Current status of lupus genetics

Table 2 Linkage effects found in OMRF pedigrees using stratification

Linkage region	LOD	Cohort ethnicity	Stratification criteria	Ref(s)
2q34*	P = 0.00002^†	AA	Nephritis	[93,94]
5p15	6.2	EA, AA, HIS	Alleged rheumatoid arthritis	[98,99]
5q14	5.0	EA	Autoimmune thyroid disease	[100]
11p13	3.7	AA	Discoid lupus, thrombocytopenia	[101,102]
11q14	4.7	AA	Hemolytic anemia, nucleolar ANA	[102-104]
17p12	4.0	EA	Vitiligo	[22,105]
19p13.2	3.6	EA	Anti-dsDNA	[87,106]

*This region is orthologous to that containing the mouse lupus susceptibility locus sle7 [107]. ^†The 2q34 region was analyzed using sib-pair methods; therefore, a P value is generated instead of a log of odds (LOD) score. AA, African-American; ANA, anti-nuclear antibody; EA, European-American; HIS, Hispanic; OMRF, Oklahoma Medical Research Foundation.

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