Infrapatellar fat pad in the knee: is local fat good or bad for knee osteoarthritis?
© Han et al.; licensee BioMed Central Ltd. 2014
Received: 15 December 2013
Accepted: 25 June 2014
Published: 9 July 2014
Recent studies regarding the infrapatellar fat pad (IPFP) mainly focus on the roles of the cells derived from the IPFP. There have been few clinical or epidemiological studies reporting on the association between the IPFP and knee osteoarthritis (OA). Our objective is to generate hypotheses regarding the associations between IPFP maximum area and knee OA measures in older adults.
A total of 977 subjects between 50 and 80 years of age (mean, 62.4 years) participated in the study. Radiographic knee osteophyte and joint space narrowing (JSN) were assessed using the Osteoarthritis Research Society International atlas. T1- or T2-weighted fat suppressed magnetic resonance imaging (MRI) was utilized to assess IPFP maximum area, cartilage volume, cartilage defects, and bone marrow lesions (BMLs). Knee pain was assessed by self-administered Western Ontario McMaster Osteoarthritis Index (WOMAC) questionnaire.
After adjustment for potential confounders, IPFP maximum area was significantly associated with joint space narrowing (odds ratio (OR): 0.75, 95% confidence interval (CI): 0.62 to 0.91 (medial), 0.77, 95% CI: 0.62 to 0.96 (lateral)) and medial osteophytes (OR: 0.52, 95% CI: 0.35 to 0.76), knee tibial and patellar cartilage volume (β: 56.9 to 164.9 mm3/cm2, all P <0.001), tibial cartilage defects (OR: 0.58, 95% CI: 0.41 to 0.81 (medial), 0.53, 95% CI: 0.40-0.71 (lateral)), any BMLs (OR: 0.77, 95% CI: 0.63 to 0.94), and knee pain on a flat surface (OR: 0.79, 95% CI: 0.63 to 0.98). IPFP maximum area was negatively, but not significantly, associated with femoral cartilage defects, lateral tibiofemoral BMLs, and total knee pain or other knee pain subscales.
IPFP maximum area is beneficially associated with radiographic OA, MRI structural pathology and knee pain on a flat surface suggesting a protective role for IPFP possibly through shock absorption. Consequently, we must pay special attention to IPFP in the clinical settings, avoiding resection of normal IPFP in knee surgery.
Osteoarthritis (OA), the most prevalent form of arthritis, is a common cause of chronic disability in older adults. It can affect one or more joints of the body but is most common in the knees. Traditionally, it is characterized by loss of articular cartilage and formation of osteophytes; however, evidence has emerged that OA involves the entire joint tissues, including the menisci, ligaments, subchondral bone, capsule, synovium, and periarticular muscle[2, 3]. Although the pathogenesis of knee OA is not fully elucidated, both mechanical and metabolic factors play roles in the progression of this disease[1, 2]. Age, female sex, and body mass index (BMI) are well-known risk factors for knee OA.
Infrapatellar fat pad (IPFP), an intracapsular but extrasynovial structure, is situated in the knee under the patella, between the patellar tendon, femoral condyle and tibial plateau, and is structurally similar to subcutaneous adipose tissue. Recent studies[10, 11] mainly focus on the roles of the cells derived from IPFP, such as inflammatory cells and substance P nerve cells in OA, and consider IPFP as an active joint tissue in the initiation and progression of knee OA, as inflammatory cells from IPFP can produce inflammatory mediators, which are able to influence the cartilage and synovium metabolism, and substance P nerve could be an important source of pain in knee OA. IPFP is commonly resected during knee surgery; however, IPFP locates so closely to cartilage and bone surface that it may reduce the impact loading and absorb forces generated through the knee joint. So far, there have been few clinical or epidemiological studies reporting the association between IPFP and knee OA measures, so the role of IPFP in knee OA is largely unknown.
Clinical features (such as joint pain) and joint structural abnormalities such as joint space narrowing (JSN), osteophytes, loss of cartilage volume, cartilage defects and bone marrow lesions (BMLs) are usually used to assess development/progression of knee OA. The aim of this study was, therefore, to generate hypotheses regarding the associations between symptoms, joint structural abnormalities and IPFP area in older adults.
