Table 1 p53 mutations in matched erosion fibroblast-like synoviocytes (FLS) and non-erosion FLS from rheumatoid arthritis(RA) patients
Patient | Erosion FLS | Non-erosion FLS | ||
|---|---|---|---|---|
Mutation | Frequency | Mutation | Frequency | |
RA1 (two lines examined) | ||||
Line 1 | Codon 318 CCA>TCA (Pro>Ser) | 1/12 | None | 0/11 |
Line 2 | None | 0/11 | ||
RA2 | Codon 194 CTT>TTT (Leu>Phe) | 1/13 | Codon 274 GTT>ATT (Val>Ile) | 1/9 |
Codon 226 GGC>GAC (Gly>Asp) | 1/13 | |||
RA3 | None | 0/13 | Codon 186 GAT>AAT (Asp>Asn) | 1/12 |
RA4 | Codon 155 ACC>GCC (Thr>Ala) | 1/12 | Codon 266 GGA>AGA (Gly>Arg) | 1/12 |
Codon 321 AAA>GAA (Lys>Glu) | 2/12 | |||
RA5 | None | 0/10 | None | 0/11 |
RA6 | None | 0/9 | Codon 276 GCC>GTC (Ala>Val) | 1/7 |
RA7 | None | 0/11 | Codon 167 CAG>CAA (Gln>Gln) | 1/10 |
Codon 312 ATC>ATT (Ile>Ile) | 1/10 | |||
RA8 | Codon 212 TTT>TTC (Phe>Phe) | 1/12 | Codon 176 TGC>TAC (Cys>Tyr) | 1/12 |
Codon 309 CCC>CCT (Pro>Pro) | 1/12 | Codon 239 AAC>AGC (Asn>Ser) | 1/12 | |
Codon 317 CAG>AG (deletion) | 1/12 | |||
RA9 | None | 0/11 | Codon 261-C262 AGT (Ser) insertion | 1/11 |
Total | 9/114 | 9/95 | ||