Volume 12 Supplement 1

The role of IFN alpha in autoimmune disease

Reviews

Edited by Jean-Michel Dayer

Publication of the supplement has been supported with funding from MedImmune, LLC.

  1. Review

    Overview of the biology of type I interferons

    Type I interferons are pleiotropic cytokines with antiviral, antitumor and immunoregulatory functions. An aspect of their complex biology is the paradox that, depending on context, type I interferons can be an...

    George D Kalliolias and Lionel B Ivashkiv

    Arthritis Research & Therapy 2010 12(Suppl 1):S1

    Published on: 14 April 2010

  2. Review

    Genetic associations in type I interferon related pathways with autoimmunity

    Type I interferons play an outstanding role in innate and adaptive immunity by enhancing functions of dendritic cells, inducing differentiation of monocytes, promoting immunoglobulin class switching in B cells...

    Angélica M Delgado-Vega, Marta E Alarcón-Riquelme and Sergey V Kozyrev

    Arthritis Research & Therapy 2010 12(Suppl 1):S2

    Published on: 14 April 2010

  3. Review

    Potential role of IFNα in adult lupus

    Patients with lupus have a continuous production of IFNα and display an increased expression of IFNα-regulated genes. The reason for the ongoing IFNα synthesis in these patients seems to be an activation of pl...

    Lars Rönnblom

    Arthritis Research & Therapy 2010 12(Suppl 1):S3

    Published on: 14 April 2010

  4. Review

    Type 1 interferons and myositis

    Recent studies suggest a mechanistic role for molecules induced by type 1 interferons in the pathogenesis of some forms of myositis. For dermatomyositis, evidence that these molecules injure myofibers seems es...

    Steven A Greenberg

    Arthritis Research & Therapy 2010 12(Suppl 1):S4

    Published on: 14 April 2010

  5. Review

    Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFNα antibody, in systemic lupus erythematosus

    Type I interferons are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Type I interferon-inducible mRNAs are widely and concordantly overexpressed in the periphery and involved tissues of...

    Yihong Yao, Brandon W Higgs, Laura Richman, Barbara White and Bahija Jallal

    Arthritis Research & Therapy 2010 12(Suppl 1):S6

    Published on: 14 April 2010

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