Ribosomal P is located in the cytoplasm. The detection of antibodies is to the 60 kda fraction. Anti-ribosomal P antibodies are highly specific for systemic lupus erythematosus (SLE), and are detected at a 15–20% frequency according to the literature. Elevated anti-ribosomal P titers correlate with disease activity and are specifically associated with neuropsychiatric disease such as psychosis/depression. and coexist with anti-dsDNA antibodies. The aim of our study was to evaluate the frequency of anti-ribosomal P antibody titers and the correlation with manifestations in SLE patients.