This study was conducted as part of the Tasmanian Older Adult Cohort (TASOAC) study, an ongoing prospective, population-based study aimed at identifying the environmental, genetic, and biochemical factors associated with the development and progression of OA (assessed by both radiography and magnetic resonance imaging (MRI)). Subjects (n = 1,100) between the age of 50 and 80 years were randomly selected from the roll of electors in southern Tasmania (population, 229,000), a comprehensive population listing with an equal number of men and women. The overall response rate was 57%. Institutionalized persons and subjects with contraindications to MRI were excluded. The study was approved by the Southern Tasmanian Health and Medical Human Research Ethics Committee, and written informed consent was obtained from all participants. Self-report of diseases including asthma, cardiovascular disease, diabetes, and rheumatoid arthritis was recorded by questionnaire.
Anthropometrics and joint pain assessment
Height was measured to the nearest 0.1 cm (with shoes, socks, and headgear removed) using a stadiometer. Weight was measured to the nearest 0.1 kg (with shoes, socks, and bulky clothing removed) by using a single pair of electronic scales (Delta Model 707, Seca, Hamburg, Germany) that were calibrated using a known weight at the beginning of each clinic. BMI (weight (kg)/height (m2)) was also calculated. Total body and trunk fat were measured by a Hologic dual-energy x-ray absorptiometry (DXA) scanner (Hologic Corp., Waltham, MA, USA).
The assessment of knee pain (on a flat surface, going up/down stairs, at night, sitting/lying, and standing upright) was self-administered, using the Western Ontario McMaster Osteoarthritis Index (WOMAC) with a 10-point scale from 0 (no pain, stiffness, or functional problems) to 9 (most severe). Each compartment of joint pain was summed to create a total pain score (0 to 45), and the presence of knee pain was defined as a total score or a subscale score ≥1[15, 16].
Lower-limb muscle strength and knee radiographic assessments
We used dynamometry to measure lower-limb muscle strength twice, and took the mean as the final result, as previously described[17, 18]. A standing anteroposterior semiflexed view of the right knee with 15 degrees of fixed-knee flexion was performed in all subjects, and radiographs were individually assessed for JSN and osteophytes on a scale of 0 to 3 (0 = normal and 3 = most severe) using the Osteoarthritis Research Society International (OARSI) atlas developed by Altman et al.. We summed the osteophyte and JSN scores as the knee total radiographic OA (ROA) score; an ROA score ≥1 was used to define the presence of knee ROA, as previously described.
Magnetic resonance imaging assessment
Knee cartilage volume was determined on T1-weighted MR images with image processing on an independent work station, as previously described[17, 18, 21]. The total cartilage volume was divided into patellar, medial and lateral tibial cartilage volume by manually drawing disarticulation contours around the cartilage boundaries, section by section, which were then re-sampled for the final three-dimensional rendering[17, 18]. The coefficients of variation (CVs) for this method in our hands were 2.1% to 2.6%[17, 18].
Cartilage defects (0 to 4 scale) were assessed at the medial tibial, medial femoral, lateral tibial, lateral femoral, and patellar sites using T1-weighted images as previously described[22, 23] and were further confirmed using T2-weighted images as follows: grade 0 = normal cartilage; grade 1 = focal blistering and intracartilaginous low-signal intensity area with an intact surface; grade 2 = irregularities on the surface or bottom and loss of thickness <50%; grade 3 = deep ulceration with loss of thickness >50%; grade 4 = full-thickness chondral wear with exposure of subchondral bone. The presence of cartilage defect was defined as a cartilage defect score ≥2 at one site. Intraobserver reliability was 0.89 to 0.94 and interobserver reliability was 0.85 to 0.93[22, 24]. Subchondral BMLs were defined as discrete areas of increased signal adjacent to the subcortical bone at the medial and lateral tibia and femur on T2-weighted MR images using a semiquantitative (0 to 3 scale) scoring system. The intraobserver reliability ranged between 0.89 to 1.00, as previously described. Tibial plateau bone area was determined by manually measuring on axial T1-weighted MR images, as previously described.
Patellofemoral synovitis was graded semiquantitatively from 0 to 3 in terms of the signal alterations in IPFP on T2-weighted MR images at the superior edge of the fat pad adjacent to the patella. Intraobserver reliability was assessed in 40 subjects with an ICC of 0.91.
