Firestein GS: Evolving concepts of rheumatoid arthritis. Nature. 2003, 423: 356-361. 10.1038/nature01661.
Article
CAS
PubMed
Google Scholar
Feldmann M, Maini RN, Bondeson J, Taylor P, Foxwell BM, Brennan FM: Cytokine blockade in rheumatoid arthritis. Adv Exp Med Biol. 2001, 490: 119-127.
Article
CAS
PubMed
Google Scholar
Joosten LA, Helsen MM, Saxne T, van De Loo FA, Heinegard D, van Den Berg WB: IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation. J Immunol. 1999, 163: 5049-5055.
CAS
PubMed
Google Scholar
Muller-Ladner U, Kriegsmann J, Franklin BN, Matsumoto S, Geiler T, Gay RE, Gay S: Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol. 1996, 149: 1607-1615.
PubMed Central
CAS
PubMed
Google Scholar
Firestein GS: Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors?. Arthritis Rheum. 1996, 39: 1781-1790.
Article
CAS
PubMed
Google Scholar
Lafyatis R, Remmers EF, Roberts AB, Yocum DE, Sporn MB, Wilder RL: Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids. J Clin Invest. 1989, 83: 1267-1276.
Article
PubMed Central
CAS
PubMed
Google Scholar
Muller-Ladner U, Kriegsmann J, Gay RE, Gay S: Oncogenes in rheumatoid arthritis. Rheum Dis Clin North Am. 1995, 21: 675-690.
CAS
PubMed
Google Scholar
Firestein GS, Echeverri F, Yeo M, Zvaifler NJ, Green DR: Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium. Proc Natl Acad Sci U S A. 1997, 94: 10895-10900. 10.1073/pnas.94.20.10895.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yamanishi Y, Boyle DL, Rosengren S, Green DR, Zvaifler NJ, Firestein GS: Regional analysis of p53 mutations in rheumatoid arthritis synovium. Proc Natl Acad Sci U S A. 2002, 99: 10025-10030. 10.1073/pnas.152333199.
Article
PubMed Central
CAS
PubMed
Google Scholar
Levine AJ: p53, the cellular gatekeeper for growth and division. Cell. 1997, 88: 323-331. 10.1016/S0092-8674(00)81871-1.
Article
CAS
PubMed
Google Scholar
Maacke H, Kessler A, Schmiegel W, Roeder C, Vogel I, Deppert W, Kalthoff H: Overexpression of p53 protein during pancreatitis. Br J Cancer. 1997, 75: 1501-1504.
Article
PubMed Central
CAS
PubMed
Google Scholar
Firestein GS, Nguyen K, Aupperle KR, Yeo M, Boyle DL, Zvaifler NJ: Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium. Am J Pathol. 1996, 149: 2143-2151.
PubMed Central
CAS
PubMed
Google Scholar
Tak PP, Smeets TJ, Boyle DL, Kraan MC, Shi Y, Zhuang S, Zvaifler NJ, Breedveld FC, Firestein GS: p53 overexpression in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis. Arthritis Rheum. 1999, 42: 948-953. 10.1002/1529-0131(199905)42:5<948::AID-ANR13>3.0.CO;2-L.
Article
CAS
PubMed
Google Scholar
Santhanam U, Ray A, Sehgal PB: Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product. Proc Natl Acad Sci U S A. 1991, 88: 7605-7609.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sun Y, Sun Y, Wenger L, Rutter JL, Brinckerhoff CE, Cheung HS: p53 down-regulates human matrix metalloproteinase-1 (collagenase-1) gene expression. J Biol Chem. 1999, 274: 11535-11540. 10.1074/jbc.274.17.11535.
Article
CAS
PubMed
Google Scholar
Yamanishi Y, Boyle DL, Pinkoski MJ, Mahboubi A, Lin T, Han Z, Zvaifler NJ, Green DR, Firestein GS: Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis. Am J Pathol. 2002, 160: 123-130.
Article
PubMed Central
CAS
PubMed
Google Scholar
Krishna M, Woda B, Savas L, Baker S, Banner B: Expression of p53 antigen in inflamed and regenerated mucosa in ulcerative colitis and Crohn's disease. Mod Pathol. 1995, 8: 654-657.
CAS
PubMed
Google Scholar
Ling G, Persson A, Berne B, Uhlen M, Lundeberg J, Ponten F: Persistent p53 mutations in single cells from normal human skin. Am J Pathol. 2001, 159: 1247-1253.
Article
PubMed Central
CAS
PubMed
Google Scholar
Imamura F, Aono H, Hasunuma T, Sumida T, Tateishi H, Maruo S, Nishioka K: Monoclonal expansion of synoviocytes in rheumatoid arthritis. Arthritis Rheum. 1998, 41: 1979-1986. 10.1002/1529-0131(199811)41:11<1979::AID-ART13>3.3.CO;2-3.
