Babior BM: Phagocytes and oxidative stress. Am J Med. 2000, 109: 33-44. 10.1016/S0002-9343(00)00481-2.
CAS
PubMed
Google Scholar
Lotz M: Neuropeptides, free radicals and nitric oxide. Rheumatology. 2003, 135-146.
Google Scholar
Olofsson P, Holmberg J, Tordsson J, Lu S, Akerstrom B, Holmdahl R: Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet. 2003, 33: 25-32. 10.1038/ng1058.
CAS
PubMed
Google Scholar
van de Loo FA, Bennink MB, Arntz OJ, Smeets RL, Lubberts E, Joosten LA, van Lent PL, Coenen-de Roo CJ, Cuzzocrea S, Segal BH, et al: Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models. Am J Pathol. 2003, 163: 1525-1537.
PubMed Central
CAS
PubMed
Google Scholar
van der Veen RC, Dietlin TA, Hofman FM, Pen L, Segal BH, Holland SM: Superoxide prevents nitric oxide-mediated suppression of helper T lymphocytes: decreased autoimmune encephalomyelitis in nicotinamide adenine dinucleotide phosphate oxidase knockout mice. J Immunol. 2000, 164: 5177-5183.
CAS
PubMed
Google Scholar
Dhar SK, Lynn BC, Daosukho C, St Clair DK: Identification of nucleophosmin as an NF-kB co-activator for the induction of the human SOD2 gene. J Biol Chem. 2004, 279: 28209-28219. 10.1074/jbc.M403553200.
PubMed Central
CAS
PubMed
Google Scholar
Tan M, Li S, Swaroop M, Guan K, Oberley LW, Sun Y: Transcriptional activation of the human glutathione peroxidase promoter by p53. J Biol Chem. 1999, 274: 12061-12066. 10.1074/jbc.274.17.12061.
CAS
PubMed
Google Scholar
Bierl C, Voetsch B, Jin RC, Handy DE, Loscalzo J: Determinants of human plasma glutathione peroxidase (GPx-3) expression. J Biol Chem. 2004, 279: 26839-26845. 10.1074/jbc.M401907200.
CAS
PubMed
Google Scholar
Yamamoto M, Yang G, Hong C, Liu J, Holle E, Yu X, Wagner T, Vatner SF, Sadoshima J: Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. J Clin Invest. 2003, 112: 1395-1406. 10.1172/JCI200317700.
PubMed Central
CAS
PubMed
Google Scholar
Turoczi T, Chang VW, Engelman RM, Maulik N, Ho YS, Das DK: Thioredoxin redox signaling in the ischemic heart: an insight with transgenic mice overexpressing Trx1. J Mol Cell Cardiol. 2003, 35: 695-704. 10.1016/S0022-2828(03)00117-2.
CAS
PubMed
Google Scholar
Das DK: Thioredoxin regulation of ischemic preconditioning. Antioxid Redox Signal. 2004, 6: 405-412. 10.1089/152308604322899477.
CAS
PubMed
Google Scholar
Maurice MM, Nakamura H, Gringhuis S, Okamoto T, Yoshida S, Kullmann F, Lechner S, van der Voort EA, Leow A, Versendaal J, Muller-Ladner U, Yodoi J, Tak PP, Breedveld FC, Verweij CL: Expression of the thioredoxin-thioredoxin reductase system in the inflamed joints of patients with rheumatoid arthritis. Arthritis Rheum. 1999, 42: 2430-2439. 10.1002/1529-0131(199911)42:11<2430::AID-ANR22>3.0.CO;2-6.
CAS
PubMed
Google Scholar
Sowers M, Lachance L: Vitamins and arthritis. The roles of vitamins A, C, D, and E. Rheum Dis Clin North Am. 1999, 25: 315-332.
CAS
PubMed
Google Scholar
Cerhan JR, Saag KG, Merlino LA, Mikuls TR, Criswell LA: Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women. Am J Epidemiol. 2003, 157: 345-354. 10.1093/aje/kwf205.
PubMed
Google Scholar
Heliovaara M, Knekt P, Aho K, Aaran RK, Alfthan G, Aromaa A: Serum antioxidants and risk of rheumatoid arthritis. Ann Rheum Dis. 1994, 53: 51-53.
PubMed Central
CAS
PubMed
Google Scholar
Hagfors L, Leanderson P, Skoldstam L, Andersson J, Johansson G: Antioxidant intake, plasma antioxidants and oxidative stress in a randomized, controlled, parallel, Mediterranean dietary intervention study on patients with rheumatoid arthritis. Nutr J. 2003, 2: 5-10.1186/1475-2891-2-5.
PubMed Central
PubMed
Google Scholar
Bae SC, Kim SJ, Sung MK: Inadequate antioxidant nutrient intake and altered plasma antioxidant status of rheumatoid arthritis patients. J Am Coll Nutr. 2003, 22: 311-315.
