s00198-009-1034-7.View ArticlePubMedGoogle Scholar
- Hansen KE, Wilson HA, Zapalowski C, Fink HA, Minisola S, Adler RA: Uncertainties in the prevention and treatment of glucocorticoid-induced osteoporosis. J Bone Miner Res. 2011, 26: 1989-1996. 10.1002/jbmr.362.View ArticlePubMedGoogle Scholar
- Russell RG, Watts NB, Ebetino FH, Rogers MJ: Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int. 2008, 19: 733-759. 10.1007/s00198-007-0540-8.View ArticlePubMedGoogle Scholar
- Masarachia P, Weinreb M, Balena R, Rodan GA: Comparison of the distribution of 3H-alendronate and 3H-etidronate in rat and mouse bones. Bone. 1996, 19: 281-290. 10.1016/8756-3282(96)00182-2.View ArticlePubMedGoogle Scholar
- Luckman SP, Hughes DE, Coxon FP, Graham R, Russell G, Rogers MJ: Nitrogencontaining bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res. 1998, 13: 581-589. 10.1359/jbmr.19188.8.131.521.View ArticlePubMedGoogle Scholar
- Watts NB, Diab DL: Long-term use of bisphosphonates in osteoporosis. J Clin Endocrinol Metab. 2010, 95: 1555-1565. 10.1210/jc.2009-1947.View ArticlePubMedGoogle Scholar
- Kelly MP, Wustrack R, Bauer DC, Palermo L, Burch S, Peters K, Cauley J, Ensrud K, Black D: Incidence of subtrochanteric and diaphyseal fractures in older white women: data from the Study of Osteoporotic Fractures. J Bone Miner Res. 2010, 25 (Suppl 1): poster presentation FR0355-Google Scholar
- Lenart BA, Neviaser AS, Lyman S, Chang CC, Edobor-Osula F, Steele B, van der Meulen MC, Lorich DG, Lane JM: Association of low-energy femoral fractures with prolonged bisphosphonate use: a case control study. Osteoporos Int. 2009, 20: 1353-1362. 10.1007/s00198-008-0805-x.PubMed CentralView ArticlePubMedGoogle Scholar
- Wang Z, Bhattacharyya T: Trends in incidence of subtrochanteric fragility fractures and bisphosphonate use among the US elderly, 1996-2007. J Bone Miner Res. 2011, 26: 553-560. 10.1002/jbmr.233.PubMed CentralView ArticlePubMedGoogle Scholar
- US Food and Drug Administration. [http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2010/ucm229171.htm]
- Burghardt AJ, Kazakia GJ, Sode M, de Papp AE, Link TM, Majumdar S: A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover. J Bone Miner Res. 2010, 25: 2558-2571. 10.1002/jbmr.157.PubMed CentralView ArticlePubMedGoogle Scholar
- Tournis S, Samdanis V, Psarelis S, Liakou C, Antoniou J, Georgoulas T, Dontas I, Papaioannou N, Gazi S, Lyritis GP: Effect of rheumatoid arthritis on volumetric bone mineral density and bone geometry, assessed by peripheral quantitative computed tomography in postmenopausal women treated with bisphosphonates. J Rheumatol. 2012, 39: 1215-1220. 10.3899/jrheum.110579.View ArticlePubMedGoogle Scholar