Etienne-Manneville S, Hall A: Rho GTPases in cell biology. Nature. 2002, 420: 629-635. 10.1038/nature01148.
Article
CAS
PubMed
Google Scholar
Bar-Sagi D, Hall A: Ras and Rho GTPases: a family reunion. Cell. 2000, 13: 227-238. 10.1016/S0092-8674(00)00115-X.
Article
Google Scholar
Yamamoto M, Marui N, Sakai T, Morii N, Kozaki S, Ikai K, Imamura S, Narumiya S: ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle. Oncogene. 1993, 8: 1449-1455.
CAS
PubMed
Google Scholar
Rodriguez-Fernandez JL, Sanchez-Martin L, Rey M, Vicente-Manzanares M, Narumiya S, Teixido J, Sanchez-Madrid F, Cabanas C: Rho and Rho-associated kinase modulate the tyrosine kinase PYK2 in T-cells through regulation of the activity of the integrin LFA-1. J Biol Chem. 2001, 276: 40518-40527. 10.1074/jbc.M102896200.
Article
CAS
PubMed
Google Scholar
Van Aelst L, D'Souza-Schorey C: Rho GTPases and signaling networks. Genes Dev. 1997, 11: 2295-2322.
Article
CAS
PubMed
Google Scholar
Coughlin SR: How the protease thrombin talks to cells. Proc Natl Acad Sci USA. 1999, 96: 11023-11027. 10.1073/pnas.96.20.11023.
Article
PubMed Central
CAS
PubMed
Google Scholar
Barr AJ, Brass LF, Manning DR: Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor. G protein coupling. J Biol Chem. 1997, 272: 2223-2229. 10.1074/jbc.272.52.32979.
Article
CAS
PubMed
Google Scholar
Vogt S, Grosse R, Schultz G, Offermanns S: Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11. J Biol Chem. 2003, 278: 28743-28749. 10.1074/jbc.M304570200.
Article
CAS
PubMed
Google Scholar
Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB: Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement. J Biol Chem. 2003, 278: 28793-28798. 10.1074/jbc.M303900200.
Article
CAS
PubMed
Google Scholar
Hart MJ, Jang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G: Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Science. 1998, 280: 2112-2114. 10.1126/science.280.5372.2112.
Article
CAS
PubMed
Google Scholar
Bhattacharyya R, Wedegaertner PB: Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. J Biol Chem. 2000, 275: 14992-14999. 10.1074/jbc.M000415200.
Article
CAS
PubMed
Google Scholar
Wells CD, Liu MY, Jackson M, Gutowski S, Sternweis PM, Rothstein JD, Kozasa T, Sternweis PC: Mechanisms for reversible regulation between G13 and Rho exchange factors. J Biol Chem. 2002, 277: 1174-1181. 10.1074/jbc.M105274200.
Article
CAS
PubMed
Google Scholar
Tharaux PL, Bukoski RC, Rocha PN, Crowley SD, Ruiz P, Nataraj C, Howell DN, Kaibuchi K, Spurney RF, Coffman TM: Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. J Immunol. 2003, 171: 96-105.
Article
CAS
PubMed
Google Scholar
Salazar-Fontana LI, Barr V, Samelson LE, Bierer BE: CD28 engagement promotes actin polymerization through the activation of the small Rho GTPase Cdc42 in human T cells. J Immunol. 2003, 171: 2225-2232.
Article
CAS
PubMed
Google Scholar
Vicente-Manzanares M, Rey M, Perez-Martinez M, Yanez-Mo M, Sancho D, Cabrero JR, Barreiro O, de la Fuente H, Itoh K, Sanchez-Madrid F: The RhoA effector mDia is induced during T cell activation and regulates actin polymerization and cell migration in T lymphocytes. J Immunol. 2003, 171: 1023-1034.
Article
CAS
PubMed
Google Scholar
Lee JR, Ha YJ, Kim HJ: Cutting edge: induced expression of a RhoA-specific guanine nucleotide exchange factor, p190RhoGEF, following CD40 stimulation and WEHI 231 B cell activation. J Immunol. 2003, 170: 19-23.
Article
CAS
PubMed
Google Scholar
Woodside DG, Wooten DK, McIntyre BW: Adenosine diphosphate (ADP)-ribosylation of the guanosine triphosphatase (GTPase) rho in resting peripheral blood human T lymphocytes results in pseudopodial extension and the inhibition of T cell activation. J Exp Med. 1998, 188: 1211-1221. 10.1084/jem.188.7.1211.