CAS
PubMed
Google Scholar
Paredes S, Girona J, Hurt-Camejo E, Vallve JC, Olive S, Heras M, Benito P, Masana L: Antioxidant vitamins and lipid peroxidation in patients with rheumatoid arthritis: association with inflammatory markers. J Rheumatol. 2002, 29: 2271-2277.
CAS
PubMed
Google Scholar
Mulherin DM, Thurnham DI, Situnayake RD: Glutathione reductase activity, riboflavin status, and disease activity in rheumatoid arthritis. Ann Rheum Dis. 1996, 55: 837-840.
PubMed Central
CAS
PubMed
Google Scholar
Dabbagh AJ, Trenam CW, Morris CJ, Blake DR: Iron in joint inflammation. Ann Rheum Dis. 1993, 52: 67-73.
PubMed Central
CAS
PubMed
Google Scholar
De Leo ME, Tranghese A, Passantino M, Mordente A, Lizzio MM, Galeotti T, Zoli A: Manganese superoxide dismutase, glutathione peroxidase, and total radical trapping antioxidant capacity in active rheumatoid arthritis. J Rheumatol. 2002, 29: 2245-2246.
PubMed
Google Scholar
Taysi S, Polat F, Gul M, Sari RA, Bakan E: Lipid peroxidation, some extracellular antioxidants, and antioxidant enzymes in serum of patients with rheumatoid arthritis. Rheumatol Int. 2002, 21: 200-204. 10.1007/s00296-001-0163-x.
CAS
PubMed
Google Scholar
Cimen MY, Cimen OB, Kacmaz M, Ozturk HS, Yorgancioglu R, Durak I: Oxidant/antioxidant status of the erythrocytes from patients with rheumatoid arthritis. Clin Rheumatol. 2000, 19: 275-277.
CAS
PubMed
Google Scholar
Marklund SL, Bjelle A, Elmqvist LG: Superoxide dismutase isoenzymes of the synovial fluid in rheumatoid arthritis and in reactive arthritides. Ann Rheum Dis. 1986, 45: 847-851.
PubMed Central
CAS
PubMed
Google Scholar
Ozturk HS, Cimen MY, Cimen OB, Kacmaz M, Durak I: Oxidant/antioxidant status of plasma samples from patients with rheumatoid arthritis. Rheumatol Int. 1999, 19: 35-37. 10.1007/s002960050097.
CAS
PubMed
Google Scholar
Henrotin YE, Bruckner P, Pujol JP: The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthritis Cartilage. 2003, 11: 747-755. 10.1016/S1063-4584(03)00150-X.
CAS
PubMed
Google Scholar
Halliwell B: Oxygen radicals, nitric oxide and human inflammatory joint disease. Ann Rheum Dis. 1995, 54: 505-510.
PubMed Central
CAS
PubMed
Google Scholar
Tak PP, Zvaifler NJ, Green DR, Firestein GS: Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases. Immunol Today. 2000, 21: 78-82. 10.1016/S0167-5699(99)01552-2.
CAS
PubMed
Google Scholar
Grootveld M, Henderson EB, Farrell A, Blake DR, Parkes HG, Haycock P: Oxidative damage to hyaluronate and glucose in synovial fluid during exercise of the inflamed rheumatoid joint. Detection of abnormal low-molecular-mass metabolites by proton-n.m.r. spectroscopy. Biochem J. 1991, 273: 459-467.
PubMed Central
CAS
PubMed
Google Scholar
Rowley D, Gutteridge JM, Blake D, Farr M, Halliwell B: Lipid peroxidation in rheumatoid arthritis: thiobarbituric acid-reactive material and catalytic iron salts in synovial fluid from rheumatoid patients. Clin Sci (Lond). 1984, 66: 691-695.
CAS
Google Scholar
Taysi S, Polat F, Gul M, Sari RA, Bakan E: Lipid peroxidation, some extracellular antioxidants, and antioxidant enzymes in serum of patients with rheumatoid arthritis. Rheumatol Int. 2002, 21: 200-204. 10.1007/s00296-001-0163-x.
CAS
PubMed
Google Scholar
Dai L, Lamb DJ, Leake DS, Kus ML, Jones HW, Morris CJ, Winyard PG: Evidence for oxidised low density lipoprotein in synovial fluid from rheumatoid arthritis patients. Free Radic Res. 2000, 32: 479-486.
CAS
PubMed
Google Scholar
Dalle-Donne I, Rossi R, Giustarini D, Milzani A, Colombo R: Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta. 2003, 329: 23-38. 10.1016/S0009-8981(03)00003-2.
CAS
PubMed
Google Scholar
Cemerski S, van Meerwijk JP, Romagnoli P: Oxidative-stress-induced T lymphocyte hyporesponsiveness is caused by structural modification rather than proteasomal degradation of crucial TCR signaling molecules. Eur J Immunol. 2003, 33: 2178-2185. 10.1002/eji.200323898.
