Volume 7 Supplement 1

25th European Workshop for Rheumatology Research

Meeting abstracts

The organizer would like to thank the following companies who have generously supported the meeting: Abbott Immunology (Main sponsor), Bristol-Myers Squibb, Schering-Plough, Wyeth, AstraZeneca, MSD, Amgen

25th European Workshop for Rheumatology Research.

Glasgow, UK24-27 February 2005

Page 1 of 4

Stem cells now and in the future in medicine

Authors: A Smith

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S1

Content type: Oral presentation Published on: 17 February 2005
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Chaperonins and the regulation of immunity

Authors: GS Panayi and VC Corrigall

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S2

Content type: Oral presentation Published on: 17 February 2005
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Autoimmune diabetes: mechanisms

Authors: A Cooke

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S3

Content type: Oral presentation Published on: 17 February 2005
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Autoimmunity or immune deficiency? On the role and function of regulatory T cells in chronic arthritis

Authors: BJ Prakken and I de Kleer

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S4

Content type: Oral presentation Published on: 17 February 2005
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Tracking immune responses in vivo

Authors: MK Jenkins

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S5

Content type: Oral presentation Published on: 17 February 2005
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Successful approaches in genetics of musculoskeletal diseases

Authors: MA Brown

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S6

Content type: Oral presentation Published on: 17 February 2005
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Defining a role for fibroblasts in the persistence of chronic inflammatory joint disease

Authors: C Buckley, A Filer, O Haworth, G Parsonage, K Raza and M Salmon

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S14

Content type: Oral presentation Published on: 17 February 2005
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Molecular signatures of rheumatoid arthritis characterized by transcriptome and proteome analysis

Authors: MO Glocker, J Kekow and H-J Thiesen

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S7

Content type: Oral presentation Published on: 17 February 2005
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Regulating apoptosis in fibroblasts

Authors: T Pap, A Cinski, A Drynda, A Wille, A Baier, S Gay and I Meinecke

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S15

Content type: Oral presentation Published on: 17 February 2005
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Mechanisms of cartilage matrix turnover: synergistic interactions of proinflammatory cytokines with oncostatin M in upregulating matrix metalloproteinases and ADAMTS metalloproteinases

Authors: TE Cawston, H Bigg, J Milner, J Catterall, T Morgan, E Barksby, W Hui and A Rowan

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S10

Content type: Oral presentation Published on: 17 February 2005
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Collagenases and aggrecanases: understanding the role of non-catalytic domains in cartilage matrix breakdown

Authors: H Nagase, R Visse, M Kashiwagi, C Gendron and Y Itoh

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S11

Content type: Oral presentation Published on: 17 February 2005
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The effects of inflammatory arthritis on bone remodeling

Authors: SR Goldring

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S12

Content type: Oral presentation Published on: 17 February 2005
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Genetics and bone disease

Authors: SH Ralston

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S13

Content type: Oral presentation Published on: 17 February 2005
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Signal transduction in T lymphocytes

Authors: D Cantrell

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S17

Content type: Oral presentation Published on: 17 February 2005
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Innate immunity and the anti-viral state of rheumatoid synovium

Authors: GS Firestein

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S16

Content type: Oral presentation Published on: 17 February 2005
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Differential effects of T-cell specific PKC-theta inhibition or selective intra-articular NF-κB inhibition on synovial inflammation in rat adjuvant arthritis

Authors: SW Tas, MJ Vervoordeldonk, N Hajji, M May, S Ghosh and PP Tak

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P1

Content type: Poster presentation Published on: 17 February 2005
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Positive cytoplasmic indirect immunofluorescence on HEp2 cells of unknown pattern: what to report to rheumatologists

Authors: Z Rotar, B Boziè, B Rozman and T Kveder

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P2

Content type: Poster presentation Published on: 17 February 2005
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Synovial hypoxia inducible factor-1α expression is inversely related to tissue oxygen levels in vivo in inflammatory arthritis

Authors: P Donatien, V Sandhu, D Peston, A Sandisson and PC Taylor

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P3

Content type: Poster presentation Published on: 17 February 2005
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Prophylactic administration of abatacept (CTLA4-Ig; BMS-188667) prevents disease induction and bone destruction in a rat model of collagen-induced arthritis

Authors: C Kliwinski, D Kukral, J Postelnek, B Krishnan, L Killar, S Nadler and R Townsend

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P4

Content type: Poster presentation Published on: 17 February 2005
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The transcription T-bet is required for optimal proinflammatory trafficking of CD4⁺T cells

