Objective
Adenovirus 5 (Ad5) receptors other than Cocksackie-ad receptor have not been well explored in rheumatoid arthritis (RA) human fibroblast-like synoviocytes (FLS). Defining these receptors may enable development of improved Ad5 vectors to specific synovial targets. As Cocksackie-ad receptor is absent in RA FLS, we investigated the efficacy and receptor usage of fibre-modified Ad5 vectors for gene delivery in vitro and ex vivo.