CAS
PubMed
Google Scholar
Bandt MD, Grossin M, Driss F, Pincemail J, Babin-Chevaye C, Pasquier C: Vitamin E uncouples joint destruction and clinical inflammation in a transgenic mouse model of rheumatoid arthritis. Arthritis Rheum. 2002, 46: 522-532. 10.1002/art.10085.
PubMed
Google Scholar
Cuzzocrea S, McDonald MC, Mota-Filipe H, Mazzon E, Costantino G, Britti D, Mazzullo G, Caputi AP, Thiemermann C: Beneficial effects of tempol, a membrane-permeable radical scavenger, in a rodent model of collagen-induced arthritis. Arthritis Rheum. 2000, 43: 320-328. 10.1002/1529-0131(200002)43:2<320::AID-ANR11>3.0.CO;2-9.
CAS
PubMed
Google Scholar
Venkatraman JT, Chu WC: Effects of dietary omega-3 and omega-6 lipids and vitamin E on serum cytokines, lipid mediators and anti-DNA antibodies in a mouse model for rheumatoid arthritis. J Am Coll Nutr. 1999, 18: 602-613.
CAS
PubMed
Google Scholar
Clancy RM, Rediske J, Tang X, Nijher N, Frenkel S, Philips M, Abramson SB: Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex. J Clin Invest. 1997, 100: 1789-1796.
PubMed Central
CAS
PubMed
Google Scholar
Rees MD, Hawkins CL, Davies MJ: Hypochlorite-mediated fragmentation of hyaluronan, chondroitin sulfates, and related N-acetyl glycosamines: evidence for chloramide intermediates, free radical transfer reactions, and site-specific fragmentation. J Am Chem Soc. 2003, 125: 13719-13733. 10.1021/ja0370591.
CAS
PubMed
Google Scholar
Rees MD, Hawkins CL, Davies MJ: Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulfates. Biochem J. 2004, 381: 175-184. 10.1042/BJ20040148.
PubMed Central
CAS
PubMed
Google Scholar
Panasyuk A, Frati E, Ribault D, Mitrovic D: Effect of reactive oxygen species on the biosynthesis and structure of newly synthesized proteoglycans. Free Radic Biol Med. 1994, 16: 157-167. 10.1016/0891-5849(94)90139-2.
CAS
PubMed
Google Scholar
Newkirk MM, LePage K, Niwa T, Rubin L: Advanced glycation endproducts (AGE) on IgG, a target for circulating antibodies in North American Indians with rheumatoid arthritis (RA). Cell Mol Biol (Noisy-le-grand). 1998, 44: 1129-1138.
CAS
Google Scholar
Newkirk MM, Goldbach-Mansky R, Lee J, Hoxworth J, McCoy A, Yarboro C, Klippel J, El Gabalawy HS: Advanced glycation end-product (AGE)-damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis. Arthritis Res Ther. 2003, 5: R82-R90. 10.1186/ar622.
PubMed Central
CAS
PubMed
Google Scholar
Bashir S, Harris G, Denman MA, Blake DR, Winyard PG: Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases. Ann Rheum Dis. 1993, 52: 659-666.
PubMed Central
CAS
PubMed
Google Scholar
Hajizadeh S, DeGroot J, TeKoppele JM, Tarkowski A, Collins LV: Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis. Arthritis Res Ther. 2003, 5: R234-R240. 10.1186/ar787.
PubMed Central
CAS
PubMed
Google Scholar
Lee SH, Chang DK, Goel A, Boland CR, Bugbee W, Boyle DL, Firestein GS: Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid arthritis. J Immunol. 2003, 170: 4869-
CAS
Google Scholar
Forrester K, Ambs S, Lupold SE, Kapust RB, Spillare EA, Weinberg WC, Felley-Bosco E, Wang XW, Geller DA, Tzeng E, et al: Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc Natl Acad Sci USA. 1996, 93: 2442-2447. 10.1073/pnas.93.6.2442.
PubMed Central
CAS
PubMed
Google Scholar
Firestein GS, Echeverri F, Yeo M, Zvaifler NJ, Green DR: Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium. Proc Natl Acad Sci USA. 1997, 94: 10895-10900. 10.1073/pnas.94.20.10895.
PubMed Central
CAS
PubMed
Google Scholar
Inazuka M, Tahira T, Horiuchi T, Harashima S, Sawabe T, Kondo M, Miyahara H, Hayashi K: Analysis of p53 tumour suppressor gene somatic mutations in rheumatoid arthritis synovium. Rheumatology (Oxford). 2000, 39: 262-266.
CAS
Google Scholar
Yamanishi Y, Boyle DL, Rosengren S, Green DR, Zvaifler NJ, Firestein GS: Regional analysis of p53 mutations in rheumatoid arthritis synovium. Proc Natl Acad Sci USA. 2002, 99: 10025-10030. 10.1073/pnas.152333199.