Authors: RM Rao, GM Lord, H Choe, AH Lichtman, FW Luscinskas and LH Glimcher

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P5

Content type: Poster presentation Published on: 17 February 2005
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Specificity of CD4 T-cell responses to aggrecan in BALB/c and DR1 transgenic mice

Authors: K Lowes, AA von Delwig, N McKie, DM Altmann, JA Goodacre, AD Rowan and JH Robinson

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P6

Content type: Poster presentation Published on: 17 February 2005
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The role of hypoxia in rheumatoid tendon disease

Authors: B Sivakumar, N Kang, P Taylor and EM Paleolog

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P7

Content type: Poster presentation Published on: 17 February 2005
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Short-fibre modification facilitates adenovirus-mediated gene delivery in rheumatoid arthritis synoviocytes and synovium: role of RGD and non-RGD binding integrins

Authors: M-L Toh, S-S Hong, L Franqueville, L Lindholm, P Boulanger and P Miossec

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P8

Content type: Poster presentation Published on: 17 February 2005
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Laminin type 1 augments the transforming growth factor beta-induced expression of matrix metalloproteinase 3 in synovial fibroblasts

Authors: M Hoberg, M Rudert and WK Aicher

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P9

Content type: Poster presentation Published on: 17 February 2005
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Peptide mimetics of anti-dsDNA idiotypes as a tool for lupus-specific IVIG preparation: specificity and efficacy in the treatment of experimental systemic lupus erythematosus

Authors: M Blank, I Nur, R Meidler, L Bar, L Slutzki and Y Shoenfeld

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P10

Content type: Poster presentation Published on: 17 February 2005
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Acceleration of apoptotic cells clearance by macrophages upon exposure to serum amyloid P component and its synthetic derivates

Authors: L Slutzky, M Blank, G Goddard, M Fridkin and Y Shoenfeld

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P11

Content type: Poster presentation Published on: 17 February 2005
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Close association between valvular heart disease and central nervous system manifestations in antiphospholipid syndrome

Authors: I Krause, S Lev, A Fraser, M Blank, J Chapman and Y Shoenfeld

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P12

Content type: Poster presentation Published on: 17 February 2005
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Elevated titers of anti-ribosomal-P antibodies in systemic lupus erythematosus

Authors: G Zandman-Goddard, B Gilburd, S Bardechevski, L Stojanovich, P Langevitz and Y Shoenfeld

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P13

Content type: Poster presentation Published on: 17 February 2005
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Human type II collagen is processed in lysosomal compartments of macrophages for presentation of the glycosylated arthritogenic epitope hCII_259–273to CD4 T cells in HLA-DR1 transgenic mice

Authors: A von Delwig, DM Altmann, JD Isaacs, R Holmdahl, N McKie and JH Robinson

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P14

Content type: Poster presentation Published on: 17 February 2005
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Does the burden of inflammation determined prospectively in patients with early inflammatory arthritis determine the progression of atherosclerosis?

Authors: WY Al-Shehhi, S Skehan, E Hefferenan, F Hughes, DJ Veale, B Bresinihan and O Fitzgerald

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P15

Content type: Poster presentation Published on: 17 February 2005
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Altered composition of CD97 splice variants in rheumatoid synovial tissue

Authors: FA van Gaalen, TCTM van der Pouw Kraan, RGHH Nelissen, TWJ Huizinga and CL Verweij

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P16

Content type: Poster presentation Published on: 17 February 2005
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Improvement of T-cell function in rheumatoid arthritis (RA) patients in clinical remission is associated with the recovery of IL-7 expression and depends on a familial history of RA

Authors: F Ponchel, AK Brown, SL Field, L Hensor, P Emery and JD Isaacs

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P17

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T-bet expression in rheumatoid arthritis patients with early, disease-modifying anti-rheumatic drug naïve disease is low and correlates with low levels of IL-7 and T-cell dysfunctions

Authors: F Ponchel, AK Brown, SL Field, M Quinn, P Conaghan, P Emery and JD Isaacs

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P18

Content type: Poster presentation Published on: 17 February 2005
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The signalling signature downstream of the notch receptor in CD4⁺CD25^highregulatory T cells in RA defines anergic cells: insight into resistance to anti-tumour necrosis factor therapies

Authors: MH Buch, K Snow, S Field, P Emery, J Isaacs and F Ponchel

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P19

Content type: Poster presentation Published on: 17 February 2005
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Citrullinated α enolase, a novel citrullinated autoantigen in rheumatoid arthritis, upregulated by chronic inflammation

Authors: A Kinloch, V Tatzer, R Wait, D Peston, S Sacre, P Donatien, D Moyes, P Taylor and PJ Venables