Article
PubMed Central
CAS
PubMed
Google Scholar
Costello PS, Walters AE, Mee PJ, Turner M, Reynolds LF, Prisco A, Sarner N, Zamoyska R, Tybulewicz VL: The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways. Proc Natl Acad Sci USA. 1999, 96: 3035-3040. 10.1073/pnas.96.6.3035.
Article
PubMed Central
CAS
PubMed
Google Scholar
Feldmann M: Pathogenesis of arthritis: recent research progress. Nat Immunol. 2001, 2: 771-773. 10.1038/ni0901-771.
Article
CAS
PubMed
Google Scholar
Mojcik CF, Shevach EM: Adhesion molecules: a rheumatologic perspective. Arthritis Rheum. 1997, 40: 991-1004.
Article
CAS
PubMed
Google Scholar
Weinberg JB, Pippen AM, Greenberg CS: Extravascular fibrin formation and dissolution in synovial tissue of patients with osteoarthritis and rheumatoid arthritis. Arthritis Rheum. 1991, 34: 996-1005.
Article
CAS
PubMed
Google Scholar
Shin H, Nakajima T, Kitajima I, Shigeta K, Abeyama K, Imamura T, Okano T, Kawahara K, Nakamura T, Maruyama I: Thrombin receptor-mediated synovial proliferation in patients with rheumatoid arthritis. Clin Immunol Immunopathol. 1995, 76: 225-233. 10.1006/clin.1995.1120.
Article
CAS
PubMed
Google Scholar
Gabazza EC, Osamu T, Yamakami T, Ibata H, Sato T, Sato Y, Shima T: Correlation between clotting and collagen metabolism markers in rheumatoid arthritis. Thromb Haemost. 1994, 71: 199-202.
CAS
PubMed
Google Scholar
Ohba T, Takase Y, Ohhara M, Kasukawa R: Thrombin in the synovial fluid of patients with rheumatoid arthritis mediates proliferation of synovial fibroblast-like cells by induction of platelet derived growth factor. J Rheumatol. 1996, 23: 1505-1511.
CAS
PubMed
Google Scholar
Shin H, Kitajima I, Nakajima T, Shao Q, Tokioka T, Takasaki I, Hanyu N, Kubo T, Maruyama I: Thrombin receptor mediated signals induce expressions of interleukin 6 and granulocyte colony stimulating factor via NF-kappa B activation in synovial fibroblasts. Ann Rheum Dis. 1999, 58: 55-60.
Article
PubMed Central
CAS
PubMed
Google Scholar
Maruyama N, Hirano F, Yoshikawa N, Migita K, Eguchi K, Tanaka H: Thrombin stimulates cell proliferation in human fibroblast-like synoviocytes in nuclear factor-kappaB activation and protein kinase C mediated pathway. J Rheumatol. 2000, 27: 2777-2785.
CAS
PubMed
Google Scholar
Malik AB, Fenton JWII: Thrombin-mediated increase in vascular endothelial permeability. Semin Thromb Hemost. 1992, 18: 193-199.
Article
CAS
PubMed
Google Scholar
Varisco PA, Peclat V, van Ness K, Bischof-Delaloye A, So A, Busso N: Effect of thrombin inhibition on synovial inflammation in antigen induced arthritis. Ann Rheum Dis. 2000, 59: 781-787. 10.1136/ard.59.10.781.
Article
PubMed Central
CAS
PubMed
Google Scholar
Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988, 31: 315-324.
Article
CAS
PubMed
Google Scholar
Altman R, Alarcon G, Appelrouth D, Bloch D, Borenstein D, Brandt K, Brown C, Cooke TD, Daniel W, Gray R, et al: The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum. 1990, 33: 1601-1610.
Article
CAS
PubMed
Google Scholar
Altman R, Alarcon G, Appelrouth D, Bloch D, Borenstein D, Brandt K, Brown C, Cooke TD, Daniel W, Feldman D, et al: The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip. Arthritis Rheum. 1991, 34: 505-514.
Article
CAS
PubMed
Google Scholar
Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M, et al: Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986, 29: 1039-1049.
Article
CAS
PubMed
Google Scholar
Maruyama Y, Nishida M, Sugimoto Y, Tanabe S, Turner JH, Kozasa T, Wada T, Nagao T, Kurose H: Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy. Circ Res. 2002, 91: 961-969. 10.1161/01.RES.0000043282.39776.7C.
Article
CAS
PubMed
Google Scholar
Tanaka Y, Albelda SM, Horgan KJ, van Seventer GA, Shimizu Y, Newman W, Hallam J, Newman PJ, Buck CA, Shaw S: CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion. J Exp Med. 1992, 176: 245-253. 10.1084/jem.176.1.245.
