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Table 1 p53 mutations in matched erosion fibroblast-like synoviocytes (FLS) and non-erosion FLS from rheumatoid arthritis(RA) patients

From: p53tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis

Patient Erosion FLS Non-erosion FLS
  Mutation Frequency Mutation Frequency
RA1 (two lines examined)     
   Line 1 Codon 318 CCA>TCA (Pro>Ser) 1/12 None 0/11
   Line 2 None 0/11   
RA2 Codon 194 CTT>TTT (Leu>Phe) 1/13 Codon 274 GTT>ATT (Val>Ile) 1/9
  Codon 226 GGC>GAC (Gly>Asp) 1/13   
RA3 None 0/13 Codon 186 GAT>AAT (Asp>Asn) 1/12
RA4 Codon 155 ACC>GCC (Thr>Ala) 1/12 Codon 266 GGA>AGA (Gly>Arg) 1/12
  Codon 321 AAA>GAA (Lys>Glu) 2/12   
RA5 None 0/10 None 0/11
RA6 None 0/9 Codon 276 GCC>GTC (Ala>Val) 1/7
RA7 None 0/11 Codon 167 CAG>CAA (Gln>Gln) 1/10
    Codon 312 ATC>ATT (Ile>Ile) 1/10
RA8 Codon 212 TTT>TTC (Phe>Phe) 1/12 Codon 176 TGC>TAC (Cys>Tyr) 1/12
  Codon 309 CCC>CCT (Pro>Pro) 1/12 Codon 239 AAC>AGC (Asn>Ser) 1/12
  Codon 317 CAG>AG (deletion) 1/12   
RA9 None 0/11 Codon 261-C262 AGT (Ser) insertion 1/11
Total   9/114   9/95
  1. Data presented as number of mutant subclones/total number of subclones analyzed. Nested PCR used for the RA4 non-erosion FLS.