Background
Collagenous repeat containing sequence of 26 kDa protein (CORS-26) is a recently discovered novel member of the TNF/C1q/adiponectin superfamily. CORS-26 has been detected in chondrocytes and osteoblasts, but its functional properties are largely unknown. As CORS-26 shows structural analogies to adiponectin, which has been shown to exert proinflammatory and destructive properties in arthritic synovium, the goal of the present study was to examine the expression and regulation of CORS-26 in adipocyte differentiation.