PubMed Central
CAS
PubMed
Google Scholar
Yakes FM, Van Houten B: Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA. 1997, 94: 514-519. 10.1073/pnas.94.2.514.
PubMed Central
CAS
PubMed
Google Scholar
Collins LV, Hajizadeh S, Holme E, Jonsson IM, Tarkowski A: Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses. J Leukoc Biol. 2004, 75: 995-1000. 10.1189/jlb.0703328.
CAS
PubMed
Google Scholar
Tiku ML, Shah R, Allison GT: Evidence linking chondrocyte lipid peroxidation to cartilage matrix protein degradation. Possible role in cartilage aging and the pathogenesis of osteoarthritis. J Biol Chem. 2000, 275: 20069-20076. 10.1074/jbc.M907604199.
CAS
PubMed
Google Scholar
Lusis AJ: Atherosclerosis. Nature. 2000, 407: 233-241. 10.1038/35025203.
PubMed Central
CAS
PubMed
Google Scholar
del Rincon I, Escalante A: Atherosclerotic cardiovascular disease in rheumatoid arthritis. Curr Rheumatol Rep. 2003, 5: 278-286.
PubMed
Google Scholar
Sattar N, McCarey DW, Capell H, McInnes IB: Explaining how 'high-grade' systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation. 2003, 108: 2957-2963. 10.1161/01.CIR.0000099844.31524.05.
PubMed
Google Scholar
Dai L, Lamb DJ, Leake DS, Kus ML, Jones HW, Morris CJ, Winyard PG: Evidence for oxidised low density lipoprotein in synovial fluid from rheumatoid arthritis patients. Free Radic Res. 2000, 32: 479-486.
CAS
PubMed
Google Scholar
Winyard PG, Tatzber F, Esterbauer H, Kus ML, Blake DR, Morris CJ: Presence of foam cells containing oxidised low density lipoprotein in the synovial membrane from patients with rheumatoid arthritis. Ann Rheum Dis. 1993, 52: 677-680.
PubMed Central
CAS
PubMed
Google Scholar
Treuhaft PS, McCarty DJ: Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases. Arthritis Rheum. 1971, 14: 475-484.
CAS
PubMed
Google Scholar
Lund-Olesen K: Oxygen tension in synovial fluids. Arthritis Rheum. 1970, 13: 769-776.
CAS
PubMed
Google Scholar
Naughton D, Whelan M, Smith EC, Williams R, Blake DR, Grootveld M: An investigation of the abnormal metabolic status of synovial fluid from patients with rheumatoid arthritis by high field proton nuclear magnetic resonance spectroscopy. FEBS Lett. 1993, 317: 135-138. 10.1016/0014-5793(93)81508-W.
CAS
PubMed
Google Scholar
Naughton DP, Haywood R, Blake DR, Edmonds S, Hawkes GE, Grootveld M: A comparative evaluation of the metabolic profiles of normal and inflammatory knee-joint synovial fluids by high resolution proton NMR spectroscopy. FEBS Lett. 1993, 332: 221-225. 10.1016/0014-5793(93)80636-9.
CAS
PubMed
Google Scholar
Taylor P, Miotla JM, Etherington P, Winlove P, Young Y, Paleolog E, Maini RN: VEGF release is associated with hypoxia in inflammatory arthritis [abstract]. Arthritis Rheum. 2000, 43 (Suppl 9): S296-
Google Scholar
Ellis GA, Edmonds SE, Gaffney K, Williams RB: Synovial tissue oxygenation profile in inflamed and non-inflamed knee joints [abstract]. Br J Rheumatol. 1994, 33 (Suppl 1): 172-
Google Scholar
Miotla J, Maciewicz R, Kendrew J, Feldmann M, Paleolog E: Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis. Lab Invest. 2000, 80: 1195-1205.
CAS
PubMed
Google Scholar
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, et al: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 1998, 394: 485-490. 10.1038/28867.
CAS
PubMed
Google Scholar
Marx J: Cell biology. How cells endure low oxygen. Science. 2004, 303: 1454-1456. 10.1126/science.303.5663.1454.
CAS
PubMed
Google Scholar
Semenza GL: HIF-1, O2, and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell. 2001, 107: 1-3. 10.1016/S0092-8674(01)00518-9.
CAS
PubMed
Google Scholar
Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, Pavletich N, Chau V, Kaelin WG: Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein. Nat Cell Biol. 2000, 2: 423-427. 10.1038/35017054.
CAS
PubMed
Google Scholar
Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH: Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J Biol Chem. 2000, 275: 25733-25741. 10.1074/jbc.M002740200.
CAS
PubMed
Google Scholar
Wenger RH: Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J. 2002, 16: 1151-1162. 10.1096/fj.01-0944rev.