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P20

Content type: Poster presentation Published on: 17 February 2005
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Abatacept (CTLA4-Ig) modulates human T-cell proliferation and cytokine production but does not affect lipopolysaccharide-induced tumor necrosis factor alpha production by monocytes

Authors: PM Davis, SG Nadler, KA Rouleau and SJ Suchard

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P21

Content type: Poster presentation Published on: 17 February 2005
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Intra-articular gene therapy blocking NF-κB using adeno-associated virus type 5 ameliorates adjuvant arthritis in rats

Authors: J Adriaansen, SW Tas, N Hajji, A Bakker, MJ Vervoordeldonk and PP Tak

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P22

Content type: Poster presentation Published on: 17 February 2005
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Collagenous repeat containing sequence of 26 kDa protein: a novel mesenchymal gene of cartilage and adipose tissue differentiation

Authors: IH Tarner, C Büchler, J Schölmerich, E Neumann, S Gay, A Schäffler and U Müller-Ladner

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P23

Content type: Poster presentation Published on: 17 February 2005
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Activation of antigen-presenting cells by endogenous retroviral RNA

Authors: D Moyes, S Sacre, N Temperton, A Lundberg, B Foxwell and P Venables

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P24

Content type: Poster presentation Published on: 17 February 2005
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Anti-tumour necrosis factor alpha treatment in patients affected by rheumatoid arthritis with anti-Ro/SSA antibodies

Authors: I Cavazzana, F Franceschini, E Danieli, P Airò and R Cattaneo

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P25

Content type: Poster presentation Published on: 17 February 2005
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Ha-Ras/ERK1-2 pathway is responsible for oxygen species generation in scleroderma fibroblasts

Authors: S Svegliati, MM Luchetti, P Paroncini, A DiCarlo, F Bevilacqua, N Campelli, E Avvedimento and A Gabrielli

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P26

Content type: Poster presentation Published on: 17 February 2005
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Magnetic resonance imaging examinations of the spine in patients with ankylosing spondylitis before and after therapy with the tumor necrosis factor alpha receptor fusion protein etanercept

Authors: X Baraliakos, J Davis, W Tsuji and J Braun

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P27

Content type: Poster presentation Published on: 17 February 2005
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Two-year follow-up results after re-administration of etanercept in active ankylosing spondylitis

Authors: X Baraliakos, J Brandt, J Listing, H Haibel, HM Rudwaleit, J Sieper and J Braun

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P28

Content type: Poster presentation Published on: 17 February 2005
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Clinical response to the anti-tumor necrosis factor alpha antibody infliximab in patients with ankylosing spondylitis over 3 years

Authors: X Baraliakos, J Brandt, J Listing, J Sieper and J Braun

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P29

Content type: Poster presentation Published on: 17 February 2005
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Clinical response to discontinuation of anti-tumor necrosis factor therapy in patients with ankylosing spondylitis after 3 years of continuous treatment with infliximab

Authors: X Baraliakos, J Listing, J Brandt, M Rudwaleit, J Sieper and J Braun

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P30

Content type: Poster presentation Published on: 17 February 2005
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Radiographic progression in patients with ankylosing spondylitis after 2 years of treatment with the tumor necrosis factor alpha antibody infliximab

Authors: X Baraliakos, J Listing, M Rudwaleit, J Brandt, J Sieper and J Braun

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P31

Content type: Poster presentation Published on: 17 February 2005
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Oxygen radical production determines chondrocyte death and regulates matrix metalloproteinase-mediated matrix degradation during interferon gamma-accelerated immune complex arthritis

Authors: PLEM van Lent, KCAM Nabbe, AEM Holthuysen, JK Kolls, SM Holland and WB van den Berg

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P32

Content type: Poster presentation Published on: 17 February 2005
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In systemic sclerosis, levels of tissue kallikrein are related to microvascular changes assayed by videocapillaroscopy and immunohistochemistry

Authors: A Del Rosso, AF Milia, LI Manneschi, O Distler, S Guiducci, A Pignone, S Gay and MM Cerinic

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P33

Content type: Poster presentation Published on: 17 February 2005
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A complete phylogenetic analysis coupling expression data from EST databases. An example with a family of genes: the peptidyl arginine deiminase genes

Authors: N Balandraud, P Gouret, E Danchin, M Blanc, D Zinn and P Pontarotti

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P34

Content type: Poster presentation Published on: 17 February 2005
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Expression of innate immune receptors in the immunopathologic lesion of primary Sjogren's syndrome: preliminary results

Authors: E Bourazopoulou, EK Kapsogeorgou, JG Routsias, DA Liakos, HM Moutsopoulos and AG Tzioufas

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P35

Content type: Poster presentation Published on: 17 February 2005
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25th European Workshop for Rheumatology Research

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