Hollander AP, Pidoux I, Reiner A, Rorabeck C, Bourne R, Poole AR: Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration. J Clin Invest. 1995, 96: 2859-2869.
Article
PubMed Central
CAS
PubMed
Google Scholar
Squires GR, Okouneff A, Ionescu M, Pool AR: The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis. Arthritis Rheum. 2003, 48: 1261-1270. 10.1002/art.10976.
Article
CAS
PubMed
Google Scholar
Aurich M, Poole AR, Reiner A, Mollenhauer C, Margulis A, Kuettner KE, Cole AA: Matrix homeostasis in aging normal human ankle cartilage. Arthritis Rheum. 2002, 46: 2903-2910. 10.1002/art.10611.
Article
CAS
PubMed
Google Scholar
Martin JA, Buckwalter JA: Roles of articular cartilage aging and chondrocyte senescence in the pathogenesis of osteoarthritis. Iowa Orthop J. 2001, 21: 1-7.
PubMed Central
CAS
PubMed
Google Scholar
Aigner T, Kurz B, Fukui N, Sandell L: Roles of chondrocytes in the pathogenesis of osteoarthritis. Curr Opin Rheumatol. 2002, 14: 578-584. 10.1097/00002281-200209000-00018.
Article
CAS
PubMed
Google Scholar
Martin JA, Ellerbroek SM, Buckwalter JA: Age-related decline in chondrocyte response to insulin-like growth factor-I: the role of growth factor binding proteins. J Orthop Res. 1997, 15: 491-498. 10.1002/jor.1100150403.
Article
CAS
PubMed
Google Scholar
Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC: Telomere reduction in human colorectal carcinoma and with aging. Nature. 1990, 346: 866-868. 10.1038/346866a0.
Article
CAS
PubMed
Google Scholar
Blackburn EH: Structure and function of telomeres. Nature. 1991, 350: 569-573. 10.1038/350569a0.
Article
CAS
PubMed
Google Scholar
Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB: Telomere length predicts replicative capacity of human fibroblast. Proc Natl Acad Sci USA. 1992, 89: 10114-10118.
Article
PubMed Central
CAS
PubMed
Google Scholar
Martin JA, Buckwalter JA: Telomere erosion and senescence in human articular cartilage chondrocytes. J Gerontol A Biol Sci Med Sci. 2001, 56: B172-B179.
Article
CAS
PubMed
Google Scholar
Toussaint O, Medrano EE, von Zglinicki T: Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol. 2000, 35: 927-945. 10.1016/S0531-5565(00)00180-7.
Article
CAS
PubMed
Google Scholar
Finkel T, Holbrook NJ: Oxidants, oxidative stress and the biology of ageing. Nature. 2000, 408: 239-247. 10.1038/35041687.
Article
CAS
PubMed
Google Scholar
Arnheim N, Cortopassi G: Deleterious mitochondrial DNA mutations accumulate in aging human tissues. Mutat Res. 1992, 275: 157-167. 10.1016/0921-8734(92)90020-P.
Article
CAS
PubMed
Google Scholar
Dumont P, Burton M, Chen QM, Frippiat C, Pascal T, Dierick JF, Eliaers F, Chainiaux F, Remacle J, Toussaint O: Human diploid fibroblasts display a decreased level of c-fos mRNA at 72 hours after exposure to sublethal H2O2 stress. Ann NY Acad Sci. 2000, 908: 306-309.
Article
CAS
PubMed
Google Scholar
Oh M, Fukuda K, Asada S, Yasuda Y, Tanaka S: Concurrent generation of nitric oxide and superoxide inhibits proteoglycan synthesis in bovine articular chondrocytes: involvement of peroxynitrite. J Rheumatol. 1998, 25: 2169-2174.
CAS
PubMed
Google Scholar
Yermilov V, Rubio J, Ohshima H: Formation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination. FEBS Lett. 1995, 376: 207-210. 10.1016/0014-5793(95)01281-6.
Article
CAS
PubMed
Google Scholar
Furumoto K, Inoue E, Nagao N, Hiyama E, Miwa N: Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci. 1998, 63: 935-948. 10.1016/S0024-3205(98)00351-8.
Article
CAS
PubMed
Google Scholar
Serra V, Grune T, Sitte N, Saretzki G, von Zglinicki T: Telomere length as a marker of oxidative stress in primary human fibroblast cultures. Ann NY Acad Sci. 2000, 908: 327-330.
Article
CAS
PubMed
Google Scholar
von Zglinicki T: Oxidative stress shortens telomeres. Trends Biochem Sci. 2002, 27: 339-344. 10.1016/S0968-0004(02)02110-2.
Article
CAS
PubMed
Google Scholar
Stadler J, Stefanovic-Racic M, Billiar TR, Curran RD, McIntyre LA, Georgescu HI, Simmons RL, Evans CH: Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol. 1991, 147: 3915-3920.
CAS
PubMed
Google Scholar
Studer R, Jaffurs D, Stefanovic-Racic M, Robbins PD, Evans CH: Nitric oxide in osteoarthritis. Osteoarthritis Cartilage. 1999, 7: 377-379. 10.1053/joca.1998.0216.
Article
CAS
PubMed
Google Scholar
Pelletier JP, Jovanovic DV, Lascau-Coman V, Fernandes JC, Manning PT, Connor JR, Currie MG, Martel-Pelletier J: Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level. Arthritis Rheum. 2000, 43: 1290-1299. 10.1002/1529-0131(200006)43:6<1290::AID-ANR11>3.0.CO;2-R.
Article
CAS
PubMed
Google Scholar
Del Carlo M, Loeser RF: Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species. Arthritis Rheum. 2002, 46: 394-403. 10.1002/art.10056.