CAS
PubMed
Google Scholar
Distler JH, Wenger RH, Gassmann M, Kurowska M, Hirth A, Gay S, Distler O: Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis. Arthritis Rheum. 2004, 50: 10-23. 10.1002/art.11425.
CAS
PubMed
Google Scholar
Matsumoto I, Staub A, Benoist C, Mathis D: Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science. 1999, 286: 1732-1735. 10.1126/science.286.5445.1732.
CAS
PubMed
Google Scholar
Schaller M, Burton DR, Ditzel HJ: Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease. Nat Immunol. 2001, 2: 746-753. 10.1038/90696.
CAS
PubMed
Google Scholar
Matsumoto I, Lee DM, Goldbach-Mansky R, Sumida T, Hitchon CA, Schur PH, Anderson RJ, Coblyn JS, Weinblatt ME, Brenner M, et al: Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders. Arthritis Rheum. 2003, 48: 944-954. 10.1002/art.10898.
CAS
PubMed
Google Scholar
Naughton DP: Hypoxia-induced upregulation of the glycolytic enzyme glucose-6-phosphate isomerase perpetuates rheumatoid arthritis. Med Hypotheses. 2003, 60: 332-334. 10.1016/S0306-9877(02)00396-1.
CAS
PubMed
Google Scholar
Cramer T, Yamanishi Y, Clausen BE, Forster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, et al: HIF-1α is essential for myeloid cell-mediated inflammation. Cell. 2003, 112: 645-657. 10.1016/S0092-8674(03)00154-5.
PubMed Central
CAS
PubMed
Google Scholar
Michiels C, Minet E, Mottet D, Raes M: Regulation of gene expression by oxygen: NF-κB and HIF-1, two extremes. Free Radic Biol Med. 2002, 33: 1231-1242. 10.1016/S0891-5849(02)01045-6.
CAS
PubMed
Google Scholar
Huang LE, Willmore WG, Gu J, Goldberg MA, Bunn HF: Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. J Biol Chem. 1999, 274: 9038-9044. 10.1074/jbc.274.13.9038.
CAS
PubMed
Google Scholar
Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, Schumacker PT: Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia: a mechanism of O2 sensing. J Biol Chem. 2000, 275: 25130-25138. 10.1074/jbc.M001914200.
CAS
PubMed
Google Scholar
Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT: Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA. 1998, 95: 11715-11720. 10.1073/pnas.95.20.11715.
PubMed Central
CAS
PubMed
Google Scholar
Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL: Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem. 2002, 277: 38205-38211. 10.1074/jbc.M203781200.
CAS
PubMed
Google Scholar
Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L: IL-1β-mediated up-regulation of HIF-1α via an NFκB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J. 2003, 17: 2115-2117.
CAS
PubMed
Google Scholar
Stiehl DP, Jelkmann W, Wenger RH, Hellwig-Burgel T: Normoxic induction of the hypoxia-inducible factor 1α by insulin and interleukin-1β involves the phosphatidylinositol 3-kinase pathway. FEBS Lett. 2002, 512: 157-162. 10.1016/S0014-5793(02)02247-0.
CAS
PubMed
Google Scholar
Zhou J, Schmid T, Brune B: Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1α through a nuclear factor-κB-dependent pathway. Mol Biol Cell. 2003, 14: 2216-2225. 10.1091/mbc.E02-09-0598.
PubMed Central
CAS
PubMed
Google Scholar
Jung Y, Isaacs JS, Lee S, Trepel J, Liu ZG, Neckers L: Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor κB activation. Biochem J. 2003, 370: 1011-1017. 10.1042/BJ20021279.
PubMed Central
CAS
PubMed
Google Scholar
Thornton RD, Lane P, Borghaei RC, Pease EA, Caro J, Mochan E: Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts. Biochem J. 2000, 350: 307-312. 10.1042/0264-6021:3500307.
PubMed Central
CAS
PubMed
Google Scholar
Minet E, Arnould T, Michel G, Roland I, Mottet D, Raes M, Remacle J, Michiels C: ERK activation upon hypoxia: involvement in HIF-1 activation. FEBS Lett. 2000, 468: 53-58. 10.1016/S0014-5793(00)01181-9.
CAS
PubMed
Google Scholar
Kasuno K, Takabuchi S, Fukuda K, Kizaka-Kondoh S, Yodoi J, Adachi T, Semenza GL, Hirota K: Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. J Biol Chem. 2004, 279: 2550-2558. 10.1074/jbc.M308197200.
CAS
PubMed
Google Scholar
Giatromanolaki A, Sivridis E, Maltezos E, Athanassou N, Papazoglou D, Gatter KC, Harris AL, Koukourakis MI: Upregulated hypoxia inducible factor-1α and -2α pathway in rheumatoid arthritis and osteoarthritis. Arthritis Res Ther. 2003, 5: R193-R201. 10.1186/ar756.