Serum biomarker measurements
Partial correlation analyses were used to examine the associations between knee cartilage volume and IPFP area, and between total tibial bone area and IPFP area. Multivariable linear regression was used to analyze the associations of IFPF area (the dependent variable) with an independent variable (age, sex, height, weight, BMI, body fat, trunk fat, leg muscle strength, patellofemoral synovitis, leptin, IL-6 or TNF-α) after adjustment for the following covariates except itself: age, sex, height (not for BMI), weight (not for BMI, fat measures), tibial bone size, disease status (diabetes, cardiovascular diseases, asthma, rheumatoid arthritis) and ROA. Univariable and multivariable linear regression analyses were used to examine the associations between knee cartilage volume/total BML score (the dependent variable) and IPFP area (the independent variable) before and after adjustment for age, sex, height, weight, tibial bone size, patellofemoral synovitis and disease status, and further ROA. Univariable and multivariable binary logistic regression analyses were used to examine the associations between IPFP area (the independent variable) and a dependent variable (knee cartilage defects, knee JSN, osteophytes, tibial or femoral BMLs, or WOMAC knee pain) before or after adjustment for the same covariates. Interactions between sex or ROA and IPFP area were investigated by regressing cartilage volume (or others, for example, BMLs) on a binary (0/1) term for sex (or ROA) within IPFP, and assessed by testing the statistical significance of the coefficient of a (sex × IPFP) or a (ROA × IPFP) product term.
Adjustments for multiple testing on regression results were undertaken using the Hochberg method. A P-value <0.05 (2-tailed) or a 95% CI not including the null point (for linear regression) or 1 (for logistic regression) was considered as statistically significant. All statistical analyses were performed using SPSS version 20.0 for Windows (SPSS Inc., Chicago, IL, USA).
Baseline characteristics of participants (n = 977)
Sex, female, n (%)
Total body fat, kg
Medial tibial cartilage volume, ml
Lateral tibial cartilage volume, ml
Patella cartilage volume, ml
Medial tibial bone area, cm2
Lateral tibial bone area, cm2
Medial joint space narrowing, n (%)
Lateral joint space narrowing, n (%)
MTF osteophytes, n (%)
LTF osteophytes, n (%)
BML present, n (%)
MTF cartilage defects, n (%)
LTF cartilage defects, n (%)
Patellar cartilage defects, n (%)
Total WOMAC knee pain, n (%)
Patellofemoral synovitis, n (%)
In multivariable analyses, IPFP area was significantly and positively associated with age (β: 1.58, 95% CI: 0.80, 2.35), height (β: 6.42, 95% CI: 5.46, 7.38), weight (β: 0.90, 95% CI: 0.47, 1.34), and negatively associated with female sex (β: -42.59, 95% CI: -59.13, -26.04) after adjustment for covariates. IPFP area was neither associated with BMI, body fat, trunk fat, leg muscle strength and patellofemoral synovitis, nor with leptin, IL-6 and TNF-α (data not shown).
Association between IPFP area and radiographic osteoarthritis
Odds ratio (95% CI)
Odds ratio (95% CI)
MTF joint space narrowing
0.75 (0.62, 0.91)
LTF joint space narrowing
0.77 (0.62, 0.96)
Associations between IPFP area, cartilage volume and cartilage defects
Cartilage volume, β (95% CI)
Medial tibial, ml/cm2
0.27 (0.24, 0.30)
0.09 (0.05, 0.13)
0.06 (0.02, 0.10)
Lateral tibial, ml/cm2
0.34 (0.31, 0.37)
0.11 (0.07, 0.16)
0.08 (0.04, 0.13)
0.44 (0.39, 0.48)
0.20 (0.14, 0.26)
0.16 (0.10, 0.23)
Cartilage defects, odds ratio (95% CI)
1.15 (0.96, 1.37)
0.72 (0.53, 0.96)
0.58 (0.41, 0.81)
1.04 (0.91, 1.19)
0.98 (0.79, 1.22)
0.93 (0.74, 1.18)
1.00 (0.87, 1.15)
0.66 (0.52, 0.84)
0.53 (0.40, 0.71)
1.22 (1.03, 1.45)
0.84 (0.63, 1.11)
0.73 (0.53, 1.00)
0.96 (0.86, 1.07)
0.91 (0.76, 1.09)
0.84 (0.69, 1.02)
Associations between IPFP area and bone marrow lesions
TF bone marrow lesions, OR (95% CI)
0.83 (0.67, 1.02)
0.93 (0.75, 1.16)
Tibial bone marrow lesions, OR (95% CI)
0.87 (0.68, 1.10)
Femoral bone marrow lesions, OR (95% CI)
0.69 (0.53, 0.92)
0.89 (0.69, 1.13)
Any bone marrow lesions, OR (95% CI)
1.11 (1.00, 1.24)
0.83 (0.69, 0.99)
Bone marrow lesions total score, β (95% CI) (cm 2 /grade)
0.04 (0.01, 0.08)
-0.08 (-0.14, -0.02)
Associations between IPFP area and prevalent WOMAC knee pain
Odds ratio (95% CI)
Odds ratio (95% CI)
Odds ratio (95% CI)
Total WOMAC knee pain
0.94 (0.84, 1.04)
0.84 (0.70, 1.00)
0.86 (0.71, 1.04)
Pain on flat surface
0.99 (0.88, 1.12)
0.80 (0.65, 0.98)
0.79 (0.63, 0.98)
Pain on stairs
0.93 (0.83, 1.03)
0.81 (0.67, 0.97)
0.83 (0.69, 1.01)
Pain in bed
0.93 (0.82, 1.04)
0.87 (0.71, 1.05)
0.83 (0.68, 1.03)