Article
CAS
PubMed
Google Scholar
Tanaka Y, Minami Y, Mine S, Hirano H, Fujimoto H, Fujii K, Saito K, Tsukada J, van Kooyk Y, Figdor CG, et al: H-Ras signals to cytoskeletal machinery in induction of integrin-mediated adhesion of T cells. J Immunol. 1999, 163: 6209-6216.
CAS
PubMed
Google Scholar
Tanaka Y, Mine S, Figdor CG, Wake A, Hirano H, Tsukada J, Aso M, Fujii K, Saito K, van Kooyk Y, et al: Constitutive chemokine production results in activation of leukocyte function-associated antigen-1 on adult T-cell leukemia cells. Blood. 1998, 91: 3909-3919.
CAS
PubMed
Google Scholar
van Nieuw Amerongen GP, van Delft S, Vermeer MA, Collard JG, van Hinsbergh VW: Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases. Circ Res. 2000, 87: 335-340.
Article
CAS
PubMed
Google Scholar
Ren XD, Kiosses WB, Schwartz MA: Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J. 1999, 18: 578-585. 10.1093/emboj/18.3.578.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wells C, Jiang X, Gutowski S, Sternweis PC: Functional characterization of p115 RhoGEF. Methods Enzymol. 2002, 345: 371-382.
Article
PubMed
Google Scholar
Yuan J, Slice LW, Rozengurt E: Activation of protein kinase D by signaling through Rho and the alpha subunit of the heterotrimeric G protein G13. J Biol Chem. 2001, 276: 38619-38627. 10.1074/jbc.M105530200.
Article
CAS
PubMed
Google Scholar
Kozasa T, Jiang X, Hart MJ, Sternweis PM, Singer WD, Gilman AG, Bollag G, Sternweis PC: p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. Science. 1998, 280: 2109-2111. 10.1126/science.280.5372.2109.
Article
CAS
PubMed
Google Scholar
Kozasa T: Regulation of G protein-mediated signal transduction by RGS proteins. Life Sci. 2001, 68: 2309-2317. 10.1016/S0024-3205(01)01020-7.
Article
CAS
PubMed
Google Scholar
Gilchrist A, Vanhauwe JF, Li A, Thomas TO, Voyno-Yasenetskaya T, Hamm HE: G alpha minigenes expressing C-terminal peptides serve as specific inhibitors of thrombin-mediated endothelial activation. J Biol Chem. 2001, 276: 25672-25679. 10.1074/jbc.M100914200.
Article
CAS
PubMed
Google Scholar
Morris R, Winyard PG, Brass LF, Blake DR, Morris CJ: Thrombin receptor expression in rheumatoid and osteoarthritic synovial tissue. Ann Rheum Dis. 1996, 55: 841-843.
Article
PubMed Central
CAS
PubMed
Google Scholar
Marra F, DeFranco R, Grappone C, Milani S, Pinzani M, Pellegrini G, Laffi G, Gentilini P: Expression of the thrombin receptor in human liver: up-regulation during acute and chronic injury. Hepatology. 1998, 27: 462-471. 10.1002/hep.510270221.
Article
CAS
PubMed
Google Scholar
Ceuppens JL, Baroja ML, Lorre K, van Damme J, Billiau A: Human T cell activation with phytohemagglutinin. The function of IL-6 as an accessory signal. J Immunol. 1988, 141: 3868-3874.
CAS
PubMed
Google Scholar
Gauldie J, Richards C, Harnish D, Lansdorp P, Baumann H: Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc Natl Acad Sci USA. 1987, 84: 7251-7255.
Article
PubMed Central
CAS
PubMed
Google Scholar
Houssiau FA, Devogelaer JP, van Damme J, de Deuxchaisnes CN, van Snick J: Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 1988, 31: 784-788.
Article
CAS
PubMed
Google Scholar
Fujii K, Tanaka Y, Hubscher S, Saito K, Ota T, Eto S: Crosslinking of CD44 on rheumatoid synovial cells augment interleukin 6 production. Lab Invest. 1999, 79: 1439-1446.
CAS
PubMed
Google Scholar
Mihara M, Moriya Y, Kishimoto T, Ohsugi Y: Interleukin-6 (IL-6) induces the proliferation of synovial fibroblastic cells in the presence of soluble IL-6 receptor. Br J Rheumatol. 1995, 34: 321-325.
Article
CAS
PubMed
Google Scholar
Kotake S, Sato K, Kim KJ, Takahashi N, Udagawa N, Nakamura I, Yamaguchi A, Kishimoto T, Suda T, Kashiwazaki S: Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res. 1996, 11: 88-95.
Article
CAS
PubMed
Google Scholar