PubMed Central
CAS
PubMed
Google Scholar
Hitchon CA, Wong K, Ma G, Reed J, Lyttle D, El Gabalawy H: Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts. Arthritis Rheum. 2002, 46: 2587-2597. 10.1002/art.10520.
CAS
PubMed
Google Scholar
Hollander AP, Corke KP, Freemont AJ, Lewis CE: Expression of hypoxia-inducible factor 1α by macrophages in the rheumatoid synovium: implications for targeting of therapeutic genes to the inflamed joint. Arthritis Rheum. 2001, 44: 1540-1544. 10.1002/1529-0131(200107)44:7<1540::AID-ART277>3.0.CO;2-7.
CAS
PubMed
Google Scholar
Jewell UR, Kvietikova I, Scheid A, Bauer C, Wenger RH, Gassmann M: Induction of HIF-1α in response to hypoxia is instantaneous. FASEB J. 2001, 15: 1312-1314.
CAS
PubMed
Google Scholar
Wauke K, Nagashima M, Ishiwata T, Asano G, Yoshino S: Expression and localization of vascular endothelial growth factor-C in rheumatoid arthritis synovial tissue. J Rheumatol. 2002, 29: 34-38.
CAS
PubMed
Google Scholar
Kasama T, Shiozawa F, Kobayashi K, Yajima N, Hanyuda M, Takeuchi HT, Mori Y, Negishi M, Ide H, Adachi M: Vascular endothelial growth factor expression by activated synovial leukocytes in rheumatoid arthritis: critical involvement of the interaction with synovial fibroblasts. Arthritis Rheum. 2001, 44: 2512-2524. 10.1002/1529-0131(200111)44:11<2512::AID-ART431>3.0.CO;2-O.
CAS
PubMed
Google Scholar
Ballara S, Taylor PC, Reusch P, Marme D, Feldmann M, Maini RN, Paleolog EM: Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis. Arthritis Rheum. 2001, 44: 2055-2064. 10.1002/1529-0131(200109)44:9<2055::AID-ART355>3.0.CO;2-2.
CAS
PubMed
Google Scholar
Pufe T, Petersen W, Tillmann B, Mentlein R: Splice variants VEGF121 and VEGF165 of the angiogenic peptide vascular endothelial cell growth factor are expressed in the synovial tissue of patients with rheumatoid arthritis. J Rheumatol. 2001, 28: 1482-1485.
CAS
PubMed
Google Scholar
Fava RA, Olsen NJ, Spencer-Green G, Yeo KT, Yeo TK, Berse B, Jackman RW, Senger DR, Dvorak HF, Brown LF: Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med. 1994, 180: 341-346. 10.1084/jem.180.1.341.
CAS
PubMed
Google Scholar
Paleolog EM, Young S, Stark AC, McCloskey RV, Feldmann M, Maini RN: Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis. Arthritis Rheum. 1998, 41: 1258-1265. 10.1002/1529-0131(199807)41:7<1258::AID-ART17>3.0.CO;2-1.
CAS
PubMed
Google Scholar
Berse B, Hunt JA, Diegel RJ, Morganelli P, Yeo K, Brown F, Fava RA: Hypoxia augments cytokine (transforming growth factor-β (TGF-β) and IL-1)-induced vascular endothelial growth factor secretion by human synovial fibroblasts. Clin Exp Immunol. 1999, 115: 176-182. 10.1046/j.1365-2249.1999.00775.x.
PubMed Central
CAS
PubMed
Google Scholar
Sanchez-Elsner T, Botella LM, Velasco B, Corbi A, Attisano L, Bernabeu C: Synergistic cooperation between hypoxia and transforming growth factor-β pathways on human vascular endothelial growth factor gene expression. J Biol Chem. 2001, 276: 38527-38535. 10.1074/jbc.M104536200.
CAS
PubMed
Google Scholar
Takahara K, Iioka T, Furukawa K, Uchida T, Nakashima M, Tsukazaki T, Shindo H: Autocrine/paracrine role of the angiopoietin-1 and -2/Tie2 system in cell proliferation and chemotaxis of cultured fibroblastic synoviocytes in rheumatoid arthritis. Hum Pathol. 2004, 35: 150-158. 10.1016/j.humpath.2003.11.010.
CAS
PubMed
Google Scholar
Fearon U, Griosios K, Fraser A, Reece R, Emery P, Jones PF, Veale DJ: Angiopoietins, growth factors, and vascular morphology in early arthritis. J Rheumatol. 2003, 30: 260-268.
CAS
PubMed
Google Scholar
DeBusk LM, Chen Y, Nishishita T, Chen J, Thomas JW, Lin PC: Tie2 receptor tyrosine kinase, a major mediator of tumor necrosis factor alpha-induced angiogenesis in rheumatoid arthritis. Arthritis Rheum. 2003, 48: 2461-2471. 10.1002/art.11213.