Article
CAS
PubMed
Google Scholar
Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988, 31: 315-324.
Article
CAS
PubMed
Google Scholar
Alvaro-Gracia JM, Zvaifler NJ, Firestein GS: Cytokines in chronic inflammatory arthritis. V. Mutual antagonism between interferon-gamma and tumor necrosis factor-alpha on HLA-DR expression, proliferation, collagenase production, and granulocyte macrophage colony-stimulating factor production by rheumatoid arthritis synoviocytes. J Clin Invest. 1990, 86: 1790-1798.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rosengren S, Firestein GS, Boyle DL: Measurement of inflammatory biomarkers in synovial tissue extracts by enzyme-linked immunosorbent assay. Clin Diagn Lab Immunol. 2003, 10: 1002-1010. 10.1128/CDLI.10.6.1002-1010.2003.
PubMed Central
CAS
PubMed
Google Scholar
Inazuka M, Tahira T, Horiuchi T, Harashima S, Sawabe T, Kondo M, Miyahara H, Hayashi K: Analysis of p53 tumour suppressor gene somatic mutations in rheumatoid arthritis synovium. Rheumatology. 2000, 39: 262-266. 10.1093/rheumatology/39.3.262.
Article
CAS
PubMed
Google Scholar
Wink DA, Kasprzak KS, Maragos CM, Elespuru RK, Misra M, Dunams TM, Cebula TA, Koch WH, Andrews AW, Allen JS, et al: DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Science. 1991, 254: 1001-1003.
Article
CAS
PubMed
Google Scholar
Nguyen T, Brunson D, Crespi CL, Penman BW, Wishnok JS, Tannenbaum SR: DNA damage and mutation in human cells exposed to nitric oxide in vitro. Proc Natl Acad Sci U S A. 1992, 89: 3030-3034.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bressac B, Kew M, Wands J, Ozturk M: Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature. 1991, 350: 429-431. 10.1038/350429a0.
Article
CAS
PubMed
Google Scholar
Puisieux A, Lim S, Groopman J, Ozturk M: Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens. Cancer Res. 1991, 51: 6185-6189.
CAS
PubMed
Google Scholar
Carbone D, Chiba I, Mitsudomi T: Polymorphism at codon 213 within the p53 gene. Oncogene. 1991, 6: 1691-1692.
CAS
PubMed
Google Scholar
Reme T, Travaglio A, Gueydon E, Adla L, Jorgensen C, Sany J: Mutations of the p53 tumour suppressor gene in erosive rheumatoid synovial tissue. Clin Exp Immunol. 1998, 111: 353-358. 10.1046/j.1365-2249.1998.00508.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kullmann F, Judex M, Neudecker I, Lechner S, Justen HP, Green DR, Wessinghage D, Firestein GS, Gay S, Scholmerich J, Muller-Ladner U: Analysis of the p53 tumor suppressor gene in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 1999, 42: 1594-1600. 10.1002/1529-0131(199908)42:8<1594::AID-ANR5>3.0.CO;2-#.
Article
CAS
PubMed
Google Scholar
Kitasato H, Okamoto R, Kawai S: Absence of p53 mutation in Japanese patients with rheumatoid arthritis: comment on the article by Han et al. Arthritis Rheum. 2000, 43: 469-470. 10.1002/1529-0131(200002)43:2<469::AID-ANR34>3.0.CO;2-D.
Article
CAS
PubMed
Google Scholar
Tak PP, Zvaifler NJ, Green DR, Firestein GS: Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases. Immunol Today. 2000, 21: 78-82. 10.1016/S0167-5699(99)01552-2.
Article
CAS
PubMed
Google Scholar
Lee SH, Chang DK, Goel A, Boland CR, Bugbee W, Boyle DL, Firestein GS: Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid arthritis. J Immunol. 2003, 170: 2214-2220.
Article
CAS
PubMed
Google Scholar
Seemayer CA, Kuchen S, Neidhart M, Kuenzler P, Rihoskova V, Neumann E, Pruschy M, Aicher WK, Muller LU, Gay RE, et al: p53 in rheumatoid arthritis synovial fibroblasts at sites of invasion. Ann Rheum Dis. 2003, 62: 1139-1144. 10.1136/ard.2003.007401.
Article
PubMed Central
CAS
PubMed
Google Scholar
Walsh NC, Gravallese EM: Bone loss in inflammatory arthritis: mechanisms and treatment strategies. Curr Opin Rheumatol. 2004, 16: 419-427. 10.1097/01.bor.0000127824.42507.68.
Article
PubMed
Google Scholar
Han Z, Boyle DL, Shi Y, Green DR, Firestein GS: Dominant-negative p53 mutations in rheumatoid arthritis. Arthritis Rheum. 1999, 42: 1088-1092. 10.1002/1529-0131(199906)42:6<1088::AID-ANR4>3.0.CO;2-E.
Article
CAS
PubMed
Google Scholar