Pain when sitting
0.94 (0.83, 1.06)
0.89 (0.73, 1.09)
0.87 (0.70, 1.08)
Pain when standing
1.07 (0.95, 1.20)
1.03 (0.85, 1.26)
0.96 (0.78, 1.19)
There were no significant interactions between sex and IPFP area or between radiographic OA and IPFP area on the outcomes (cartilage volume, cartilage defects, BMLs) (data not shown) so male and female subjects or participants with and without radiographic OA were combined for analyses. The results remained largely unchanged when subjects with rheumatoid arthritis were excluded for analyses (data not shown). All associations (except the association with knee pain) remained significant after adjustment for multiple comparisons (data not shown).
To our knowledge, this cross-sectional study is the first to report the significant associations between IPFP area and clinical and structural abnormalities of the knee joint in older people. We found consistent evidence that IPFP area was beneficially associated with radiographic OA, knee structural abnormalities and pain. This was independent of patellofemoral synovitis, body size, tibial bone area and other covariates, suggesting IPFP area has an important protective role in knee OA.
In a previous study, Chuckpaiwong et al. measured IPFP volume using MRI in a cohort of 15 control subjects and 15 knee OA subjects, and reported that BMI was not significantly associated with IPFP volume in either the control or the OA group, and age was significantly and positively associated with IPFP volume in the OA group and the whole cohort. Our findings on age and BMI were consistent with this study, but we found that weight and height, measures of body size rather than obesity status, were significantly and positively associated with IPFP area. Furthermore, we found that women had a smaller IPFP area than men, and a larger tibial bone area (a measure of knee size) was associated with greater IPFP area, providing support for the construct validity of IPFP area measurement. All these factors (except for BMI) were used as adjusting variables in our analyses.
Body mass and/or fat are considered strong risk factors for knee OA. However, the role of regional fat is much less clear. The major adipose tissue in the knee joint is IPFP, and in vitro and animal studies have reported that IPFP can produce inflammatory cytokines and adipokines that may have detrimental effects on cartilage in knee OA[30–32]; in contrast, a meeting abstract reported that in mice, although high-fat diet increased IPFP volume, the adipocytes in the IPFP did not become hypertrophic. IPFP adipocytes may be protected from obesity-induced macrophage infiltration and inflammation, suggesting that IPFP is not a source of microphage-mediated inflammation in a diet-induced obese model of early-onset knee OA. A recent study reported that medium conditioned by IPFP from end-stage OA inhibited nitric oxide (NO) production as well as matrix metalloproteinase (MMP)-1, MMP-3 and collagen type II gene expression, and thus may contribute to the inhibition of cartilage catabolism. Considering the intra-articular position of the IPFP with a flexible and displaceable structure, IPFP is likely to absorb force and reduce overloading of the knee joint, and have a protective effect on the knee.
Chuckpaiwong et al. reported that there was no difference in IPFP volume between control and OA groups, possibly due to a small sample size. In contrast, we found that IPFP area was significantly and beneficially associated with cartilage volume and cartilage defects in the current study. Additionally, IPFP area was associated with decreased presence of JSN, an indirect estimate of cartilage loss on radiography, in both medial and lateral tibiofemoral compartments. While these data are cross-sectional, they provide very consistent evidence in support of a protective effect of local joint fat on articular cartilage, which is opposite to the effects of systematic fat. We found that IPFP area was not associated with systematic fat mass, and metabolic and inflammatory biomarkers, all of which were associated with increased knee symptoms and cartilage loss[15, 27, 28, 36]. This suggests that systemic metabolic changes do not necessarily affect the size of IPFP.
The commonest subchondral bone abnormalities in knee OA are osteophytes and BMLs. Both are associated with knee pain, cartilage defects and cartilage loss, and need for total knee replacement. In this study we reported that osteophytes and BMLs were negatively associated with IPFP area, particularly in the medial compartment. These findings further support that IPFP is protective against knee structural changes in OA.