CAS
PubMed
Google Scholar
Gravallese EM, Pettit AR, Lee R, Madore R, Manning C, Tsay A, Gaspar J, Goldring MB, Goldring SR, Oettgen P: Angiopoietin-1 is expressed in the synovium of patients with rheumatoid arthritis and is induced by tumour necrosis factor alpha. Ann Rheum Dis. 2003, 62: 100-107. 10.1136/ard.62.2.100.
PubMed Central
CAS
PubMed
Google Scholar
Stevens CR, Blake DR, Merry P, Revell PA, Levick JR: A comparative study by morphometry of the microvasculature in normal and rheumatoid synovium. Arthritis Rheum. 1991, 34: 1508-1513.
CAS
PubMed
Google Scholar
Levick JR: Hypoxia and acidosis in chronic inflammatory arthritis; relation to vascular supply and dynamic effusion pressure. J Rheumatol. 1990, 17: 579-582.
CAS
PubMed
Google Scholar
James MJ, Cleland LG, Rofe AM, Leslie AL: Intraarticular pressure and the relationship between synovial perfusion and metabolic demand. J Rheumatol. 1990, 17: 521-527.
CAS
PubMed
Google Scholar
Bonizzi G, Piette J, Merville MP, Bours V: Cell type-specific role for reactive oxygen species in nuclear factor-κB activation by interleukin-1. Biochem Pharmacol. 2000, 59: 7-11. 10.1016/S0006-2952(99)00290-7.
CAS
PubMed
Google Scholar
Bonizzi G, Piette J, Schoonbroodt S, Greimers R, Havard L, Merville MP, Bours V: Reactive oxygen intermediate-dependent NF-κB activation by interleukin-1β requires 5-lipoxygenase or NADPH oxidase activity. Mol Cell Biol. 1999, 19: 1950-1960.
PubMed Central
CAS
PubMed
Google Scholar
D'Angio CT, Finkelstein JN: Oxygen regulation of gene expression: a study in opposites. Mol Genet Metab. 2000, 71: 371-380. 10.1006/mgme.2000.3074.
PubMed
Google Scholar
Han MK, Kim JS, Park BH, Kim JR, Hwang BY, Lee HY, Song EK, Yoo WH: NF-κB-dependent lymphocyte hyperadhesiveness to synovial fibroblasts by hypoxia and reoxygenation: potential role in rheumatoid arthritis. J Leukoc Biol. 2003, 73: 525-529. 10.1189/jlb.0502256.
CAS
PubMed
Google Scholar
Uchiyama T, Engelman RM, Maulik N, Das DK: Role of Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning. Circulation. 2004, 109: 3042-3049. 10.1161/01.CIR.0000130647.29030.90.
CAS
PubMed
Google Scholar
Jones NM, Bergeron M: Hypoxia-induced ischemic tolerance in neonatal rat brain involves enhanced ERK1/2 signaling. J Neurochem. 2004, 89: 157-167.
CAS
PubMed
Google Scholar
Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E: Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4-hydroxylases. Biochem J. 2004, 381: 761-767. 10.1042/BJ20040620.
PubMed Central
CAS
PubMed
Google Scholar
Haqqi TM, Anthony DD, Gupta S, Ahmad N, Lee MS, Kumar GK, Mukhtar H: Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc Natl Acad Sci USA. 1999, 96: 4524-4529. 10.1073/pnas.96.8.4524.
PubMed Central
CAS
PubMed
Google Scholar
Singh R, Ahmed S, Islam N, Goldberg VM, Haqqi TM: Epigallocatechin-3-gallate inhibits interleukin-1β-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor κB activation by degradation of the inhibitor of nuclear factor κB. Arthritis Rheum. 2002, 46: 2079-2086. 10.1002/art.10443.
CAS
PubMed
Google Scholar
Ahmed S, Wang N, Lalonde M, Goldberg VM, Haqqi TM: Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1β-induced expression of matrix metalloproteinase-1 and -13 in human chondrocytes. J Pharmacol Exp Ther. 2004, 308: 767-773. 10.1124/jpet.103.059220.
CAS
PubMed
Google Scholar
Ahmed S, Rahman A, Hasnain A, Lalonde M, Goldberg VM, Haqqi TM: Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1β-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. Free Radic Biol Med. 2002, 33: 1097-1105. 10.1016/S0891-5849(02)01004-3.
CAS
PubMed
Google Scholar
Skoldstam L, Hagfors L, Johansson G: An experimental study of a Mediterranean diet intervention for patients with rheumatoid arthritis. Ann Rheum Dis. 2003, 62: 208-214. 10.1136/ard.62.3.208.
PubMed Central
CAS
PubMed
Google Scholar
Jaswal S, Mehta HC, Sood AK, Kaur J: Antioxidant status in rheumatoid arthritis and role of antioxidant therapy. Clin Chim Acta. 2003, 338: 123-129. 10.1016/j.cccn.2003.08.011.
