Objective
Dendritic cells (DC) play an important role for initiation and regulation of immune response. Recent experimental evidence points out the fact that immature dendritic cells (iDC) can mediate tolerance, presumably by the induction of regulatory T cells. Therefore, we explored the effects of iDC injection on the development of collagen-induced arthritis in mice and compared them with tumour necrosis factor-matured DC, which we were previously shown efficient in collagen-induced arthritis.