Abnormalities of some joint structures, such as subchondral bone, capsule, ligaments, meniscus and synovium, have been associated with knee pain. It has been suggested that the sensory nerves located in these joint tissues can release substance P, calcitonin gene-related peptide (CGRP), neuropeptide Y and vasoactive intestinal peptide (VIP) into the local microenvironment, which act as the signals of pain. IPFP has been regarded as an important source of pain in knee OA as it contains substance P nerve; however, the association between IPFP and knee pain has not been clarified, though a previous study reported that IPFP volume was not associated with knee pain. Our current study demonstrated that the IPFP area was associated with decreased presence of knee pain when walking on a flat surface and, and to a lesser extent, pain when walking upstairs/downstairs, which is opposite to what was expected, thus it had a protective effect on mechanical knee pain, which is biologically plausible.
The reasons underlying the protective effects of IPFP on joint structures and symptoms are unclear. It may be that some biochemical factors secreted from IPFP are protective, because it has been shown that medium conditioned by OA IPFP inhibits catabolic processes in cartilage; it may most likely be due to the shock-absorbing nature of IPFP. As we know, biomechanical factors, especially abnormal mechanical stress/loading, play an important role in the initiation and progression of OA. IPFP may have the same function as meniscus that can reduce mechanical overloading (especially in knee flexion) and absorb shock (an alteration in the environment of the joint, which can lead to cartilage degradation) through the joint. Additionally, IPFP, having the same anatomical location as the patellar ligament around the joint, may reduce instability and injury to the joint, and thus prevent the onset and progression of OA. Based on these finding, we conclude that IPFP, especially its size, plays a beneficial rather than detrimental role in the initiation or progression of OA. In the clinical setting, the IPFP is often deliberately partially or totally resected for clear visualization of the joint for the surgeons. This study suggests this may be deleterious.
The main strength of this study is that we selected participants randomly from the community, with a large sample size, and obtained both structural and symptomatic measurements. This study has several potential limitations. First, this study measured IPFP area on two-dimensional T2-weighted MRI, rather than IPFP volume on three-dimensional T1-weighted MRI. However, the boundary of IPFP on two-dimensional T2-weighted MRI is clearer than that on three-dimensional T1-weighted MRI; also IPFP area was highly correlated to IPFP volume in our analysis (r = 0.87) (unpublished data). IPFP volume measurement is also time-consuming. We did not measure IPFP quality, such as edema and fibrosis, which may be associated with the progression of OA. Second, measurement error may influence results. However, all measures were highly reproducible suggesting this is unlikely. Third, a large number of statistical tests have been performed, which may induce false positive results due to multiple testing; however, almost all significant associations remained after adjustment for multiple comparisons. Though the associations between IPFP area and knee pain did not pass the Hochberg correction, the consistent associations with weight-bearing knee pain subscales (walking on a flat surface and going up/down stairs) suggest the findings are biologically plausible, and may not be false positives. Last, the cross-sectional nature of this study precludes any inference about cause and effect relationships. Longitudinal studies are needed to address causality.
In conclusion, IPFP maximum area is beneficially associated with radiographic OA, MRI structural pathology and knee pain on a flat surface, suggesting a protective role for IPFP, possibly through shock absorption. Consequently, we must pay special attention to IPFP in the clinical setting, avoiding resection of normal IPFP in knee surgery.
body mass index
bone marrow lesion
coefficient of variation
infrapatellar fat pad
joint space narrowing
magnetic resonance imaging
Osteoarthritis Research Society International
tumor necrosis factor-α
Western Ontario McMaster Osteoarthritis Index.
We especially thank the participants who made this study possible, and we gratefully acknowledge the role of the staff and volunteers in collecting the data, particularly research nurses C Boon and P Boon. R Warren assessed MR images and Dr G Zhai scored bone marrow lesions. Dr V Srikanth and Dr H Cooley assessed radiographs. This study was supported by the National Health and Medical Research Council of Australia; Arthritis Foundation of Australia; Tasmanian Community Fund; Masonic Centenary Medical Research Foundation, Royal Hobart Hospital Research Foundation, and University of Tasmania Institutional Research Grants Scheme. G Jones is supported by a National Health and Medical Research Council Practitioner Fellowship. D Aitken is supported by a National Health and Medical Research Council Early Career Fellowship. C Ding is supported by an Australian Research Council Future Fellowship.
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