CAS
PubMed
Google Scholar
Edmonds SE, Winyard PG, Guo R, Kidd B, Merry P, Langrish-Smith A, Hansen C, Ramm S, Blake DR: Putative analgesic activity of repeated oral doses of vitamin E in the treatment of rheumatoid arthritis. Results of a prospective placebo controlled double blind trial. Ann Rheum Dis. 1997, 56: 649-655.
PubMed Central
CAS
PubMed
Google Scholar
Koch AE: Angiogenesis as a target in rheumatoid arthritis. Ann Rheum Dis. 2003, 62 (Suppl 2): ii60-67.
PubMed Central
CAS
PubMed
Google Scholar
Trabold O, Wagner S, Wicke C, Scheuenstuhl H, Hussain MZ, Rosen N, Seremetiev A, Becker HD, Hunt TK: Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing. Wound Repair Regen. 2003, 11: 504-509. 10.1046/j.1524-475X.2003.11621.x.
PubMed
Google Scholar
Albina JE, Reichner JS: Oxygen and the regulation of gene expression in wounds. Wound Repair Regen. 2003, 11: 445-451. 10.1046/j.1524-475X.2003.11619.x.
PubMed
Google Scholar
Haroon ZA, Raleigh JA, Greenberg CS, Dewhirst MW: Early wound healing exhibits cytokine surge without evidence of hypoxia. Ann Surg. 2000, 231: 137-147. 10.1097/00000658-200001000-00020.
PubMed Central
CAS
PubMed
Google Scholar
Ozawa K, Kondo T, Hori O, Kitao Y, Stern DM, Eisenmenger W, Ogawa S, Ohshima T: Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport. J Clin Invest. 2001, 108: 41-50. 10.1172/JCI200111772.
PubMed Central
CAS
PubMed
Google Scholar
Scheid A, Wenger RH, Christina H, Camenisch I, Ferenc A, Stauffer UG, Gassmann M, Meuli M: Hypoxia-regulated gene expression in fetal wound regeneration and adult wound repair. Pediatr Surg Int. 2000, 16: 232-236. 10.1007/s003830050735.
CAS
PubMed
Google Scholar
Albina JE, Mastrofrancesco B, Vessella JA, Louis CA, Henry WL Jr, Reichner JS: HIF-1 expression in healing wounds: HIF-1α induction in primary inflammatory cells by TNF-α. Am J Physiol Cell Physiol. 2001, 281: C1971-C1977.
CAS
PubMed
Google Scholar
Giaccia A, Siim BG, Johnson RS: HIF-1 as a target for drug development. Nat Rev Drug Discov. 2003, 2: 803-811. 10.1038/nrd1199.
CAS
PubMed
Google Scholar
Semenza GL: Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003, 3: 721-732. 10.1038/nrc1187.
CAS
PubMed
Google Scholar
Pufe T, Lemke A, Kurz B, Petersen W, Tillmann B, Grodzinsky AJ, Mentlein R: Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor. Am J Pathol. 2004, 164: 185-192.
PubMed Central
CAS
PubMed
Google Scholar
Stokes DG, Liu G, Coimbra IB, Piera-Velazquez S, Crowl RM, Jimenez SA: Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis. Arthritis Rheum. 2002, 46: 404-419. 10.1002/art.10106.
CAS
PubMed
Google Scholar
Coimbra IB, Jimenez SA, Hawkins DF, Piera-Velazquez S, Stokes DG: Hypoxia inducible factor-1α expression in human normal and osteoarthritic chondrocytes. Osteoarthritis Cartilage. 2004, 12: 336-345. 10.1016/j.joca.2003.12.005.
PubMed
Google Scholar
Rajpurohit R, Koch CJ, Tao Z, Teixeira CM, Shapiro IM: Adaptation of chondrocytes to low oxygen tension: relationship between hypoxia and cellular metabolism. J Cell Physiol. 1996, 168: 424-432. 10.1002/(SICI)1097-4652(199608)168:2<424::AID-JCP21>3.0.CO;2-1.
CAS
PubMed
Google Scholar
Schipani E, Ryan HE, Didrickson S, Kobayashi T, Knight M, Johnson RS: Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival. Genes Dev. 2001, 15: 2865-2876.
PubMed Central
CAS
PubMed
Google Scholar
Bodamyali T, Stevens CR, Billingham ME, Ohta S, Blake DR: Influence of hypoxia in inflammatory synovitis. Ann Rheum Dis. 1998, 57: 703-710.
PubMed Central
CAS
PubMed
Google Scholar
Marshall DA, Hunter JA, Capell HA: Double blind, placebo controlled study of metronidazole as a disease modifying agent in the treatment of rheumatoid arthritis. Ann Rheum Dis. 1992, 51: 758-760.
PubMed Central
CAS
PubMed
Google Scholar