Article
CAS
PubMed
Google Scholar
Ignarro LJ, Fukuto JM, Griscavage JM, Rogers NE, Byrns RE: Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine. Proc Natl Acad Sci USA. 1993, 90: 8103-8107.
Article
PubMed Central
CAS
PubMed
Google Scholar
Reiter CD, Teng RJ, Beckman JS: Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite. J Biol Chem. 2000, 275: 32460-32466. 10.1074/jbc.M910433199.
Article
CAS
PubMed
Google Scholar
Loeser RF, Carlson CS, Del Carlo M, Cole A: Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1. Arthritis Rheum. 2002, 46: 2349-2357. 10.1002/art.10496.
Article
CAS
PubMed
Google Scholar
Collins DH: The Pathology of Articular and Spinal Diseases. In Histological changes in osteoarthritis from human articular cartilage. 1949, London: Edward Arnold and Co, 76-79.
Google Scholar
Muehleman C, Bareither D, Huch K, Cole AA, Kuettner KE: Prevalence of degenerative morphological changes in the joints of the lower extremity. Osteoarthritis Cartilage. 1997, 5: 23-37.
Article
CAS
PubMed
Google Scholar
Mankin HJ, Dorfman H, Lippiello L, Zarins A: Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am. 1971, 53: 523-537.
CAS
PubMed
Google Scholar
Parsch D, Brummendorf TH, Richter W, Fellenberg J: Replicative aging of human articular chondrocytes during ex vivo expansion. Arthritis Rheum. 2002, 46: 2911-2916. 10.1002/art.10626.
Article
CAS
PubMed
Google Scholar
Farndale RW, Buttle DJ, Barrett AJ: Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta. 1986, 883: 173-177.
Article
CAS
PubMed
Google Scholar
Martin GM, Sprahue CA, Epstein CJ: Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype. Lab Invest. 1970, 23: 86-92.
CAS
PubMed
Google Scholar
Smith JR, Braunschweiger KI: Growth of human embryonic fibroblasts at clonal density: concordance with results from mass cultures. J Cell Physiol. 1979, 98: 597-601. 10.1002/jcp.1040980317.
Article
CAS
PubMed
Google Scholar
Yudoh K, Matsuno H, Osada R, Nakazawa F, Katayama R, Kimura T: Decreased cellular activity and replicative capacity of osteoblastic cells isolated from the periarticular bone of rheumatoid arthritis patients compared with osteoarthritis patients. Arthritis Rheum. 2000, 43: 2178-2188. 10.1002/1529-0131(200010)43:10<2178::AID-ANR5>3.0.CO;2-Z.
Article
CAS
PubMed
Google Scholar
Harly CB, Futcher AB, Greider CW: Telomeres shorten during aging of human fibroblasts. Nature. 1990, 345: 458-460. 10.1038/345458a0.
Article
Google Scholar
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW: Specific association of human telomerase activity with immortal cells and cancer. Science. 1994, 266: 2011-2015.
Article
CAS
PubMed
Google Scholar
Fermor B, Weinberg JB, Pisetsky DS, Misukonis MA, Fink C, Guilak F: Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway. Osteoarthritis Cartilage. 2002, 10: 792-798. 10.1053/joca.2002.0832.
Article
CAS
PubMed
Google Scholar
Cernanec J, Guilak F, Weinberg JB, Pisetsky DS, Fermor B: Influence of hypoxia and reoxygenation on cytokine-induced production of proinflammatory mediators in articular cartilage. Arthritis Rheum. 2002, 46: 968-975. 10.1002/art.10213.
Article
CAS
PubMed
Google Scholar
Patwari P, Cook MN, DiMicco MA, Blake SM, James IE, Kumar S, Cole AA, Lark MW, Grodzinsky AJ: Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines. Arthritis Rheum. 2003, 48: 1292-1301. 10.1002/art.10892.
Article
CAS
PubMed
Google Scholar
Rathakrishnan C, Tiku K, Raghavan A, Tiku ML: Release of oxygen radicals by articular chondrocytes: a study of luminol-dependent chemiluminescence and hydrogen peroxide secretion. J Bone Miner Res. 1992, 7: 1139-1148.
Article
CAS
PubMed
Google Scholar
Rajpurohit R, Koch CJ, Tao Z, Teixeira CM, Shapiro IM: Adaptation of chondrocytes to low oxygen tension: relationship between hypoxia and cellular metabolism. J Cell Physiol. 1996, 168: 424-432. 10.1002/(SICI)1097-4652(199608)168:2<424::AID-JCP21>3.0.CO;2-1.
Article
CAS
PubMed
Google Scholar
Schipani E, Ryan HE, Didrickson S, Kobayashi T, Knight M, Johnson RS: Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev. 2001, 15: 2865-2876.
PubMed Central
CAS
PubMed
Google Scholar
Wenger RH: Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J. 2002, 16: 1151-1162. 10.1096/fj.01-0944rev.
Article
CAS
PubMed
Google Scholar
Silver IA: Measurement of pH and ionic composition of pericellular sites. Philos Trans R Soc Lond B Biol Sci. 1975, 271: 261-272.
Article
CAS
PubMed
Google Scholar
Cernanec J, Guilak F, Weinberg JB, Pisetsky DS, Fermor B: Influence of hypoxia and reoxygenation on cytokine-induced production of proinflammatory mediators in articular cartilage. Arthritis Rheum. 2002, 46: 968-975. 10.1002/art.10213.
Article
CAS
PubMed
Google Scholar
Saretzki G, Sitte N, Merkel U, Wurm RE, von Zglinicki T: Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments. Oncogene. 1999, 18: 5148-5158. 10.1038/sj.onc.1202898.
Article
CAS
PubMed
Google Scholar