Figure 2
From: Rheumatoid arthritis as a hyper-endoplasmic reticulum-associated degradation disease
Schematic representation of the proposed biological functions of Synoviolin. Synoviolin has important functions in the endoplasmic reticulum (ER)-associated degradation (ERAD) system. Synoviolin maintains ER function by eliminating unfolded proteins. ATF6, activating transcription factor 6; IRE1, inositol-requiring enzyme 1; PERK, PKR-like ER kinase; Ub, ubiquitin; UPR, unfolded protein response.